8UD0
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8UCZ
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8UCY
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8P2M
| C. elegans TIR-1 protein. | Descriptor: | NAD(+) hydrolase tir-1 | Authors: | Isupov, M.N, Opatowsky, Y. | Deposit date: | 2023-05-16 | Release date: | 2023-09-06 | Method: | ELECTRON MICROSCOPY (3.82 Å) | Cite: | Structure-function analysis of ceTIR-1/hSARM1 explains the lack of Wallerian axonal degeneration in C. elegans. Cell Rep, 42, 2023
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8J1I
| Crystal Structure of EphA8/SASH1 Complex | Descriptor: | Ephrin type-A receptor 8, SAM and SH3 domain-containing protein 1 | Authors: | Liu, W, Li, J, Ding, Y. | Deposit date: | 2023-04-12 | Release date: | 2024-02-28 | Last modified: | 2024-09-11 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | SASH1: A Novel Eph Receptor Partner and Insights into SAM-SAM Interactions. J.Mol.Biol., 435, 2023
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8IJR
| The cryo-EM structure of human sphingomyelin synthase-related protein in complex with diacylglycerol/phosphoethanolamine | Descriptor: | (2S)-1-(hexadecanoyloxy)-3-hydroxypropan-2-yl (11Z)-octadec-11-enoate, PHOSPHORIC ACID MONO-(2-AMINO-ETHYL) ESTER, Sphingomyelin synthase-related protein 1 | Authors: | Hu, K, Zhang, Q, Chen, Y, Yao, D, Zhou, L, Cao, Y. | Deposit date: | 2023-02-28 | Release date: | 2024-02-28 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.29 Å) | Cite: | Cryo-EM structure of human sphingomyelin synthase and its mechanistic implications for sphingomyelin synthesis. Nat.Struct.Mol.Biol., 31, 2024
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8BW8
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8BW9
| Cryo-EM structure of the RAF activating complex KSR-MEK-CNK-HYP | Descriptor: | Connector enhancer of KSR protein CNK, Dual specificity mitogen-activated protein kinase kinase dSOR1, KSR, ... | Authors: | Maisonneuve, P, Fronzes, R, Sicheri, F. | Deposit date: | 2022-12-06 | Release date: | 2024-02-21 | Last modified: | 2024-07-31 | Method: | ELECTRON MICROSCOPY (3.32 Å) | Cite: | The CNK-HYP scaffolding complex promotes RAF activation by enhancing KSR-MEK interaction. Nat.Struct.Mol.Biol., 31, 2024
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8B10
| Crystal Structure of Shank2-SAM mutant domain - L1800W | Descriptor: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Bento, I, Gracia Alai, M, Kreienkamp, J.-H. | Deposit date: | 2022-09-08 | Release date: | 2022-11-30 | Last modified: | 2024-09-11 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structural deficits in key domains of Shank2 lead to alterations in postsynaptic nanoclusters and to a neurodevelopmental disorder in humans. Mol Psychiatry, 29, 2024
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8ATJ
| Crystal Structure of Shank2-SAM domain | Descriptor: | CHLORIDE ION, FORMIC ACID, Isoform 4 of SH3 and multiple ankyrin repeat domains protein 2, ... | Authors: | Bento, I, Gracia Alai, M, Kreienkamp, J.-H. | Deposit date: | 2022-08-23 | Release date: | 2022-11-30 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.117 Å) | Cite: | Structural deficits in key domains of Shank2 lead to alterations in postsynaptic nanoclusters and to a neurodevelopmental disorder in humans. Mol Psychiatry, 2022
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7KJB
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7KJA
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7KJC
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6LUK
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6LUJ
| Crystal structure of the SAMD1 SAM domain | Descriptor: | Atherin, SULFATE ION | Authors: | Cao, Y, Zhou, Y, Wang, Z. | Deposit date: | 2020-01-29 | Release date: | 2021-02-03 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.12 Å) | Cite: | The SAM domain-containing protein 1 (SAMD1) acts as a repressive chromatin regulator at unmethylated CpG islands. Sci Adv, 7, 2021
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6KR4
| Crystal structure of the liprin-alpha3_SAM123/LAR_D1D2 complex | Descriptor: | HEXAETHYLENE GLYCOL, Liprin-alpha-3, PHOSPHATE ION, ... | Authors: | Xie, X, Liang, M, Luo, L, Wei, Z. | Deposit date: | 2019-08-20 | Release date: | 2020-01-15 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Structural basis of liprin-alpha-promoted LAR-RPTP clustering for modulation of phosphatase activity. Nat Commun, 11, 2020
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6KIP
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5ZRX
| Crystal Structure of EphA2/SHIP2 Complex | Descriptor: | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2,Ephrin type-A receptor 2 | Authors: | Wang, Y, Shang, Y, Li, J, Chen, W, Li, G, Wan, J, Liu, W, Zhang, M. | Deposit date: | 2018-04-25 | Release date: | 2018-05-30 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Specific Eph receptor-cytoplasmic effector signaling mediated by SAM-SAM domain interactions. Elife, 7, 2018
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5ZRY
| Crystal Structure of EphA6/Odin Complex | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Ankyrin repeat and SAM domain-containing protein 1A,Ephrin type-A receptor 6, ... | Authors: | Wang, Y, Shang, Y, Li, J, Chen, W, Li, G, Wan, J, Liu, W, Zhang, M. | Deposit date: | 2018-04-25 | Release date: | 2018-05-30 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Specific Eph receptor-cytoplasmic effector signaling mediated by SAM-SAM domain interactions. Elife, 7, 2018
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5ZRZ
| Crystal Structure of EphA5/SAMD5 Complex | Descriptor: | Ephrin type-A receptor 5, Sterile alpha motif domain-containing protein 5 | Authors: | Wang, Y, Shang, Y, Li, J, Chen, W, Li, G, Wan, J, Liu, W, Zhang, M. | Deposit date: | 2018-04-25 | Release date: | 2018-05-30 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Specific Eph receptor-cytoplasmic effector signaling mediated by SAM-SAM domain interactions. Elife, 7, 2018
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6G8O
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6FXF
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6F7M
| NMR structure of EphA2-Sam stapled peptides (S13ST) | Descriptor: | Ephrin type-A receptor 2 | Authors: | Mercurio, F.A, Leone, M. | Deposit date: | 2017-12-11 | Release date: | 2018-08-01 | Last modified: | 2023-11-15 | Method: | SOLUTION NMR | Cite: | Sam domain-based stapled peptides: Structural analysis and interaction studies with the Sam domains from the EphA2 receptor and the lipid phosphatase Ship2. Bioorg. Chem., 80, 2018
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5NZ9
| NMR structure of an EphA2-Sam fragment | Descriptor: | Ephrin type-A receptor 2 | Authors: | Mercurio, F.A, Leone, M. | Deposit date: | 2017-05-12 | Release date: | 2017-12-20 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | The Sam-Sam interaction between Ship2 and the EphA2 receptor: design and analysis of peptide inhibitors. Sci Rep, 7, 2017
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5L1M
| CASKIN2 SAM domain tandem | Descriptor: | Caskin-2 | Authors: | Donaldson, L.W, Kwan, J.J, Saridakis, V. | Deposit date: | 2016-07-29 | Release date: | 2016-08-10 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.751 Å) | Cite: | A new mode of SAM domain mediated oligomerization observed in the CASKIN2 neuronal scaffolding protein. Cell Commun. Signal, 14, 2016
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