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8C5H
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BU of 8c5h by Molmil
NbSyt1 anti-(rat Synaptotagmin-1) nanobody bound to target cytosolic domain of Synaptotagmin-1
Descriptor: CALCIUM ION, GLYCEROL, NbSyt1 nanobody, ...
Authors:Martinez-Carranza, M, Stenmark, P.
Deposit date:2023-01-09
Release date:2023-08-02
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:A Versatile Synaptotagmin-1 Nanobody Provides Perturbation-Free Live Synaptic Imaging And Low Linkage-Error in Super-Resolution Microscopy.
Small Methods, 7, 2023
4WEE
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BU of 4wee by Molmil
High-resolution structure of Synaptotagmin 1 C2A
Descriptor: SODIUM ION, SULFATE ION, Synaptotagmin-1
Authors:Sutton, R.B, Fuson, K.L.
Deposit date:2014-09-09
Release date:2014-10-01
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (0.891 Å)
Cite:High-resolution structure of Synaptotagmin 1 C2A
To Be Published
6IEJ
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BU of 6iej by Molmil
The C2 domain of cytosolic phospholipase A2 alpha bound to phosphatidylcholine
Descriptor: 1,2-dihexanoyl-sn-glycero-3-phosphocholine, CALCIUM ION, Cytosolic phospholipase A2, ...
Authors:Hirano, Y, Gao, Y.G, Stephenson, D.J, Vu, N.T, Malinina, L, Chalfant, C.E, Patel, D.J, Brown, R.E.
Deposit date:2018-09-14
Release date:2019-05-22
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.206 Å)
Cite:Structural basis of phosphatidylcholine recognition by the C2-domain of cytosolic phospholipase A2alpha.
Elife, 8, 2019
3W57
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BU of 3w57 by Molmil
Structure of a C2 domain
Descriptor: C2 domain protein, CALCIUM ION
Authors:Traore, D.A.K, Whisstock, J.C.
Deposit date:2013-01-24
Release date:2013-10-23
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.662 Å)
Cite:Defining the interaction of perforin with calcium and the phospholipid membrane.
Biochem.J., 456, 2013
2B3R
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BU of 2b3r by Molmil
Crystal structure of the C2 domain of class II phosphatidylinositide 3-kinase C2
Descriptor: Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide, SULFATE ION
Authors:Liu, L, Song, X, He, D, Komma, C, Kita, A, Verbasius, J.V, Bellamy, H, Miki, K, Czech, M.P, Zhou, G.W.
Deposit date:2005-09-20
Release date:2005-12-13
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of the C2 domain of class II phosphatidylinositide 3-kinase C2alpha.
J.Biol.Chem., 281, 2006
7A1R
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BU of 7a1r by Molmil
Crystal structure of the C2B domain of Trypanosoma brucei extended synaptotagmin (E-Syt)
Descriptor: ACETATE ION, CALCIUM ION, CHLORIDE ION, ...
Authors:Dong, G.
Deposit date:2020-08-13
Release date:2021-06-02
Last modified:2024-05-15
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural studies of the shortest extended synaptotagmin with only two C2 domains from Trypanosoma brucei .
Iscience, 24, 2021
1K5W
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BU of 1k5w by Molmil
THREE-DIMENSIONAL STRUCTURE OF THE SYNAPTOTAGMIN 1 C2B-DOMAIN: SYNAPTOTAGMIN 1 AS A PHOSPHOLIPID BINDING MACHINE
Descriptor: CALCIUM ION, Synaptotagmin I
Authors:Fernandez, I, Arac, D, Ubach, J, Gerber, S.H, Shin, O, Gao, Y, Anderson, R.G.W, Sudhof, T.C, Rizo, J.
Deposit date:2001-10-12
Release date:2002-01-23
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:Three-dimensional structure of the synaptotagmin 1 C2B-domain: synaptotagmin 1 as a phospholipid binding machine.
Neuron, 32, 2001
6EI6
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BU of 6ei6 by Molmil
CC2D1B coordinates ESRCT-III activity during the mitotic reformation of the nuclear envelope
Descriptor: Coiled-coil and C2 domain-containing protein 1-like, DI(HYDROXYETHYL)ETHER, SULFATE ION
Authors:Ventimiglia, L.N, Cuesta-Geijo, M.A, Martinelli, N, Caballe, A, Macheboeuf, P, Miguet, N, Parnham, I.M, Olmos, Y, Carlton, J.G, Weissehorn, W, martin-Serrano, J.
