2P9R
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HUMAN ALPHA2-MACROGLOGULIN IS COMPOSED OF MULTIPLE DOMAINS, AS PREDICTED BY HOMOLOGY WITH COMPLEMENT COMPONENT C3
Descriptor:Alpha-2-macroglobulin
Authors:Doan, N.
Deposit date:2007-03-26
Release date:2007-08-21
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Human alpha2-macroglobulin is composed of multiple domains, as predicted by homology with complement component C3.
Biochem.J., 407, 2007
2A73
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HUMAN COMPLEMENT COMPONENT C3
Descriptor:Complement Component C3
Authors:Janssen, B.J.C., Huizinga, E.G., Raaijmakers, H.C.A., Roos, A., Daha, M.R., Nilsson-Ekdahl, K., Nilsson, B., Gros, P.
Deposit date:2005-07-04
Release date:2005-09-27
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structures of complement component C3 provide insights into the function and evolution of immunity.
Nature, 437, 2005
2A74
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HUMAN COMPLEMENT COMPONENT C3C
Descriptor:Human Complement Component C3c
Authors:Janssen, B.J.C., Huizinga, E.G., Raaijmakers, H.C.A., Roos, A., Daha, M.R., Nilsson-Ekdahl, K., Nilsson, B., Gros, P.
Deposit date:2005-07-04
Release date:2005-09-27
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structures of complement component C3 provide insights into the function and evolution of immunity.
Nature, 437, 2005
2I07
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HUMAN COMPLEMENT COMPONENT C3B
Descriptor:Complement C3
Authors:Janssen, B.J.C., Christodoulidou, A., McCarthy, A., Lambris, J.D., Gros, P.
Deposit date:2006-08-10
Release date:2006-10-24
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (4 Å)
Cite:Structure of C3b reveals conformational changes that underlie complement activity.
Nature, 444, 2006
2ICE
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CRIG BOUND TO C3C
Descriptor:Complement C3 beta chain, Complement C3 alpha chain, V-set and immunoglobulin domain-containing protein 4
Authors:Wiesmann, C.
Deposit date:2006-09-12
Release date:2006-11-07
Modification date:2012-09-05
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure of C3b in complex with CRIg gives insights into regulation of complement activation.
Nature, 444, 2006
2ICF
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CRIG BOUND TO C3B
Descriptor:Complement C3 beta chain, Complement C3 alpha chain, V-set and immunoglobulin domain-containing protein 4
Authors:Wiesmann, C.
Deposit date:2006-09-12
Release date:2006-11-07
Modification date:2013-09-18
Method:X-RAY DIFFRACTION (4.1 Å)
Cite:Structure of C3b in complex with CRIg gives insights into regulation of complement activation.
Nature, 444, 2006
2QKI
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HUMAN C3C IN COMPLEX WITH THE INHIBITOR COMPSTATIN
Descriptor:Complement C3
Authors:Janssen, B.J.C., Halff, E.F., Lambris, J.D., Gros, P.
Deposit date:2007-07-11
Release date:2007-08-14
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of compstatin in complex with complement component C3c reveals a new mechanism of complement inhibition.
J.Biol.Chem., 282, 2007
2WII
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COMPLEMENT C3B IN COMPLEX WITH FACTOR H DOMAINS 1-4
Descriptor:COMPLEMENT C3 BETA CHAIN, COMPLEMENT C3B ALPHA' CHAIN, COMPLEMENT FACTOR H
Authors:Wu, J., Janssen, B.J.C., Gros, P.
Deposit date:2009-05-12
Release date:2009-06-09
Modification date:2009-08-04
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure of Complement Fragment C3B-Factor H and Implications for Host Protection by Complement Regulators.
Nat.Immunol., 10, 2009
2WIN
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C3 CONVERTASE (C3BBB) STABILIZED BY SCIN
Descriptor:COMPLEMENT C3 BETA CHAIN, COMPLEMENT C3B ALPHA' CHAIN, COMPLEMENT FACTOR B (E.C.3.4.21.47), STAPHYLOCOCCAL COMPLEMENT INHIBITOR
Authors:Wu, J., Janssen, B.J., Gros, P.
Deposit date:2009-05-13
Release date:2009-06-09
Modification date:2009-09-01
Method:X-RAY DIFFRACTION (3.9 Å)
Cite:Structural and Functional Implications of the Alternative Complement Pathway C3 Convertase Stabilized by a Staphylococcal Inhibitor.
Nat.Immunol., 10, 2009
2XWB
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CRYSTAL STRUCTURE OF COMPLEMENT C3B IN COMPLEX WITH FACTORS B AND D
Descriptor:COMPLEMENT C3B BETA CHAIN, COMPLEMENT C3B ALPHA' CHAIN, COMPLEMENT FACTOR B (E.C.3.4.21.47), COMPLEMENT FACTOR D (E.C.3.4.21.46)
Authors:Forneris, F., Ricklin, D., Wu, J., Tzekou, A., Wallace, R.S., Lambris, J.D., Gros, P.
