6KIK
 
 | | Crystal structure of a thermostable aldo-keto reductase Tm1743 in complex with inhibitor tolrestat | | Descriptor: | Oxidoreductase, aldo/keto reductase family, TOLRESTAT | | Authors: | Zhang, C.Y, Liu, X.M, Wang, C, Tang, W.R. | | Deposit date: | 2019-07-18 | | Release date: | 2019-09-25 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.601 Å) | | Cite: | Tolrestat acts atypically as a competitive inhibitor of the thermostable aldo-keto reductase Tm1743 from Thermotoga maritima.
Febs Lett., 594, 2020
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1DC1
 | | RESTRICTION ENZYME BSOBI/DNA COMPLEX STRUCTURE: ENCIRCLEMENT OF THE DNA AND HISTIDINE-CATALYZED HYDROLYSIS WITHIN A CANONICAL RESTRICTION ENZYME FOLD | | Descriptor: | 1,4-DIETHYLENE DIOXIDE, BSOBI RESTRICTION ENDONUCLEASE, DNA (5'-D(*T*AP*TP*AP*CP*TP*CP*GP*AP*GP*TP*AP*T)-3') | | Authors: | van der Woerd, M.J, Pelletier, J.J, Xu, S.-Y, Friedman, A.M. | | Deposit date: | 1999-11-04 | | Release date: | 2001-02-21 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Restriction enzyme BsoBI-DNA complex: a tunnel for recognition of degenerate DNA sequences and potential histidine catalysis.
Structure, 9, 2001
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6KY6
 | | Crystal structure of a thermostable aldo-keto reductase Tm1743 in complexs with inhibitor epalrestat in space group P3221cc | | Descriptor: | 2,5-diketo-D-gluconic acid reductase, CHLORIDE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | | Authors: | Zhang, C.Y, Min, Z.Z, Liu, X.M, Wang, C, Tang, W.R. | | Deposit date: | 2019-09-16 | | Release date: | 2019-10-02 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.07 Å) | | Cite: | Tolrestat acts atypically as a competitive inhibitor of the thermostable aldo-keto reductase Tm1743 from Thermotoga maritima.
Febs Lett., 594, 2020
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6KIY
 | | Crystal structure of a thermostable aldo-keto reductase Tm1743 in complex with inhibitor Epalrestat | | Descriptor: | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Oxidoreductase, aldo/keto reductase family, ... | | Authors: | Zhang, C.Y, Liu, X.M, Wang, C, Min, Z.Z, Xu, X.L. | | Deposit date: | 2019-07-20 | | Release date: | 2019-09-25 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Tolrestat acts atypically as a competitive inhibitor of the thermostable aldo-keto reductase Tm1743 from Thermotoga maritima.
Febs Lett., 594, 2020
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1AQZ
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1AZ1
 | | ALRESTATIN BOUND TO C298A/W219Y MUTANT HUMAN ALDOSE REDUCTASE | | Descriptor: | ALDOSE REDUCTASE, ALRESTATIN, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | Authors: | Harrison, D.H.T, Bohren, K.M, Petsko, G.A, Ringe, D, Gabbay, K.H. | | Deposit date: | 1997-11-24 | | Release date: | 1998-03-18 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | The alrestatin double-decker: binding of two inhibitor molecules to human aldose reductase reveals a new specificity determinant.
Biochemistry, 36, 1997
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3P2D
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7DFB
 | | Crystal of Arrestin2-V2Rpp-6-7-Fab30 complex | | Descriptor: | Beta-arrestin-1, FAB30 HEAVY CHAIN, FAB30 LIGHT CHAIN, ... | | Authors: | Sun, J.P, Yu, X, Xiao, P, He, Q.T, Lin, J.Y, Zhu, Z.L. | | Deposit date: | 2020-11-06 | | Release date: | 2021-07-28 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (3.28 Å) | | Cite: | Structural studies of phosphorylation-dependent interactions between the V2R receptor and arrestin-2.
