Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

3P48
DownloadVisualize
BU of 3p48 by Molmil
Structure of the yeast dUTPase DUT1 in complex with dUMPNPP
Descriptor: 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, Deoxyuridine 5'-triphosphate nucleotidohydrolase, MAGNESIUM ION
Authors:Petit, P, Singer, A.U, Evdokimova, E, Kudritska, M, Edwards, A.M, Yakunin, A.F, Savchenko, A, Ontario Centre for Structural Proteomics (OCSP)
Deposit date:2010-10-06
Release date:2010-10-27
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:Structure and activity of the Saccharomyces cerevisiae dUTP pyrophosphatase DUT1, an essential housekeeping enzyme.
Biochem.J., 437, 2011
5H4J
DownloadVisualize
BU of 5h4j by Molmil
Crystal structure of Human dUTPase in complex with N-[(1R)-1-[3-(Cyclopentyloxy)-phenyl]-ethyl]-3-[(3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)methoxy]-1-propanesulfonamide
Descriptor: DIMETHYL SULFOXIDE, Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial, ...
Authors:Chong, K.T, Miyahara, S, Miyakoshi, H, Fukuoka, M.
Deposit date:2016-11-01
Release date:2017-11-01
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:TAS-114, a First-in-Class Dual dUTPase/DPD Inhibitor, Demonstrates Potential to Improve Therapeutic Efficacy of Fluoropyrimidine-Based Chemotherapy.
Mol. Cancer Ther., 17, 2018
4WRK
DownloadVisualize
BU of 4wrk by Molmil
The 3D structure of D95N mutant DUTPase from phage phi11 of S. aureus reveals the molecular details for the coordination of a structural Mg(II) ion
Descriptor: 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, DUTPase, MAGNESIUM ION
Authors:Bendes, A.A, Leveles, I, Vertessy, B.G.
Deposit date:2014-10-24
Release date:2015-12-23
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:The 3D structure of D95N mutant DUTPase from phage phi11 of S. aureus reveals the molecular details for the coordination of a structural Mg(II) ion
To Be Published
1VYQ
DownloadVisualize
BU of 1vyq by Molmil
Novel inhibitors of Plasmodium Falciparum dUTPase provide a platform for anti-malarial drug design
Descriptor: 2,3-DEOXY-3-FLUORO-5-O-TRITYLURIDINE, DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE
Authors:Whittingham, J.L, Leal, I, Kasinathan, G, Nguyen, C, Bell, E, Jones, A.F, Berry, C, Benito, A, Turkenburg, J.P, Dodson, E.J, Ruiz Perez, L.M, Wilkinson, A.J, Johansson, N.G, Brun, R, Gilbert, I.H, Gonzalez Pacanowska, D, Wilson, K.S.
Deposit date:2004-05-05
Release date:2005-05-26
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Dutpase as a Platform for Antimalarial Drug Design: Structural Basis for the Selectivity of a Class of Nucleoside Inhibitors.
Structure, 13, 2005
8HRV
DownloadVisualize
BU of 8hrv by Molmil
dutpase of helicobacter pylori 26695
Descriptor: 1,2-ETHANEDIOL, 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, Deoxyuridine 5'-triphosphate nucleotidohydrolase, ...
Authors:Kumari, K, Gourinath, S.
Deposit date:2022-12-16
Release date:2024-01-17
Method:X-RAY DIFFRACTION (2 Å)
Cite:dutpase of helicobacter pylori 26695
To Be Published
5VJY
DownloadVisualize
BU of 5vjy by Molmil
Crystal Structure of dUTP pyrophosphatase protein, from Naegleria fowleri
Descriptor: 1,2-ETHANEDIOL, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, dUTP pyrophosphatase
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2017-04-20
Release date:2017-05-03
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of dUTP pyrophosphatase protein, from Naegleria fowleri
to be published
4LHR
DownloadVisualize
BU of 4lhr by Molmil
Crystal structure of a deoxyuridine 5'-triphosphate nucleotidohydrolase from Burkholderia thailandensis
Descriptor: Deoxyuridine 5'-triphosphate nucleotidohydrolase, TETRAETHYLENE GLYCOL
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2013-07-01
Release date:2013-08-07
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal structure of a deoxyuridine 5'-triphosphate nucleotidohydrolase from Burkholderia thailandensis
TO BE PUBLISHED
7BPD
DownloadVisualize
BU of 7bpd by Molmil
Crystal structural analysis of Swine dUTPase
Descriptor: Deoxyuridine triphosphatase
Authors:Liang, R, Peng, G.Q.
Deposit date:2020-03-22
Release date:2021-03-24
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Crystal structural analysis of swine dUTPase
To Be Published
8CGA
DownloadVisualize
BU of 8cga by Molmil
Structure of Mycobacterium tuberculosis dUTPase delta 133A-137S mutant
Descriptor: 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Deoxyuridine 5'-triphosphate nucleotidohydrolase, ...
