Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

9CYR
DownloadVisualize
BU of 9cyr by Molmil
Crystal structure of D245G mutant human PTP1B (PTPN1) at room temperature (298 K)
Descriptor: BETA-MERCAPTOETHANOL, MAGNESIUM ION, Tyrosine-protein phosphatase non-receptor type 1
Authors:Ebrahim, A, Perdikari, A, Woods, V.A, Lawler, K, Bounds, R, Singh, N.I, Mehlman, T, Riley, B.T, Sharma, S, Morris, J.W, Keogh, J.M, Henning, E, Smith, M, Farooqi, I.S, Keedy, D.A.
Deposit date:2024-08-02
Release date:2024-08-21
Last modified:2024-09-04
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structures of human PTP1B variants reveal allosteric sites to target for weight loss therapy.
Biorxiv, 2024
9CYQ
DownloadVisualize
BU of 9cyq by Molmil
Crystal structure of Q78R mutant human PTP1B (PTPN1) at room temperature (298 K)
Descriptor: BETA-MERCAPTOETHANOL, MAGNESIUM ION, Tyrosine-protein phosphatase non-receptor type 1
Authors:Ebrahim, A, Perdikari, A, Woods, V.A, Lawler, K, Bounds, R, Singh, N.I, Mehlman, T, Riley, B.T, Sharma, S, Morris, J.W, Keogh, J.M, Henning, E, Smith, M, Farooqi, I.S, Keedy, D.A.
Deposit date:2024-08-02
Release date:2024-08-21
Last modified:2024-09-04
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structures of human PTP1B variants reveal allosteric sites to target for weight loss therapy.
Biorxiv, 2024
9CYP
DownloadVisualize
BU of 9cyp by Molmil
Crystal structure of I19V mutant human PTP1B (PTPN1) at room temperature (298 K)
Descriptor: BETA-MERCAPTOETHANOL, MAGNESIUM ION, Tyrosine-protein phosphatase non-receptor type 1
Authors:Ebrahim, A, Perdikari, A, Woods, V.A, Lawler, K, Bounds, R, Singh, N.I, Mehlman, T, Riley, B.T, Sharma, S, Morris, J.W, Keogh, J.M, Henning, E, Smith, M, Farooqi, I.S, Keedy, D.A.
Deposit date:2024-08-02
Release date:2024-08-21
Last modified:2024-09-04
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Structures of human PTP1B variants reveal allosteric sites to target for weight loss therapy.
Biorxiv, 2024
9CYO
DownloadVisualize
BU of 9cyo by Molmil
Crystal structure of wild-type human PTP1B (PTPN1) at room temperature (298 K)
Descriptor: BETA-MERCAPTOETHANOL, MAGNESIUM ION, Tyrosine-protein phosphatase non-receptor type 1
Authors:Ebrahim, A, Perdikari, A, Woods, V.A, Lawler, K, Bounds, R, Singh, N.I, Mehlman, T, Riley, B.T, Sharma, S, Morris, J.W, Keogh, J.M, Henning, E, Smith, M, Farooqi, I.S, Keedy, D.A.
Deposit date:2024-08-02
Release date:2024-08-21
Last modified:2024-09-04
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Structures of human PTP1B variants reveal allosteric sites to target for weight loss therapy.
Biorxiv, 2024
9C56
DownloadVisualize
BU of 9c56 by Molmil
Crystal structure of human PTPN2 in complex with allosteric inhibitor
Descriptor: 3-(3,5-DIBROMO-4-HYDROXY-BENZOYL)-2-ETHYL-BENZOFURAN-6-SULFONIC ACID [4-(THIAZOL-2-YLSULFAMOYL)-PHENYL]-AMIDE, Tyrosine-protein phosphatase non-receptor type 2
Authors:Bester, S.M, Linwood, R, Wu, W.-I, Mou, T.-C.
Deposit date:2024-06-05
Release date:2024-09-04
Last modified:2024-09-18
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:Enhancing the apo protein tyrosine phosphatase non-receptor type 2 crystal soaking strategy through inhibitor-accessible binding sites.
Acta Crystallogr.,Sect.F, 80, 2024
9C55
DownloadVisualize
BU of 9c55 by Molmil
Crystal structure of human PTPN2 in complex with active site inhibitor
Descriptor: 5-(3-{[1-(BENZYLSULFONYL)PIPERIDIN-4-YL]AMINO}PHENYL)-4-BROMO-3-(CARBOXYMETHOXY)THIOPHENE-2-CARBOXYLIC ACID, Tyrosine-protein phosphatase non-receptor type 2
Authors:Bester, S.M, Linwood, R, Wu, W.-I, Mou, T.-C.
