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4WUA
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BU of 4wua by Molmil
Crystal structure of human SRPK1 complexed to an inhibitor SRPIN340
Descriptor: CITRIC ACID, N-[2-(1-piperidinyl)-5-(trifluoromethyl)phenyl]-4-pyridinecarboxamide, SRSF protein kinase 1, ...
Authors:Hoshina, M, Ikura, T, Hosoya, T, Hagiwara, M, Ito, N.
Deposit date:2014-10-31
Release date:2015-09-16
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:Identification of a Dual Inhibitor of SRPK1 and CK2 That Attenuates Pathological Angiogenesis of Macular Degeneration in Mice
Mol.Pharmacol., 88, 2015
3BEG
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BU of 3beg by Molmil
Crystal structure of SR protein kinase 1 complexed to its substrate ASF/SF2
Descriptor: ALANINE, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, PHOSPHOSERINE, ...
Authors:Ngo, J.C, Giang, K, Chakrabarti, S, Ma, C.-T, Huynh, N, Hagopian, J, Dorrestein, P.C, Fu, X.-D, Adams, J.A, Ghosh, G.
Deposit date:2007-11-18
Release date:2008-04-01
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:A sliding docking interaction is essential for sequential and processive phosphorylation of an SR protein by SRPK1
Mol.Cell, 29, 2008
5MY8
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BU of 5my8 by Molmil
Crystal structure of SRPK1 in complex with SPHINX31
Descriptor: 1,2-ETHANEDIOL, CITRIC ACID, DIMETHYL SULFOXIDE, ...
Authors:Chaikuad, A, von Delft, F, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2017-01-25
Release date:2017-05-10
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Development of Potent, Selective SRPK1 Inhibitors as Potential Topical Therapeutics for Neovascular Eye Disease.
ACS Chem. Biol., 12, 2017
5MXX
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BU of 5mxx by Molmil
Crystal structure of human SR protein kinase 1 (SRPK1) in complex with compound 1
Descriptor: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 5-methyl-~{N}-[2-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)phenyl]furan-2-carboxamide, ...
Authors:Tallant, C, Redondo, C, Batson, J, Toop, H.D, Babaebi-Jadidib, R, Savitsky, P, Elkins, J.M, Newman, J.A, Burgess-Brown, N, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Bates, D.O, Morris, J.C, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2017-01-25
Release date:2017-05-24
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Development of Potent, Selective SRPK1 Inhibitors as Potential Topical Therapeutics for Neovascular Eye Disease.
ACS Chem. Biol., 12, 2017
5XV7
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BU of 5xv7 by Molmil
SRPK1 in complex with Alectinib
Descriptor: 1,2-ETHANEDIOL, 9-ethyl-6,6-dimethyl-8-[4-(morpholin-4-yl)piperidin-1-yl]-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile, serine-arginine (SR) protein kinase 1
Authors:Zeng, C, Ngo, J.C.K.
Deposit date:2017-06-26
Release date:2018-03-14
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.32 Å)
Cite:SRPKIN-1: A Covalent SRPK1/2 Inhibitor that Potently Converts VEGF from Pro-angiogenic to Anti-angiogenic Isoform
Cell Chem Biol, 25, 2018
7PQS
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BU of 7pqs by Molmil
SRPK1 in complex with MSC2711186
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, CITRIC ACID, ...
Authors:Schroeder, M, Leiendecker, M, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2021-09-20
Release date:2021-12-15
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:SRPK1 in complex with MSC2711186
To Be Published
7ZKS
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BU of 7zks by Molmil
SRPK1 IN COMPLEX WITH INHIBITOR
Descriptor: CHLORIDE ION, N-[3-[[[2-(6-chloranyl-5-fluoranyl-1H-benzimidazol-2-yl)pyrimidin-4-yl]amino]methyl]pyridin-2-yl]-N-methyl-methanesulfonamide, SRSF protein kinase 1
Authors:Graedler, U.
Deposit date:2022-04-13
Release date:2023-02-22
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:MSC-1186, a Highly Selective Pan-SRPK Inhibitor Based on an Exceptionally Decorated Benzimidazole-Pyrimidine Core.
J.Med.Chem., 66, 2023
1WBP
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BU of 1wbp by Molmil
SRPK1 bound to 9mer docking motif peptide
Descriptor: ACETATE ION, ADENOSINE-5'-DIPHOSPHATE, MEMBRANE-ASSOCIATED GUANYLATE KINASE, ...
Authors:Ngo, J.C, Gullinsgrud, J, Chakrabarti, S, Nolen, B, Aubol, B.E, Fu, X.-D, Adams, J.A, McCammon, J.A, Ghosh, G.
Deposit date:2004-11-04
Release date:2005-10-19
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Interplay between Srpk and Clk/Sty Kinases in Phosphorylation of the Splicing Factor Asf/Sf2 is Regulated by a Docking Motif in Asf/Sf2
Mol.Cell, 20, 2005
6FAD
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BU of 6fad by Molmil
SR protein kinase 1 (SRPK1) in complex with the RGG-box of HSV1 ICP27
Descriptor: PHOSPHATE ION, SRSF protein kinase 1, mRNA export factor
Authors:Tunnicliffe, R.B, Levy, C, Mould, A.P, Mckenzie, E.A, Sandri-Goldin, R.M, Golovanov, A.P.
