1ZM8
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APO CRYSTAL STRUCTURE OF NUCLEASE A FROM ANABAENA SP.
Descriptor:Nuclease (E.C.3.1.30.-)
Authors:Ghosh, M., Meiss, G., Pingoud, A., London, R.E., Pedersen, L.C.
Deposit date:2005-05-10
Release date:2005-06-21
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Insights into the Mechanism of Nuclease A, a beta beta alpha Metal Nuclease from Anabaena.
J.Biol.Chem., 280, 2005
3S5B
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CRYSTAL STRUCTURE OF CED-3 PROTEASE SUPPRESSOR-6 (CPS-6) FROM CAENORHABDITIS ELEGANS
Descriptor:Endonuclease G (E.C.3.1.30.-)
Authors:Yuan, H.S., Lin, J.L.J.
Deposit date:2011-05-23
Release date:2012-01-11
Modification date:2013-06-19
Method:X-RAY DIFFRACTION (1.796 Å)
Cite:Structural insights into apoptotic DNA degradation by CED-3 protease suppressor-6 (CPS-6) from Caenorhabditis elegans
J.Biol.Chem., 287, 2012
4A1N
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HUMAN MITOCHONDRIAL ENDO-EXONUCLEASE
Descriptor:NUCLEASE EXOG, MITOCHONDRIAL (E.C.3.1.30.-)
Authors:Welin, M., Moche, M., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Edwards, A.M., Flodin, S., Graslund, S., Hammarstrom, M., Johansson, I., Karlberg, T., Kotenyova, T., Nyman, T., Persson, C., Schuler, H., Thorsell, A.G., Tresaugues, L., Weigelt, J., Nordlund, P.
Deposit date:2011-09-16
Release date:2012-02-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Human Mitochondrial Endo-Exonuclease
To be Published
4QN0
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CRYSTAL STRUCTURE OF THE CPS-6 MUTANT Q130K
Descriptor:Endonuclease G, mitochondrial (E.C.3.1.30.-)
Authors:Lin, J.L.J., Yuan, H.S.
Deposit date:2014-06-17
Release date:2015-06-17
Method:X-RAY DIFFRACTION (2.74 Å)
Cite:Crystal structure of the CPS-6 mutant Q130K
To be Published
2O3B
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CRYSTAL STRUCTURE COMPLEX OF NUCLEASE A (NUCA) WITH INTRA-CELLULAR INHIBITOR NUIA
Descriptor:Nuclease (E.C.3.1.30.-), Sugar-non-specific nuclease inhibitor
Authors:Ghosh, M., Meiss, G., Pingoud, A.M., London, R.E., Pedersen, L.C.
Deposit date:2006-12-01
Release date:2006-12-19
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The nuclease a-inhibitor complex is characterized by a novel metal ion bridge.
J.Biol.Chem., 282, 2007
3ISM
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CRYSTAL STRUCTURE OF THE ENDOG/ENDOGI COMPLEX: MECHANISM OF ENDOG INHIBITION
Descriptor:CG8862, CG4930 (E.C.3.6.1.3)
Authors:Loll, B., Gebhardt, M., Wahle, E., Meinhart, A.
Deposit date:2009-08-26
Release date:2009-09-08
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of the EndoG/EndoGI complex: mechanism of EndoG inhibition.
Nucleic Acids Res., 37, 2009
4GTW
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CRYSTAL STRUCTURE OF MOUSE ENPP1 IN COMPLEX WITH AMP
Descriptor:Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, Alkaline phosphodiesterase I (E.C.3.1.4.39)
Authors:Kato, K., Nishimasu, H., Ishitani, R., Nureki, O.
Deposit date:2012-08-29
Release date:2012-11-07
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of Enpp1, an extracellular glycoprotein involved in bone mineralization and insulin signaling.
Proc.Natl.Acad.Sci.USA, 109, 2012
4GTZ
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CRYSTAL STRUCTURE OF MOUSE ENPP1 IN COMPLEX WITH CMP
Descriptor:Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, Alkaline phosphodiesterase I (E.C.3.1.4.39)
Authors:Kato, K., Nishimasu, H., Ishitani, R., Nureki, O.
Deposit date:2012-08-29
Release date:2012-11-07
Method:X-RAY DIFFRACTION (3.191 Å)
Cite:Crystal structure of Enpp1, an extracellular glycoprotein involved in bone mineralization and insulin signaling.
Proc.Natl.Acad.Sci.USA, 109, 2012
2XR9
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CRYSTAL STRUCTURE OF AUTOTAXIN (ENPP2)
Descriptor:ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE FAMILY MEMBER 2 (E.C.3.1.4.39)
Authors:Kamtekar, S., Hausmann, J., Day, J.E., Christodoulou, E., Perrakis, A.