Authors:Toth, Z.S, Benedek, A, Leveles, I, Vertessy, B.G.
Deposit date:2023-02-03
Release date:2024-05-15
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Structure of Mycobacterium tuberculosis dUTPase delta 133A-137S mutant
To Be Published
5NZ2
DownloadVisualize
BU of 5nz2 by Molmil
Twist and induce: Dissecting the link between the enzymatic activity and the SaPI inducing capacity of the phage 80 dUTPase. D95E mutant from dUTPase 80alpha phage.
Descriptor: 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, DUTPase, MAGNESIUM ION
Authors:Alite, C, Humphrey, S, Donderis, J, Maiques, E, Ciges-Tomas, J.R, Penades, J.R, Marina, A.
Deposit date:2017-05-12
Release date:2017-09-20
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Dissecting the link between the enzymatic activity and the SaPI inducing capacity of the phage 80 alpha dUTPase.
Sci Rep, 7, 2017
5NYZ
DownloadVisualize
BU of 5nyz by Molmil
Twist and induce: Dissecting the link between the enzymatic activity and the SaPI inducing capacity of the phage 80 dUTPase. D95E mutant from dUTPase 80alpha phage.
Descriptor: 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, DUTPase, MAGNESIUM ION
Authors:Alite, C, Humphrey, S, Donderis, J, Maiques, E, Ciges-Tomas, J.R, Penades, J.R, Marina, A.
Deposit date:2017-05-12
Release date:2017-09-20
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Dissecting the link between the enzymatic activity and the SaPI inducing capacity of the phage 80 alpha dUTPase.
Sci Rep, 7, 2017
4OOQ
DownloadVisualize
BU of 4ooq by Molmil
apo-dUTPase from Arabidopsis thaliana
Descriptor: Deoxyuridine 5'-triphosphate nucleotidohydrolase, MAGNESIUM ION, SULFATE ION
Authors:Inoguchi, N, Bajaj, M, Moriyama, H.
Deposit date:2014-02-03
Release date:2015-07-22
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.004 Å)
Cite:Structural insights into the mechanism defining substrate affinity in Arabidopsis thaliana dUTPase: the role of tryptophan 93 in ligand orientation.
BMC Res Notes, 8, 2015
4OOP
DownloadVisualize
BU of 4oop by Molmil
Arabidopsis thaliana dUTPase with with magnesium and alpha,beta-imido-dUTP
Descriptor: 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, Deoxyuridine 5'-triphosphate nucleotidohydrolase, MAGNESIUM ION
Authors:Inoguchi, N, Bajaj, M, Moriyama, H.
Deposit date:2014-02-03
Release date:2015-04-08
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural insights into the mechanism defining substrate affinity in Arabidopsis thaliana dUTPase: the role of tryptophan 93 in ligand orientation.
BMC Res Notes, 8, 2015
7N6S
DownloadVisualize
BU of 7n6s by Molmil
Crystal Structure of deoxyuridine 5'-triphosphate nucleotidohydrolase from Rickettsia prowazekii str. Madrid E in complex with 2'-deoxyuridine 5'-monophoephate (dUMP)
Descriptor: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, Deoxyuridine 5'-triphosphate nucleotidohydrolase
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2021-06-09
Release date:2021-06-23
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Crystal Structure of deoxyuridine 5'-triphosphate nucleotidohydrolase from Rickettsia prowazekii str. Madrid E in complex with 2'-deoxyuridine 5'-monophoephate (dUMP)
to be published
7N56
DownloadVisualize
BU of 7n56 by Molmil
Crystal Structure of deoxyuridine 5'-triphosphate nucleotidohydrolase from Rickettsia prowazekii str. Madrid E
Descriptor: Deoxyuridine 5'-triphosphate nucleotidohydrolase, SULFATE ION
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2021-06-04
Release date:2021-07-07
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Crystal Structure of deoxyuridine 5'-triphosphate nucleotidohydrolase from Rickettsia prowazekii str. Madrid E
to be published
6HDE
DownloadVisualize
BU of 6hde by Molmil
Structure of Escherichia coli dUTPase Q93H mutant
Descriptor: 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, Deoxyuridine 5'-triphosphate nucleotidohydrolase, MAGNESIUM ION
Authors:Benedek, A, Vertessy, B.G, Leveles, I.
Deposit date:2018-08-17
Release date:2019-08-28
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:The Role of a Key Amino Acid Position in Species-Specific Proteinaceous dUTPase Inhibition.
Biomolecules, 9, 2019
5Y5Q
DownloadVisualize
BU of 5y5q by Molmil
Crystal structure of the WSSV dUTPase D88N/R158E mutant in complex with dUTP
Descriptor: DEOXYURIDINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Wsv112
Authors:Ma, Q, Zang, K.