Deposit date:2017-09-18
Release date:2018-10-10
Last modified:2018-12-19
Method:X-RAY DIFFRACTION (2.461 Å)
Cite:CC2D1B Coordinates ESCRT-III Activity during the Mitotic Reformation of the Nuclear Envelope.
Dev. Cell, 47, 2018
4LDC
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BU of 4ldc by Molmil
Crystal Structure of DOC2B C2B domain
Descriptor: CALCIUM ION, CITRATE ANION, Double C2-like domain-containing protein beta
Authors:Giladi, M, Almagor, L, Hirsch, J.A.
Deposit date:2013-06-24
Release date:2013-09-11
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.264 Å)
Cite:The C2B Domain Is the Primary Ca(2+) Sensor in DOC2B: A Structural and Functional Analysis.
J.Mol.Biol., 425, 2013
4V11
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BU of 4v11 by Molmil
Structure of Synaptotagmin-1 with SV2A peptide phosphorylated at Thr84
Descriptor: CALCIUM ION, GLYCEROL, SYNAPTIC VESICLE GLYCOPROTEIN 2A, ...
Authors:Zhang, N, Gordon, S.L, Fritsch, M.J, Esoof, N, Campbell, D, Gourlay, R, Velupillai, S, Macartney, T, Peggie, M, vanAalten, D.M.F, Cousin, M.A, Alessi, D.R.
Deposit date:2014-09-22
Release date:2015-02-25
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Phosphorylation of Synaptic Vesicle Protein 2A at Thr84 by Casein Kinase 1 Family Kinases Controls the Specific Retrieval of Synaptotagmin-1.
J.Neurosci., 35, 2015
4LCV
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BU of 4lcv by Molmil
Crystal Structure of DOC2B C2A domain
Descriptor: BETA-MERCAPTOETHANOL, CALCIUM ION, CITRATE ANION, ...
Authors:Giladi, M, Almagor, L, Hirsch, J.A.
Deposit date:2013-06-23
Release date:2013-09-11
Last modified:2013-11-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:The C2B Domain Is the Primary Ca(2+) Sensor in DOC2B: A Structural and Functional Analysis.
J.Mol.Biol., 425, 2013
4V29
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BU of 4v29 by Molmil
The crystal structure of Arabidopsis thaliana CAR4 in complex with two calcium ions
Descriptor: AT3G17980, CALCIUM ION
Authors:Diaz, M, Albert, A.
Deposit date:2014-10-07
Release date:2014-12-17
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:C2-Domain Abscisic Acid-Related Proteins Mediate the Interaction of Pyr/Pyl/Rcar Abscisic Acid Receptors with the Plasma Membrane and Regulate Abscisic Acid Sensitivity in Arabidopsis.
Plant Cell, 26, 2014
4Y1S
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BU of 4y1s by Molmil
Structural basis for Ca2+-mediated interaction of the perforin C2 domain with lipid membranes
Descriptor: CALCIUM ION, Perforin-1
Authors:Conroy, P.J, Yagi, H, Whisstock, J.C, Norton, R.S.
Deposit date:2015-02-09
Release date:2015-09-02
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.611 Å)
Cite:Structural Basis for Ca2+-mediated Interaction of the Perforin C2 Domain with Lipid Membranes.
J.Biol.Chem., 290, 2015
6EWP
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BU of 6ewp by Molmil
Mus musculus CEP120 third C2 domain (C2C)
Descriptor: Centrosomal protein of 120 kDa, HEXAETHYLENE GLYCOL
Authors:van Breugel, M, al-Jassar, C.
Deposit date:2017-11-06
Release date:2018-05-02
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Disease-Associated Mutations in CEP120 Destabilize the Protein and Impair Ciliogenesis.
Cell Rep, 23, 2018
4Y1T
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BU of 4y1t by Molmil
Structural basis for Ca2+-mediated interaction of the perforin C2 domain with lipid membranes
Descriptor: CALCIUM ION, Perforin-1
Authors:Conroy, P.J, Yagi, H, Whisstock, J.C, Norton, R.S.
Deposit date:2015-02-09
Release date:2015-09-02
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.666 Å)
Cite:Structural Basis for Ca2+-mediated Interaction of the Perforin C2 Domain with Lipid Membranes.
J.Biol.Chem., 290, 2015
2R83
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BU of 2r83 by Molmil
Crystal structure analysis of human synaptotagmin 1 C2A-C2B
Descriptor: CHLORIDE ION, Synaptotagmin-1
Authors:Sutton, R.B, Fuson, K.L, Montes, M, Robert, J.J.
