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12CA	ALTERING THE MOUTH OF A HYDROPHOBIC POCKET. STRUCTURE AND KINETICS OF HUMAN CARBONIC ANHYDRASE II MUTANTS AT RESIDUE VAL-121 Descriptor: CARBONIC ANHYDRASE II, MERCURY (II) ION, ZINC ION Authors: Nair, S.K, Christianson, D.W. Deposit date: 1991-10-01 Release date: 1992-10-15 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Altering the mouth of a hydrophobic pocket. Structure and kinetics of human carbonic anhydrase II mutants at residue Val-121. J.Biol.Chem., 266, 1991
1A42	HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH BRINZOLAMIDE Descriptor: (4R)-2-(2-ethoxyethyl)-4-(ethylamino)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide, CARBONIC ANHYDRASE II, MERCURY (II) ION, ... Authors: Boriack-Sjodin, P.A, Christianson, D.W. Deposit date: 1998-02-10 Release date: 1999-03-23 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Structures of murine carbonic anhydrase IV and human carbonic anhydrase II complexed with brinzolamide: molecular basis of isozyme-drug discrimination. Protein Sci., 7, 1998
1AM6	CARBONIC ANHYDRASE II INHIBITOR: ACETOHYDROXAMATE Descriptor: ACETOHYDROXAMIC ACID, CARBONIC ANHYDRASE, MERCURY (II) ION, ... Authors: Scolnick, L.R, Clements, A.M, Christianson, D.W. Deposit date: 1997-06-24 Release date: 1998-06-24 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2 Å) Cite: Novel Binding Mode of Hydroxamate Inhibitors to Human Carbonic Anhydrase II J.Am.Chem.Soc., 119, 1997
1AVN	HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH THE HISTAMINE ACTIVATOR Descriptor: AZIDE ION, CARBONIC ANHYDRASE II, HISTAMINE, ... Authors: Briganti, F, Mangani, S, Orioli, P, Scozzafava, A, Vernaglione, G, Supuran, C.T. Deposit date: 1997-09-17 Release date: 1997-12-24 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2 Å) Cite: Carbonic anhydrase activators: X-ray crystallographic and spectroscopic investigations for the interaction of isozymes I and II with histamine. Biochemistry, 36, 1997
1AZM	DRUG-PROTEIN INTERACTIONS: STRUCTURE OF SULFONAMIDE DRUG COMPLEXED WITH HUMAN CARBONIC ANHYDRASE I Descriptor: 5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE, CARBONIC ANHYDRASE I, ZINC ION Authors: Chakravarty, S, Kannan, K.K. Deposit date: 1993-11-28 Release date: 1994-04-30 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2 Å) Cite: Drug-protein interactions. Refined structures of three sulfonamide drug complexes of human carbonic anhydrase I enzyme. J.Mol.Biol., 243, 1994
1BCD	X-RAY CRYSTALLOGRAPHIC STRUCTURE OF A COMPLEX BETWEEN HUMAN CARBONIC ANHYDRASE II AND A NEW TOPICAL INHIBITOR, TRIFLUOROMETHANE SULPHONAMIDE Descriptor: CARBONIC ANHYDRASE II, TRIFLUOROMETHANE SULFONAMIDE, ZINC ION Authors: Hakansson, K, Liljas, A. Deposit date: 1993-08-31 Release date: 1993-10-31 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.9 Å) Cite: The structure of a complex between carbonic anhydrase II and a new inhibitor, trifluoromethane sulphonamide. FEBS Lett., 350, 1994
1BIC	CRYSTALLOGRAPHIC ANALYSIS OF THR-200-> HIS HUMAN CARBONIC ANHYDRASE II AND ITS COMPLEX WITH THE SUBSTRATE, HCO3- Descriptor: BICARBONATE ION, CARBONIC ANHYDRASE II, METHYL MERCURY ION, ... Authors: Xue, Y, Vidgren, J, Svensson, L.A, Liljas, A, Jonsson, B.-H, Lindskog, S. Deposit date: 1992-09-01 Release date: 1993-10-31 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystallographic analysis of Thr-200-->His human carbonic anhydrase II and its complex with the substrate, HCO3-. Proteins, 15, 1993
1BN1	CARBONIC ANHYDRASE II INHIBITOR Descriptor: CARBONIC ANHYDRASE, MERCURY (II) ION, THIOPHENE-2,5-DISULFONIC ACID 2-AMIDE-5-(4-METHYL-BENZYLAMIDE), ... Authors: Boriack-Sjodin, P.A, Zeitlin, S, Christianson, D.W. Deposit date: 1998-07-31 Release date: 1999-05-18 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structural analysis of inhibitor binding to human carbonic anhydrase II. Protein Sci., 7, 1998
