7A0M
| TSC1 N-terminal domain | Descriptor: | SULFATE ION, TSC1 N-terminal domain | Authors: | Zech, R, Kiontke, S, Kuemmel, D. | Deposit date: | 2020-08-10 | Release date: | 2021-05-26 | Last modified: | 2021-07-14 | Method: | X-RAY DIFFRACTION (2.32 Å) | Cite: | TSC1 binding to lysosomal PIPs is required for TSC complex translocation and mTORC1 regulation. Mol.Cell, 81, 2021
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8JAT
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5EJC
| Crystal structural of the TSC1-TBC1D7 complex | Descriptor: | Hamartin, TBC1 domain family member 7 | Authors: | Wang, Z, Qin, J, Gong, W, Xu, W. | Deposit date: | 2015-11-01 | Release date: | 2016-03-02 | Last modified: | 2019-11-27 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structural Basis of the Interaction between Tuberous Sclerosis Complex 1 (TSC1) and Tre2-Bub2-Cdc16 Domain Family Member 7 (TBC1D7). J.Biol.Chem., 291, 2016
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4KK1
| Crystal Structure of TSC1 core domain from S. pombe | Descriptor: | Tuberous sclerosis 1 protein homolog | Authors: | Sun, W, Zhu, Y, Wang, Z.Z, Zhong, Q, Gao, F, Lou, J.Z, Gong, W.M, Xu, W.Q. | Deposit date: | 2013-05-05 | Release date: | 2013-07-17 | Last modified: | 2013-07-31 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Crystal structure of the yeast TSC1 core domain and implications for tuberous sclerosis pathological mutations. Nat Commun, 4, 2013
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4KK0
| Crystal Structure of TSC1 core domain from S. pombe | Descriptor: | Tuberous sclerosis 1 protein homolog | Authors: | Sun, W, Zhu, Y, Wang, Z.Z, Zhong, Q, Gao, F, Lou, J.Z, Gong, W.M, Xu, W.Q. | Deposit date: | 2013-05-05 | Release date: | 2013-07-17 | Last modified: | 2013-07-31 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Crystal structure of the yeast TSC1 core domain and implications for tuberous sclerosis pathological mutations. Nat Commun, 4, 2013
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7A0N
| Structure of TSC1 NTD and linker domain | Descriptor: | Uncharacterized protein,Uncharacterized protein | Authors: | Fitzian, K, Kuemmel, D. | Deposit date: | 2020-08-10 | Release date: | 2021-05-26 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (4.3 Å) | Cite: | TSC1 binding to lysosomal PIPs is required for TSC complex translocation and mTORC1 regulation. Mol.Cell, 81, 2021
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4Z6Y
| Structure of the TBC1D7-TSC1 complex | Descriptor: | Hamartin, TBC1 domain family member 7 | Authors: | Gai, Z, Wu, G. | Deposit date: | 2015-04-06 | Release date: | 2016-04-20 | Method: | X-RAY DIFFRACTION (2.81 Å) | Cite: | Structure of the TBC1D7-TSC1 complex To Be Published
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7DL2
| Cryo-EM structure of human TSC complex | Descriptor: | Hamartin, Isoform 7 of Tuberin, TBC1 domain family member 7, ... | Authors: | Yang, H, Yu, Z, Chen, X, Li, J, Li, N, Cheng, J, Gao, N, Yuan, H, Ye, D, Guan, K, Xu, Y. | Deposit date: | 2020-11-25 | Release date: | 2020-12-16 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (4.4 Å) | Cite: | Structural insights into TSC complex assembly and GAP activity on Rheb. Nat Commun, 12, 2021
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6EMK
| Cryo-EM Structure of Saccharomyces cerevisiae Target of Rapamycin Complex 2 | Descriptor: | Serine/threonine-protein kinase TOR2, Target of rapamycin complex 2 subunit AVO1, Target of rapamycin complex 2 subunit AVO2, ... | Authors: | Karuppasamy, M, Kusmider, B, Oliveira, T.M, Gaubitz, C, Prouteau, M, Loewith, R, Schaffitzel, C. | Deposit date: | 2017-10-02 | Release date: | 2017-12-06 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (7.9 Å) | Cite: | Cryo-EM structure of Saccharomyces cerevisiae target of rapamycin complex 2. Nat Commun, 8, 2017
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5HIU
| Structure of the TSC2 N-terminus | Descriptor: | GTPase activator-like protein | Authors: | Zech, R, Kiontke, S, Kummel, D. | Deposit date: | 2016-01-12 | Release date: | 2016-08-10 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure of the Tuberous Sclerosis Complex 2 (TSC2) N Terminus Provides Insight into Complex Assembly and Tuberous Sclerosis Pathogenesis. J.Biol.Chem., 291, 2016
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3LQ9
| Crystal structure of human REDD1, a hypoxia-induced regulator of mTOR | Descriptor: | DNA-damage-inducible transcript 4 protein | Authors: | Vega-Rubin-de-Celis, S, Abdallah, Z, Brugarolas, J, Zhang, X. | Deposit date: | 2010-02-08 | Release date: | 2010-03-09 | Last modified: | 2017-11-01 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural analysis and functional implications of the negative mTORC1 regulator REDD1. Biochemistry, 49, 2010
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6SSH
| Structure of the TSC2 GAP domain | Descriptor: | 1,2-ETHANEDIOL, GTPase activator-like protein | Authors: | Hansmann, P, Kiontke, S, Kummel, D. | Deposit date: | 2019-09-06 | Release date: | 2020-05-27 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Structure of the TSC2 GAP Domain: Mechanistic Insight into Catalysis and Pathogenic Mutations. Structure, 28, 2020
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3QWL
