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7SN6
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BU of 7sn6 by Molmil
U2AF65 UHM BOUND TO SF3B155 ULM5
Descriptor: ISOPROPYL ALCOHOL, Splicing factor 3B subunit 1, Splicing factor U2AF 65 kDa subunit
Authors:Loerch, S, Jenkins, J.L, Kielkopf, C.L.
Deposit date:2021-10-27
Release date:2022-07-27
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A UHM-ULM interface with unusual structural features contributes to U2AF2 and SF3B1 association for pre-mRNA splicing.
J.Biol.Chem., 298, 2022
6N3F
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BU of 6n3f by Molmil
Structure of HIV Tat-specific factor 1 U2AF Homology Motif bound to SF3b1 ULM5
Descriptor: DI(HYDROXYETHYL)ETHER, GLYCEROL, HIV Tat-specific factor 1, ...
Authors:Leach, J.R, Jenkins, J.L, Kielkopf, C.L.
Deposit date:2018-11-15
Release date:2019-01-02
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.099 Å)
Cite:The pre-mRNA splicing and transcription factor Tat-SF1 is a functional partner of the spliceosome SF3b1 subunit via a U2AF homology motif interface.
J. Biol. Chem., 294, 2019
3LQV
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BU of 3lqv by Molmil
Branch Recognition by SF3b14
Descriptor: ADENINE, Pre-mRNA branch site protein p14, Splicing factor 3B subunit 1
Authors:Schellenberg, M.J, MacMillan, A.M.
Deposit date:2010-02-10
Release date:2011-01-26
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:Branch Recognition by SF3b14
Rna, 17, 2011
4OZ1
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BU of 4oz1 by Molmil
Crystal structure of human CAPERalpha UHM bound to SF3b155 ULM5
Descriptor: CHLORIDE ION, LYSINE, POTASSIUM ION, ...
Authors:Loerch, S, Kielkopf, C.L.
Deposit date:2014-02-13
Release date:2014-05-14
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Cancer-relevant splicing factor CAPER alpha engages the essential splicing factor SF3b155 in a specific ternary complex.
J.Biol.Chem., 289, 2014
2FHO
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BU of 2fho by Molmil
NMR solution structure of the human spliceosomal protein complex p14-SF3b155
Descriptor: spliceosomal protein SF3b155, spliceosomal protein p14
Authors:Kuwasako, K, Dohmae, N, Inoue, M, Shirouzu, M, Guntert, P, Seraphin, B, Muto, Y, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-12-26
Release date:2006-12-26
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:NMR solution structure of the human spliceosomal protein complex p14-SF3b155
To be Published
6N3E
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BU of 6n3e by Molmil
Structure of HIV Tat-specific factor 1 U2AF Homology Motif bound to U2AF ligand motif 4
Descriptor: FORMIC ACID, GLYCEROL, HIV Tat-specific factor 1, ...
Authors:Loerch, S, Jenkins, J.L, Kielkopf, C.L.
Deposit date:2018-11-15
Release date:2019-01-02
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.893 Å)
Cite:The pre-mRNA splicing and transcription factor Tat-SF1 is a functional partner of the spliceosome SF3b1 subunit via a U2AF homology motif interface.
J. Biol. Chem., 294, 2019
8EJM
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BU of 8ejm by Molmil
Crystal structure of human DEAH-box helicase DHX15 in complex with SUGP1 G-patch
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ATP-dependent RNA helicase DHX15, CHLORIDE ION, ...
Authors:Huang, J, Tong, L.
Deposit date:2022-09-17
Release date:2022-12-14
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:DHX15 is involved in SUGP1-mediated RNA missplicing by mutant SF3B1 in cancer.
Proc.Natl.Acad.Sci.USA, 119, 2022
6N3D
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BU of 6n3d by Molmil
Structure of HIV Tat-specific factor 1 U2AF Homology Motif (APO-State)
Descriptor: CHLORIDE ION, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
Authors:Loerch, S, Jenkins, J.L, Kielkopf, C.L.
Deposit date:2018-11-15
Release date:2019-01-02
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.13 Å)
Cite:The pre-mRNA splicing and transcription factor Tat-SF1 is a functional partner of the spliceosome SF3b1 subunit via a U2AF homology motif interface.
J. Biol. Chem., 294, 2019
2F9J
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BU of 2f9j by Molmil
3.0 angstrom resolution structure of a Y22M mutant of the spliceosomal protein p14 bound to a region of SF3b155
Descriptor: Pre-mRNA branch site protein p14, Splicing factor 3B subunit 1
Authors:Schellenberg, M.J, MacMillan, A.M.