Deposit date:2010-11-01
Release date:2011-01-12
Modification date:2012-04-11
Method:X-RAY DIFFRACTION (3.49 Å)
Cite:Structures of C3B in Complex with Factors B and D Give Insight Into Complement Convertase Formation.
Science, 330, 2010
2XWJ
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CRYSTAL STRUCTURE OF COMPLEMENT C3B IN COMPLEX WITH FACTOR B
Descriptor:COMPLEMENT C3 BETA CHAIN, COMPLEMENT C3 ALPHA CHAIN, COMPLEMENT FACTOR B
Authors:Forneris, F., Ricklin, D., Wu, J., Tzekou, A., Wallace, R.S., Lambris, J.D., Gros, P.
Deposit date:2010-11-04
Release date:2011-01-12
Modification date:2012-04-11
Method:X-RAY DIFFRACTION (4 Å)
Cite:Structures of C3B in Complex with Factors B and D Give Insight Into Complement Convertase Formation.
Science, 330, 2010
3G6J
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C3B IN COMPLEX WITH A C3B SPECIFIC FAB
Descriptor:Complement C3 beta chain, Complement C3 alpha chain, Fab light chain, Fab heavy chain
Authors:Wiesmann, C.
Deposit date:2009-02-06
Release date:2009-03-10
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural and Functional Analysis of a C3b-specific Antibody That Selectively Inhibits the Alternative Pathway of Complement
J.Biol.Chem., 284, 2009
3L3O
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STAPHYLOCOCCAL COMPLEMENT INHIBITOR (SCIN) IN COMPLEX WITH HUMAN COMPLEMENT COMPONENT C3C
Descriptor:Complement C3, Staphylococcal complement inhibitor
Authors:Geisbrecht, B.V., Garcia, B.G.
Deposit date:2009-12-17
Release date:2010-08-04
Modification date:2010-09-15
Method:X-RAY DIFFRACTION (3.405 Å)
Cite:Molecular Basis for Complement Recognition and Inhibition Determined by Crystallographic Studies of the Staphylococcal Complement Inhibitor (SCIN) Bound to C3c and C3b.
J.Mol.Biol., 402, 2010
3L5N
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STAPHYLOCOCCAL COMPLEMENT INHIBITOR (SCIN) IN COMPLEX WITH HUMAN COMPLEMENT COMPONENT C3B
Descriptor:Complement C3, Staphylococcal complement inhibitor
Authors:Geisbrecht, B.V., Garcia, B.L.
Deposit date:2009-12-22
Release date:2010-08-04
Modification date:2010-09-15
Method:X-RAY DIFFRACTION (7.536 Å)
Cite:Molecular Basis for Complement Recognition and Inhibition Determined by Crystallographic Studies of the Staphylococcal Complement Inhibitor (SCIN) Bound to C3c and C3b.
J.Mol.Biol., 402, 2010
3NMS
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STAPHYLOCOCCAL COMPLEMENT INHIBITOR (SCIN) IN COMPLEX WITH HUMAN COMPLEMENT C3C
Descriptor:Complement C3, Staphylococcal complement inhibitor
Authors:Geisbrecht, B.V., Garcia, B.L.
Deposit date:2010-06-22
Release date:2010-08-04
Modification date:2010-09-15
Method:X-RAY DIFFRACTION (4.1 Å)
Cite:Molecular Basis for Complement Recognition and Inhibition Determined by Crystallographic Studies of the Staphylococcal Complement Inhibitor (SCIN) Bound to C3c and C3b.
J.Mol.Biol., 402, 2010
3OHX
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MOLECULAR BASIS FOR COMPLEMENT RECOGNITION AND INHIBITION DETERMINED BY CRYSTALLOGRAPHIC STUDIES OF THE STAPHYLOCOCCAL COMPLEMENT INHIBITOR (SCIN) BOUND TO C3C AND C3B
Descriptor:Complement C3, Staphylococcal complement inhibitor
Authors:Geisbrecht, B.V., Garcia, B.L.
Deposit date:2010-08-18
Release date:2010-09-01
Modification date:2013-04-24
Method:X-RAY DIFFRACTION (3.503 Å)
Cite:Molecular Basis for Complement Recognition and Inhibition Determined by Crystallographic Studies of the Staphylococcal Complement Inhibitor (SCIN) Bound to C3c and C3b.
J.Mol.Biol., 402, 2010
3T4A
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STRUCTURE OF A TRUNCATED FORM OF STAPHYLOCOCCAL COMPLEMENT INHIBITOR B BOUND TO HUMAN C3C AT 3.4 ANGSTROM RESOLUTION
Descriptor:Complement C3 beta chain, Complement C3c alpha' chain fragment 1, Complement C3c alpha' chain fragment 2, Fibrinogen-binding protein
Authors:Garcia, B.L., Geisbrecht, B.V., Summers, B.J.