Deposit date:2024-06-05
Release date:2024-09-04
Last modified:2024-09-18
Method:X-RAY DIFFRACTION (2.36 Å)
Cite:Enhancing the apo protein tyrosine phosphatase non-receptor type 2 crystal soaking strategy through inhibitor-accessible binding sites.
Acta Crystallogr.,Sect.F, 80, 2024
9C54
DownloadVisualize
BU of 9c54 by Molmil
Crystal structure of human PTPN2 catalytic domain
Descriptor: Tyrosine-protein phosphatase non-receptor type 2
Authors:Bester, S.M, Linwood, R, Wu, W.-I, Mou, T.-C.
Deposit date:2024-06-05
Release date:2024-09-04
Last modified:2024-09-18
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Enhancing the apo protein tyrosine phosphatase non-receptor type 2 crystal soaking strategy through inhibitor-accessible binding sites.
Acta Crystallogr.,Sect.F, 80, 2024
9BLG
DownloadVisualize
BU of 9blg by Molmil
Crystal structure of non-receptor protein tyrosine phosphatase SHP2 in complex with PF-07284892
Descriptor: (1S)-1'-{6-[(2-amino-3-chloropyridin-4-yl)sulfanyl]-1,2,4-triazin-3-yl}-1,3-dihydrospiro[indene-2,4'-piperidin]-1-amine, Tyrosine-protein phosphatase non-receptor type 11
Authors:Bester, S.M, Wu, W.-I, Mou, T.-C.
Deposit date:2024-04-30
Release date:2024-05-29
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:SHP2 Inhibition Sensitizes Diverse Oncogene-Addicted Solid Tumors to Re-treatment with Targeted Therapy.
Cancer Discov, 13, 2023
8YHI
DownloadVisualize
BU of 8yhi by Molmil
The Crystal Structure of SHP1 from Biortus.
Descriptor: 1,2-ETHANEDIOL, SULFATE ION, Tyrosine-protein phosphatase non-receptor type 6
Authors:Wang, F, Cheng, W, Yuan, Z, Qi, J, Shen, Z.
Deposit date:2024-02-28
Release date:2024-03-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:The Crystal Structure of SHP1 from Biortus.
To Be Published
8XQD
DownloadVisualize
BU of 8xqd by Molmil
The Crystal Structure of PTPRG from Biortus.
Descriptor: Receptor-type tyrosine-protein phosphatase gamma
Authors:Wang, F, Cheng, W, Lv, Z, Ju, C, Ni, C.
Deposit date:2024-01-05
Release date:2024-03-06
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:The Crystal Structure of PTPRG from Biortus.
To Be Published
8XOY
DownloadVisualize
BU of 8xoy by Molmil
The Crystal Structure of PTP1B from Biortus.
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, GLYCEROL, ...
Authors:Wang, F, Cheng, W, Lv, Z, Meng, Q, Li, J.
Deposit date:2024-01-02
Release date:2024-01-24
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:The Crystal Structure of PTP1B from Biortus.
To Be Published
8WX7
DownloadVisualize
BU of 8wx7 by Molmil
Crystal structure of SHP2 in complex with JAB-3186
Descriptor: (5~{S})-1'-[6-azanyl-5-(2-azanyl-3-chloranyl-pyridin-4-yl)sulfanyl-pyrazin-2-yl]spiro[5,7-dihydrocyclopenta[b]pyridine-6,4'-piperidine]-5-amine, 1,2-ETHANEDIOL, CHLORIDE ION, ...
Authors:Ma, C, Gao, P, Kang, D, Han, H, Sun, X, Zhang, W, Qian, D, Wang, Y, Long, W.
Deposit date:2023-10-27
Release date:2024-08-14
Last modified:2024-09-04
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Discovery of JAB-3312, a Potent SHP2 Allosteric Inhibitor for Cancer Treatment.
J.Med.Chem., 67, 2024
8WFY
DownloadVisualize
BU of 8wfy by Molmil
The Crystal Structure of SHP2 from Biortus.
Descriptor: 6-(4-azanyl-4-methyl-piperidin-1-yl)-3-[2,3-bis(chloranyl)phenyl]pyrazin-2-amine, Tyrosine-protein phosphatase non-receptor type 11
Authors:Wang, F, Cheng, W, Yuan, Z, Qi, J, Li, J.