| Crystal structure of human TBC1 domain family member 7 | Descriptor: | TBC1 domain family member 7, UNKNOWN ATOM OR ION | Authors: | Guan, X, Tempel, W, Tong, Y, Wernimont, A.K, Landry, R, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Park, H, Structural Genomics Consortium (SGC) | Deposit date: | 2011-02-28 | Release date: | 2011-06-01 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal structure of human TBC1 domain family member 7 to be published
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6IYY
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6KLR
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6XK9
| Cereblon in complex with DDB1, CC-90009, and GSPT1 | Descriptor: | 2-(4-chlorophenyl)-N-({2-[(3S)-2,6-dioxopiperidin-3-yl]-1-oxo-2,3-dihydro-1H-isoindol-5-yl}methyl)-2,2-difluoroacetamide, DNA damage-binding protein 1, Eukaryotic peptide chain release factor GTP-binding subunit ERF3A, ... | Authors: | Clayton, T.L, Tran, E.T, Zhu, J, Pagarigan, B.E, Matyskiela, M.E, Chamberlain, P.P. | Deposit date: | 2020-06-25 | Release date: | 2020-12-02 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.64 Å) | Cite: | CC-90009, a novel cereblon E3 ligase modulator, targets acute myeloid leukemia blasts and leukemia stem cells. Blood, 137, 2021
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1YZ1
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8QOF
| Cryo-EM structure of the yeast SPT-Orm2-Dimer complex | Descriptor: | 2-{[(4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranosyl)oxy]methyl}-4-{[(3beta,9beta,14beta,17beta,25R)-spirost-5-en-3-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranoside, ORM2 isoform 1, PYRIDOXAL-5'-PHOSPHATE, ... | Authors: | Schaefer, J, Koerner, C, Moeller, A, Froehlich, F. | Deposit date: | 2023-09-28 | Release date: | 2024-09-04 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | The structure of the Orm2-containing serine palmitoyltransferase complex reveals distinct inhibitory potentials of yeast Orm proteins. Cell Rep, 43, 2024
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8QOG
| Cryo-EM structure of the yeast SPT-Orm2-Monomer complex | Descriptor: | 2-{[(4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranosyl)oxy]methyl}-4-{[(3beta,9beta,14beta,17beta,25R)-spirost-5-en-3-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranoside, ORM2 isoform 1, PYRIDOXAL-5'-PHOSPHATE, ... | Authors: | Schaefer, J, Koerner, C, Moeller, A, Froehlich, F. | Deposit date: | 2023-09-28 | Release date: | 2024-09-04 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | The structure of the Orm2-containing serine palmitoyltransferase complex reveals distinct inhibitory potentials of yeast Orm proteins. Cell Rep, 43, 2024
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8C80
| Cryo-EM structure of the yeast SPT-Orm1-Monomer complex | Descriptor: | 2-{[(4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranosyl)oxy]methyl}-4-{[(3beta,9beta,14beta,17beta,25R)-spirost-5-en-3-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranoside, ERGOSTEROL, N-[(2S,3S,4R)-1,3,4-trihydroxyoctadecan-2-yl]hexacosanamide, ... | Authors: | Schaefer, J, Koerner, C, Parey, K, Januliene, D, Moeller, A, Froehlich, F. | Deposit date: | 2023-01-18 | Release date: | 2023-10-11 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structure of the ceramide-bound SPOTS complex. Nat Commun, 14, 2023
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8C81
| Cryo-EM structure of the yeast SPT-Orm1-Sac1 complex | Descriptor: | 2-{[(4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranosyl)oxy]methyl}-4-{[(3beta,9beta,14beta,17beta,25R)-spirost-5-en-3-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranoside, ERGOSTEROL, N-[(2S,3S,4R)-1,3,4-trihydroxyoctadecan-2-yl]hexacosanamide, ... | Authors: | Schaefer, J, Koerner, C, Parey, K, Januliene, D, Moeller, A, Froehlich, F. | Deposit date: | 2023-01-18 | Release date: | 2023-10-11 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structure of the ceramide-bound SPOTS complex. Nat Commun, 14, 2023
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8C82
| Cryo-EM structure of the yeast SPT-Orm1-Dimer complex | Descriptor: | 2-{[(4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranosyl)oxy]methyl}-4-{[(3beta,9beta,14beta,17beta,25R)-spirost-5-en-3-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranoside, N-[(2S,3S,4R)-1,3,4-trihydroxyoctadecan-2-yl]hexacosanamide, PYRIDOXAL-5'-PHOSPHATE, ... | Authors: | Schaefer, J, Koerner, C, Parey, K, Januliene, D, Moeller, A, Froehlich, F. | Deposit date: | 2023-01-18 | Release date: | 2023-10-11 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structure of the ceramide-bound SPOTS complex. Nat Commun, 14, 2023
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1XTQ
| Structure of small GTPase human Rheb in complex with GDP | Descriptor: | GTP-binding protein Rheb, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION | Authors: | Yu, Y, Ding, J. | Deposit date: | 2004-10-24 | Release date: | 2005-03-08 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural Basis for the Unique Biological Function of Small GTPase RHEB J.Biol.Chem., 280, 2005
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1XTS
| Structure of small GTPase human Rheb in complex with GTP | Descriptor: | GTP-binding protein Rheb, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION | Authors: | Yu, Y, Ding, J. | Deposit date: | 2004-10-24 | Release date: | 2005-03-08 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural Basis for the Unique Biological Function of Small GTPase RHEB J.Biol.Chem., 280, 2005
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1XTR
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