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7A0M
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BU of 7a0m by Molmil
TSC1 N-terminal domain
Descriptor: SULFATE ION, TSC1 N-terminal domain
Authors:Zech, R, Kiontke, S, Kuemmel, D.
Deposit date:2020-08-10
Release date:2021-05-26
Last modified:2021-07-14
Method:X-RAY DIFFRACTION (2.32 Å)
Cite:TSC1 binding to lysosomal PIPs is required for TSC complex translocation and mTORC1 regulation.
Mol.Cell, 81, 2021
8JAT
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BU of 8jat by Molmil
Crystal structure of the 3-ketodihydrosphingosine reductase TSC10 from Cryptococcus neoformans
Descriptor: 3-ketodihydrosphingosine reductase TSC10, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Zhao, P, Kuang, Z.
Deposit date:2023-05-07
Release date:2023-06-21
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structure of the 3-ketodihydrosphingosine reductase TSC10 from Cryptococcus neoformans.
Biochem.Biophys.Res.Commun., 670, 2023
5EJC
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BU of 5ejc by Molmil
Crystal structural of the TSC1-TBC1D7 complex
Descriptor: Hamartin, TBC1 domain family member 7
Authors:Wang, Z, Qin, J, Gong, W, Xu, W.
Deposit date:2015-11-01
Release date:2016-03-02
Last modified:2019-11-27
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural Basis of the Interaction between Tuberous Sclerosis Complex 1 (TSC1) and Tre2-Bub2-Cdc16 Domain Family Member 7 (TBC1D7).
J.Biol.Chem., 291, 2016
4KK1
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BU of 4kk1 by Molmil
Crystal Structure of TSC1 core domain from S. pombe
Descriptor: Tuberous sclerosis 1 protein homolog
Authors:Sun, W, Zhu, Y, Wang, Z.Z, Zhong, Q, Gao, F, Lou, J.Z, Gong, W.M, Xu, W.Q.
Deposit date:2013-05-05
Release date:2013-07-17
Last modified:2013-07-31
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Crystal structure of the yeast TSC1 core domain and implications for tuberous sclerosis pathological mutations.
Nat Commun, 4, 2013
4KK0
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BU of 4kk0 by Molmil
Crystal Structure of TSC1 core domain from S. pombe
Descriptor: Tuberous sclerosis 1 protein homolog
Authors:Sun, W, Zhu, Y, Wang, Z.Z, Zhong, Q, Gao, F, Lou, J.Z, Gong, W.M, Xu, W.Q.
Deposit date:2013-05-05
Release date:2013-07-17
Last modified:2013-07-31
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structure of the yeast TSC1 core domain and implications for tuberous sclerosis pathological mutations.
Nat Commun, 4, 2013
7A0N
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BU of 7a0n by Molmil
Structure of TSC1 NTD and linker domain
Descriptor: Uncharacterized protein,Uncharacterized protein
Authors:Fitzian, K, Kuemmel, D.
Deposit date:2020-08-10
Release date:2021-05-26
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (4.3 Å)
Cite:TSC1 binding to lysosomal PIPs is required for TSC complex translocation and mTORC1 regulation.
Mol.Cell, 81, 2021
4Z6Y
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BU of 4z6y by Molmil
Structure of the TBC1D7-TSC1 complex
Descriptor: Hamartin, TBC1 domain family member 7
Authors:Gai, Z, Wu, G.
Deposit date:2015-04-06
Release date:2016-04-20
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:Structure of the TBC1D7-TSC1 complex
To Be Published
7DL2
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BU of 7dl2 by Molmil
Cryo-EM structure of human TSC complex
Descriptor: Hamartin, Isoform 7 of Tuberin, TBC1 domain family member 7, ...
Authors:Yang, H, Yu, Z, Chen, X, Li, J, Li, N, Cheng, J, Gao, N, Yuan, H, Ye, D, Guan, K, Xu, Y.
Deposit date:2020-11-25
Release date:2020-12-16
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:Structural insights into TSC complex assembly and GAP activity on Rheb.
Nat Commun, 12, 2021
6EMK
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BU of 6emk by Molmil
Cryo-EM Structure of Saccharomyces cerevisiae Target of Rapamycin Complex 2
Descriptor: Serine/threonine-protein kinase TOR2, Target of rapamycin complex 2 subunit AVO1, Target of rapamycin complex 2 subunit AVO2, ...
Authors:Karuppasamy, M, Kusmider, B, Oliveira, T.M, Gaubitz, C, Prouteau, M, Loewith, R, Schaffitzel, C.
