9IJE
 
 | | Epinephrine-activated human beta3 adrenergic receptor | | Descriptor: | Beta-3 adrenergic receptor, Camelid antibody VHH fragment, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Zheng, S, Zhang, S, Dai, S, Chen, K, Gao, K, Lin, B, Liu, X. | | Deposit date: | 2024-06-22 | | Release date: | 2024-08-21 | | Method: | ELECTRON MICROSCOPY (2.34 Å) | | Cite: | Molecular Mechanism of the beta 3AR Agonist Activity of a beta-Blocker.
Chempluschem, 2024
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9IJD
 | | Carazolol-activated human beta3 adrenergic receptor | | Descriptor: | (2S)-1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)propan-2-ol, Beta-3 adrenergic receptor, Camelid antibody VHH fragment, ... | | Authors: | Zheng, S, Zhang, S, Dai, S, Chen, K, Gao, K, Lin, B, Liu, X. | | Deposit date: | 2024-06-22 | | Release date: | 2024-08-21 | | Method: | ELECTRON MICROSCOPY (2.76 Å) | | Cite: | Molecular Mechanism of the beta 3AR Agonist Activity of a beta-Blocker.
Chempluschem, 2024
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8JJP
 | | G protein-coupled receptor 1 | | Descriptor: | CHOLESTEROL, Chemerin-like receptor 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Liu, A, Liu, Y, Chen, G, Ye, F. | | Deposit date: | 2023-05-31 | | Release date: | 2024-08-21 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | G protein-coupled receptor 1
To Be Published
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8XGM
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8U02
 | | CryoEM structure of D2 dopamine receptor in complex with GoA KE mutant and dopamine | | Descriptor: | D(2) dopamine receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Krumm, B.E, Kapolka, N.J, Fay, J.F, Roth, B.L. | | Deposit date: | 2023-08-28 | | Release date: | 2024-08-21 | | Method: | ELECTRON MICROSCOPY (3.28 Å) | | Cite: | A neurodevelopmental disorder mutation locks G proteins in the transitory pre-activated state.
Nat Commun, 15, 2024
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8TZQ
 | | CryoEM structure of D2 dopamine receptor in complex with GoA KE Mutant, scFv16, and dopamine | | Descriptor: | D(2) dopamine receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Krumm, B.E, Kapolka, N.J, Fay, J.F, Roth, B.L. | | Deposit date: | 2023-08-27 | | Release date: | 2024-08-21 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | A neurodevelopmental disorder mutation locks G proteins in the transitory pre-activated state.
Nat Commun, 15, 2024
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8ZFJ
 | | cryo-EM structure of GPR4-Gs complex at pH 8.5 | | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | | Authors: | Ma, Y, Tang, M, Ru, H, Song, G. | | Deposit date: | 2024-05-07 | | Release date: | 2024-08-07 | | Last modified: | 2024-08-14 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | cryo-EM structure of GPR4-Gs complex at pH 8.5
to be published
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8YW5
 | | Cryo-EM structure of the retatrutide-bound human GCGR-Gs complex | | Descriptor: | Glucagon receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Li, W.Z, Zhou, Q.T, Cong, Z.T, Yuan, Q.N, Li, W.X, Zhao, F.H, Xu, H.E, Zhao, L.H, Yang, D.H, Wang, M.W. | | Deposit date: | 2024-03-29 | | Release date: | 2024-08-07 | | Method: | ELECTRON MICROSCOPY (2.84 Å) | | Cite: | Structural insights into the triple agonism at GLP-1R, GIPR and GCGR manifested by retatrutide.
