1F16
  • Download 1f16
  • View 1f16
Molmil generated image of 1f16
SOLUTION STRUCTURE OF A PRO-APOPTOTIC PROTEIN BAX
Descriptor:SOLUTION STRUCTURE OF A PRO-APOPTOTIC PROTEIN BAX
Authors:Suzuki, M., Youle, R.J., Tjandra, N.
Deposit date:2000-05-18
Release date:2000-11-22
Modification date:2009-02-24
Method:SOLUTION NMR
Cite:Structure of Bax: coregulation of dimer formation and intracellular localization.
Cell(Cambridge,Mass.), 103, 2000
1K3K
  • Download 1k3k
  • View 1k3k
Molmil generated image of 1k3k
SOLUTION STRUCTURE OF A BCL-2 HOMOLOG FROM KAPOSI'S SARCOMA VIRUS
Descriptor:functional anti-apoptotic factor vBCL-2 homolog
Authors:Huang, Q., Petros, A.M., Virgin, H.W., Fesik, S.W., Olejniczak, E.T.
Deposit date:2001-10-03
Release date:2002-04-10
Modification date:2009-02-24
Method:SOLUTION NMR
Cite:Solution structure of a Bcl-2 homolog from Kaposi sarcoma virus.
Proc.Natl.Acad.Sci.USA, 99, 2002
1Q59
  • Download 1q59
  • View 1q59
Molmil generated image of 1q59
SOLUTION STRUCTURE OF THE BHRF1 PROTEIN FROM EPSTEIN-BARR VIRUS, A HOMOLOG OF HUMAN BCL-2
Descriptor:Early antigen protein R
Authors:Huang, Q., Petros, A.M., Virgin, H.W., Fesik, S.W., Olejniczak, E.T.
Deposit date:2003-08-06
Release date:2003-09-23
Modification date:2009-02-24
Method:SOLUTION NMR
Cite:Solution Structure of the BHRF1 Protein From Epstein-Barr Virus, a Homolog of Human Bcl-2
J.Mol.Biol., 332, 2003
1WSX
  • Download 1wsx
  • View 1wsx
Molmil generated image of 1wsx
SOLUTION STRUCTURE OF MCL-1
Descriptor:myeloid cell leukemia sequence 1
Authors:Day, C.L., Chen, L., Richardson, S.J., Harrison, P.J., Huang, D.C., Hinds, M.G.
Deposit date:2004-11-12
Release date:2004-11-23
Modification date:2009-02-24
Method:SOLUTION NMR
Cite:Solution Structure of Prosurvival Mcl-1 and Characterization of Its Binding by Proapoptotic BH3-only Ligands
J.Biol.Chem., 280, 2005
2IMS
  • Download 2ims
  • View 2ims
Molmil generated image of 2ims
THE X-RAY STRUCTURE OF A BAK HOMODIMER REVEALS AN INHIBITORY ZINC BINDING SITE
Descriptor:Apoptosis regulator BAK
Authors:Moldoveanu, T., Liu, Q., Tocilj, A., Watson, M., Shore, G.C., Gehring, K.B.
Deposit date:2006-10-04
Release date:2006-12-26
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:The X-Ray Structure of a BAK Homodimer Reveals an Inhibitory Zinc Binding Site
Mol.Cell, 24, 2006
2IMT
  • Download 2imt
  • View 2imt
Molmil generated image of 2imt
THE X-RAY STRUCTURE OF A BAK HOMODIMER REVEALS AN INHIBITORY ZINC BINDING SITE
Descriptor:Apoptosis regulator BAK
Authors:Moldoveanu, T., Liu, Q., Tocilj, A., Watson, M., Shore, G.C., Gehring, K.B.
Deposit date:2006-10-04
Release date:2007-01-23
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:The X-ray structure of a BAK homodimer reveals an inhibitory zinc binding site.
