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8JXS
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BU of 8jxs by Molmil
Structure of nanobody-bound DRD1_PF-6142 complex
Descriptor: 4-[3-methyl-4-(6-methylimidazo[1,2-a]pyrazin-5-yl)phenoxy]furo[3,2-c]pyridine, D(1A) dopamine receptor, Fab 8D3 heavy chain, ...
Authors:Zhuang, Y, Xu, Y, Fan, L, Wang, S, Xu, H.E.
Deposit date:2023-07-01
Release date:2024-09-04
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural basis of psychedelic LSD recognition at dopamine D 1 receptor.
Neuron, 2024
8JXR
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BU of 8jxr by Molmil
Structure of nanobody-bound DRD1_LSD complex
Descriptor: (8alpha)-N,N-diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide, D(1A) dopamine receptor, Fab 8D3 heavy chain, ...
Authors:Zhuang, Y, Xu, Y, Fan, L, Wang, S, Xu, H.E.
Deposit date:2023-07-01
Release date:2024-09-04
Method:ELECTRON MICROSCOPY (3.57 Å)
Cite:Structural basis of psychedelic LSD recognition at dopamine D 1 receptor.
Neuron, 2024
8ZMF
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BU of 8zmf by Molmil
Crystal structure of an inverse agonist antipsychotic drug derivative-bound 5-HT2C
Descriptor: 1-[(4-fluorophenyl)methyl]-1-[(8~{S})-5-methyl-5-azaspiro[2.5]octan-8-yl]-3-[[4-(2-methylpropoxy)phenyl]methyl]urea, 5-hydroxytryptamine receptor 2C,Soluble cytochrome b562
Authors:Oguma, T, Asada, H, Sekiguchi, Y, Imono, M, Iwata, S, Kusakabe, K.
Deposit date:2024-05-23
Release date:2024-08-28
Last modified:2024-09-04
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Dual 5-HT 2A and 5-HT 2C Receptor Inverse Agonist That Affords In Vivo Antipsychotic Efficacy with Minimal hERG Inhibition for the Treatment of Dementia-Related Psychosis.
J.Med.Chem., 67, 2024
8XVJ
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BU of 8xvj by Molmil
Cryo-EM structure of ETAR bound with Macitentan
Descriptor: 6-[2-(5-bromanylpyrimidin-2-yl)oxyethoxy]-5-(4-bromophenyl)-~{N}-(propylsulfamoyl)pyrimidin-4-amine, Endoglucanase H,Endothelin-1 receptor,Soluble cytochrome b562, anti-BRIL Fab Heavy chain, ...
Authors:Hou, J.Y, Liu, S.H, Wu, L.J, Liu, Z.J, Hua, T.
Deposit date:2024-01-15
Release date:2024-08-28
Method:ELECTRON MICROSCOPY (3.26 Å)
Cite:Structural basis of antagonist selectivity in endothelin receptors.
Cell Discov, 10, 2024
8XVK
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BU of 8xvk by Molmil
Cryo-EM structure of ETAR bound with Ambrisentan
Descriptor: (2~{S})-2-(4,6-dimethylpyrimidin-2-yl)oxy-3-methoxy-3,3-diphenyl-propanoic acid, Endoglucanase H,Endothelin-1 receptor,Soluble cytochrome b562, anti-BRIL Fab Heavy chain, ...
Authors:Hou, J.Y, Liu, S.H, Wu, L.J, Liu, Z.J, Hua, T.
Deposit date:2024-01-15
Release date:2024-08-28
Method:ELECTRON MICROSCOPY (3.21 Å)
Cite:Structural basis of antagonist selectivity in endothelin receptors.
Cell Discov, 10, 2024
8XVL
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BU of 8xvl by Molmil
Cryo-EM structure of ETAR bound with Zibotentan
Descriptor: Endoglucanase H,Endothelin-1 receptor,Soluble cytochrome b562, anti-BRIL Fab Heavy chain, anti-BRIL Fab Light chain, ...
Authors:Hou, J.Y, Liu, S.H, Wu, L.J, Liu, Z.J, Hua, T.
Deposit date:2024-01-15
Release date:2024-08-28
Method:ELECTRON MICROSCOPY (3.22 Å)
Cite:Structural basis of antagonist selectivity in endothelin receptors.
Cell Discov, 10, 2024
8XVI
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BU of 8xvi by Molmil
Cryo-EM structure of ETAR bound with Endothelin1
Descriptor: Endoglucanase H,Endothelin-1 receptor, Endothelin-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Hou, J.Y, Liu, S.H, Wu, L.J, Liu, Z.J, Hua, T.
