2CPK
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CRYSTAL STRUCTURE OF THE CATALYTIC SUBUNIT OF CYCLIC ADENOSINE MONOPHOSPHATE-DEPENDENT PROTEIN KINASE
Descriptor:CAMP-DEPENDENT PROTEIN KINASE (E.C.2.7.1.37) (CAPK) (CATALYTIC SUBUNIT)
Authors:Knighton, D.R., Zheng, J., Teneyck, L.F., Ashford, V.A., Xuong, N.-H., Taylor, S.S., Sowadski, J.M.
Deposit date:1992-10-21
Release date:1993-01-15
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase.
Science, 253, 1991
1ATP
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2.2 ANGSTROM REFINED CRYSTAL STRUCTURE OF THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH MNATP AND A PEPTIDE INHIBITOR
Descriptor:CAMP-DEPENDENT PROTEIN KINASE (E.C.2.7.1.37) (C/APK) (CATALYTIC SUBUNIT) COMPLEX WITH THE PEPTIDE INHIBITOR PKI(5-24) AND MNATP (A TERNARY COMPLEX OF CAPK)
Authors:Zheng, J., Trafny, E.A., Knighton, D.R., Xuong, N.-H., Taylor, S.S., Teneyck, L.F., Sowadski, J.M.
Deposit date:1993-01-08
Release date:1993-04-15
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:2.2 A refined crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MnATP and a peptide inhibitor.
Acta Crystallogr.,Sect.D, 49, 1993
1APM
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2.0 ANGSTROM REFINED CRYSTAL STRUCTURE OF THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH A PEPTIDE INHIBITOR AND DETERGENT
Descriptor:CAMP-DEPENDENT PROTEIN KINASE (E.C.2.7.1.37) (C/APK) (CATALYTIC SUBUNIT) "ALPHA" ISOENZYME MUTANT WITH SER 139 REPLACED BY ALA (S139A) COMPLEX WITH THE PEPTIDE INHIBITOR PKI(5-24) AND THE DETERGENT MEGA-8
Authors:Knighton, D.R., Bell, S.M., Zheng, J., Teneyck, L.F., Xuong, N.-H., Taylor, S.S., Sowadski, J.M.
Deposit date:1993-01-18
Release date:1993-04-15
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:2.0 A refined crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with a peptide inhibitor and detergent.
Acta Crystallogr.,Sect.D, 49, 1993
1CTP
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STRUCTURE OF THE MAMMALIAN CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE AND AN INHIBITOR PEPTIDE DISPLAYS AN OPEN CONFORMATION
Descriptor:CAMP-DEPENDENT PROTEIN KINASE (E.C.2.7.1.37) (CAPK) (CATALYTIC SUBUNIT)
Authors:Karlsson, R., Zheng, J., Xuong, N.H., Taylor, S.S., Sowadski, J.M.
Deposit date:1993-04-08
Release date:1994-01-31
Modification date:2012-07-18
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure of the mammalian catalytic subunit of cAMP-dependent protein kinase and an inhibitor peptide displays an open conformation.
Acta Crystallogr.,Sect.D, 49, 1993
1CMK
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CRYSTAL STRUCTURES OF THE MYRISTYLATED CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE REVEAL OPEN AND CLOSED CONFORMATIONS
Descriptor:CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT (E.C.2.7.1.37)
Authors:Zheng, J., Knighton, D.R., Xuong, N.-H., Taylor, S.S., Sowadski, J.M., Ten Eyck, L.F.
Deposit date:1993-11-18
Release date:1994-05-31
Modification date:2012-08-01
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structures of the myristylated catalytic subunit of cAMP-dependent protein kinase reveal open and closed conformations.