Mol.Cell, 24, 2006
2JCN
  • Download 2jcn
  • View 2jcn
Molmil generated image of 2jcn
THE CRYSTAL STRUCTURE OF BAK1 - A MITOCHONDRIAL APOPTOSIS REGULATOR
Descriptor:BCL-2 HOMOLOGOUS ANTAGONIST/KILLER
Authors:Moche, M., Stenmark, P., Arrowsmith, C., Berglund, H., Busam, R., Collins, R., Edwards, A., Ericsson, U.B., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Hallberg, B.M., Holmberg Schiavone, L., Johansson, I., Karlberg, T., Kosinska, U., Kotenyova, T., Lundgren, S., Nilsson, M.E., Nyman, T., Ogg, D., Persson, C., Sagemark, J., Sundstrom, M., Uppenberg, J., Upsten, M., Thorsell, A.G., van den Berg, S., Weigelt, J., Nordlund, P., Structural Genomics Consortium (SGC)
Deposit date:2006-12-27
Release date:2007-01-04
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The Crystal Structure of Bak1 - an Apoptosis Trigger in the Mitochondrial Outer Membrane
To be Published
2KUA
  • Download 2kua
  • View 2kua
Molmil generated image of 2kua
SOLUTION STRUCTURE OF A DIVERGENT BCL-2 PROTEIN
Descriptor:Bcl-2-like protein 10
Authors:Rautureau, G.J., Day, C.L., Hinds, M.G.
Deposit date:2010-02-16
Release date:2010-03-23
Modification date:2010-05-19
Method:SOLUTION NMR
Cite:The structure of Boo/Diva reveals a divergent Bcl-2 protein.
Proteins, 78, 2010
2LR1
  • Download 2lr1
  • View 2lr1
Molmil generated image of 2lr1
STRUCTURAL MECHANISM FOR BAX INHIBITION BY CYTOMEGALOVIRUS PROTEIN VMIA
Descriptor:Apoptosis regulator BAX, Immediate early glycoprotein
Authors:Ma, J.
Deposit date:2012-03-20
Release date:2012-12-05
Modification date:2013-01-16
Method:SOLUTION NMR
Cite:Structural mechanism of Bax inhibition by cytomegalovirus protein vMIA.
Proc.Natl.Acad.Sci.USA, 109, 2012
2MHS
  • Download 2mhs
  • View 2mhs
Molmil generated image of 2mhs
NMR STRUCTURE OF HUMAN MCL-1
Descriptor:Induced myeloid leukemia cell differentiation protein Mcl-1
Authors:Liu, G., Poppe, L., Aoki, K., Yamane, H., Lewis, J., Szyperski, T.
Deposit date:2013-12-04
Release date:2014-05-14
Method:SOLUTION NMR
Cite:High-Quality NMR Structure of Human Anti-Apoptotic Protein Domain Mcl-1(171-327) for Cancer Drug Design.
Plos One, 9, 2014
2PQK
  • Download 2pqk
  • View 2pqk
Molmil generated image of 2pqk
X-RAY CRYSTAL STRUCTURE OF HUMAN MCL-1 IN COMPLEX WITH BIM BH3
Descriptor:Induced myeloid leukemia cell differentiation protein Mcl-1, Bim BH3 peptide
Authors:Bare, E., Grant, R.A., Keating, A.E.
Deposit date:2007-05-02
Release date:2007-06-19
Modification date:2013-04-10
Method:X-RAY DIFFRACTION (2 Å)
Cite:Mcl-1-Bim complexes accommodate surprising point mutations via minor structural changes.
Protein Sci., 19, 2010
2W3L
  • Download 2w3l
  • View 2w3l
Molmil generated image of 2w3l
CRYSTAL STRUCTURE OF CHIMAERIC BCL2-XL AND PHENYL TETRAHYDROISOQUINOLINE AMIDE COMPLEX
Descriptor:APOPTOSIS REGULATOR BCL-2
Authors:Porter, J., Payne, A., De Candole, B., Ford, D., Hutchinson, B., Trevitt, G., Turner, J., Edwards, C., Watkins, C., Whitcombe, I., Davis, J., Stubberfield, C., Fisher, M., Lamers, M.
Deposit date:2008-11-13
Release date:2008-12-09
Modification date:2008-12-23
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Tetrahydroisoquinoline Amide Substituted Phenyl Pyrazoles as Selective Bcl-2 Inhibitors.
Bioorg.Med.Chem.Lett., 19, 2009
2YV6
  • Download 2yv6
  • View 2yv6
Molmil generated image of 2yv6
CRYSTAL STRUCTURE OF HUMAN BCL-2 FAMILY PROTEIN BAK
Descriptor:Bcl-2 homologous antagonist/killer
Authors:Wang, H., Kishishita, S., Murayama, K., Takemoto, C., Terada, T., Shirouzu, M., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2007-04-09
Release date:2008-04-15
Modification date:2010-02-02
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Novel dimerization mode of the human Bcl-2 family protein Bak, a mitochondrial apoptosis regulator.