Deposit date:2024-01-15
Release date:2024-08-28
Method:ELECTRON MICROSCOPY (3.32 Å)
Cite:Structural basis of antagonist selectivity in endothelin receptors.
Cell Discov, 10, 2024
8XVE
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BU of 8xve by Molmil
Cryo-EM structure of ETBR bound with BQ3020
Descriptor: BQ3020, Exo-alpha-sialidase,Endothelin receptor type B, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Hou, J.Y, Liu, S.H, Wu, L.J, Liu, Z.J, Hua, T.
Deposit date:2024-01-15
Release date:2024-08-28
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural basis of antagonist selectivity in endothelin receptors.
Cell Discov, 10, 2024
8XVH
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BU of 8xvh by Molmil
Cryo-EM structure of ETBR bound with Endothelin1
Descriptor: Endothelin-1, Exo-alpha-sialidase,Endothelin receptor type B, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Hou, J.Y, Liu, S.H, Wu, L.J, Liu, Z.J, Hua, T.
Deposit date:2024-01-15
Release date:2024-08-28
Method:ELECTRON MICROSCOPY (3.26 Å)
Cite:Structural basis of antagonist selectivity in endothelin receptors.
Cell Discov, 10, 2024
8ZMG
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BU of 8zmg by Molmil
Crystal structure of an inverse agonist antipsychotic drug pimavanserin-bound 5-HT2A
Descriptor: 5-hydroxytryptamine receptor 2A,Soluble cytochrome b562, Pimavanserin
Authors:Oguma, T, Asada, H, Sekiguchi, Y, Imono, M, Iwata, S, Kusakabe, K.
Deposit date:2024-05-23
Release date:2024-08-28
Last modified:2024-09-04
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Dual 5-HT 2A and 5-HT 2C Receptor Inverse Agonist That Affords In Vivo Antipsychotic Efficacy with Minimal hERG Inhibition for the Treatment of Dementia-Related Psychosis.
J.Med.Chem., 67, 2024
9IJE
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BU of 9ije by Molmil
Epinephrine-activated human beta3 adrenergic receptor
Descriptor: Beta-3 adrenergic receptor, Camelid antibody VHH fragment, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Zheng, S, Zhang, S, Dai, S, Chen, K, Gao, K, Lin, B, Liu, X.
Deposit date:2024-06-22
Release date:2024-08-21
Method:ELECTRON MICROSCOPY (2.34 Å)
Cite:Molecular Mechanism of the beta 3AR Agonist Activity of a beta-Blocker.
Chempluschem, 2024
9IJD
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BU of 9ijd by Molmil
Carazolol-activated human beta3 adrenergic receptor
Descriptor: (2S)-1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)propan-2-ol, Beta-3 adrenergic receptor, Camelid antibody VHH fragment, ...
Authors:Zheng, S, Zhang, S, Dai, S, Chen, K, Gao, K, Lin, B, Liu, X.
Deposit date:2024-06-22
Release date:2024-08-21
Method:ELECTRON MICROSCOPY (2.76 Å)
Cite:Molecular Mechanism of the beta 3AR Agonist Activity of a beta-Blocker.
Chempluschem, 2024
8JJP
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BU of 8jjp by Molmil
G protein-coupled receptor 1
Descriptor: CHOLESTEROL, Chemerin-like receptor 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Liu, A, Liu, Y, Chen, G, Ye, F.
Deposit date:2023-05-31
Release date:2024-08-21
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:G protein-coupled receptor 1
To Be Published
8XGM
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BU of 8xgm by Molmil
Cryo-EM structure of human GPR1 bound to chemerin
Descriptor: CHOLESTEROL, G-protein coupled receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Liu, A.J, Liu, Y.Z, Ye, R.D.
Deposit date:2023-12-15
Release date:2024-08-21
Method:ELECTRON MICROSCOPY (3.29 Å)
Cite:Cryo-EM structure of human GPR1 bound to chemerin
To Be Published
8U02
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BU of 8u02 by Molmil
CryoEM structure of D2 dopamine receptor in complex with GoA KE mutant and dopamine
Descriptor: D(2) dopamine receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Krumm, B.E, Kapolka, N.J, Fay, J.F, Roth, B.L.
Deposit date:2023-08-28
Release date:2024-08-21
Method:ELECTRON MICROSCOPY (3.28 Å)
Cite:A neurodevelopmental disorder mutation locks G proteins in the transitory pre-activated state.