Cell Discov, 10, 2024
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8K6N
 | | Structural complex of neuropeptide Y receptor 2 | | Descriptor: | C-flanking peptide of NPY, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Shen, S.Y, Zhao, C, Shao, Z.H. | | Deposit date: | 2023-07-25 | | Release date: | 2024-07-31 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structural complex of neuropeptide Y receptor 2
To Be Published
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8K6O
 | | Structural complex of neuropeptide Y receptor 1 | | Descriptor: | C-flanking peptide of NPY, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Shen, S.Y, Zhao, C, Shao, Z.H. | | Deposit date: | 2023-07-25 | | Release date: | 2024-07-31 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Structural complex of neuropeptide Y receptor 1
To Be Published
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8K6M
 | | Structural complex of neuropeptide Y receptor 1 | | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-2, ... | | Authors: | Shen, S.Y, Zhao, C, Shao, Z.H. | | Deposit date: | 2023-07-25 | | Release date: | 2024-07-31 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Structural complex of neuropeptide Y receptor 1
To Be Published
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8KGG
 | | LPS-bound P2Y10 in complex with G13 | | Descriptor: | (2~{S})-2-$l^{4}-azanyl-3-[[(2~{R})-3-octadecanoyloxy-2-oxidanyl-propoxy]-oxidanyl-oxidanylidene-$l^{6}-phosphanyl]oxy-propanoic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | He, Y, Yin, Y. | | Deposit date: | 2023-08-19 | | Release date: | 2024-07-31 | | Method: | ELECTRON MICROSCOPY (3.06 Å) | | Cite: | LPS-bound P2Y10 in complex with G13
To Be Published
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8K4P
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8K4O
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9IJ9
 | | A Cryo-EM structure of Bitter taste receptor TAS2R14 with Gi complex | | Descriptor: | 4-methyl-N-[(2M)-2-(1H-tetrazol-5-yl)phenyl]-6-(trifluoromethyl)pyrimidin-2-amine, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Yuan, Q, Duan, J, Tao, L, Xu, E.H. | | Deposit date: | 2024-06-21 | | Release date: | 2024-07-24 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Bitter taste receptor TAS2R14 activation and G protein assembly by an intracellular agonist.
Cell Res., 2024
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8K3Z
 | | Cryo-EM structure of CXCR4 in complex with CXCL12 | | Descriptor: | C-X-C chemokine receptor type 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Liu, Y.Z, Liu, A.J, Liao, Q.W, Ye, R.D. | | Deposit date: | 2023-07-17 | | Release date: | 2024-07-17 | | Method: | ELECTRON MICROSCOPY (2.81 Å) | | Cite: | Cryo-EM structure of CXCR4 in complex with CXCL12
To Be Published
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8XQN
 | | Structure of human class T GPCR TAS2R14-DNGi complex with Aristolochic acid A. | | Descriptor: | 8-methoxy-6-nitro-naphtho[1,2-e][1,3]benzodioxole-5-carboxylic acid, CHOLESTEROL, Exo-alpha-sialidase,Taste receptor type 2 member 14,LgBiT, ... | | Authors: | Hu, X.L, Wu, L.J, Hua, T, Liu, Z.J. | | Deposit date: | 2024-01-05 | | Release date: | 2024-07-10 | | Last modified: | 2024-07-31 | | Method: | ELECTRON MICROSCOPY (3.05 Å) | | Cite: | Bitter taste TAS2R14 activation by intracellular tastants and cholesterol.
Nature, 631, 2024
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8XQT
 | | Structure of human class T GPCR TAS2R14-Gi complex. | | Descriptor: | CHOLESTEROL, Exo-alpha-sialidase,Taste receptor type 2 member 14,LgBiT, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Hu, X.L, Pei, Y, Wu, L.J, Hua, T, Liu, Z.J. | | Deposit date: | 2024-01-05 | | Release date: | 2024-07-10 | | Last modified: | 2024-07-24 | | Method: | ELECTRON MICROSCOPY (2.94 Å) | | Cite: | Bitter taste TAS2R14 activation by intracellular tastants and cholesterol.
Nature, 631, 2024
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8ZBE
 | | cryo-EM structure of the octreotide-bound SSTR5-Gi complex | | Descriptor: | Beta-2 adrenergic receptor,Somatostatin receptor type 5,lgbit (fusion protein), Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | | Authors: | Li, Y.G, Meng, X.Y, Yang, X.R, Ling, S.L, Shi, P, Tian, C.L, Yang, F. | | Deposit date: | 2024-04-26 | | Release date: | 2024-07-10 | | Method: | ELECTRON MICROSCOPY (3.24 Å) | | Cite: | Structural insights into somatostatin receptor 5 bound with cyclic peptides.
