1F16
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SOLUTION STRUCTURE OF A PRO-APOPTOTIC PROTEIN BAX
Descriptor:SOLUTION STRUCTURE OF A PRO-APOPTOTIC PROTEIN BAX
Authors:Suzuki, M., Youle, R.J., Tjandra, N.
Deposit date:2000-05-18
Release date:2000-11-22
Modification date:2009-02-24
Method:SOLUTION NMR
Cite:Structure of Bax: coregulation of dimer formation and intracellular localization.
Cell(Cambridge,Mass.), 103, 2000
1Q59
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SOLUTION STRUCTURE OF THE BHRF1 PROTEIN FROM EPSTEIN-BARR VIRUS, A HOMOLOG OF HUMAN BCL-2
Descriptor:Early antigen protein R
Authors:Huang, Q., Petros, A.M., Virgin, H.W., Fesik, S.W., Olejniczak, E.T.
Deposit date:2003-08-06
Release date:2003-09-23
Modification date:2009-02-24
Method:SOLUTION NMR
Cite:Solution Structure of the BHRF1 Protein From Epstein-Barr Virus, a Homolog of Human Bcl-2
J.Mol.Biol., 332, 2003
1WSX
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SOLUTION STRUCTURE OF MCL-1
Descriptor:myeloid cell leukemia sequence 1
Authors:Day, C.L., Chen, L., Richardson, S.J., Harrison, P.J., Huang, D.C., Hinds, M.G.
Deposit date:2004-11-12
Release date:2004-11-23
Modification date:2009-02-24
Method:SOLUTION NMR
Cite:Solution Structure of Prosurvival Mcl-1 and Characterization of Its Binding by Proapoptotic BH3-only Ligands
J.Biol.Chem., 280, 2005
2IMS
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THE X-RAY STRUCTURE OF A BAK HOMODIMER REVEALS AN INHIBITORY ZINC BINDING SITE
Descriptor:Apoptosis regulator BAK
Authors:Moldoveanu, T., Liu, Q., Tocilj, A., Watson, M., Shore, G.C., Gehring, K.B.
Deposit date:2006-10-04
Release date:2006-12-26
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:The X-Ray Structure of a BAK Homodimer Reveals an Inhibitory Zinc Binding Site
Mol.Cell, 24, 2006
2IMT
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THE X-RAY STRUCTURE OF A BAK HOMODIMER REVEALS AN INHIBITORY ZINC BINDING SITE
Descriptor:Apoptosis regulator BAK
Authors:Moldoveanu, T., Liu, Q., Tocilj, A., Watson, M., Shore, G.C., Gehring, K.B.
Deposit date:2006-10-04
Release date:2007-01-23
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:The X-ray structure of a BAK homodimer reveals an inhibitory zinc binding site.
Mol.Cell, 24, 2006
2JBY
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A VIRAL PROTEIN UNEXPECTEDLY MIMICS THE STRUCTURE AND FUNCTION OF PRO-SURVIVAL BCL-2
Descriptor:M11L PROTEIN, BCL-2 HOMOLOGOUS ANTAGONIST/KILLER 2
Authors:Kvansakul, M., Van Delft, M.F., Lee, E.F., Gulbis, J.M., Fairlie, W.D., Huang, D.C.S., Colman, P.M.
Deposit date:2006-12-14
Release date:2007-03-27
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:A Structural Viral Mimic of Prosurvival Bcl-2: A Pivotal Role for Sequestering Proapoptotic Bax and Bak.
Mol.Cell, 25, 2007
2JCN
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THE CRYSTAL STRUCTURE OF BAK1 - A MITOCHONDRIAL APOPTOSIS REGULATOR
Descriptor:BCL-2 HOMOLOGOUS ANTAGONIST/KILLER
Authors:Moche, M., Stenmark, P., Arrowsmith, C., Berglund, H., Busam, R., Collins, R., Edwards, A., Ericsson, U.B., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Hallberg, B.M., Holmberg Schiavone, L., Johansson, I., Karlberg, T., Kosinska, U., Kotenyova, T., Lundgren, S., Nilsson, M.E., Nyman, T., Ogg, D., Persson, C., Sagemark, J., Sundstrom, M., Uppenberg, J., Upsten, M., Thorsell, A.G., van den Berg, S., Weigelt, J., Nordlund, P., Structural Genomics Consortium (SGC)
Deposit date:2006-12-27
Release date:2007-01-04
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The Crystal Structure of Bak1 - an Apoptosis Trigger in the Mitochondrial Outer Membrane
To be Published
2KUA
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SOLUTION STRUCTURE OF A DIVERGENT BCL-2 PROTEIN
Descriptor:Bcl-2-like protein 10
Authors:Rautureau, G.J., Day, C.L., Hinds, M.G.
Deposit date:2010-02-16
Release date:2010-03-23
Modification date:2010-05-19
Method:SOLUTION NMR
Cite:The structure of Boo/Diva reveals a divergent Bcl-2 protein.
