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3IXS
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BU of 3ixs by Molmil
Ring1B C-terminal domain/RYBP C-terminal domain Complex
Descriptor: 1,2-ETHANEDIOL, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, E3 ubiquitin-protein ligase RING2, ...
Authors:Wang, R, Taylor, A.B, Kim, C.A.
Deposit date:2009-09-04
Release date:2010-08-25
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Polycomb Group Targeting through Different Binding Partners of RING1B C-Terminal Domain.
Structure, 18, 2010
4S3O
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BU of 4s3o by Molmil
PCGF5-RING1B-UbcH5c complex
Descriptor: E3 ubiquitin-protein ligase RING2, Polycomb group RING finger protein 5, Ubiquitin-conjugating enzyme E2 D3, ...
Authors:Taherbhoy, A.M, Cochran, A.G.
Deposit date:2015-03-23
Release date:2015-07-15
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:BMI1-RING1B is an autoinhibited RING E3 ubiquitin ligase.
Nat Commun, 6, 2015
3GS2
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BU of 3gs2 by Molmil
Ring1B C-terminal domain/Cbx7 Cbox Complex
Descriptor: Chromobox protein homolog 7, E3 ubiquitin-protein ligase RING2, SULFATE ION, ...
Authors:Wang, R, Taylor, A.B, Kim, C.A.
Deposit date:2009-03-26
Release date:2010-08-25
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.699 Å)
Cite:Polycomb Group Targeting through Different Binding Partners of RING1B C-Terminal Domain.
Structure, 18, 2010
3H8H
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BU of 3h8h by Molmil
Structure of the C-terminal domain of human RNF2/RING1B;
Descriptor: CHLORIDE ION, E3 ubiquitin-protein ligase RING2, GLYCEROL, ...
Authors:Walker, J.R, Bezsonova, I, Bacik, J, Duan, S, Weigelt, J, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC)
Deposit date:2009-04-29
Release date:2009-06-23
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2 Å)
Cite:Ring1B contains a ubiquitin-like docking module for interaction with Cbx proteins.
Biochemistry, 48, 2009
2CKL
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BU of 2ckl by Molmil
Ring1b-Bmi1 E3 catalytic domain structure
Descriptor: IODIDE ION, POLYCOMB GROUP RING FINGER PROTEIN 4, UBIQUITIN LIGASE PROTEIN RING2, ...
Authors:Buchwald, G, van der Stoop, P, Weichenrieder, O, Perrakis, A, van Lohuizen, M, Sixma, T.K.
Deposit date:2006-04-20
Release date:2006-05-11
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure and E3-Ligase Activity of the Ring-Ring Complex of Polycomb Proteins Bmi1 and Ring1B.
Embo J., 25, 2006
3RPG
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BU of 3rpg by Molmil
Bmi1/Ring1b-UbcH5c complex structure
Descriptor: E3 ubiquitin-protein ligase RING2, Polycomb complex protein BMI-1, Ubiquitin-conjugating enzyme E2 D3, ...
Authors:Bentley, M.L, Dong, K.C, Cochran, A.G.
Deposit date:2011-04-26
Release date:2011-08-17
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.6485 Å)
Cite:Recognition of UbcH5c and the nucleosome by the Bmi1/Ring1b ubiquitin ligase complex.
Embo J., 30, 2011
2H0D
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BU of 2h0d by Molmil
Structure of a Bmi-1-Ring1B Polycomb group ubiquitin ligase complex
Descriptor: B lymphoma Mo-MLV insertion region, Ubiquitin ligase protein RING2, ZINC ION
Authors:Xu, R.M.
Deposit date:2006-05-14
Release date:2006-05-23
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of a Bmi-1-Ring1B Polycomb Group Ubiquitin Ligase Complex.
J.Biol.Chem., 281, 2006
5XVW
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BU of 5xvw by Molmil
Crystal structure of AL2 PAL domain in complex with AtRing1a distal site
Descriptor: AtRing1a distal binding site, PHD finger protein ALFIN-LIKE 2
Authors:Peng, L, Wang, L.L, Huang, Y.
Deposit date:2017-06-28
Release date:2018-07-04
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.849 Å)
Cite:Structural Analysis of the Arabidopsis AL2-PAL and PRC1 Complex Provides Mechanistic Insight into Active-to-Repressive Chromatin State Switch
J. Mol. Biol., 430, 2018
5Y21
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BU of 5y21 by Molmil
Crystal structure of AL2 PAL domain in complex with AtRing1a proximal site
Descriptor: AtRing1a proximal binding site peptide, PHD finger protein ALFIN-LIKE 2
Authors:Peng, L, Wang, L.L, Huang, Y.
