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2K7Z
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BU of 2k7z by Molmil
Solution Structure of the Catalytic Domain of Procaspase-8
Descriptor: Caspase-8
Authors:Keller, N, Zerbe, O, Mares, J, Gruetter, M.G.
Deposit date:2008-08-28
Release date:2009-03-24
Last modified:2024-05-08
Method:SOLUTION NMR
Cite:Structural and biochemical studies on procaspase-8: new insights on initiator caspase activation.
Structure, 17, 2009
3R7N
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BU of 3r7n by Molmil
Caspase-2 bound with two copies of Ac-DVAD-CHO
Descriptor: Caspase-2 subunit p12, Caspase-2 subunit p18, Peptide Inhibitor (ACE)DVAD-CHO
Authors:Tang, Y, Wells, J, Arkin, M.
Deposit date:2011-03-22
Release date:2011-07-27
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:Structural and enzymatic insights into caspase-2 protein substrate recognition and catalysis.
J.Biol.Chem., 286, 2011
7SEO
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BU of 7seo by Molmil
Crystal Structure of Caspase-3 with Peptide Inhibitor Ac-VDV(DAB)D-CHO
Descriptor: ACE-VAL-ASP-VAL-DAB-ASP, Caspase-3 subunit p12, Caspase-3 subunit p17
Authors:Fuller, J.L, Finzel, B.C.
Deposit date:2021-09-30
Release date:2022-01-05
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Structure-Based Design and Biological Evaluation of Novel Caspase-2 Inhibitors Based on the Peptide AcVDVAD-CHO and the Caspase-2-Mediated Tau Cleavage Sequence YKPVD314.
Acs Pharmacol Transl Sci, 5, 2022
8A53
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BU of 8a53 by Molmil
Crystal structure of AtMCA-IIf C147A (metacaspase 9) from Arabidopsis thaliana
Descriptor: Metacaspase-9, NITRATE ION
Authors:Sabljic, I, Stael, S, Stahlberg, J, Bozhkov, P.
Deposit date:2022-06-14
Release date:2023-05-31
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structure-function study of a Ca 2+ -independent metacaspase involved in lateral root emergence.
Proc.Natl.Acad.Sci.USA, 120, 2023
1BMQ
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BU of 1bmq by Molmil
CRYSTAL STRUCTURE OF THE COMPLEX OF INTERLEUKIN-1BETA CONVERTING ENZYME (ICE) WITH A PEPTIDE BASED INHIBITOR, (3S )-N-METHANESULFONYL-3-({1-[N-(2-NAPHTOYL)-L-VALYL]-L-PROLYL }AMINO)-4-OXOBUTANAMIDE
Descriptor: (3S)-N-METHANESULFONYL-3-({1-[N-(2-NAPHTOYL)-L-VALYL]-L-PROLYL}AMINO)-4-OXOBUTANAMIDE, PROTEIN (INTERLEUKIN-1 BETA CONVERTASE)
Authors:Okamoto, Y, Anan, H, Nakai, E, Morihira, K, Yonetoku, Y, Kurihara, H, Katayama, N, Sakashita, H, Terai, Y, Takeuchi, M, Shibanuma, T, Isomura, Y.
Deposit date:1998-07-24
Release date:1998-07-29
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Peptide based interleukin-1 beta converting enzyme (ICE) inhibitors: synthesis, structure activity relationships and crystallographic study of the ICE-inhibitor complex.
Chem.Pharm.Bull., 47, 1999
7JL7
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BU of 7jl7 by Molmil
Zebrafish Caspase N213T
Descriptor: ASP-GLU-VAL-ASP peptide, Caspase 3, apoptosis-related cysteine protease a
Authors:Clark, A.C, Swartz, P.D.
Deposit date:2020-07-29
Release date:2021-01-27
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Remodeling hydrogen bond interactions results in relaxed specificity of Caspase-3.