Deposit date:2011-07-25
Release date:2011-11-23
Modification date:2013-05-22
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Diversity in the C3b Convertase Contact Residues and Tertiary Structures of the Staphylococcal Complement Inhibitor (SCIN) Protein Family.
J.Biol.Chem., 287, 2012
4FXG
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COMPLEMENT C4 IN COMPLEX WITH MASP-2
Descriptor:Complement C4-A, Mannan-binding lectin serine protease 2 (E.C.3.4.21.104)
Authors:Kidmose, R.T., Laursen, N.S., Andersen, G.R.
Deposit date:2012-07-03
Release date:2012-08-22
Modification date:2012-10-03
Method:X-RAY DIFFRACTION (3.75 Å)
Cite:Structural basis for activation of the complement system by component C4 cleavage.
Proc.Natl.Acad.Sci.USA, 109, 2012
4FXK
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HUMAN COMPLEMENT C4
Descriptor:Complement C4-A
Authors:Kidmose, R.T., Laursen, N.S., Andersen, G.R.
Deposit date:2012-07-03
Release date:2012-08-22
Modification date:2012-10-03
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Structural basis for activation of the complement system by component C4 cleavage.
Proc.Natl.Acad.Sci.USA, 109, 2012
4XAM
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COMPLEMENT COMPONENT C4B
Descriptor:Complement C4b-A
Authors:Mortensen, S., Kidmose, R.T., Petersen, S.V., Szilagyi, A., Andersen, G.R.
Deposit date:2014-12-15
Release date:2015-05-06
Modification date:2015-05-27
Method:X-RAY DIFFRACTION (4.2 Å)
Cite:Structural Basis for the Function of Complement Component C4 within the Classical and Lectin Pathways of Complement.
J Immunol., 194, 2015
5FO7
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CRYSTAL STRUCTURE OF HUMAN COMPLEMENT C3B AT 2.8 ANGSTROM RESOLUTION
Descriptor:COMPLEMENT C3 BETA CHAIN, COMPLEMENT C3B ALPHA' CHAIN
Authors:Forneris, F., Wu, J., Xue, X., Gros, P.
Deposit date:2015-11-18
Release date:2016-04-06
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Regulators of Complement Activity Mediate Inhibitory Mechanisms Through a Common C3B-Binding Mode.
Embo J., 2016
5FO8
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CRYSTAL STRUCTURE OF HUMAN COMPLEMENT C3B IN COMPLEX WITH MCP (CCP1-4)
Descriptor:COMPLEMENT C3 (E.C.3.4.21.47), MEMBRANE COFACTOR PROTEIN
Authors:Forneris, F., Wu, J., Xue, X., Gros, P.
Deposit date:2015-11-18
Release date:2016-04-06
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Regulators of Complement Activity Mediate Inhibitory Mechanisms Through a Common C3B-Binding Mode.
Embo J., 2016
5FO9
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CRYSTAL STRUCTURE OF HUMAN COMPLEMENT C3B IN COMPLEX WITH CR1 (CCP15- 17)
Descriptor:COMPLEMENT C3 BETA CHAIN, COMPLEMENT C3B ALPHA' CHAIN, COMPLEMENT RECEPTOR TYPE 1
Authors:Forneris, F., Wu, J., Xue, X., Gros, P.
Deposit date:2015-11-18
Release date:2016-04-06
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Regulators of Complement Activity Mediate Inhibitory Mechanisms Through a Common C3B-Binding Mode.
Embo J., 2016
5FOA
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CRYSTAL STRUCTURE OF HUMAN COMPLEMENT C3B IN COMPLEX WITH DAF (CCP2-4)
Descriptor:COMPLEMENT C3 BETA CHAIN, COMPLEMENT C3B ALPHA CHAIN, DECAY ACCELERATING FACTOR, CD55
Authors:Forneris, F., Wu, J., Xue, X., Gros, P.
Deposit date:2015-11-18
Release date:2016-04-06
Method:X-RAY DIFFRACTION (4.188 Å)
Cite:Regulators of Complement Activity Mediate Inhibitory Mechanisms Through a Common C3B-Binding Mode.
Embo J., 2016
5FOB
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CRYSTAL STRUCTURE OF HUMAN COMPLEMENT C3B IN COMPLEX WITH SMALLPOX INHIBITOR OF COMPLEMENT (SPICE)
Descriptor:COMPLEMENT C3 BETA CHAIN, COMPLEMENT C3B ALPHA' CHAIN, SMALLPOX INHIBITOR OF COMPLEMENT SPICE, D15L
Authors:Forneris, F., Wu, J., Xue, X., Gros, P.
Deposit date:2015-11-18
Release date:2016-04-06
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Regulators of Complement Activity Mediate Inhibitory Mechanisms Through a Common C3B-Binding Mode.
Embo J., 2016
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