Proteins, 78, 2010
2LR1
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STRUCTURAL MECHANISM FOR BAX INHIBITION BY CYTOMEGALOVIRUS PROTEIN VMIA
Descriptor:Apoptosis regulator BAX, Immediate early glycoprotein
Authors:Ma, J.
Deposit date:2012-03-20
Release date:2012-12-05
Modification date:2013-01-16
Method:SOLUTION NMR
Cite:Structural mechanism of Bax inhibition by cytomegalovirus protein vMIA.
Proc.Natl.Acad.Sci.USA, 109, 2012
2MHS
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NMR STRUCTURE OF HUMAN MCL-1
Descriptor:Induced myeloid leukemia cell differentiation protein Mcl-1
Authors:Liu, G., Poppe, L., Aoki, K., Yamane, H., Lewis, J., Szyperski, T.
Deposit date:2013-12-04
Release date:2014-05-14
Method:SOLUTION NMR
Cite:High-Quality NMR Structure of Human Anti-Apoptotic Protein Domain Mcl-1(171-327) for Cancer Drug Design.
Plos One, 9, 2014
2PQK
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X-RAY CRYSTAL STRUCTURE OF HUMAN MCL-1 IN COMPLEX WITH BIM BH3
Descriptor:Induced myeloid leukemia cell differentiation protein Mcl-1, Bim BH3 peptide
Authors:Bare, E., Grant, R.A., Keating, A.E.
Deposit date:2007-05-02
Release date:2007-06-19
Modification date:2013-04-10
Method:X-RAY DIFFRACTION (2 Å)
Cite:Mcl-1-Bim complexes accommodate surprising point mutations via minor structural changes.
Protein Sci., 19, 2010
2W3L
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CRYSTAL STRUCTURE OF CHIMAERIC BCL2-XL AND PHENYL TETRAHYDROISOQUINOLINE AMIDE COMPLEX
Descriptor:APOPTOSIS REGULATOR BCL-2
Authors:Porter, J., Payne, A., De Candole, B., Ford, D., Hutchinson, B., Trevitt, G., Turner, J., Edwards, C., Watkins, C., Whitcombe, I., Davis, J., Stubberfield, C., Fisher, M., Lamers, M.
Deposit date:2008-11-13
Release date:2008-12-09
Modification date:2008-12-23
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Tetrahydroisoquinoline Amide Substituted Phenyl Pyrazoles as Selective Bcl-2 Inhibitors.
Bioorg.Med.Chem.Lett., 19, 2009
2YV6
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CRYSTAL STRUCTURE OF HUMAN BCL-2 FAMILY PROTEIN BAK
Descriptor:Bcl-2 homologous antagonist/killer
Authors:Wang, H., Kishishita, S., Murayama, K., Takemoto, C., Terada, T., Shirouzu, M., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2007-04-09
Release date:2008-04-15
Modification date:2010-02-02
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Novel dimerization mode of the human Bcl-2 family protein Bak, a mitochondrial apoptosis regulator.
J.Struct.Biol., 166, 2009
3KZ0
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MCL-1 COMPLEX WITH MCL-1-SPECIFIC SELECTED PEPTIDE
Descriptor:Induced myeloid leukemia cell differentiation protein Mcl-1, MCL-1 specific peptide B7
Authors:Dutta, S., Fire, E., Grant, R.A., Sauer, R.T., Keating, A.E.
Deposit date:2009-12-07
Release date:2010-05-05
Modification date:2010-05-19
Method:X-RAY DIFFRACTION (2.349 Å)
Cite:Determinants of BH3 binding specificity for Mcl-1 versus Bcl-xL.
J.Mol.Biol., 398, 2010
3QBR
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BAKBH3 IN COMPLEX WITH SJA
Descriptor:SJCHGC06286 protein, Bcl-2 homologous antagonist/killer
Authors:Lee, E.F., Clarke, O.B., Fairlie, W.D., Colman, P.M., Evangelista, M., Feng, Z., Speed, T.P., Tchoubrieva, E., Strasser, A., Kalinna, B.
Deposit date:2011-01-13
Release date:2011-04-13
Modification date:2013-06-26
Method:X-RAY DIFFRACTION (2.601 Å)
Cite:Discovery and molecular characterization of a Bcl-2-regulated cell death pathway in schistosomes.
Proc.Natl.Acad.Sci.USA, 108, 2011
3WIX
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CRYSTAL STRUCTURE OF MCL-1 IN COMPLEX WITH COMPOUND 4
Descriptor:Induced myeloid leukemia cell differentiation protein Mcl-1
Authors:Sogabe, S., Igaki, S., Hayano, Y.
Deposit date:2013-09-26
Release date:2013-11-27
Modification date:2014-03-12
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Discovery of potent Mcl-1/Bcl-xL dual inhibitors by using a hybridization strategy based on structural analysis of target proteins.
J.Med.Chem., 56, 2013
3WIY
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CRYSTAL STRUCTURE OF MCL-1 IN COMPLEX WITH COMPOUND 10
Descriptor:Induced myeloid leukemia cell differentiation protein Mcl-1
Authors:Sogabe, S., Igaki, S., Hayano, Y.