Biosci.Rep., 41, 2021
6F6R
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BU of 6f6r by Molmil
Crystal structure of human Caspase-1 with N-{3-[1-((S)-2-Hydroxy-5-oxo-tetrahydro-furan-3-ylcarbamoyl)-ethyl]-1-methyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl}-4-(quinoxalin-2-ylamino)-benzamide
Descriptor: (3~{S})-3-[[(2~{R})-2-[3-methyl-2,6-bis(oxidanylidene)-5-[[4-(quinoxalin-2-ylamino)phenyl]carbonylamino]pyrimidin-1-yl]propanoyl]amino]-4-oxidanyl-butanoic acid, Caspase-1, SULFATE ION
Authors:Fournier, J.F, Clary, L, Chambon, S, Dumais, L, Harris, C.S, Millois-Barbuis, C, Pierre, R, Talano, S, Thoreau, E, Aubert, J, Aurelly, M, Bouix-Peter, C, Brethon, A, Chantalat, L, Christin, O, Comino, C, El-Bazbouz, G, Ghilini, A.L, Isabet, T, Lardy, C, Luzy, A.P, Mathieu, C, Mebrouk, K, Orfila, D, Pascau, J, Reverse, K, Roche, D, Rodeschini, V, Hennequin, L.F.
Deposit date:2017-12-06
Release date:2018-05-02
Last modified:2018-05-23
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Rational Drug Design of Topically Administered Caspase 1 Inhibitors for the Treatment of Inflammatory Acne.
J. Med. Chem., 61, 2018
5MTK
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Crystal structure of human Caspase-1 with (3S,6S,10aS)-N-((2S,3S)-2-hydroxy-5-oxotetrahydrofuran-3-yl)-6-(isoquinoline-1-carboxamido)-5-oxodecahydropyrrolo[1,2-a]azocine-3-carboxamide (PGE-3935199)
Descriptor: (3~{S})-3-[[(3~{S},6~{S},10~{a}~{S})-6-(isoquinolin-1-ylcarbonylamino)-5-oxidanylidene-2,3,6,7,8,9,10,10~{a}-octahydro-1~{H}-pyrrolo[1,2-a]azocin-3-yl]carbonylamino]-4-oxidanyl-butanoic acid, Caspase-1
Authors:Brethon, A, Chantalat, L, Christin, O, Clary, L, Fournier, J.F, Gastreich, M, Harris, C, Pascau, J, Isabet, T, Rodeschin, V, Thoreau, E, Roche, D.
Deposit date:2017-01-09
Release date:2018-02-28
Method:X-RAY DIFFRACTION (2.53 Å)
Cite:Playing against the odds: scaffold hopping from 3D-fragments
To Be Published
1QTN
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BU of 1qtn by Molmil
CRYSTAL STRUCTURE OF THE COMPLEX OF CASPASE-8 WITH THE TETRAPEPTIDE INHIBITOR ACE-IETD-ALDEHYDE
Descriptor: ACETYL-ILE-GLU-THR-ASP-ALDEHYDE, CASPASE-8, DITHIANE DIOL
Authors:Watt, W, Watenpaugh, K.D.
Deposit date:1999-06-28
Release date:2000-09-20
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:The atomic-resolution structure of human caspase-8, a key activator of apoptosis.
Structure Fold.Des., 7, 1999
5K20
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BU of 5k20 by Molmil
Caspase-7 S239E Phosphomimetic
Descriptor: Caspase-7 large subunit, Caspase-7 small subunit, FORMIC ACID
Authors:Eron, S.J, Hardy, J.A.
Deposit date:2016-05-18
Release date:2017-01-11
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:PAK2 Phosphorylation Inhibits Caspase-7 by Two Divergent Mechanisms: Slowing Activation and Blocking Substrate Binding
To Be Published
5MMV
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BU of 5mmv by Molmil
Crystal structure of human Caspase-1 with 2-((2-naphthoyl)-L-valyl)-4-hydroxy-N-((3S)-2-hydroxy-5-oxotetrahydrofuran-3-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide (Compound 1)
Descriptor: (3~{S})-3-[[(3~{S})-2-[(2~{S})-3-methyl-2-(naphthalen-2-ylcarbonylamino)butanoyl]-4-oxidanyl-2-azabicyclo[2.2.2]octan-3-yl]carbonylamino]-4-oxidanyl-butanoic acid, Caspase-1
Authors:Brethon, A, Chantalat, L, Christin, O, Clary, L, Fournier, J.F, Gastreich, M, Harris, C, Pascau, J, Isabet, T, Rodeschin, V, Thoreau, E, Roche, D.