Nat Commun, 12, 2021
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7DF9
 | | Crystal of Arrestin2-V2Rpp-1-Fab30 complex | | Descriptor: | Beta-arrestin-1, FAB30 HEAVY CHAIN, FAB30 LIGHT CHAIN, ... | | Authors: | Sun, J.P, Yu, X, Xiao, P, He, Q.T, Lin, J.Y, Zhu, Z.L. | | Deposit date: | 2020-11-06 | | Release date: | 2021-07-28 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (3.17 Å) | | Cite: | Structural studies of phosphorylation-dependent interactions between the V2R receptor and arrestin-2.
Nat Commun, 12, 2021
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7DFA
 | | Crystal of Arrestin2-V2Rpp-4-Fab30 complex | | Descriptor: | Beta-arrestin-1, FAB30 HEAVY CHAIN, FAB30 LIGHT CHAIN, ... | | Authors: | Sun, J.P, Yu, X, Xiao, P, He, Q.T, Lin, J.Y, Zhu, Z.L. | | Deposit date: | 2020-11-06 | | Release date: | 2021-07-28 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.54 Å) | | Cite: | Structural studies of phosphorylation-dependent interactions between the V2R receptor and arrestin-2.
Nat Commun, 12, 2021
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7DFC
 | | Crystal of Arrestin2-V2Rpp-3-Fab30 complex | | Descriptor: | Beta-arrestin-1, FAB30 HEAVY CHAIN, FAB30 LIGHT CHAIN, ... | | Authors: | Sun, J.P, Yu, X, Xiao, P, He, Q.T, Lin, J.Y, Zhu, Z.L. | | Deposit date: | 2020-11-06 | | Release date: | 2021-07-28 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.49 Å) | | Cite: | Structural studies of phosphorylation-dependent interactions between the V2R receptor and arrestin-2.
Nat Commun, 12, 2021
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8J97
 | | Structure of Muscarinic receptor (M2R) in complex with beta-arrestin1 (Local refine, cross-linked) | | Descriptor: | Beta-arrestin-1, Fab30 Heavy Chain, Fab30 Light Chain, ... | | Authors: | Maharana, J, Sano, F.K, Shihoya, W, Banerjee, R, Nureki, O, Shukla, A.K. | | Deposit date: | 2023-05-02 | | Release date: | 2023-12-27 | | Last modified: | 2024-01-17 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Molecular insights into atypical modes of beta-arrestin interaction with seven transmembrane receptors.
Science, 383, 2024
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8J8R
 | | Structure of beta-arrestin2 in complex with M2Rpp | | Descriptor: | Beta-arrestin-2, Fab30 Heavy Chain, Fab30 Light Chain, ... | | Authors: | Maharana, J, Sano, F.K, Shihoya, W, Banerjee, R, Nureki, O, Shukla, A.K. | | Deposit date: | 2023-05-02 | | Release date: | 2023-12-27 | | Last modified: | 2024-01-17 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Molecular insights into atypical modes of beta-arrestin interaction with seven transmembrane receptors.
Science, 383, 2024
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8JA3
 | | Structure of beta-arrestin1 in complex with C3aRpp | | Descriptor: | Beta-arrestin-1, C3a anaphylatoxin chemotactic receptor, Fab30 heavy chain, ... | | Authors: | Maharana, J, Sarma, P, Yadav, M.K, Chami, M, Banerjee, R, Shukla, A.K. | | Deposit date: | 2023-05-05 | | Release date: | 2023-12-27 | | Last modified: | 2024-01-17 | | Method: | ELECTRON MICROSCOPY (3.94 Å) | | Cite: | Molecular insights into atypical modes of beta-arrestin interaction with seven transmembrane receptors.
Science, 383, 2024
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8JRU
 | | Cryo-EM structure of the glucagon receptor bound to beta-arrestin 1 in ligand-free state | | Descriptor: | Beta-arrestin 1 and single-chain fragment variable 30 (scFv30), HA signal peptide,HPC4 purification tag,Glucagon receptor,C-terminal tail of Vasopressin V2 receptor, Nanobody 32, ... | | Authors: | Chen, K, Zhang, C, Lin, S, Zhao, Q, Wu, B. | | Deposit date: | 2023-06-17 | | Release date: | 2023-08-16 | | Last modified: | 2023-09-13 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Tail engagement of arrestin at the glucagon receptor.