J.Struct.Biol., 166, 2009
3KZ0
  • Download 3kz0
  • View 3kz0
Molmil generated image of 3kz0
MCL-1 COMPLEX WITH MCL-1-SPECIFIC SELECTED PEPTIDE
Descriptor:Induced myeloid leukemia cell differentiation protein Mcl-1, MCL-1 specific peptide B7
Authors:Dutta, S., Fire, E., Grant, R.A., Sauer, R.T., Keating, A.E.
Deposit date:2009-12-07
Release date:2010-05-05
Modification date:2010-05-19
Method:X-RAY DIFFRACTION (2.349 Å)
Cite:Determinants of BH3 binding specificity for Mcl-1 versus Bcl-xL.
J.Mol.Biol., 398, 2010
3WIX
  • Download 3wix
  • View 3wix
Molmil generated image of 3wix
CRYSTAL STRUCTURE OF MCL-1 IN COMPLEX WITH COMPOUND 4
Descriptor:Induced myeloid leukemia cell differentiation protein Mcl-1
Authors:Sogabe, S., Igaki, S., Hayano, Y.
Deposit date:2013-09-26
Release date:2013-11-27
Modification date:2014-03-12
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Discovery of potent Mcl-1/Bcl-xL dual inhibitors by using a hybridization strategy based on structural analysis of target proteins.
J.Med.Chem., 56, 2013
3WIY
  • Download 3wiy
  • View 3wiy
Molmil generated image of 3wiy
CRYSTAL STRUCTURE OF MCL-1 IN COMPLEX WITH COMPOUND 10
Descriptor:Induced myeloid leukemia cell differentiation protein Mcl-1
Authors:Sogabe, S., Igaki, S., Hayano, Y.
Deposit date:2013-09-26
Release date:2013-11-27
Modification date:2014-03-12
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Discovery of potent Mcl-1/Bcl-xL dual inhibitors by using a hybridization strategy based on structural analysis of target proteins.
J.Med.Chem., 56, 2013
4BD7
  • Download 4bd7
  • View 4bd7
Molmil generated image of 4bd7
BAX DOMAIN SWAPPED DIMER INDUCED BY OCTYLMALTOSIDE
Descriptor:APOPTOSIS REGULATOR BAX
Authors:Czabotar, P.E., Westphal, D., Adams, J.M., Colman, P.M.
Deposit date:2012-10-05
Release date:2013-02-13
Method:X-RAY DIFFRACTION (2.801 Å)
Cite:Bax Crystal Structures Reveal How Bh3 Domains Activate Bax and Nucleate its Oligomerization to Induce Apoptosis.
Cell(Cambridge,Mass.), 152, 2013
4BD8
  • Download 4bd8
  • View 4bd8
Molmil generated image of 4bd8
BAX DOMAIN SWAPPED DIMER INDUCED BY BIMBH3 WITH CHAPS
Descriptor:APOPTOSIS REGULATOR BAX
Authors:Czabotar, P.E., Westphal, D., Adams, J.M., Colman, P.M.
Deposit date:2012-10-05
Release date:2013-02-13
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:Bax Crystal Structures Reveal How Bh3 Domains Activate Bax and Nucleate its Oligomerization to Induce Apoptosis.
Cell(Cambridge,Mass.), 152, 2013
4G35
  • Download 4g35
  • View 4g35
Molmil generated image of 4g35
MCL-1 IN COMPLEX WITH A BIPHENYL CROSS-LINKED NOXA PEPTIDE.
Descriptor:Induced myeloid leukemia cell differentiation protein Mcl-1 homolog, Noxa BH3 (cysteine-mediated cross-linked)
Authors:Drake, E., Edwardraja, S., Lin, Q., Gulick, A.M.
Deposit date:2012-07-13
Release date:2012-12-05
Modification date:2013-06-26
Method:X-RAY DIFFRACTION (2 Å)
Cite:Rational design of proteolytically stable, cell-permeable peptide-based selective Mcl-1 inhibitors.