Deposit date:2016-12-12
Release date:2017-12-20
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Crystal structure of human Caspase-1 with 2-((2-naphthoyl)-L-valyl)-4-hydroxy-N-((3S)-2-hydroxy-5-oxotetrahydrofuran-3-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide (Compound 1)
To Be Published
2XYH
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BU of 2xyh by Molmil
Caspase-3:CAS60254719
Descriptor: 5-CHLORO-4-OXOPENTANOIC ACID, CASPASE-3 SUBUNIT P12, CASPASE-3 SUBUNIT P17
Authors:Ganesan, R, Jelakovic, S, Grutter, M.G, Mittl, P.R.
Deposit date:2010-11-17
Release date:2011-08-17
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:In Silico Identification and Crystal Structure Validation of Caspase-3 Inhibitors without a P1 Aspartic Acid Moiety.
Acta Crystallogr.,Sect.F, 67, 2011
1QX3
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BU of 1qx3 by Molmil
Conformational restrictions in the active site of unliganded human caspase-3
Descriptor: Apopain
Authors:Ni, C.-Z, Li, C, Wu, J.C, Spada, A.P, Ely, K.R.
Deposit date:2003-09-04
Release date:2003-10-07
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Conformational restrictions in the active site of unliganded human caspase-3
J.MOL.RECOG., 16, 2003
2XYP
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BU of 2xyp by Molmil
Caspase-3:CAS26049945
Descriptor: CASPASE-3 SUBUNIT P12, CASPASE-3 SUBUNIT P17, PHENYLMETHYL N-[(2S)-4-CHLORO-3-OXO-1-PHENYL-BUTAN-2-YL]CARBAMATE
Authors:Ganesan, R, Jelakovic, S, Grutter, M.G, Mittl, P.R.
Deposit date:2010-11-18
Release date:2011-08-17
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:In Silico Identification and Crystal Structure Validation of Caspase-3 Inhibitors without a P1 Aspartic Acid Moiety.
Acta Crystallogr.,Sect.F, 67, 2011
6NRY
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BU of 6nry by Molmil
Crystal structure of human caspase-4
Descriptor: Caspase-4, GLYCEROL
Authors:Yang, J, Liu, Z, Shi, W, Xiao, T.S.
Deposit date:2019-01-24
Release date:2020-07-29
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.184 Å)
Cite:Crystal structure of human caspase-4
To Be Published
6PZP
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BU of 6pzp by Molmil
Crystal structure of caspase-1 in complex with VX-765
Descriptor: Caspase-1, N-(4-amino-3-chlorobenzene-1-carbonyl)-3-methyl-L-valyl-N-[(2S)-1-carboxy-3-oxopropan-2-yl]-L-prolinamide
Authors:Yang, J, Liu, Z, Xiao, T.S.
Deposit date:2019-08-01
Release date:2020-08-05
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Crystal structure of caspase-1 in complex with VX-765
To Be Published
5V6Z
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BU of 5v6z by Molmil
Crystal structure of human caspase-7 soaked with allosteric inhibitor 2-{[2-(4-chlorophenyl)-2-oxoethyl]sulfanyl}benzoic acid
Descriptor: 2-{[2-(4-chlorophenyl)-2-oxoethyl]sulfanyl}benzoic acid, Caspase-7
Authors:Vance, N.R, Gakhar, L, Spies, M.A.
Deposit date:2017-03-17
Release date:2018-03-21
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of human caspase-7 soaked with allosteric inhibitor
To Be Published
8DGZ
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BU of 8dgz by Molmil
Caspase-7 bound to substrate mimic and allosteric inhibitor
Descriptor: 2-{[2-(4-chlorophenyl)-2-oxoethyl]sulfanyl}benzoic acid, Ac-Asp-Glu-Val-Asp-Aldehyde, Caspase-7
Authors:Propp, J, Kalenkiewicz, A, Kathryn, F.H, Spies, M.A.