1BN3	CARBONIC ANHYDRASE II INHIBITOR Descriptor: 2-(3-METHOXYPHENYL)-2H-THIENO-[3,2-E]-1,2-THIAZINE-6-SULFINAMIDE-1,1-DIOXIDE, CARBONIC ANHYDRASE, MERCURY (II) ION, ... Authors: Boriack-Sjodin, P.A, Zeitlin, S, Christianson, D.W. Deposit date: 1998-07-31 Release date: 1999-05-18 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structural analysis of inhibitor binding to human carbonic anhydrase II. Protein Sci., 7, 1998
1BN4	CARBONIC ANHYDRASE II INHIBITOR Descriptor: CARBONIC ANHYDRASE, MERCURY (II) ION, N-[(4-METHOXYPHENYL)METHYL]2,5-THIOPHENEDESULFONAMIDE, ... Authors: Boriack-Sjodin, P.A, Zeitlin, S, Christianson, D.W. Deposit date: 1998-07-31 Release date: 1999-05-18 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structural analysis of inhibitor binding to human carbonic anhydrase II. Protein Sci., 7, 1998
1BNM	CARBONIC ANHYDRASE II INHIBITOR Descriptor: (R)-3,4-DIHYDRO-2-(3-METHOXYPHENYL)-4-METHYLAMINO-2H-THIENO[3,2-E]-1,2-THIAZINE-6-SULFONAMIDE-1,1-DIOXIDE, CARBONIC ANHYDRASE, MERCURY (II) ION, ... Authors: Boriack-Sjodin, P.A, Zeitlin, S, Christianson, D.W. Deposit date: 1998-07-30 Release date: 1999-05-18 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structural analysis of inhibitor binding to human carbonic anhydrase II. Protein Sci., 7, 1998
1BNN	CARBONIC ANHYDRASE II INHIBITOR Descriptor: 3,,4-DIHYDRO-2-(3-METHOXYPHENYL)-2H-THIENO-[3,2-E]-1,2-THIAZINE-6-SULFONAMIDE-1,1-DIOXIDE, CARBONIC ANHYDRASE, MERCURY (II) ION, ... Authors: Boriack-Sjodin, P.A, Zeitlin, S, Christianson, D.W. Deposit date: 1998-07-30 Release date: 1999-05-18 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural analysis of inhibitor binding to human carbonic anhydrase II. Protein Sci., 7, 1998
1BNQ	CARBONIC ANHYDRASE II INHIBITOR Descriptor: (R)-4-ETHYLAMINO-3,4-DIHYDRO-2-(2-METHOYLETHYL)-2H-THIENO[3,2-E]-1,2-THIAZINE-6-SULFONAMIDE-1,1-DIOXIDE, CARBONIC ANHYDRASE, MERCURY (II) ION, ... Authors: Boriack-Sjodin, P.A, Zeitlin, S, Christianson, D.W. Deposit date: 1998-07-30 Release date: 1999-06-15 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structural analysis of inhibitor binding to human carbonic anhydrase II. Protein Sci., 7, 1998
1BNT	CARBONIC ANHYDRASE II INHIBITOR Descriptor: 3,4-DIHYDRO-4-HYDROXY-2-(4-METHOXYPHENYL)-2H-THIENO[3,2-E]-1,2-THIAZINE-6-SULFONAMIDE-1,1-DIOXIDE, CARBONIC ANHYDRASE, MERCURY (II) ION, ... Authors: Boriack-Sjodin, P.A, Zeitlin, S, Christianson, D.W. Deposit date: 1998-07-30 Release date: 1999-06-15 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Structural analysis of inhibitor binding to human carbonic anhydrase II. Protein Sci., 7, 1998
1BNU	CARBONIC ANHYDRASE II INHIBITOR Descriptor: 3,4-DIHYDRO-4-HYDROXY-2-(2-THIENYMETHYL)-2H-THIENO[3,2-E]-1,2-THIAZINE-6-SULFONAMIDE-1,1-DIOXIDE, CARBONIC ANHYDRASE, MERCURY (II) ION, ... Authors: Boriack-Sjodin, P.A, Zeitlin, S, Christianson, D.W. Deposit date: 1998-07-30 Release date: 1999-06-15 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Structural analysis of inhibitor binding to human carbonic anhydrase II. Protein Sci., 7, 1998
1BNV	CARBONIC ANHYDRASE II INHIBITOR Descriptor: (S)-3,4-DIHYDRO-2-(3-METHOXYPHENYL)-4-METHYLAMINO-2H-THIENO[3,2-E]-1,2-THIAZINE-6-SULFONAMIDE-1,1-DIOXIDE, CARBONIC ANHYDRASE, MERCURY (II) ION, ... Authors: Boriack-Sjodin, P.A, Zeitlin, S, Christianson, D.W. Deposit date: 1998-07-30 Release date: 1999-02-16 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structural analysis of inhibitor binding to human carbonic anhydrase II. Protein Sci., 7, 1998