Protein Sci., 2, 1993
1CDK
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CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT (E.C.2.7.1.37) (PROTEIN KINASE A) COMPLEXED WITH PROTEIN KINASE INHIBITOR PEPTIDE FRAGMENT 5-24 (PKI(5-24) ISOELECTRIC VARIANT CA) AND MN2+ ADENYLYL IMIDODIPHOSPHATE (MNAMP-PNP) AT PH 5.6 AND 7C AND 4C
Descriptor:CAMP-DEPENDENT PROTEIN KINASE, PROTEIN KINASE INHIBITOR, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, MYRISTIC ACID
Authors:Bossemeyer, D., Engh, R.A., Kinzel, V., Ponstingl, H., Huber, R.
Deposit date:1994-07-04
Release date:1995-10-15
Modification date:2012-08-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Phosphotransferase and substrate binding mechanism of the cAMP-dependent protein kinase catalytic subunit from porcine heart as deduced from the 2.0 A structure of the complex with Mn2+ adenylyl imidodiphosphate and inhibitor peptide PKI(5-24).
EMBO J., 12, 1993
1CSN
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BINARY COMPLEX OF CASEIN KINASE-1 WITH MGATP
Descriptor:CASEIN KINASE-1, ADENOSINE-5'-TRIPHOSPHATE
Authors:Xu, R.-M., Cheng, X.
Deposit date:1995-04-25
Release date:1995-07-31
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of casein kinase-1, a phosphate-directed protein kinase.
EMBO J., 14, 1995
1CKI
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RECOMBINANT CASEIN KINASE I DELTA TRUNCATION MUTANT CONTAINING RESIDUES 1-317
Descriptor:CASEIN KINASE I DELTA
Authors:Longenecker, K.L., Roach, P.J., Hurley, T.D.
Deposit date:1995-08-25
Release date:1995-12-07
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Three-dimensional structure of mammalian casein kinase I: molecular basis for phosphate recognition.
J.Mol.Biol., 257, 1996
1CKJ
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CASEIN KINASE I DELTA TRUNCATION MUTANT CONTAINING RESIDUES 1-317 COMPLEX WITH BOUND TUNGSTATE
Descriptor:RECOMBINANT CASEIN KINASE I DELTA
Authors:Longenecker, K.L., Roach, P.J., Hurley, T.D.
Deposit date:1995-08-25
Release date:1995-12-07
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.46 Å)
Cite:Three-dimensional structure of mammalian casein kinase I: molecular basis for phosphate recognition.
J.Mol.Biol., 257, 1996
2CSN
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BINARY COMPLEX OF CASEIN KINASE-1 WITH CKI7
Descriptor:CASEIN KINASE-1, N-(2-AMINOETHYL)-5-CHLOROISOQUINOLINE-8-SULFONAMIDE
Authors:Xu, R.-M., Cheng, X.
Deposit date:1995-10-11
Release date:1996-03-08
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for selectivity of the isoquinoline sulfonamide family of protein kinase inhibitors.
Proc.Natl.Acad.Sci.USA, 93, 1996
1GOL
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COORDINATES OF RAT MAP KINASE ERK2 WITH AN ARGININE MUTATION AT POSITION 52
Descriptor:EXTRACELLULAR REGULATED KINASE 2, ADENOSINE-5'-TRIPHOSPHATE
Authors:Harkins, P.C., Zhang, F., Goldsmith, E.J.
Deposit date:1996-01-23
Release date:1997-03-12
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Mutation of position 52 in ERK2 creates a nonproductive binding mode for adenosine 5'-triphosphate.
Biochemistry, 35, 1996
1PHK
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TWO STRUCTURES OF THE CATALYTIC DOMAIN OF PHOSPHORYLASE, KINASE: AN ACTIVE PROTEIN KINASE COMPLEXED WITH NUCLEOTIDE, SUBSTRATE-ANALOGUE AND PRODUCT
Descriptor:PHOSPHORYLASE KINASE, ADENOSINE-5'-TRIPHOSPHATE
Authors:Owen, D.J., Noble, M.E.M., Garman, E.F., Papageorgiou, A.C., Johnson, L.N.
Deposit date:1996-03-15
Release date:1996-08-17
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Two structures of the catalytic domain of phosphorylase kinase: an active protein kinase complexed with substrate analogue and product.