Deposit date:2022-06-24
Release date:2023-07-05
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Allosteric Tuning of Caspase-7: Establishing the Nexus of Structure and Catalytic Power.
Chemistry, 29, 2023
8DJ3
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BU of 8dj3 by Molmil
Caspase-7 bound to novel allosteric inhibitor
Descriptor: 2-[(2-{[(3s,5s,7s)-adamantan-1-yl]sulfamoyl}phenyl)sulfanyl]benzoic acid, Caspase-7
Authors:Propp, J, Kalenkiewicz, A, Kathryn, F.H, Spies, M.A.
Deposit date:2022-06-29
Release date:2023-07-05
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Allosteric Tuning of Caspase-7: Establishing the Nexus of Structure and Catalytic Power.
Chemistry, 29, 2023
5V6U
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BU of 5v6u by Molmil
Crystal structure of human caspase-7 soaked with allosteric inhibitor 2-[(2-acetylphenyl)sulfanyl]benzoic acid
Descriptor: 2-[(2-acetylphenyl)sulfanyl]benzoic acid, Caspase-7
Authors:Vance, N.R, Gakhar, L, Spies, M.A.
Deposit date:2017-03-17
Release date:2017-10-18
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Allosteric Tuning of Caspase-7: A Fragment-Based Drug Discovery Approach.
Angew. Chem. Int. Ed. Engl., 56, 2017
6NS7
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BU of 6ns7 by Molmil
Crystal structure of murine caspase-11
Descriptor: Caspase-11, SULFATE ION
Authors:Yang, J, Liu, Z, Xiao, T.S.
Deposit date:2019-01-24
Release date:2020-07-29
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of murine caspase-11
To Be Published
6PX9
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BU of 6px9 by Molmil
Crystal structure of procaspase-8 in complex with covalent small molecule inhibitor 63-R
Descriptor: Caspase-8, N-{(3R)-1-[4-(morpholin-4-yl)benzene-1-carbonyl]piperidin-3-yl}-N-phenylacetamide
Authors:Xu, J.H, Wolan, D.W.
Deposit date:2019-07-25
Release date:2020-01-29
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.88 Å)
Cite:Integrative X-ray Structure and Molecular Modeling for the Rationalization of Procaspase-8 Inhibitor Potency and Selectivity.
Acs Chem.Biol., 15, 2020
5JFT
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BU of 5jft by Molmil
Zebra Fish Caspase-3
Descriptor: (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, ACE-ASP-GLU-VAL-ASK, ...
Authors:Tucker, M.B, MacKenzie, S.H, Maciag, J.J, Dirscherl, H, Swartz, P.D, Yoder, J.A, Hamilton, P.T, Clark, A.C.
Deposit date:2016-04-19
Release date:2016-10-26
Last modified:2016-11-02
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Phage display and structural studies reveal plasticity in substrate specificity of caspase-3a from zebrafish.
Protein Sci., 25, 2016
2P2C
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BU of 2p2c by Molmil
Inhibition of caspase-2 by a designed ankyrin repeat protein (DARPin)
Descriptor: Caspase-2
Authors:Roschitzki Voser, H, Briand, C, Capitani, G, Gruetter, M.G.
Deposit date:2007-03-07
Release date:2007-05-22
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3.24 Å)
Cite:Inhibition of Caspase-2 by a Designed Ankyrin Repeat Protein: Specificity, Structure, and Inhibition Mechanism.
Structure, 15, 2007
2NN3
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BU of 2nn3 by Molmil
structure of pro-sf-caspase-1
Descriptor: Caspase-1
Authors:Fisher, A.J, Ni, L.
Deposit date:2006-10-23
Release date:2007-10-23
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3 Å)
Cite:Pro-sfcapsase-1, structural insights into activation mechanism of caspases
To be Published

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