Nature, 620, 2023
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8JRV
 | | Cryo-EM structure of the glucagon receptor bound to glucagon and beta-arrestin 1 | | Descriptor: | Beta-arrestin 1 and single-chain fragment variable 30 (scFv30), Glucagon, HA signal peptide,HPC4 purification tag,Glucagon receptor,C-terminal tail of Vasopressin V2 receptor, ... | | Authors: | Chen, K, Zhang, C, Lin, S, Zhao, Q, Wu, B. | | Deposit date: | 2023-06-17 | | Release date: | 2023-08-16 | | Last modified: | 2023-09-13 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Tail engagement of arrestin at the glucagon receptor.
Nature, 620, 2023
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3LLO
 | | Crystal structure of the STAS domain of motor protein prestin (anion transporter SLC26A5) | | Descriptor: | Prestin, octyl beta-D-glucopyranoside | | Authors: | Pasqualetto, E, Aiello, R, Bonetto, G, Battistutta, R. | | Deposit date: | 2010-01-29 | | Release date: | 2010-05-26 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.57 Å) | | Cite: | Structure of the cytosolic portion of the motor protein prestin and functional role of the STAS domain in SLC26/SulP anion transporters.
J.Mol.Biol., 400, 2010
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4J2Q
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5DWA
 | | Crystal structure of pre-specific restriction endonuclease AgeI-DNA complex | | Descriptor: | DNA (5'-D(*TP*CP*GP*AP*CP*CP*GP*GP*TP*CP*G*)-3'), Type-2 restriction enzyme AgeI | | Authors: | Tamulaitiene, G, Jovaisaite, V, Grazulis, S, Siksnys, V. | | Deposit date: | 2015-09-22 | | Release date: | 2016-10-05 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Restriction endonuclease AgeI is a monomer which dimerizes to cleave DNA.
Nucleic Acids Res., 45, 2017
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5DWC
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5DWB
 | | Crystal structure of specific restriction endonuclease AgeI-DNA complex | | Descriptor: | DNA (5'-D(*TP*TP*CP*GP*AP*CP*CP*GP*GP*TP*CP*GP*A*)-3'), Type-2 restriction enzyme AgeI | | Authors: | Tamulaitiene, G, Jovaisaite, V, Grazulis, S, Siksnys, V. | | Deposit date: | 2015-09-22 | | Release date: | 2016-09-28 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Restriction endonuclease AgeI is a monomer which dimerizes to cleave DNA.
Nucleic Acids Res., 45, 2017
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2OAA
 | | Restriction endonuclease MvaI-cognate DNA substrate complex | | Descriptor: | 5'-D(*CP*AP*TP*CP*CP*AP*GP*GP*TP*AP*C)-3', 5'-D(*GP*GP*TP*AP*CP*CP*TP*GP*GP*AP*T)-3', CALCIUM ION, ... | | Authors: | Kaus-Drobek, M, Czapinska, H, Sokolowska, M, Tamulaitis, G, Szczepanowski, R.H, Urbanke, K, Siksnys, V, Bochtler, M. | | Deposit date: | 2006-12-15 | | Release date: | 2007-02-20 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Restriction endonuclease MvaI is a monomer that recognizes its target sequence asymmetrically.
Nucleic Acids Res., 35, 2007
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2OA9
 | | Restriction endonuclease MvaI in the absence of DNA | | Descriptor: | ACETATE ION, CADMIUM ION, CHLORIDE ION, ... | | Authors: | Kaus-Drobek, M, Czapinska, H, Sokolowska, M, Tamulaitis, G, Szczepanowski, R.H, Urbanke, K, Siksnys, V, Bochtler, M. | | Deposit date: | 2006-12-15 | | Release date: | 2007-02-20 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Restriction endonuclease MvaI is a monomer that recognizes its target sequence asymmetrically.
Nucleic Acids Res., 35, 2007
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1AYR
 | | ARRESTIN FROM BOVINE ROD OUTER SEGMENTS | | Descriptor: | ARRESTIN | | Authors: | Granzin, J, Wilden, U, Choe, H.-W, Labahn, J, Krafft, B, Bueldt, G. | | Deposit date: | 1997-11-10 | | Release date: | 1998-11-25 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | X-ray crystal structure of arrestin from bovine rod outer segments.
Nature, 391, 1998
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1VCP
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