Deposit date:2007-09-10
Release date:2008-02-12
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure of human synaptotagmin 1 C2AB in the absence of Ca2+ reveals a novel domain association.
Biochemistry, 46, 2007
3L9B
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BU of 3l9b by Molmil
Crystal Structure of Rat Otoferlin C2A
Descriptor: MAGNESIUM ION, Otoferlin
Authors:Helfmann, S, Neumann, P.
Deposit date:2010-01-04
Release date:2011-01-19
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:The crystal structure of the C2A domain of otoferlin reveals an unconventional top loop region.
J.Mol.Biol., 406, 2011
4DNL
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BU of 4dnl by Molmil
Crystal structure of a C2 domain of a protein kinase C alpha (PRKCA) from Homo sapiens at 1.90 A resolution
Descriptor: Protein kinase C alpha type, SODIUM ION
Authors:Joint Center for Structural Genomics (JCSG), Partnership for T-Cell Biology (TCELL)
Deposit date:2012-02-08
Release date:2012-02-22
Last modified:2023-02-01
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of a C2 domain of a protein kinase C alpha (PRKCA) from Homo sapiens at 1.90 A resolution
To be published
6NYT
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BU of 6nyt by Molmil
Munc13-1 C2B-domain, calcium bound
Descriptor: CALCIUM ION, CHLORIDE ION, GLYCEROL, ...
Authors:Tomchick, D.R, Rizo, J, Machius, M, Lu, J.
Deposit date:2019-02-12
Release date:2019-02-20
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.369 Å)
Cite:Munc13 C2B domain is an activity-dependent Ca2+ regulator of synaptic exocytosis.
Nat. Struct. Mol. Biol., 17, 2010
6NYC
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BU of 6nyc by Molmil
Munc13-1 C2B-domain, calcium free
Descriptor: 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, Munc13-1
Authors:Tomchick, D.R, Rizo, J, Machius, M, Lu, J.
Deposit date:2019-02-11
Release date:2019-02-20
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.893 Å)
Cite:Munc13 C2B domain is an activity-dependent Ca2+ regulator of synaptic exocytosis.
Nat. Struct. Mol. Biol., 17, 2010
2UZP
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BU of 2uzp by Molmil
Crystal structure of the C2 domain of human protein kinase C gamma.
Descriptor: 1,2-ETHANEDIOL, CALCIUM ION, COBALT (II) ION, ...
Authors:Pike, A.C.W, Amos, A, Johansson, C, Sobott, F, Savitsky, P, Berridge, G, Fedorov, O, Umeano, C, Gorrec, F, Bunkoczi, G, Debreczeni, J, von Delft, F, Arrowsmith, C.H, Edwards, A, Weigelt, J, Sundstrom, M, Knapp, S.
Deposit date:2007-04-30
Release date:2007-05-29
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of C2 Domain of Protein Kinase C Gamma
To be Published
3TWY
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BU of 3twy by Molmil
RAT PKC C2 DOMAIN BOUND TO PB
Descriptor: LEAD (II) ION, Protein kinase C alpha type, SULFATE ION
Authors:Li, P.
Deposit date:2011-09-22
Release date:2011-11-02
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Pb2+ as Modulator of Protein-Membrane Interactions.
J.Am.Chem.Soc., 133, 2011
5T0R
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BU of 5t0r by Molmil
Synaptotagmin 1 C2A domain, cadmium-bound
Descriptor: CADMIUM ION, Synaptotagmin-1
Authors:Taylor, A.B, Hart, P.J, Igumenova, T.I.
Deposit date:2016-08-16
Release date:2017-06-14
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Non-Native Metal Ion Reveals the Role of Electrostatics in Synaptotagmin 1-Membrane Interactions.
Biochemistry, 56, 2017
5T0S
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BU of 5t0s by Molmil
Synaptotagmin 1 C2B domain, cadmium-bound
Descriptor: CADMIUM ION, SODIUM ION, Synaptotagmin-1
Authors:Taylor, A.B, Hart, P.J, Igumenova, T.I.
Deposit date:2016-08-16
Release date:2017-06-14
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:Non-Native Metal Ion Reveals the Role of Electrostatics in Synaptotagmin 1-Membrane Interactions.
Biochemistry, 56, 2017
3W56
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BU of 3w56 by Molmil
Structure of a C2 domain
Descriptor: C2 domain protein
Authors:Traore, D.A.K, Whisstock, J.C.
Deposit date:2013-01-24
Release date:2013-10-23
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Defining the interaction of perforin with calcium and the phospholipid membrane.
Biochem.J., 456, 2013

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