Deposit date:2023-09-20
Release date:2023-11-22
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The Crystal Structure of SHP2 from Biortus.
To Be Published
8U7X
DownloadVisualize
BU of 8u7x by Molmil
Crystal structure of non-receptor protein tyrosine phosphatase SHP2 in complex with inhibitor compound 24
Descriptor: (3S,4S)-8-{6-[(2-amino-3-chloropyridin-4-yl)sulfanyl]pyrido[2,3-b]pyrazin-2-yl}-3-methyl-2-oxa-8-azaspiro[4.5]decan-4-amine, Tyrosine-protein phosphatase non-receptor type 11
Authors:Mou, T.C.
Deposit date:2023-09-15
Release date:2024-01-03
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Discovery of 5-Azaquinoxaline Derivatives as Potent and Orally Bioavailable Allosteric SHP2 Inhibitors.
Acs Med.Chem.Lett., 14, 2023
8U7W
DownloadVisualize
BU of 8u7w by Molmil
Crystal structure of non-receptor protein tyrosine phosphatase SHP2 in complex with inhibitor compound 7
Descriptor: 1-{6-[(2,3-dichlorophenyl)sulfanyl]pyrido[2,3-b]pyrazin-2-yl}-4-methylpiperidin-4-amine, Tyrosine-protein phosphatase non-receptor type 11
Authors:Mou, T.C.
Deposit date:2023-09-15
Release date:2024-01-03
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Discovery of 5-Azaquinoxaline Derivatives as Potent and Orally Bioavailable Allosteric SHP2 Inhibitors.
Acs Med.Chem.Lett., 14, 2023
8U1E
DownloadVisualize
BU of 8u1e by Molmil
Apo protein tyrosine phosphatase 1B (PTP1B) at high resolution (1.43 A) in space group P43212 with two distinctly ordered chains
Descriptor: MAGNESIUM ION, Tyrosine-protein phosphatase non-receptor type 1
Authors:Sharma, S, Mehlman, S.T, Keedy, D.A.
Deposit date:2023-08-31
Release date:2023-09-27
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.43 Å)
Cite:High-resolution double vision of the allosteric phosphatase PTP1B.
Acta Crystallogr.,Sect.F, 80, 2024
8U0H
DownloadVisualize
BU of 8u0h by Molmil
Crystal structure of PTPN2 with a PROTAC
Descriptor: (5P)-3-(carboxymethoxy)-4-chloro-5-(3-{[(4S)-1-({3-[2-(4-{3-[(3R)-2,6-dioxopiperidin-3-yl]-2-oxo-2,3-dihydro-1,3-benzoxazol-6-yl}piperidin-1-yl)acetamido]phenyl}methanesulfonyl)-2,2-dimethylpiperidin-4-yl]amino}phenyl)thiophene-2-carboxylic acid, ACETATE ION, PTPN2, ...
Authors:Jain, R, Longenecker, K, Qiu, W.
Deposit date:2023-08-29
Release date:2024-09-04
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Mechanistic insights into a heterobifunctional degrader-induced PTPN2/N1 complex.
Commun Chem, 7, 2024
8T8Q
DownloadVisualize
BU of 8t8q by Molmil
Identification of GDC-1971 (RLY-1971), a SHP2 inhibitor designed for the treatment of solid tumors
Descriptor: 1-[(3P)-3-(3-chloro-2-fluorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-4-methylpiperidin-4-amine, Tyrosine-protein phosphatase non-receptor type 11
Authors:Tang, Y, Nguyen, V, Wilbur, J.D.
Deposit date:2023-06-23
Release date:2023-10-11
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Identification of GDC-1971 (RLY-1971), a SHP2 Inhibitor Designed for the Treatment of Solid Tumors.
J.Med.Chem., 66, 2023
8T7Q
DownloadVisualize
BU of 8t7q by Molmil
Identification of GDC-1971 (RLY-1971), a SHP2 inhibitor designed for the treatment of solid tumors
Descriptor: 1-{3-[(2-chlorophenyl)sulfanyl]-1H-pyrazolo[3,4-b]pyrazin-6-yl}-4-methylpiperidin-4-amine, Tyrosine-protein phosphatase non-receptor type 11
Authors:Tang, Y, Nguyen, V, Wilbur, J.D.
Deposit date:2023-06-21
Release date:2023-10-11
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Identification of GDC-1971 (RLY-1971), a SHP2 Inhibitor Designed for the Treatment of Solid Tumors.
