1DT6

STRUCTURE OF MAMMALIAN CYTOCHROME P450 2C5

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	CYTOCHROME P450 2C5	polymer	473	53884.3	1	UniProt (P00179) Pfam (PF00067) In PDB	Oryctolagus cuniculus (rabbit)	PROGESTERONE 21-HYDROXYLASE, CYPIIC5 P450 1, P450IIC5
2	A	SAMARIUM (III) ION	non-polymer		150.4	1	Chemie (SM)
3	A	SULFATE ION	non-polymer		96.1	3	Chemie (SO4)
4	A	PROTOPORPHYRIN IX CONTAINING FE	non-polymer		616.5	1	Chemie (HEM)

Sequence modifications

A: 21 - 487 (UniProt: P00179)

PDB	External Database	Details
Met 19	-	expression tag
Ala 20	-	expression tag
Lys 22	Gln 22	engineered mutation
Thr 23	Asn 23	engineered mutation
Ser 25	Gly 25	engineered mutation
Lys 26	Arg 26	engineered mutation
Arg 97	Thr 97	engineered mutation
His 202	Asn 202	engineered mutation
Glu 206	Arg 206	engineered mutation
Leu 207	Ile 207	engineered mutation
Gly 209	Ser 209	engineered mutation
Thr 210	Ser 210	engineered mutation
Gln 252	Glu 252	engineered mutation
His 488	-	expression tag
His 489	-	expression tag
His 490	-	expression tag
His 491	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	53884.3
Non-Polymers*	Number of molecules	5
	Total formula weight	1055.0
All*	Total formula weight	54939.3

*Water molecules are not included.