Deposit date:2005-12-06
Release date:2006-01-24
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of a core spliceosomal protein interface
Proc.Natl.Acad.Sci.Usa, 103, 2006
2F9D
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BU of 2f9d by Molmil
2.5 angstrom resolution structure of the spliceosomal protein p14 bound to region of SF3b155
Descriptor: Pre-mRNA branch site protein p14, Splicing factor 3B subunit 1
Authors:Schellenberg, M.J, Edwards, R.A, Ritchie, D.B, Glover, J.N.M, Macmillan, A.M.
Deposit date:2005-12-05
Release date:2006-01-24
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of a core spliceosomal protein interface
Proc.Natl.Acad.Sci.Usa, 103, 2006
6NSX
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BU of 6nsx by Molmil
Yeast Hsh155 Ligand bound to Human Tat-SF1 Motif
Descriptor: CHLORIDE ION, HIV Tat-specific factor 1, Hsh155
Authors:Jenkins, J.L, Leach, J.R, Kielkopf, C.L.
Deposit date:2019-01-25
Release date:2019-06-05
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Cus2 enforces the first ATP-dependent step of splicing by binding to yeast SF3b1 through a UHM-ULM interaction.
Rna, 25, 2019
2PEH
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BU of 2peh by Molmil
Crystal structure of the UHM domain of human SPF45 in complex with SF3b155-ULM5
Descriptor: Splicing factor 3B subunit 1, Splicing factor 45
Authors:Corsini, L, Basquin, J, Hothorn, M, Sattler, M.
Deposit date:2007-04-03
Release date:2007-06-26
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:U2AF-homology motif interactions are required for alternative splicing regulation by SPF45.
Nat.Struct.Mol.Biol., 14, 2007
8GXL
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BU of 8gxl by Molmil
HUMAN SUGP1 433-577
Descriptor: SURP and G-patch domain-containing protein 1
Authors:Xu, K, Tong, L.
Deposit date:2022-09-20
Release date:2022-12-14
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:DHX15 is involved in SUGP1-mediated RNA missplicing by mutant SF3B1 in cancer.
Proc.Natl.Acad.Sci.USA, 119, 2022
8GXM
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BU of 8gxm by Molmil
HUMAN SUGP1 433-586
Descriptor: SURP and G-patch domain-containing protein 1
Authors:Xu, K, Tong, L.
Deposit date:2022-09-20
Release date:2022-12-14
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:DHX15 is involved in SUGP1-mediated RNA missplicing by mutant SF3B1 in cancer.
Proc.Natl.Acad.Sci.USA, 119, 2022
4OZ0
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BU of 4oz0 by Molmil
Crystal structure of human CAPERalpha U2AF homology motif (apo-state)
Descriptor: CHLORIDE ION, RNA-binding protein 39
Authors:Loerch, S, Kielkopf, C.L.
Deposit date:2014-02-13
Release date:2014-05-14
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Cancer-relevant splicing factor CAPER alpha engages the essential splicing factor SF3b155 in a specific ternary complex.
J.Biol.Chem., 289, 2014
5GVQ
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BU of 5gvq by Molmil
Solution structure of the first RRM domain of human spliceosomal protein SF3b49
Descriptor: Splicing factor 3B subunit 4
Authors:Kuwasako, K, Nameki, N, Tsuda, K, Takahashi, M, Sato, A, Tochio, N, Inoue, M, Terada, T, Kigawa, T, Kobayashi, N, Shirouzu, M, Ito, T, Sakamoto, T, Wakamatsu, K, Guntert, P, Takahashi, S, Yokoyama, S, Muto, Y, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2016-09-06
Release date:2017-04-12
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Solution structure of the first RNA recognition motif domain of human spliceosomal protein SF3b49 and its mode of interaction with a SF3b145 fragment.
Protein Sci., 26, 2017
5HY7
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BU of 5hy7 by Molmil
SF3B10-SF3B130 from Chaetomium thermophilum
Descriptor: CALCIUM ION, Putative pre-mRNA splicing protein, YSF3
Authors:Ponce-Salvatierra, A, Schmitzova, J, Pena, V.
Deposit date:2016-02-01
Release date:2016-10-26
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Molecular Architecture of SF3b and Structural Consequences of Its Cancer-Related Mutations.