Acta Pharmacol.Sin., 2024
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8ZQE
 | | Cryo-EM structure of the GPR15L(C11)-bound GPR15 complex | | Descriptor: | GPR15, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Zhang, Z.Y, Zheng, Y, Xu, F. | | Deposit date: | 2024-06-02 | | Release date: | 2024-07-10 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Molecular recognition of the atypical chemokine-like peptide GPR15L by its cognate receptor GPR15.
Cell Discov, 10, 2024
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8XQO
 | | Structure of human class T GPCR TAS2R14-Gi complex with Aristolochic acid A. | | Descriptor: | 8-methoxy-6-nitro-naphtho[1,2-e][1,3]benzodioxole-5-carboxylic acid, CHOLESTEROL, Exo-alpha-sialidase,Taste receptor type 2 member 14,LgBiT, ... | | Authors: | Hu, X.L, Wu, L.J, Hua, T, Liu, Z.J. | | Deposit date: | 2024-01-05 | | Release date: | 2024-07-10 | | Last modified: | 2024-07-24 | | Method: | ELECTRON MICROSCOPY (2.77 Å) | | Cite: | Bitter taste TAS2R14 activation by intracellular tastants and cholesterol.
Nature, 631, 2024
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8ZCJ
 | | Cryo-EM structure of the pasireotide-bound SSTR5-Gi complex | | Descriptor: | 004-DTR-LYS-TYR-PHA-HYP, Beta-2 adrenergic receptor,Somatostatin receptor type 5,lgbit (fusion protein), Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Li, Y.G, Meng, X.Y, Yang, X.R, Ling, S.L, Shi, P, Tian, C.L, Yang, F. | | Deposit date: | 2024-04-29 | | Release date: | 2024-07-10 | | Method: | ELECTRON MICROSCOPY (3.09 Å) | | Cite: | Structural insights into somatostatin receptor 5 bound with cyclic peptides.
Acta Pharmacol.Sin., 2024
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8XQS
 | | Structure of human class T GPCR TAS2R14-DNGi complex with Flufenamic acid. | | Descriptor: | 2-[[3-(TRIFLUOROMETHYL)PHENYL]AMINO] BENZOIC ACID, CHOLESTEROL, Exo-alpha-sialidase,Taste receptor type 2 member 14,LgBiT, ... | | Authors: | Hu, X.L, Wu, L.J, Hua, T, Liu, Z.J. | | Deposit date: | 2024-01-05 | | Release date: | 2024-07-10 | | Last modified: | 2024-07-24 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Bitter taste TAS2R14 activation by intracellular tastants and cholesterol.
Nature, 631, 2024
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8ZJE
 | | Cryo-EM structure of kisspeptin receptor bound to TAK-448 | | Descriptor: | ACY-DTY-HYP-ASN-THR-PHE-XZA-LEU-NMM-TRP-NH2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Shen, S, Liu, H, Xu, H.E. | | Deposit date: | 2024-05-14 | | Release date: | 2024-07-03 | | Method: | ELECTRON MICROSCOPY (3.07 Å) | | Cite: | Cryo-EM structure of kisspeptin receptor bound to TAK-448
To Be Published
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8ZH8
 | | Human GPR103 -Gq complex bound to QRFP26 | | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2,Guanine nucleotide-binding protein G(i) subunit alpha-2,Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Iwama, A, Akasaka, H, Sano, F.K, Oshima, H.S, Shihoya, W, Nureki, O. | | Deposit date: | 2024-05-10 | | Release date: | 2024-07-03 | | Method: | ELECTRON MICROSCOPY (3.19 Å) | | Cite: | Structure and dynamics of the pyroglutamylated RF-amide peptide QRFP receptor GPR103.
Nat Commun, 15, 2024
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