Structure, 3, 1995
1HCK
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HUMAN CYCLIN-DEPENDENT KINASE 2
Descriptor:HUMAN CYCLIN-DEPENDENT KINASE 2, ADENOSINE-5'-TRIPHOSPHATE
Authors:Schulze-Gahmen, U., De Bondt, H.L., Kim, S.-H.
Deposit date:1996-06-03
Release date:1996-12-07
Modification date:2009-07-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:High-resolution crystal structures of human cyclin-dependent kinase 2 with and without ATP: bound waters and natural ligand as guides for inhibitor design.
J.Med.Chem., 39, 1996
1HCL
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HUMAN CYCLIN-DEPENDENT KINASE 2
Descriptor:HUMAN CYCLIN-DEPENDENT KINASE 2
Authors:Schulze-Gahmen, U., De Bondt, H.L., Kim, S.-H.
Deposit date:1996-06-03
Release date:1996-12-07
Modification date:2009-07-14
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:High-resolution crystal structures of human cyclin-dependent kinase 2 with and without ATP: bound waters and natural ligand as guides for inhibitor design.
J.Med.Chem., 39, 1996
1KOA
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TWITCHIN KINASE FRAGMENT (C.ELEGANS), AUTOREGULATED PROTEIN KINASE AND IMMUNOGLOBULIN DOMAINS
Descriptor:TWITCHIN
Authors:Kobe, B., Heierhorst, J., Feil, S.C., Parker, M.W., Benian, G.M., Weiss, K.R., Kemp, B.E.
Deposit date:1996-06-28
Release date:1997-03-12
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Giant protein kinases: domain interactions and structural basis of autoregulation.
EMBO J., 15, 1996
1KOB
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TWITCHIN KINASE FRAGMENT (APLYSIA), AUTOREGULATED PROTEIN KINASE DOMAIN
Descriptor:TWITCHIN, VALINE
Authors:Kobe, B., Heierhorst, J., Feil, S.C., Parker, M.W., Benian, G.M., Weiss, K.R., Kemp, B.E.
Deposit date:1996-06-28
Release date:1997-03-12
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Giant protein kinases: domain interactions and structural basis of autoregulation.
EMBO J., 15, 1996
1JST
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PHOSPHORYLATED CYCLIN-DEPENDENT KINASE-2 BOUND TO CYCLIN A
Descriptor:CYCLIN-DEPENDENT KINASE-2, CYCLIN A, ADENOSINE-5'-TRIPHOSPHATE
Authors:Russo, A.A., Jeffrey, P.D., Pavletich, N.P.
Deposit date:1996-07-03
Release date:1997-01-11
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural basis of cyclin-dependent kinase activation by phosphorylation.
Nat.Struct.Biol., 3, 1996
1JSU
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P27(KIP1)/CYCLIN A/CDK2 COMPLEX
Descriptor:CYCLIN-DEPENDENT KINASE-2, CYCLIN A, P27
Authors:Russo, A.A., Jeffrey, P.D., Pavletich, N.P.
Deposit date:1996-07-03
Release date:1997-07-29
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex.
Nature, 382, 1996
1FIN
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CYCLIN A-CYCLIN-DEPENDENT KINASE 2 COMPLEX
Descriptor:CYCLIN-DEPENDENT KINASE 2, CYCLIN A, ADENOSINE-5'-TRIPHOSPHATE
Authors:Jeffrey, P.D., Russo, A.A., Pavletich, N.P.
Deposit date:1996-07-14
Release date:1997-01-27
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex.
Nature, 376, 1995
1YDR
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STRUCTURE OF CAMP-DEPENDENT PROTEIN KINASE, ALPHA-CATALYTIC SUBUNIT IN COMPLEX WITH H7 PROTEIN KINASE INHIBITOR 1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE
Descriptor:C-AMP-DEPENDENT PROTEIN KINASE, PROTEIN KINASE INHIBITOR PEPTIDE, 1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE
Authors:Engh, R.A., Girod, A., Kinzel, V., Huber, R., Bossemeyer, D.