Deposit date:2017-07-22
Release date:2018-07-25
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.769 Å)
Cite:Structural Analysis of the Arabidopsis AL2-PAL and PRC1 Complex Provides Mechanistic Insight into Active-to-Repressive Chromatin State Switch
J. Mol. Biol., 430, 2018
5UDH
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BU of 5udh by Molmil
HHARI/ARIH1-UBCH7~Ubiquitin
Descriptor: E3 ubiquitin-protein ligase ARIH1, Ubiquitin C variant, Ubiquitin-conjugating enzyme E2 L3, ...
Authors:Miller, D.J, Schulman, B.A.
Deposit date:2016-12-27
Release date:2017-06-14
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (3.24 Å)
Cite:Structural Studies of HHARI/UbcH7Ub Reveal Unique E2Ub Conformational Restriction by RBR RING1.
Structure, 25, 2017
6WI7
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BU of 6wi7 by Molmil
RING1B-BMI1 fusion in closed conformation
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, E3 ubiquitin-protein ligase RING2, Polycomb complex protein BMI-1 chimera, ...
Authors:Cho, H.J, Cierpicki, T.
Deposit date:2020-04-08
Release date:2021-04-14
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (1.702 Å)
Cite:Small-molecule inhibitors targeting Polycomb repressive complex 1 RING domain.
Nat.Chem.Biol., 17, 2021
3ZYJ
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BU of 3zyj by Molmil
NetrinG1 in complex with NGL1
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, LEUCINE-RICH REPEAT-CONTAINING PROTEIN 4C, ...
Authors:Seiradake, E, Coles, C.H, Perestenko, P.V, Harlos, K, McIlhinney, R.A.J, Aricescu, A.R, Jones, E.Y.
Deposit date:2011-08-23
Release date:2011-10-05
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Structural Basis for Cell Surface Patterning Through Netring-Ngl Interactions.
Embo J., 30, 2011
7V8G
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BU of 7v8g by Molmil
Crystal structure of HOIP RING1 domain bound to IpaH1.4 LRR domain
Descriptor: E3 ubiquitin-protein ligase RNF31, RING-type E3 ubiquitin transferase, ZINC ION
Authors:Liu, J, Wang, Y, Pan, L.
Deposit date:2021-08-23
Release date:2022-03-30
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Mechanistic insights into the subversion of the linear ubiquitin chain assembly complex by the E3 ligase IpaH1.4 of Shigella flexneri.
Proc.Natl.Acad.Sci.USA, 119, 2022
7V8F
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BU of 7v8f by Molmil
Crystal structure of UBE2L3 bound to HOIP RING1 domain.
Descriptor: E3 ubiquitin-protein ligase RNF31, Ubiquitin-conjugating enzyme E2 L3, ZINC ION
Authors:Liu, J, Wang, Y, Pan, L.
Deposit date:2021-08-22
Release date:2022-03-30
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:Mechanistic insights into the subversion of the linear ubiquitin chain assembly complex by the E3 ligase IpaH1.4 of Shigella flexneri.
Proc.Natl.Acad.Sci.USA, 119, 2022
7SEE
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BU of 7see by Molmil
Structure of E. coli LetB delta (Ring6) mutant, Ring1 in the closed state (Model 1)
Descriptor: MCE family protein, Intermembrane transport protein YebT chimera, UNKNOWN ATOM OR ION
Authors:Vieni, C, Coudray, N, Bhabha, G, Ekiert, D.
Deposit date:2021-09-30
Release date:2022-02-09
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Role of Ring6 in the Function of the E. coli MCE Protein LetB.
J.Mol.Biol., 434, 2022
8PP6
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BU of 8pp6 by Molmil
human RYBP-PRC1 bound to H2AK118ub1 nucleosome
Descriptor: DNA (215-MER), Histone H2A, Histone H2B, ...
Authors:Ciapponi, M, Benda, C, Mueller, J.
Deposit date:2023-07-06
Release date:2024-04-03
Last modified:2024-07-31
Method:ELECTRON MICROSCOPY (3.18 Å)
Cite:Structural basis of the histone ubiquitination read-write mechanism of RYBP-PRC1.
Nat.Struct.Mol.Biol., 31, 2024
4R8P
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BU of 4r8p by Molmil
Crystal structure of the Ring1B/Bmi1/UbcH5c PRC1 ubiquitylation module bound to the nucleosome core particle
Descriptor: DNA (147-mer), E3 ubiquitin-protein ligase RING2, Ubiquitin-conjugating enzyme E2 D3, ...
Authors:McGinty, R.K, Henrici, R.C, Tan, S.
Deposit date:2014-09-02
Release date:2014-11-05
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.2846 Å)
Cite:Crystal structure of the PRC1 ubiquitylation module bound to the nucleosome.