Deposit date:2017-10-02
Release date:2017-12-06
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (7.9 Å)
Cite:Cryo-EM structure of Saccharomyces cerevisiae target of rapamycin complex 2.
Nat Commun, 8, 2017
5HIU
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BU of 5hiu by Molmil
Structure of the TSC2 N-terminus
Descriptor: GTPase activator-like protein
Authors:Zech, R, Kiontke, S, Kummel, D.
Deposit date:2016-01-12
Release date:2016-08-10
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of the Tuberous Sclerosis Complex 2 (TSC2) N Terminus Provides Insight into Complex Assembly and Tuberous Sclerosis Pathogenesis.
J.Biol.Chem., 291, 2016
3LQ9
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BU of 3lq9 by Molmil
Crystal structure of human REDD1, a hypoxia-induced regulator of mTOR
Descriptor: DNA-damage-inducible transcript 4 protein
Authors:Vega-Rubin-de-Celis, S, Abdallah, Z, Brugarolas, J, Zhang, X.
Deposit date:2010-02-08
Release date:2010-03-09
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural analysis and functional implications of the negative mTORC1 regulator REDD1.
Biochemistry, 49, 2010
6SSH
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BU of 6ssh by Molmil
Structure of the TSC2 GAP domain
Descriptor: 1,2-ETHANEDIOL, GTPase activator-like protein
Authors:Hansmann, P, Kiontke, S, Kummel, D.
Deposit date:2019-09-06
Release date:2020-05-27
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structure of the TSC2 GAP Domain: Mechanistic Insight into Catalysis and Pathogenic Mutations.
Structure, 28, 2020
3QWL
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BU of 3qwl by Molmil
Crystal structure of human TBC1 domain family member 7
Descriptor: TBC1 domain family member 7, UNKNOWN ATOM OR ION
Authors:Guan, X, Tempel, W, Tong, Y, Wernimont, A.K, Landry, R, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Park, H, Structural Genomics Consortium (SGC)
Deposit date:2011-02-28
Release date:2011-06-01
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of human TBC1 domain family member 7
to be published
6IYY
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BU of 6iyy by Molmil
Crystal structure of human WIPI3,loop deletion mutant
Descriptor: SULFATE ION, WD repeat domain phosphoinositide-interacting protein 3
Authors:Liang, R.B, Ren, J.Q, Feng, W.
Deposit date:2018-12-17
Release date:2019-03-13
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.796 Å)
Cite:Structural Conservation of the Two Phosphoinositide-Binding Sites in WIPI Proteins.
J. Mol. Biol., 431, 2019
6KLR
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BU of 6klr by Molmil
Crystal structure of human WIPI3 in complex with the WIR-peptide from ATG2A
Descriptor: chimera ATG2A and WIPI3
Authors:Ren, J.Q, Liang, R.B, Feng, W.
Deposit date:2019-07-30
Release date:2020-04-29
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Multi-site-mediated entwining of the linear WIR-motif around WIPI beta-propellers for autophagy.
Nat Commun, 11, 2020
6XK9
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BU of 6xk9 by Molmil
Cereblon in complex with DDB1, CC-90009, and GSPT1
Descriptor: 2-(4-chlorophenyl)-N-({2-[(3S)-2,6-dioxopiperidin-3-yl]-1-oxo-2,3-dihydro-1H-isoindol-5-yl}methyl)-2,2-difluoroacetamide, DNA damage-binding protein 1, Eukaryotic peptide chain release factor GTP-binding subunit ERF3A, ...
Authors:Clayton, T.L, Tran, E.T, Zhu, J, Pagarigan, B.E, Matyskiela, M.E, Chamberlain, P.P.
Deposit date:2020-06-25
Release date:2020-12-02
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.64 Å)
Cite:CC-90009, a novel cereblon E3 ligase modulator, targets acute myeloid leukemia blasts and leukemia stem cells.
Blood, 137, 2021
1YZ1
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BU of 1yz1 by Molmil
Crystal structure of human translationally controlled tumour associated protein
Descriptor: Translationally controlled tumor protein
Authors:Cavarelli, J, Moras, D, Amson, R, Telerman, A.
Deposit date:2005-02-26
Release date:2006-05-16
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:TCTP protects from apoptotic cell death by antagonizing bax function
Cell Death Differ., 15, 2008
8QOF
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BU of 8qof by Molmil
Cryo-EM structure of the yeast SPT-Orm2-Dimer complex
Descriptor: 2-{[(4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranosyl)oxy]methyl}-4-{[(3beta,9beta,14beta,17beta,25R)-spirost-5-en-3-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranoside, ORM2 isoform 1, PYRIDOXAL-5'-PHOSPHATE, ...