Deposit date:2010-09-13
Release date:2011-01-19
Modification date:2011-02-16
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural Basis of Substrate Discrimination and Integrin Binding by Autotaxin.
Nat.Struct.Mol.Biol., 18, 2011
2XRG
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CRYSTAL STRUCTURE OF AUTOTAXIN (ENPP2) IN COMPLEX WITH THE HA155 BORONIC ACID INHIBITOR
Descriptor:ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE FAMILY MEMBER 2 (E.C.3.1.4.39)
Authors:Hausmann, J., Albers, H.M.H.G., Perrakis, A.
Deposit date:2010-09-14
Release date:2011-01-19
Modification date:2011-02-16
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural Basis of Substrate Discrimination and Integrin Binding by Autotaxin.
Nat.Struct.Mol.Biol., 18, 2011
3NKM
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CRYSTAL STRUCTURE OF MOUSE AUTOTAXIN
Descriptor:Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (E.C.3.1.4.39)
Authors:Nishimasu, H., Ishitani, R., Mihara, E., Takagi, J., Aoki, J., Nureki, O.
Deposit date:2010-06-20
Release date:2011-01-19
Modification date:2014-02-19
Method:X-RAY DIFFRACTION (2.002 Å)
Cite:Crystal structure of autotaxin and insight into GPCR activation by lipid mediators
Nat.Struct.Mol.Biol., 18, 2011
3NKN
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CRYSTAL STRUCTURE OF MOUSE AUTOTAXIN IN COMPLEX WITH 14:0-LPA
Descriptor:Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (E.C.3.1.4.39)
Authors:Nishimasu, H., Ishitani, R., Mihara, E., Takagi, J., Aoki, J., Nureki, O.
Deposit date:2010-06-20
Release date:2011-01-19
Modification date:2014-02-19
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of autotaxin and insight into GPCR activation by lipid mediators
Nat.Struct.Mol.Biol., 18, 2011
3NKO
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CRYSTAL STRUCTURE OF MOUSE AUTOTAXIN IN COMPLEX WITH 16:0-LPA
Descriptor:Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (E.C.3.1.4.39)
Authors:Nishimasu, H., Ishitani, R., Mihara, E., Takagi, J., Aoki, J., Nureki, O.
Deposit date:2010-06-20
Release date:2011-01-19
Modification date:2014-02-19
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Crystal structure of autotaxin and insight into GPCR activation by lipid mediators
Nat.Struct.Mol.Biol., 18, 2011
3NKP
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CRYSTAL STRUCTURE OF MOUSE AUTOTAXIN IN COMPLEX WITH 18:1-LPA
Descriptor:Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (E.C.3.1.4.39)
Authors:Nishimasu, H., Ishitani, R., Mihara, E., Takagi, J., Aoki, J., Nureki, O.
Deposit date:2010-06-20
Release date:2011-01-19
Modification date:2014-02-19
Method:X-RAY DIFFRACTION (1.751 Å)
Cite:Crystal structure of autotaxin and insight into GPCR activation by lipid mediators
Nat.Struct.Mol.Biol., 18, 2011
3NKQ
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CRYSTAL STRUCTURE OF MOUSE AUTOTAXIN IN COMPLEX WITH 18:3-LPA
Descriptor:Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (E.C.3.1.4.39)
Authors:Nishimasu, H., Ishitani, R., Mihara, E., Takagi, J., Aoki, J., Nureki, O.
Deposit date:2010-06-20
Release date:2011-01-19
Modification date:2014-02-19
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure of autotaxin and insight into GPCR activation by lipid mediators
Nat.Struct.Mol.Biol., 18, 2011
3NKR
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CRYSTAL STRUCTURE OF MOUSE AUTOTAXIN IN COMPLEX WITH 22:6-LPA
Descriptor:Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (E.C.3.1.4.39)
Authors:Nishimasu, H., Ishitani, R., Mihara, E., Takagi, J., Aoki, J., Nureki, O.
Deposit date:2010-06-20
Release date:2011-01-19
Modification date:2014-02-19
Method:X-RAY DIFFRACTION (1.704 Å)
Cite:Crystal structure of autotaxin and insight into GPCR activation by lipid mediators
Nat.Struct.Mol.Biol., 18, 2011
3WAV
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CRYSTAL STRUCTURE OF AUTOTAXIN IN COMPLEX WITH COMPOUND 10
Descriptor:Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (E.C.3.1.4.39)
Authors:Nishimasu, H., Ishitani, R., Nureki, O.
Deposit date:2013-05-09
Release date:2013-07-31
Modification date:2013-10-16
Method:X-RAY DIFFRACTION (1.797 Å)
Cite:Screening and X-ray Crystal Structure-based Optimization of Autotaxin (ENPP2) Inhibitors, Using a Newly Developed Fluorescence Probe
Acs Chem.Biol., 8, 2013
3WAW
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CRYSTAL STRUCTURE OF AUTOTAXIN IN COMPLEX WITH 2BOA
Descriptor:Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (E.C.3.1.4.39)
Authors:Nishimasu, H., Ishitani, R., Nureki, O.