Nature, 514, 2014
6WI8
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BU of 6wi8 by Molmil
Inhibitor compound-induced confrontational change in Ring1b-Bmi1 domain structure
Descriptor: E3 ubiquitin-protein ligase RING2,Polycomb complex protein BMI-1 chimera, ZINC ION
Authors:Cho, H.J, Cierpicki, T.
Deposit date:2020-04-09
Release date:2021-04-14
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.092 Å)
Cite:Small-molecule inhibitors targeting Polycomb repressive complex 1 RING domain.
Nat.Chem.Biol., 17, 2021
6N13
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BU of 6n13 by Molmil
UbcH7-Ub Complex with R0RBR Parkin and phosphoubiquitin
Descriptor: E3 ubiquitin-protein ligase parkin, Ubiquitin-conjugating enzyme E2 L3, ZINC ION, ...
Authors:Condos, T.E.C, Dunkerley, K.M, Freeman, E.A, Barber, K.R, Aguirre, J.D, Chaugule, V.K, Xiao, Y, Konermann, L, Walden, H, Shaw, G.S.
Deposit date:2018-11-08
Release date:2018-11-28
Last modified:2020-01-08
Method:SOLUTION NMR
Cite:Synergistic recruitment of UbcH7~Ub and phosphorylated Ubl domain triggers parkin activation.
EMBO J., 37, 2018
7ND1
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BU of 7nd1 by Molmil
First-in-class small molecule inhibitors of Polycomb Repressive Complex 1 (PRC1) RING domain
Descriptor: 3-(2-chlorophenyl)-4-ethyl-5-(1~{H}-indol-4-yl)-1~{H}-pyrrole-2-carboxylic acid, E3 ubiquitin-protein ligase RING2, Polycomb complex protein BMI-1, ...
Authors:Cierpicki, T, Lund, G, Jaremko, L.
Deposit date:2021-01-29
Release date:2021-06-16
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Small-molecule inhibitors targeting Polycomb repressive complex 1 RING domain.
Nat.Chem.Biol., 17, 2021
8PP7
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BU of 8pp7 by Molmil
human RYBP-PRC1 bound to mononucleosome
Descriptor: DNA (215-mer), E3 ubiquitin-protein ligase RING2, Histone H2A, ...
Authors:Ciapponi, M, Benda, C, Mueller, J.
Deposit date:2023-07-06
Release date:2024-03-27
Last modified:2024-07-31
Method:ELECTRON MICROSCOPY (2.91 Å)
Cite:Structural basis of the histone ubiquitination read-write mechanism of RYBP-PRC1.
Nat.Struct.Mol.Biol., 31, 2024
8GRM
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BU of 8grm by Molmil
Cryo-EM structure of PRC1 bound to H2AK119-UbcH5b-Ub nucleosome
Descriptor: COMMD3 protein, DNA (144-MER), DNA (145-MER), ...
Authors:Ai, H.S, Zebin, T, Zhihend, D, Jiakun, T, Liying, Z, Jia-Bin, L, Man, P, Liu, L.
Deposit date:2022-09-02
Release date:2023-04-12
Last modified:2024-07-03
Method:ELECTRON MICROSCOPY (3.05 Å)
Cite:Synthetic E2-Ub-nucleosome conjugates for studying nucleosome ubiquitination.
Chem, 2023
3ZYI
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BU of 3zyi by Molmil
NetrinG2 in complex with NGL2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, LEUCINE-RICH REPEAT-CONTAINING PROTEIN 4, ...
Authors:Seiradake, E, Coles, C.H, Perestenko, P.V, Harlos, K, McIlhinney, R.A.J, Aricescu, A.R, Jones, E.Y.
Deposit date:2011-08-23
Release date:2011-10-05
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural Basis for Cell Surface Patterning Through Netring-Ngl Interactions
Embo J., 30, 2011
3ZYG
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BU of 3zyg by Molmil
NETRING2 LAM AND EGF1 DOMAINS
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, NETRIN-G2
Authors:Seiradake, E, Coles, C.H, Perestenko, P.V, Harlos, K, Mcilhinney, R.A.J, Aricescu, A.R, Jones, E.Y.
Deposit date:2011-08-22
Release date:2011-10-05
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Basis for Cell Surface Patterning Through Netring-Ngl Interactions.
Embo J., 30, 2011
4GPR
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BU of 4gpr by Molmil
Crystal structure of EhUbc5, a ubiquitin conjugating enzyme from Entamoeba histolytica
Descriptor: COBALT (II) ION, Ubiquitin-conjugating enzyme family protein
Authors:Bosch, D.E, Siderovski, D.P.
Deposit date:2012-08-21
Release date:2012-12-12
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural Determinants of Ubiquitin Conjugation in Entamoeba histolytica.
J.Biol.Chem., 288, 2013

 

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