1BNW	CARBONIC ANHYDRASE II INHIBITOR Descriptor: CARBONIC ANHYDRASE, MERCURY (II) ION, N-(2-THIENYLMETHYL)-2,5-THIOPHENEDISULFONAMIDE, ... Authors: Boriack-Sjodin, P.A, Zeitlin, S, Christianson, D.W. Deposit date: 1998-07-30 Release date: 1999-06-15 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Structural analysis of inhibitor binding to human carbonic anhydrase II. Protein Sci., 7, 1998
1BV3	HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH UREA Descriptor: 4-(HYDROXYMERCURY)BENZOIC ACID, PROTEIN (CARBONIC ANHYDRASE II), UREA, ... Authors: Briganti, F, Mangani, S, Scozzafava, A, Vernaglione, G, Supuran, C.T. Deposit date: 1998-09-22 Release date: 1999-09-28 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Carbonic anhydrase catalyzes cyanamide hydration to urea: is it mimicking the physiological reaction? J.Biol.Inorg.Chem., 4, 1999
1BZM	DRUG-PROTEIN INTERACTIONS: STRUCTURE OF SULFONAMIDE DRUG COMPLEXED WITH HUMAN CARBONIC ANHYDRASE I Descriptor: CARBONIC ANHYDRASE I, N-(3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2(3H)-ylidene)acetamide, ZINC ION Authors: Chakravarty, S, Kannan, K.K. Deposit date: 1993-11-28 Release date: 1994-04-30 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2 Å) Cite: Drug-protein interactions. Refined structures of three sulfonamide drug complexes of human carbonic anhydrase I enzyme. J.Mol.Biol., 243, 1994
1CA2	REFINED STRUCTURE OF HUMAN CARBONIC ANHYDRASE II AT 2.0 ANGSTROMS RESOLUTION Descriptor: CARBONIC ANHYDRASE II, ZINC ION Authors: Eriksson, A.E, Jones, T.A, Liljas, A. Deposit date: 1989-02-06 Release date: 1990-01-15 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2 Å) Cite: Refined structure of human carbonic anhydrase II at 2.0 A resolution. Proteins, 4, 1988
1CA3	UNEXPECTED PH-DEPENDENT CONFORMATION OF HIS-64, THE PROTON SHUTTLE OF CARBONIC ANHYDRASE II. Descriptor: CARBONIC ANHYDRASE II, MERCURY (II) ION, ZINC ION Authors: Nair, S.K, Christianson, D.W. Deposit date: 1991-11-18 Release date: 1992-10-15 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Unexpected Ph-Dependent Conformation of His-64, the Proton Shuttle of Carbonic Anhydrase II. J.Am.Chem.Soc., 113, 1991
1CAH	STRUCTURE OF COBALT CARBONIC ANHYDRASE COMPLEXED WITH BICARBONATE Descriptor: BICARBONATE ION, CARBONIC ANHYDRASE II, COBALT (II) ION Authors: Hakansson, K, Wehnert, A. Deposit date: 1992-06-25 Release date: 1993-10-31 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.88 Å) Cite: Structure of cobalt carbonic anhydrase complexed with bicarbonate. J.Mol.Biol., 228, 1992
1CAI	STRUCTURAL ANALYSIS OF THE ZINC HYDROXIDE-THR 199-GLU 106 HYDROGEN BONDING NETWORK IN HUMAN CARBONIC ANHYDRASE II Descriptor: CARBONIC ANHYDRASE II, SULFATE ION, ZINC ION Authors: Xue, Y, Liljas, A, Jonsson, B.-H, Lindskog, S. Deposit date: 1992-09-17 Release date: 1993-10-31 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structural analysis of the zinc hydroxide-Thr-199-Glu-106 hydrogen-bond network in human carbonic anhydrase II. Proteins, 17, 1993
1CAJ	STRUCTURAL ANALYSIS OF THE ZINC HYDROXIDE-THR 199-GLU 106 HYDROGEN BONDING NETWORK IN HUMAN CARBONIC ANHYDRASE II Descriptor: CARBONIC ANHYDRASE II, SULFATE ION, ZINC ION Authors: Xue, Y, Liljas, A, Jonsson, B.-H, Lindskog, S. Deposit date: 1992-09-17 Release date: 1993-10-31 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural analysis of the zinc hydroxide-Thr-199-Glu-106 hydrogen-bond network in human carbonic anhydrase II. Proteins, 17, 1993
1CAK	STRUCTURAL ANALYSIS OF THE ZINC HYDROXIDE-THR 199-GLU 106 HYDROGEN BONDING NETWORK IN HUMAN CARBONIC ANHYDRASE II Descriptor: CARBONIC ANHYDRASE II, SULFATE ION, ZINC ION Authors: Xue, Y, Liljas, A, Jonsson, B.-H, Lindskog, S. Deposit date: 1992-09-17 Release date: 1993-10-31 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural analysis of the zinc hydroxide-Thr-199-Glu-106 hydrogen-bond network in human carbonic anhydrase II. Proteins, 17, 1993

 

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