Deposit date:2013-09-26
Release date:2013-11-27
Modification date:2014-03-12
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Discovery of potent Mcl-1/Bcl-xL dual inhibitors by using a hybridization strategy based on structural analysis of target proteins.
J.Med.Chem., 56, 2013
4BD7
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BAX DOMAIN SWAPPED DIMER INDUCED BY OCTYLMALTOSIDE
Descriptor:APOPTOSIS REGULATOR BAX
Authors:Czabotar, P.E., Westphal, D., Adams, J.M., Colman, P.M.
Deposit date:2012-10-05
Release date:2013-02-13
Method:X-RAY DIFFRACTION (2.801 Å)
Cite:Bax Crystal Structures Reveal How Bh3 Domains Activate Bax and Nucleate its Oligomerization to Induce Apoptosis.
Cell(Cambridge,Mass.), 152, 2013
4BD8
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BAX DOMAIN SWAPPED DIMER INDUCED BY BIMBH3 WITH CHAPS
Descriptor:APOPTOSIS REGULATOR BAX
Authors:Czabotar, P.E., Westphal, D., Adams, J.M., Colman, P.M.
Deposit date:2012-10-05
Release date:2013-02-13
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:Bax Crystal Structures Reveal How Bh3 Domains Activate Bax and Nucleate its Oligomerization to Induce Apoptosis.
Cell(Cambridge,Mass.), 152, 2013
4BDU
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BAX BH3-IN-GROOVE DIMER (GFP)
Descriptor:GREEN FLUORESCENT PROTEIN, APOPTOSIS REGULATOR BAX
Authors:Czabotar, P.E., Colman, P.M.
Deposit date:2012-10-08
Release date:2013-02-13
Method:X-RAY DIFFRACTION (2.998 Å)
Cite:Bax Crystal Structures Reveal How Bh3 Domains Activate Bax and Nucleate its Oligomerization to Induce Apoptosis.
Cell(Cambridge,Mass.), 152, 2013
4D2L
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VACCINIA VIRUS F1L BOUND TO BAK BH3
Descriptor:PROTEIN F1L, BCL-2 HOMOLOGOUS ANTAGONIST/KILLER
Authors:Kvansakul, M., Colman, P.M.
Deposit date:2014-05-12
Release date:2014-06-04
Modification date:2014-08-27
Method:X-RAY DIFFRACTION (2.903 Å)
Cite:Structural Insight Into Bh3-Domain Binding of Vaccinia Virus Anti-Apoptotic F1L.
J.Virol., 88, 2014
4G35
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MCL-1 IN COMPLEX WITH A BIPHENYL CROSS-LINKED NOXA PEPTIDE.
Descriptor:Induced myeloid leukemia cell differentiation protein Mcl-1 homolog, Noxa BH3 (cysteine-mediated cross-linked)
Authors:Drake, E., Edwardraja, S., Lin, Q., Gulick, A.M.
Deposit date:2012-07-13
Release date:2012-12-05
Modification date:2013-06-26
Method:X-RAY DIFFRACTION (2 Å)
Cite:Rational design of proteolytically stable, cell-permeable peptide-based selective Mcl-1 inhibitors.
J.Am.Chem.Soc., 134, 2012
4HW2
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DISCOVERY OF POTENT MCL-1 INHIBITORS USING FRAGMENT-BASED METHODS AND STRUCTURE-BASED DESIGN
Descriptor:Induced myeloid leukemia cell differentiation protein Mcl-1
Authors:Zhao, B.
Deposit date:2012-11-07
Release date:2013-01-09
Modification date:2013-03-06
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Discovery of potent myeloid cell leukemia 1 (Mcl-1) inhibitors using fragment-based methods and structure-based design.
J.Med.Chem., 56, 2013
4HW3
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DISCOVERY OF POTENT MCL-1 INHIBITORS USING FRAGMENT-BASED METHODS AND STRUCTURE-BASED DESIGN
Descriptor:Induced myeloid leukemia cell differentiation protein Mcl-1
Authors:Zhao, B.
Deposit date:2012-11-07
Release date:2013-01-09
Modification date:2013-03-06
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Discovery of potent myeloid cell leukemia 1 (Mcl-1) inhibitors using fragment-based methods and structure-based design.
J.Med.Chem., 56, 2013
4HW4
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DISCOVERY OF POTENT MCL-1 INHIBITORS USING FRAGMENT-BASED METHODS AND STRUCTURE-BASED DESIGN
Descriptor:Induced myeloid leukemia cell differentiation protein Mcl-1, Mcl-1 BH3 peptide
Authors:Friberg, A., Zhao, B.
Deposit date:2012-11-07
Release date:2013-01-09
Modification date:2013-03-06
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Discovery of potent myeloid cell leukemia 1 (Mcl-1) inhibitors using fragment-based methods and structure-based design.
J.Med.Chem., 56, 2013
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