Authors:Schaefer, J, Koerner, C, Moeller, A, Froehlich, F.
Deposit date:2023-09-28
Release date:2024-09-04
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:The structure of the Orm2-containing serine palmitoyltransferase complex reveals distinct inhibitory potentials of yeast Orm proteins.
Cell Rep, 43, 2024
8QOG
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BU of 8qog by Molmil
Cryo-EM structure of the yeast SPT-Orm2-Monomer complex
Descriptor: 2-{[(4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranosyl)oxy]methyl}-4-{[(3beta,9beta,14beta,17beta,25R)-spirost-5-en-3-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranoside, ORM2 isoform 1, PYRIDOXAL-5'-PHOSPHATE, ...
Authors:Schaefer, J, Koerner, C, Moeller, A, Froehlich, F.
Deposit date:2023-09-28
Release date:2024-09-04
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:The structure of the Orm2-containing serine palmitoyltransferase complex reveals distinct inhibitory potentials of yeast Orm proteins.
Cell Rep, 43, 2024
8C80
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BU of 8c80 by Molmil
Cryo-EM structure of the yeast SPT-Orm1-Monomer complex
Descriptor: 2-{[(4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranosyl)oxy]methyl}-4-{[(3beta,9beta,14beta,17beta,25R)-spirost-5-en-3-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranoside, ERGOSTEROL, N-[(2S,3S,4R)-1,3,4-trihydroxyoctadecan-2-yl]hexacosanamide, ...
Authors:Schaefer, J, Koerner, C, Parey, K, Januliene, D, Moeller, A, Froehlich, F.
Deposit date:2023-01-18
Release date:2023-10-11
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structure of the ceramide-bound SPOTS complex.
Nat Commun, 14, 2023
8C81
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BU of 8c81 by Molmil
Cryo-EM structure of the yeast SPT-Orm1-Sac1 complex
Descriptor: 2-{[(4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranosyl)oxy]methyl}-4-{[(3beta,9beta,14beta,17beta,25R)-spirost-5-en-3-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranoside, ERGOSTEROL, N-[(2S,3S,4R)-1,3,4-trihydroxyoctadecan-2-yl]hexacosanamide, ...
Authors:Schaefer, J, Koerner, C, Parey, K, Januliene, D, Moeller, A, Froehlich, F.
Deposit date:2023-01-18
Release date:2023-10-11
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structure of the ceramide-bound SPOTS complex.
Nat Commun, 14, 2023
8C82
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BU of 8c82 by Molmil
Cryo-EM structure of the yeast SPT-Orm1-Dimer complex
Descriptor: 2-{[(4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranosyl)oxy]methyl}-4-{[(3beta,9beta,14beta,17beta,25R)-spirost-5-en-3-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranoside, N-[(2S,3S,4R)-1,3,4-trihydroxyoctadecan-2-yl]hexacosanamide, PYRIDOXAL-5'-PHOSPHATE, ...
Authors:Schaefer, J, Koerner, C, Parey, K, Januliene, D, Moeller, A, Froehlich, F.
Deposit date:2023-01-18
Release date:2023-10-11
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structure of the ceramide-bound SPOTS complex.
Nat Commun, 14, 2023
1XTQ
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BU of 1xtq by Molmil
Structure of small GTPase human Rheb in complex with GDP
Descriptor: GTP-binding protein Rheb, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
Authors:Yu, Y, Ding, J.
Deposit date:2004-10-24
Release date:2005-03-08
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Basis for the Unique Biological Function of Small GTPase RHEB
J.Biol.Chem., 280, 2005
1XTS
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BU of 1xts by Molmil
Structure of small GTPase human Rheb in complex with GTP
Descriptor: GTP-binding protein Rheb, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION
Authors:Yu, Y, Ding, J.
Deposit date:2004-10-24
Release date:2005-03-08
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Basis for the Unique Biological Function of Small GTPase RHEB
J.Biol.Chem., 280, 2005
1XTR
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BU of 1xtr by Molmil
Structure of small GTPase human Rheb in complex with GppNHp
Descriptor: GLYCEROL, GTP-binding protein Rheb, MAGNESIUM ION, ...
Authors:Yu, Y, Ding, J.
Deposit date:2004-10-24
Release date:2005-03-08
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structural Basis for the Unique Biological Function of Small GTPase RHEB
J.Biol.Chem., 280, 2005

 

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