Deposit date:2013-05-09
Release date:2013-07-31
Modification date:2013-10-16
Method:X-RAY DIFFRACTION (1.954 Å)
Cite:Screening and X-ray Crystal Structure-based Optimization of Autotaxin (ENPP2) Inhibitors, Using a Newly Developed Fluorescence Probe
Acs Chem.Biol., 8, 2013
3WAX
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CRYSTAL STRUCTURE OF AUTOTAXIN IN COMPLEX WITH 3BOA
Descriptor:Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (E.C.3.1.4.39)
Authors:Nishimasu, H., Ishitani, R., Nureki, O.
Deposit date:2013-05-09
Release date:2013-07-31
Modification date:2013-10-16
Method:X-RAY DIFFRACTION (1.899 Å)
Cite:Screening and X-ray Crystal Structure-based Optimization of Autotaxin (ENPP2) Inhibitors, Using a Newly Developed Fluorescence Probe
Acs Chem.Biol., 8, 2013
3WAY
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CRYSTAL STRUCTURE OF AUTOTAXIN IN COMPLEX WITH 4BOA
Descriptor:Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (E.C.3.1.4.39)
Authors:Nishimasu, H., Ishitani, R., Nureki, O.
Deposit date:2013-05-09
Release date:2013-07-31
Modification date:2013-10-16
Method:X-RAY DIFFRACTION (1.746 Å)
Cite:Screening and X-ray Crystal Structure-based Optimization of Autotaxin (ENPP2) Inhibitors, Using a Newly Developed Fluorescence Probe
Acs Chem.Biol., 8, 2013
4B56
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STRUCTURE OF ECTONUCLEOTIDE PYROPHOSPHATASE-PHOSPHODIESTERASE-1 (NPP1)
Descriptor:ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE FAMILY MEMBER 1 (E.C.3.1.4.1, 3.6.1.9)
Authors:Jansen, S., Perrakis, A., Ulens, C., Winkler, C., Andries, M., Joosten, R.P., Van Acker, M., Luyten, F.P., Moolenaar, W.H., Bollen, M.
Deposit date:2012-08-02
Release date:2012-09-19
Modification date:2012-11-21
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of Npp1, an Ectonucleotide Pyrophosphatase/Phosphodiesterase Involved in Tissue Calcification.
Structure, 20, 2012
4GTX
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CRYSTAL STRUCTURE OF MOUSE ENPP1 IN COMPLEX WITH TMP
Descriptor:Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, Alkaline phosphodiesterase I (E.C.3.1.4.39)
Authors:Kato, K., Nishimasu, H., Ishitani, R., Nureki, O.
Deposit date:2012-08-29
Release date:2012-11-07
Method:X-RAY DIFFRACTION (3.201 Å)
Cite:Crystal structure of Enpp1, an extracellular glycoprotein involved in bone mineralization and insulin signaling.
Proc.Natl.Acad.Sci.USA, 109, 2012
4GTY
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CRYSTAL STRUCTURE OF MOUSE ENPP1 IN COMPLEX WITH GMP
Descriptor:Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, Alkaline phosphodiesterase I (E.C.3.1.4.39)
Authors:Kato, K., Nishimasu, H., Ishitani, R., Nureki, O.
Deposit date:2012-08-29
Release date:2012-11-07
Method:X-RAY DIFFRACTION (3.19 Å)
Cite:Crystal structure of Enpp1, an extracellular glycoprotein involved in bone mineralization and insulin signaling.
Proc.Natl.Acad.Sci.USA, 109, 2012
4ZG6
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STRUCTURAL BASIS FOR INHIBITION OF HUMAN AUTOTAXIN BY FOUR NOVEL COMPOUNDS
Descriptor:Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (E.C.3.1.4.39)
Authors:Stein, A.J., Bain, G., Hutchinson, J.H., Evans, J.F.
Deposit date:2015-04-22
Release date:2015-10-14
Modification date:2015-11-11
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural Basis for Inhibition of Human Autotaxin by Four Potent Compounds with Distinct Modes of Binding.
Mol.Pharmacol., 88, 2015
4ZG7
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STRUCTURAL BASIS FOR INHIBITION OF HUMAN AUTOTAXIN BY FOUR NOVEL COMPOUNDS
Descriptor:Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (E.C.3.1.4.39)
Authors:Stein, A.J., Bain, G., Hutchinson, J.H., Evans, J.F.
Deposit date:2015-04-22
Release date:2015-10-14
Modification date:2015-11-11
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural Basis for Inhibition of Human Autotaxin by Four Potent Compounds with Distinct Modes of Binding.
Mol.Pharmacol., 88, 2015
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