J.Am.Chem.Soc., 134, 2012
4HW2
  • Download 4hw2
  • View 4hw2
Molmil generated image of 4hw2
DISCOVERY OF POTENT MCL-1 INHIBITORS USING FRAGMENT-BASED METHODS AND STRUCTURE-BASED DESIGN
Descriptor:Induced myeloid leukemia cell differentiation protein Mcl-1
Authors:Zhao, B.
Deposit date:2012-11-07
Release date:2013-01-09
Modification date:2013-03-06
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Discovery of potent myeloid cell leukemia 1 (Mcl-1) inhibitors using fragment-based methods and structure-based design.
J.Med.Chem., 56, 2013
4HW3
  • Download 4hw3
  • View 4hw3
Molmil generated image of 4hw3
DISCOVERY OF POTENT MCL-1 INHIBITORS USING FRAGMENT-BASED METHODS AND STRUCTURE-BASED DESIGN
Descriptor:Induced myeloid leukemia cell differentiation protein Mcl-1
Authors:Zhao, B.
Deposit date:2012-11-07
Release date:2013-01-09
Modification date:2013-03-06
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Discovery of potent myeloid cell leukemia 1 (Mcl-1) inhibitors using fragment-based methods and structure-based design.
J.Med.Chem., 56, 2013
4HW4
  • Download 4hw4
  • View 4hw4
Molmil generated image of 4hw4
DISCOVERY OF POTENT MCL-1 INHIBITORS USING FRAGMENT-BASED METHODS AND STRUCTURE-BASED DESIGN
Descriptor:Induced myeloid leukemia cell differentiation protein Mcl-1, Mcl-1 BH3 peptide
Authors:Friberg, A., Zhao, B.
Deposit date:2012-11-07
Release date:2013-01-09
Modification date:2013-03-06
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Discovery of potent myeloid cell leukemia 1 (Mcl-1) inhibitors using fragment-based methods and structure-based design.
J.Med.Chem., 56, 2013
4OQ5
  • Download 4oq5
  • View 4oq5
Molmil generated image of 4oq5
CRYSTAL STRUCTURE OF HUMAN MCL-1 BOUND TO INHIBITOR 4-(4-METHYLNAPHTHALEN-1-YL)-2-{[(4-PHENOXYPHENYL)SULFONYL]AMINO}BENZOIC ACID
Descriptor:Induced myeloid leukemia cell differentiation protein Mcl-1
Authors:Petros, A.M., Swann, S.L., Song, D., Swinger, K., Park, C., Zhang, H., Wendt, M.D., Kunzer, A.R., Souers, A.J., Sun, C.
Deposit date:2014-02-07
Release date:2014-03-12
Method:X-RAY DIFFRACTION (2.86 Å)
Cite:Fragment-based discovery of potent inhibitors of the anti-apoptotic MCL-1 protein.
Bioorg.Med.Chem.Lett., 24, 2014
4OQ6
  • Download 4oq6
  • View 4oq6
Molmil generated image of 4oq6
CRYSTAL STRUCTURE OF HUMAN MCL-1 BOUND TO INHIBITOR 4-HYDROXY-4'-PROPYLBIPHENYL-3-CARBOXYLIC ACID
Descriptor:Induced myeloid leukemia cell differentiation protein Mcl-1
Authors:Petros, A.M., Swann, S.L., Song, D., Swinger, K., Park, C., Zhang, H., Wendt, M.D., Kunzer, A.R., Souers, A.J., Sun, C.
Deposit date:2014-02-07
Release date:2014-03-12
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Fragment-based discovery of potent inhibitors of the anti-apoptotic MCL-1 protein.
Bioorg.Med.Chem.Lett., 24, 2014
4OYD
  • Download 4oyd
  • View 4oyd
Molmil generated image of 4oyd
CRYSTAL STRUCTURE OF A COMPUTATIONALLY DESIGNED INHIBITOR OF AN EPSTEIN-BARR VIRAL BCL-2 PROTEIN
Descriptor:Bcl-2, HBRF1
Authors:Shen, B., Procko, E., Baker, D., Stoddard, B.
Deposit date:2014-02-11
Release date:2014-07-09
Modification date:2015-01-14
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A computationally designed inhibitor of an epstein-barr viral bcl-2 protein induces apoptosis in infected cells.
Cell, 157, 2014
PDBj@FacebookPDBj@TwitterwwPDBwwPDB FoundationEM DataBank

Copyright © 2013-2016 Protein Data Bank Japan
This is the static version of the PDBj web interface with limited functionality. Try the full version instead.