1BX6

CRYSTAL STRUCTURE OF THE POTENT NATURAL PRODUCT INHIBITOR BALANOL IN COMPLEX WITH THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE

Summary for 1BX6

Entry DOI	10.2210/pdb1bx6/pdb
Descriptor	CAMP-DEPENDENT PROTEIN KINASE, BALANOL (3 entities in total)
Functional Keywords	serine/threonine-protein kinase, balanol, conformational changes, inhibition, protein kinase pka, serine-threonine-protein kinase complex
Biological source	Mus musculus (house mouse)
Cellular location	Cytoplasm (By similarity): P05132
Total number of polymer chains	1
Total formula weight	41287.81
Authors	Narayana, N.,Xuong, N.-H.,Ten Eyck, L.F.,Taylor, S.S. (deposition date: 1998-10-13, release date: 1999-04-27, Last modification date: 2023-08-09)
Primary citation	Narayana, N.,Diller, T.C.,Koide, K.,Bunnage, M.E.,Nicolaou, K.C.,Brunton, L.L.,Xuong, N.H.,Ten Eyck, L.F.,Taylor, S.S. Crystal structure of the potent natural product inhibitor balanol in complex with the catalytic subunit of cAMP-dependent protein kinase. Biochemistry, 38:2367-2376, 1999 Cited by PubMed: 10029530 DOI: 10.1021/bi9820659 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation