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2P9R
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2p9r
HUMAN ALPHA2-MACROGLOGULIN IS COMPOSED OF MULTIPLE DOMAINS, AS PREDICTED BY HOMOLOGY WITH COMPLEMENT COMPONENT C3
Descriptor:Alpha-2-macroglobulin
Authors:Doan, N.
Deposit date:2007-03-26
Release date:2007-08-21
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Human alpha2-macroglobulin is composed of multiple domains, as predicted by homology with complement component C3.
Biochem.J., 407, 2007
2A73
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2a73
HUMAN COMPLEMENT COMPONENT C3
Descriptor:Complement Component C3
Authors:Janssen, B.J.C., Huizinga, E.G., Raaijmakers, H.C.A., Roos, A., Daha, M.R., Nilsson-Ekdahl, K., Nilsson, B., Gros, P.
Deposit date:2005-07-04
Release date:2005-09-27
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structures of complement component C3 provide insights into the function and evolution of immunity.
Nature, 437, 2005
2A74
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2a74
HUMAN COMPLEMENT COMPONENT C3C
Descriptor:Human Complement Component C3c
Authors:Janssen, B.J.C., Huizinga, E.G., Raaijmakers, H.C.A., Roos, A., Daha, M.R., Nilsson-Ekdahl, K., Nilsson, B., Gros, P.
Deposit date:2005-07-04
Release date:2005-09-27
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structures of complement component C3 provide insights into the function and evolution of immunity.
Nature, 437, 2005
2HR0
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2hr0
STRUCTURE OF COMPLEMENT C3B: INSIGHTS INTO COMPLEMENT ACTIVATION AND REGULATION
Descriptor:Complement C3 beta chain, Complement C3 alpha' chain
Authors:Abdul Ajees, A., Gunasekaran, K., Volanakis, J.E., Narayana, S.V., Kotwal, G.J., Krishna Murthy, H.M.
Deposit date:2006-07-19
Release date:2006-10-31
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:The structure of complement C3b provides insights into complement activation and regulation.
Nature, 444, 2006
2I07
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2i07
HUMAN COMPLEMENT COMPONENT C3B
Descriptor:Complement C3
Authors:Janssen, B.J.C., Christodoulidou, A., McCarthy, A., Lambris, J.D., Gros, P.
Deposit date:2006-08-10
Release date:2006-10-24
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (4 Å)
Cite:Structure of C3b reveals conformational changes that underlie complement activity.
Nature, 444, 2006
2ICE
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2ice
CRIG BOUND TO C3C
Descriptor:Complement C3 beta chain, Complement C3 alpha chain, V-set and immunoglobulin domain-containing protein 4
Authors:Wiesmann, C.
Deposit date:2006-09-12
Release date:2006-11-07
Modification date:2012-09-05
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure of C3b in complex with CRIg gives insights into regulation of complement activation.
Nature, 444, 2006
2ICF
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2icf
CRIG BOUND TO C3B
Descriptor:Complement C3 beta chain, Complement C3 alpha chain, V-set and immunoglobulin domain-containing protein 4
Authors:Wiesmann, C.
Deposit date:2006-09-12
Release date:2006-11-07
Modification date:2013-09-18
Method:X-RAY DIFFRACTION (4.1 Å)
Cite:Structure of C3b in complex with CRIg gives insights into regulation of complement activation.
Nature, 444, 2006
2QKI
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2qki
HUMAN C3C IN COMPLEX WITH THE INHIBITOR COMPSTATIN
Descriptor:Complement C3
Authors:Janssen, B.J.C., Halff, E.F., Lambris, J.D., Gros, P.
Deposit date:2007-07-11
Release date:2007-08-14
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of compstatin in complex with complement component C3c reveals a new mechanism of complement inhibition.
J.Biol.Chem., 282, 2007
2WII
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2wii
COMPLEMENT C3B IN COMPLEX WITH FACTOR H DOMAINS 1-4
Descriptor:COMPLEMENT C3 BETA CHAIN, COMPLEMENT C3B ALPHA' CHAIN, COMPLEMENT FACTOR H
Authors:Wu, J., Janssen, B.J.C., Gros, P.
Deposit date:2009-05-12
Release date:2009-06-09
Modification date:2009-08-04
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure of Complement Fragment C3B-Factor H and Implications for Host Protection by Complement Regulators.
Nat.Immunol., 10, 2009
2WIN
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2win
C3 CONVERTASE (C3BBB) STABILIZED BY SCIN
Descriptor:COMPLEMENT C3 BETA CHAIN, COMPLEMENT C3B ALPHA' CHAIN, COMPLEMENT FACTOR B (E.C.3.4.21.47), STAPHYLOCOCCAL COMPLEMENT INHIBITOR
Authors:Wu, J., Janssen, B.J., Gros, P.
Deposit date:2009-05-13
Release date:2009-06-09
Modification date:2009-09-01
Method:X-RAY DIFFRACTION (3.9 Å)
Cite:Structural and Functional Implications of the Alternative Complement Pathway C3 Convertase Stabilized by a Staphylococcal Inhibitor.
Nat.Immunol., 10, 2009
2XWB
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2xwb
CRYSTAL STRUCTURE OF COMPLEMENT C3B IN COMPLEX WITH FACTORS B AND D
Descriptor:COMPLEMENT C3B BETA CHAIN, COMPLEMENT C3B ALPHA' CHAIN, COMPLEMENT FACTOR B (E.C.3.4.21.47), COMPLEMENT FACTOR D (E.C.3.4.21.46)
Authors:Forneris, F., Ricklin, D., Wu, J., Tzekou, A., Wallace, R.S., Lambris, J.D., Gros, P.
Deposit date:2010-11-01
Release date:2011-01-12
Modification date:2012-04-11
Method:X-RAY DIFFRACTION (3.49 Å)
Cite:Structures of C3B in Complex with Factors B and D Give Insight Into Complement Convertase Formation.
Science, 330, 2010
2XWJ
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2xwj
CRYSTAL STRUCTURE OF COMPLEMENT C3B IN COMPLEX WITH FACTOR B
Descriptor:COMPLEMENT C3 BETA CHAIN, COMPLEMENT C3 ALPHA CHAIN, COMPLEMENT FACTOR B
Authors:Forneris, F., Ricklin, D., Wu, J., Tzekou, A., Wallace, R.S., Lambris, J.D., Gros, P.
Deposit date:2010-11-04
Release date:2011-01-12
Modification date:2012-04-11
Method:X-RAY DIFFRACTION (4 Å)
Cite:Structures of C3B in Complex with Factors B and D Give Insight Into Complement Convertase Formation.
Science, 330, 2010
3FRP
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3frp
CRYSTAL STRUCTURE OF COBRA VENOM FACTOR, A CO-FACTOR FOR C3- AND C5 CONVERTASE CVFBB
Descriptor:Cobra venom factor alpha chain, Cobra venom factor gamma chain, Cobra venom factor beta chain
Authors:Krishnan, V., Narayana, S.V.L.
Deposit date:2009-01-08
Release date:2009-04-28
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:The Crystal Structure of Cobra Venom Factor, a Cofactor for C3- and C5-Convertase CVFBb.
Structure, 17, 2009
3G6J
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3g6j
C3B IN COMPLEX WITH A C3B SPECIFIC FAB
Descriptor:Complement C3 beta chain, Complement C3 alpha chain, Fab light chain, Fab heavy chain
Authors:Wiesmann, C.
Deposit date:2009-02-06
Release date:2009-03-10
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural and Functional Analysis of a C3b-specific Antibody That Selectively Inhibits the Alternative Pathway of Complement
J.Biol.Chem., 284, 2009
3HRZ
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3hrz
COBRA VENOM FACTOR (CVF) IN COMPLEX WITH HUMAN FACTOR B
Descriptor:Cobra venom factor, Complement factor B (E.C.3.4.21.47)
Authors:Janssen, B.J.C., Gomes, L., Koning, R.I., Svergun, D.I., Koster, A.J., Fritzinger, D.C., Vogel, C.-W., Gros, P.
Deposit date:2009-06-10
Release date:2009-07-07
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Insights into complement convertase formation based on the structure of the factor B-cobra venom factor complex
Embo J., 28, 2009
3HS0
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3hs0
COBRA VENOM FACTOR (CVF) IN COMPLEX WITH HUMAN FACTOR B
Descriptor:Cobra venom factor, Complement factor B (E.C.3.4.21.47)
Authors:Janssen, B.J.C., Gomes, L., Koning, R.I., Svergun, D.I., Koster, A.J., Fritzinger, D.C., Vogel, C.-W., Gros, P.
Deposit date:2009-06-10
Release date:2009-07-07
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Insights into complement convertase formation based on the structure of the factor B-cobra venom factor complex
Embo J., 28, 2009
3L3O
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3l3o
STAPHYLOCOCCAL COMPLEMENT INHIBITOR (SCIN) IN COMPLEX WITH HUMAN COMPLEMENT COMPONENT C3C
Descriptor:Complement C3, Staphylococcal complement inhibitor
Authors:Geisbrecht, B.V., Garcia, B.G.
Deposit date:2009-12-17
Release date:2010-08-04
Modification date:2010-09-15
Method:X-RAY DIFFRACTION (3.405 Å)
Cite:Molecular Basis for Complement Recognition and Inhibition Determined by Crystallographic Studies of the Staphylococcal Complement Inhibitor (SCIN) Bound to C3c and C3b.
J.Mol.Biol., 402, 2010
3L5N
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3l5n
STAPHYLOCOCCAL COMPLEMENT INHIBITOR (SCIN) IN COMPLEX WITH HUMAN COMPLEMENT COMPONENT C3B
Descriptor:Complement C3, Staphylococcal complement inhibitor
Authors:Geisbrecht, B.V., Garcia, B.L.
Deposit date:2009-12-22
Release date:2010-08-04
Modification date:2010-09-15
Method:X-RAY DIFFRACTION (7.536 Å)
Cite:Molecular Basis for Complement Recognition and Inhibition Determined by Crystallographic Studies of the Staphylococcal Complement Inhibitor (SCIN) Bound to C3c and C3b.
J.Mol.Biol., 402, 2010
3NMS
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3nms
STAPHYLOCOCCAL COMPLEMENT INHIBITOR (SCIN) IN COMPLEX WITH HUMAN COMPLEMENT C3C
Descriptor:Complement C3, Staphylococcal complement inhibitor
Authors:Geisbrecht, B.V., Garcia, B.L.
Deposit date:2010-06-22
Release date:2010-08-04
Modification date:2010-09-15
Method:X-RAY DIFFRACTION (4.1 Å)
Cite:Molecular Basis for Complement Recognition and Inhibition Determined by Crystallographic Studies of the Staphylococcal Complement Inhibitor (SCIN) Bound to C3c and C3b.
J.Mol.Biol., 402, 2010
3OHX
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3ohx
MOLECULAR BASIS FOR COMPLEMENT RECOGNITION AND INHIBITION DETERMINED BY CRYSTALLOGRAPHIC STUDIES OF THE STAPHYLOCOCCAL COMPLEMENT INHIBITOR (SCIN) BOUND TO C3C AND C3B
Descriptor:Complement C3, Staphylococcal complement inhibitor
Authors:Geisbrecht, B.V., Garcia, B.L.
Deposit date:2010-08-18
Release date:2010-09-01
Modification date:2013-04-24
Method:X-RAY DIFFRACTION (3.503 Å)
Cite:Molecular Basis for Complement Recognition and Inhibition Determined by Crystallographic Studies of the Staphylococcal Complement Inhibitor (SCIN) Bound to C3c and C3b.
J.Mol.Biol., 402, 2010
3T4A
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3t4a
STRUCTURE OF A TRUNCATED FORM OF STAPHYLOCOCCAL COMPLEMENT INHIBITOR B BOUND TO HUMAN C3C AT 3.4 ANGSTROM RESOLUTION
Descriptor:Complement C3 beta chain, Complement C3c alpha' chain fragment 1, Complement C3c alpha' chain fragment 2, Fibrinogen-binding protein
Authors:Garcia, B.L., Geisbrecht, B.V., Summers, B.J.
Deposit date:2011-07-25
Release date:2011-11-23
Modification date:2013-05-22
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Diversity in the C3b Convertase Contact Residues and Tertiary Structures of the Staphylococcal Complement Inhibitor (SCIN) Protein Family.
J.Biol.Chem., 287, 2012
4FXG
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4fxg
COMPLEMENT C4 IN COMPLEX WITH MASP-2
Descriptor:Complement C4-A, Mannan-binding lectin serine protease 2 (E.C.3.4.21.104)
Authors:Kidmose, R.T., Laursen, N.S., Andersen, G.R.
Deposit date:2012-07-03
Release date:2012-08-22
Modification date:2012-10-03
Method:X-RAY DIFFRACTION (3.75 Å)
Cite:Structural basis for activation of the complement system by component C4 cleavage.
Proc.Natl.Acad.Sci.USA, 109, 2012
4FXK
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4fxk
HUMAN COMPLEMENT C4
Descriptor:Complement C4-A
Authors:Kidmose, R.T., Laursen, N.S., Andersen, G.R.
Deposit date:2012-07-03
Release date:2012-08-22
Modification date:2012-10-03
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Structural basis for activation of the complement system by component C4 cleavage.
Proc.Natl.Acad.Sci.USA, 109, 2012
4U48
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4u48
CRYSTAL STRUCTURE OF SALMONELLA ALPHA-2-MACROGLOBULIN
Descriptor:alpha-2-macroglobulin
Authors:Wong, S.G., Dessen, A.
Deposit date:2014-07-23
Release date:2014-09-17
Modification date:2014-10-01
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Structure of a bacterial alpha 2-macroglobulin reveals mimicry of eukaryotic innate immunity.
Nat Commun, 5, 2014
4U4J
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4u4j
CRYSTAL STRUCTURE OF SALMONELLA ALPHA-2-MACROGLOBULIN MUTANT Y1175G
Descriptor:alpha-2-macroglobulin
Authors:Wong, S.G., Dessen, A.
Deposit date:2014-07-23
Release date:2014-09-17
Modification date:2014-10-01
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure of a bacterial alpha 2-macroglobulin reveals mimicry of eukaryotic innate immunity.
Nat Commun, 5, 2014
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entries available on 2014-12-17
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