Deposit date:1996-07-24
Release date:1997-04-01
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structures of catalytic subunit of cAMP-dependent protein kinase in complex with isoquinolinesulfonyl protein kinase inhibitors H7, H8, and H89. Structural implications for selectivity.
J.Biol.Chem., 271, 1996
1YDS
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STRUCTURE OF CAMP-DEPENDENT PROTEIN KINASE, ALPHA-CATALYTIC SUBUNIT IN COMPLEX WITH H8 PROTEIN KINASE INHIBITOR [N-(2-METHYLAMINO)ETHYL]-5-ISOQUINOLINESULFONAMIDE
Descriptor:C-AMP-DEPENDENT PROTEIN KINASE, PROTEIN KINASE INHIBITOR PEPTIDE, N-[2-(METHYLAMINO)ETHYL]-5-ISOQUINOLINESULFONAMIDE
Authors:Engh, R.A., Girod, A., Kinzel, V., Huber, R., Bossemeyer, D.
Deposit date:1996-07-24
Release date:1997-04-01
Modification date:2012-02-15
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structures of catalytic subunit of cAMP-dependent protein kinase in complex with isoquinolinesulfonyl protein kinase inhibitors H7, H8, and H89. Structural implications for selectivity.
J.Biol.Chem., 271, 1996
1YDT
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STRUCTURE OF CAMP-DEPENDENT PROTEIN KINASE, ALPHA-CATALYTIC SUBUNIT IN COMPLEX WITH H89 PROTEIN KINASE INHIBITOR N-[2-(4-BROMOCINNAMYLAMINO)ETHYL]-5-ISOQUINOLINE
Descriptor:C-AMP-DEPENDENT PROTEIN KINASE, PROTEIN KINASE INHIBITOR PEPTIDE, N-[2-(4-BROMOCINNAMYLAMINO)ETHYL]-5-ISOQUINOLINE SULFONAMIDE
Authors:Engh, R.A., Girod, A., Kinzel, V., Huber, R., Bossemeyer, D.
Deposit date:1996-07-24
Release date:1997-04-01
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structures of catalytic subunit of cAMP-dependent protein kinase in complex with isoquinolinesulfonyl protein kinase inhibitors H7, H8, and H89. Structural implications for selectivity.
J.Biol.Chem., 271, 1996
1ERK
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STRUCTURE OF SIGNAL-REGULATED KINASE
Descriptor:EXTRACELLULAR REGULATED KINASE 2
Authors:Harkins, P.C., Goldsmith, E.J.
Deposit date:1996-08-06
Release date:1997-05-15
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Atomic structure of the MAP kinase ERK2 at 2.3 A resolution.
Nature, 367, 1994
1WFC
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STRUCTURE OF APO, UNPHOSPHORYLATED, P38 MITOGEN ACTIVATED PROTEIN KINASE P38 (P38 MAP KINASE) THE MAMMALIAN HOMOLOGUE OF THE YEAST HOG1 PROTEIN
Descriptor:MITOGEN-ACTIVATED PROTEIN KINASE P38
Authors:Wilson, K.P., Fitzgibbon, M.J., Caron, P.R., Griffith, J.P., Chen, W., Mccaffrey, P. G., Chambers, S.P., Su, M.S.-S.
Deposit date:1996-09-13
Release date:1997-09-19
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of p38 mitogen-activated protein kinase.
J.Biol.Chem., 271, 1996
1IAN
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HUMAN P38 MAP KINASE INHIBITOR COMPLEX
Descriptor:P38 MAP KINASE, 4-[5-(3-IODO-PHENYL)-2-(4-METHANESULFINYL-PHENYL)-1H-IMIDAZOL-4-YL]-PYRIDINE
Authors:Tong, L.
Deposit date:1997-03-07
Release date:1998-05-06
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket.
Nat.Struct.Biol., 4, 1997
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