Deposit date:2017-12-15
Release date:2019-09-25
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.801 Å)
Cite:Molecular Mechanism of SR Protein Kinase 1 Inhibition by the Herpes Virus Protein ICP27.
Mbio, 10, 2019
7DD1
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BU of 7dd1 by Molmil
Crystal structure of SRPK1 in complex with a peptide inhibitor
Descriptor: ARG-GLU-ARG-ALA-ARG-THR-ARG, SRSF protein kinase 1,SRSF protein kinase 1
Authors:Li, Q.Y, Yung, K.W.Y, Ngo, J.C.K.
Deposit date:2020-10-27
Release date:2021-04-21
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Protein-Protein Interaction Inhibitor of SRPKs Alters the Splicing Isoforms of VEGF and Inhibits Angiogenesis.
Iscience, 24, 2021
1WAK
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BU of 1wak by Molmil
X-ray structure of SRPK1
Descriptor: 1,2-ETHANEDIOL, SERINE/THREONINE-PROTEIN KINASE SPRK1
Authors:Ngo, J.C, Gullingsrud, J, Chakrabarti, S, Nolen, B, Aubol, B.E, Fu, X.D, Adams, J.A, Mccammon, J.A, Ghosh, G.
Deposit date:2004-10-26
Release date:2006-07-11
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Sr Protein Kinase 1 is Resilient to Inactivation.
Structure, 15, 2007
5MYV
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BU of 5myv by Molmil
Crystal structure of SRPK2 in complex with compound 1
Descriptor: 5-methyl-~{N}-[2-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)phenyl]furan-2-carboxamide, DIMETHYL SULFOXIDE, SRSF protein kinase 2,SRSF protein kinase 2, ...
Authors:Chaikuad, A, Pike, A.C.W, Savitsky, P, von Delft, F, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2017-01-29
Release date:2017-05-10
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Development of Potent, Selective SRPK1 Inhibitors as Potential Topical Therapeutics for Neovascular Eye Disease.
ACS Chem. Biol., 12, 2017
5NNG
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BU of 5nng by Molmil
Crystal Structure of the first bromodomain of human BRD4 in complex with an acetylated SRPK1 peptide (K585ac)
Descriptor: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, VAG(ALY)YS(ALY)EFFY
Authors:Filippakopoulos, P, Picaud, S, Newman, J, Sorrell, F, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Structural Genomics Consortium (SGC)
Deposit date:2017-04-08
Release date:2018-05-16
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.
Mol. Cell, 73, 2019
2EU9
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BU of 2eu9 by Molmil
Crystal Structure of CLK3
Descriptor: 1,2-ETHANEDIOL, Dual specificity protein kinase CLK3
Authors:Papagrigoriou, E, Rellos, P, Das, S, Ugochukwu, E, Turnbull, A, von Delft, F, Bunkoczi, G, Sobott, F, Bullock, A, Fedorov, O, Gileadi, C, Savitsky, P, Edwards, A, Aerrowsmith, C, Weigelt, J, Sundstrom, M, Knapp, S.
Deposit date:2005-10-28
Release date:2005-11-08
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Kinase domain insertions define distinct roles of CLK kinases in SR protein phosphorylation.
Structure, 17, 2009
1Z57
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BU of 1z57 by Molmil
Crystal structure of human CLK1 in complex with 10Z-Hymenialdisine
Descriptor: DEBROMOHYMENIALDISINE, Dual specificity protein kinase CLK1
Authors:Debreczeni, J, Das, S, Knapp, S, Bullock, A, Guo, K, Amos, A, Fedorov, O, Edwards, A, Sundstrom, M, von Delft, F, Niesen, F.H, Ball, L, Sobott, F, Arrowsmith, C, Structural Genomics Consortium (SGC)
Deposit date:2005-03-17
Release date:2005-04-12
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Kinase domain insertions define distinct roles of CLK kinases in SR protein phosphorylation.
Structure, 17, 2009
7ZKX
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BU of 7zkx by Molmil
SRPK2 IN COMPLEX WITH INHIBITOR
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, N-[3-[[[2-(6-chloranyl-5-fluoranyl-1H-benzimidazol-2-yl)pyrimidin-4-yl]amino]methyl]pyridin-2-yl]-N-methyl-methanesulfonamide, ...
Authors:Graedler, U.
Deposit date:2022-04-13
Release date:2023-02-22
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:MSC-1186, a Highly Selective Pan-SRPK Inhibitor Based on an Exceptionally Decorated Benzimidazole-Pyrimidine Core.
J.Med.Chem., 66, 2023
4FIC
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BU of 4fic by Molmil
Kinase domain of cSrc in complex with a hinge region-binding fragment
Descriptor: 6-phenyl[1,2,4]triazolo[1,5-a]pyrazin-2-amine, Proto-oncogene tyrosine-protein kinase Src
Authors:Richters, A, Rauh, D.
Deposit date:2012-06-08
Release date:2013-04-10
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:De novo design of protein kinase inhibitors by in silico identification of hinge region-binding fragments.
Acs Chem.Biol., 8, 2013

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