J.Med.Chem., 66, 2023
8T6G
DownloadVisualize
BU of 8t6g by Molmil
Identification of GDC-1971 (RLY-1971), a SHP2 inhibitor designed for the treatment of solid tumors
Descriptor: (1S)-1-{6-[(1S)-1-amino-1,3-dihydrospiro[indene-2,4'-piperidin]-1'-yl]-3-(3,4-dihydro-1,5-naphthyridin-1(2H)-yl)-1H-pyrazolo[3,4-b]pyrazin-5-yl}ethan-1-ol, SULFATE ION, Tyrosine-protein phosphatase non-receptor type 11
Authors:Tang, Y, Nugyen, V, Wilbur, J.D.
Deposit date:2023-06-15
Release date:2023-10-11
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Identification of GDC-1971 (RLY-1971), a SHP2 Inhibitor Designed for the Treatment of Solid Tumors.
J.Med.Chem., 66, 2023
8T6D
DownloadVisualize
BU of 8t6d by Molmil
Identification of GDC-1971 (RLY-1971), a SHP2 inhibitor designed for the treatment of solid tumors
Descriptor: (3R)-1'-[3-(3,4-dihydro-1,5-naphthyridin-1(2H)-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-3H-spiro[[1]benzofuran-2,4'-piperidin]-3-amine, SULFATE ION, Tyrosine-protein phosphatase non-receptor type 11
Authors:Tang, Y, Nguyen, V, Wilbur, J.D.
Deposit date:2023-06-15
Release date:2023-10-11
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Identification of GDC-1971 (RLY-1971), a SHP2 Inhibitor Designed for the Treatment of Solid Tumors.
J.Med.Chem., 66, 2023
8SLU
DownloadVisualize
BU of 8slu by Molmil
Crystal structure of human STEP (PTPN5) at cryogenic temperature (100 K) and high pressure (205 MPa)
Descriptor: GLYCEROL, SULFATE ION, Tyrosine-protein phosphatase non-receptor type 5
Authors:Ebrahim, A, Guerrero, L, Riley, B.T, Kim, M, Huang, Q, Finke, A.D, Keedy, D.A.
Deposit date:2023-04-24
Release date:2023-06-21
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Pushed to extremes: distinct effects of high temperature vs. pressure on the structure of an atypical phosphatase.
Biorxiv, 2023
8SLT
DownloadVisualize
BU of 8slt by Molmil
Crystal structure of human STEP (PTPN5) at physiological temperature (310 K) and ambient pressure (0.1 MPa)
Descriptor: SULFATE ION, Tyrosine-protein phosphatase non-receptor type 5
Authors:Ebrahim, A, Guerrero, L, Riley, B.T, Kim, M, Huang, Q, Finke, A.D, Keedy, D.A.
Deposit date:2023-04-24
Release date:2023-06-21
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Pushed to extremes: distinct effects of high temperature vs. pressure on the structure of an atypical phosphatase.
Biorxiv, 2023
8SLS
DownloadVisualize
BU of 8sls by Molmil
Crystal structure of human STEP (PTPN5) at cryogenic temperature (100 K) and ambient pressure (0.1 MPa)
Descriptor: GLYCEROL, SULFATE ION, Tyrosine-protein phosphatase non-receptor type 5
Authors:Ebrahim, A, Guerrero, L, Riley, B.T, Kim, M, Huang, Q, Finke, A.D, Keedy, D.A.
Deposit date:2023-04-24
Release date:2023-06-21
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.71 Å)
Cite:Pushed to extremes: distinct effects of high temperature vs. pressure on the structure of an atypical phosphatase.
Biorxiv, 2023
8SKL
DownloadVisualize
BU of 8skl by Molmil
PTP1B in complex with 182
Descriptor: 1,2-ETHANEDIOL, 5-[1-fluoro-3-hydroxy-7-(3-hydroxy-3-methylbutoxy)naphthalen-2-yl]-1lambda~6~,2,5-thiadiazolidine-1,1,3-trione, CHLORIDE ION, ...
Authors:Babon, J.J, Chen, H, Tiganis, T.
Deposit date:2023-04-20
Release date:2023-08-02
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:A small molecule inhibitor of PTP1B and PTPN2 enhances T cell anti-tumor immunity.
Nat Commun, 14, 2023

225158

PDB entries from 2024-09-18

PDB statisticsPDBj update infoContact PDBjnumon