Mol.Cell, 64, 2016
6Y53
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BU of 6y53 by Molmil
human 17S U2 snRNP low resolution part
Descriptor: HIV Tat-specific factor 1, Probable ATP-dependent RNA helicase DDX46, Small nuclear ribonucleoprotein E, ...
Authors:Zhang, Z, Will, C.L, Bertram, K, Luehrmann, R, Stark, H.
Deposit date:2020-02-24
Release date:2020-06-17
Last modified:2024-05-22
Method:ELECTRON MICROSCOPY (7.1 Å)
Cite:Molecular architecture of the human 17S U2 snRNP.
Nature, 583, 2020
7VPX
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BU of 7vpx by Molmil
The cryo-EM structure of the human pre-A complex
Descriptor: 5SS, DnaJ homolog subfamily C member 8, PHD finger-like domain-containing protein 5A, ...
Authors:Zhang, X, Zhan, X, Shi, Y.
Deposit date:2021-10-18
Release date:2023-05-03
Last modified:2024-05-22
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural insights into branch site proofreading by human spliceosome.
Nat.Struct.Mol.Biol., 2024
7EVO
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BU of 7evo by Molmil
The cryo-EM structure of the human 17S U2 snRNP
Descriptor: HIV Tat-specific factor 1, PHD finger-like domain-containing protein 5A, RNA helicase, ...
Authors:Zhang, X, Zhan, X, Shi, Y.
Deposit date:2021-05-21
Release date:2022-08-03
Last modified:2024-05-22
Method:ELECTRON MICROSCOPY (2.5 Å)
Cite:Structural insights into branch site proofreading by human spliceosome.
Nat.Struct.Mol.Biol., 2024
8CH6
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BU of 8ch6 by Molmil
Structure of a late-stage activated spliceosome (BAqr) arrested with a dominant-negative Aquarius mutant (state B complex).
Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, BUD13 homolog, Cell division cycle 5-like protein, ...
Authors:Cretu, C, Schmitzova, J, Pena, V.
Deposit date:2023-02-07
Release date:2023-05-10
Last modified:2024-07-24
Method:ELECTRON MICROSCOPY (5.9 Å)
Cite:Structural basis of catalytic activation in human splicing.
Nature, 617, 2023
5IFE
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BU of 5ife by Molmil
Crystal structure of the human SF3b core complex
Descriptor: PHD finger-like domain-containing protein 5A, POTASSIUM ION, Splicing factor 3B subunit 1, ...
Authors:Cretu, C, Dybkov, O, De Laurentiis, E, Will, C.L, Luhrmann, R, Pena, V.
Deposit date:2016-02-25
Release date:2016-10-26
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Molecular Architecture of SF3b and Structural Consequences of Its Cancer-Related Mutations.
Mol.Cell, 64, 2016
6Y50
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BU of 6y50 by Molmil
5'domain of human 17S U2 snRNP
Descriptor: HIV Tat-specific factor 1, PHD finger-like domain-containing protein 5A, Probable ATP-dependent RNA helicase DDX46, ...
Authors:Zhang, Z, Will, C.L, Bertram, K, Luehrmann, R, Stark, H.
Deposit date:2020-02-24
Release date:2020-07-01
Last modified:2024-05-22
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Molecular architecture of the human 17S U2 snRNP.
Nature, 583, 2020
6Y5Q
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BU of 6y5q by Molmil
human 17S U2 snRNP
Descriptor: HIV Tat-specific factor 1, PHD finger-like domain-containing protein 5A, Probable ATP-dependent RNA helicase DDX46, ...
Authors:Zhang, Z, Will, C.L, Bertram, K, Luehrmann, R, Stark, H.
Deposit date:2020-02-25
Release date:2020-06-17
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (7.1 Å)
Cite:Molecular architecture of the human 17S U2 snRNP.
Nature, 583, 2020
5ZYA
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BU of 5zya by Molmil
SF3b spliceosomal complex bound to E7107
Descriptor: PHD finger-like domain-containing protein 5A, POTASSIUM ION, Splicing factor 3B subunit 1, ...
Authors:Finci, L.I, Larsen, N.A.
Deposit date:2018-05-23
Release date:2018-06-20
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3.95 Å)
Cite:The cryo-EM structure of the SF3b spliceosome complex bound to a splicing modulator reveals a pre-mRNA substrate competitive mechanism of action
Genes Dev., 32, 2018

 

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