Deposit date:2017-08-09
Release date:2017-12-06
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:The dUTPase of white spot syndrome virus assembles its active sites in a noncanonical manner.
J. Biol. Chem., 293, 2018
2HR6
DownloadVisualize
BU of 2hr6 by Molmil
Crystal structure of dUTPase in complex with substrate analogue dUDP and manganese
Descriptor: 1,2-ETHANEDIOL, DEOXYURIDINE-5'-DIPHOSPHATE, Deoxyuridine 5'-triphosphate nucleotidohydrolase, ...
Authors:Barabas, O, Kovari, J, Tapai, R, Vertessy, B.G.
Deposit date:2006-07-19
Release date:2007-07-31
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Methylene substitution at the alpha-beta bridging position within the phosphate chain of dUDP profoundly perturbs ligand accommodation into the dUTPase active site.
Proteins, 71, 2008
5Y5O
DownloadVisualize
BU of 5y5o by Molmil
Crystal structure of the dUTPase of white spot syndrome virus in the apo state
Descriptor: Wsv112
Authors:Ma, Q, Zang, K.
Deposit date:2017-08-09
Release date:2017-12-06
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The dUTPase of white spot syndrome virus assembles its active sites in a noncanonical manner.
J. Biol. Chem., 293, 2018
4GCY
DownloadVisualize
BU of 4gcy by Molmil
Structure of Mycobacterium tuberculosis dUTPase H21W mutant
Descriptor: 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Deoxyuridine 5'-triphosphate nucleotidohydrolase, ...
Authors:Toth, J, Vertessy, B.G, Leveles, I, Bendes, A.
Deposit date:2012-07-31
Release date:2013-07-03
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:RAMD identification of substrate binding pathways to the active site of dUTPase
To be Published
2HQU
DownloadVisualize
BU of 2hqu by Molmil
Human dUTPase in complex with alpha,beta-iminodUTP and magnesium ion
Descriptor: 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, CHLORIDE ION, Deoxyuridine 5'-triphosphate nucleotidohydrolase, ...
Authors:Barabas, O, Varga, B, Vertessy, B.G.
Deposit date:2006-07-19
Release date:2007-07-24
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Active site closure facilitates juxtaposition of reactant atoms for initiation of catalysis by human dUTPase.
Febs Lett., 581, 2007
1MQ7
DownloadVisualize
BU of 1mq7 by Molmil
CRYSTAL STRUCTURE OF DUTPASE FROM MYCOBACTERIUM TUBERCULOSIS (RV2697C)
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE
Authors:Sawaya, M.R, Chan, S, Segelke, B.W, Lekin, T, Heike, K, Cho, U.S, Naranjo, C, Perry, L.J, Yeates, T.O, Eisenberg, D, TB Structural Genomics Consortium (TBSGC)
Deposit date:2002-09-13
Release date:2002-10-09
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal structure of the Mycobacterium tuberculosis dUTPase: insights into the catalytic mechanism.
J.Mol.Biol., 341, 2004
8K6W
DownloadVisualize
BU of 8k6w by Molmil
dUTPase of helicobacter pylori 26695
Descriptor: Deoxyuridine 5'-triphosphate nucleotidohydrolase
Authors:Kumari, K, Samudrala, G.
Deposit date:2023-07-25
Release date:2024-07-31
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:dUTPase of helicobacter pylori 26695
To Be Published
5Y5P
DownloadVisualize
BU of 5y5p by Molmil
Crystal structure of the dUTPase of white spot syndrome virus in complex with dU,PPi and Mg2+
Descriptor: 2'-DEOXYURIDINE, MAGNESIUM ION, PYROPHOSPHATE 2-, ...
Authors:Ma, Q, Zang, K.
Deposit date:2017-08-09
Release date:2017-12-06
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:The dUTPase of white spot syndrome virus assembles its active sites in a noncanonical manner.
J. Biol. Chem., 293, 2018
2HRM
DownloadVisualize
BU of 2hrm by Molmil
Crystal structure of dUTPase complexed with substrate analogue methylene-dUTP
Descriptor: 1,2-ETHANEDIOL, 2'-DEOXY-5'-O-[(S)-HYDROXY(PHOSPHONOMETHYL)PHOSPHORYL]URIDINE, Deoxyuridine 5'-triphosphate nucleotidohydrolase
Authors:Barabas, O, Kovari, J, Tapai, R, Vertessy, B.G.
Deposit date:2006-07-20
Release date:2007-07-31
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Methylene substitution at the alpha-beta bridging position within the phosphate chain of dUDP profoundly perturbs ligand accommodation into the dUTPase active site.
Proteins, 71, 2008

225158

PDB entries from 2024-09-18

PDB statisticsPDBj update infoContact PDBjnumon