Nat Commun, 15, 2024
8TZQ
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BU of 8tzq by Molmil
CryoEM structure of D2 dopamine receptor in complex with GoA KE Mutant, scFv16, and dopamine
Descriptor: D(2) dopamine receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Krumm, B.E, Kapolka, N.J, Fay, J.F, Roth, B.L.
Deposit date:2023-08-27
Release date:2024-08-21
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:A neurodevelopmental disorder mutation locks G proteins in the transitory pre-activated state.
Nat Commun, 15, 2024
8WKY
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BU of 8wky by Molmil
Crystal structure of the Melanocortin-4 Receptor (MC4R) in complex with S25
Descriptor: CALCIUM ION, Melanocortin receptor 4, N-(2-aminoethyl)-5-(2-{[4-(morpholin-4-yl)pyridin-2-yl]amino}-1,3-thiazol-5-yl)pyridine-3-carboxamide, ...
Authors:Gimenez, L.E, Martin, C, Yu, J, Hollanders, C, Hernandez, C, Dahir, N.S, Wu, Y, Yao, D, Han, G.W, Wu, L, Poorten, O.V, Lamouroux, A, Mannes, M, Tourwe, D, Zhao, S, Stevens, R.C, Cone, R.D, Ballet, S.
Deposit date:2023-09-28
Release date:2024-08-07
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Novel Cocrystal Structures of Peptide Antagonists Bound to the Human Melanocortin Receptor 4 Unveil Unexplored Grounds for Structure-Based Drug Design.
J.Med.Chem., 67, 2024
8WKZ
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BU of 8wkz by Molmil
Crystal structure of the Melanocortin-4 Receptor (MC4R) in complex with S31
Descriptor: CALCIUM ION, Melanocortin receptor 4, OLEIC ACID, ...
Authors:Gimenez, L.E, Martin, C, Yu, J, Hollanders, C, Hernandez, C, Dahir, N.S, Wu, Y, Yao, D, Han, G.W, Wu, L, Poorten, O.V, Lamouroux, A, Mannes, M, Tourwe, D, Zhao, S, Stevens, R.C, Cone, R.D, Ballet, S.
Deposit date:2023-09-28
Release date:2024-08-07
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Novel Cocrystal Structures of Peptide Antagonists Bound to the Human Melanocortin Receptor 4 Unveil Unexplored Grounds for Structure-Based Drug Design.
J.Med.Chem., 67, 2024
8ZFJ
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BU of 8zfj by Molmil
cryo-EM structure of GPR4-Gs complex at pH 8.5
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ...
Authors:Ma, Y, Tang, M, Ru, H, Song, G.
Deposit date:2024-05-07
Release date:2024-08-07
Last modified:2024-08-14
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:cryo-EM structure of GPR4-Gs complex at pH 8.5
to be published
8K6N
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BU of 8k6n by Molmil
Structural complex of neuropeptide Y receptor 2
Descriptor: C-flanking peptide of NPY, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Shen, S.Y, Zhao, C, Shao, Z.H.
Deposit date:2023-07-25
Release date:2024-07-31
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structural complex of neuropeptide Y receptor 2
To Be Published
8K6O
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BU of 8k6o by Molmil
Structural complex of neuropeptide Y receptor 1
Descriptor: C-flanking peptide of NPY, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Shen, S.Y, Zhao, C, Shao, Z.H.
Deposit date:2023-07-25
Release date:2024-07-31
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structural complex of neuropeptide Y receptor 1
To Be Published
8K6M
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BU of 8k6m by Molmil
Structural complex of neuropeptide Y receptor 1
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-2, ...
Authors:Shen, S.Y, Zhao, C, Shao, Z.H.
Deposit date:2023-07-25
Release date:2024-07-31
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structural complex of neuropeptide Y receptor 1
To Be Published
8KGG
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BU of 8kgg by Molmil
LPS-bound P2Y10 in complex with G13
Descriptor: (2~{S})-2-$l^{4}-azanyl-3-[[(2~{R})-3-octadecanoyloxy-2-oxidanyl-propoxy]-oxidanyl-oxidanylidene-$l^{6}-phosphanyl]oxy-propanoic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:He, Y, Yin, Y.
Deposit date:2023-08-19
Release date:2024-07-31
Method:ELECTRON MICROSCOPY (3.06 Å)
Cite:LPS-bound P2Y10 in complex with G13
To Be Published
8K4P
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BU of 8k4p by Molmil
Cryo-EM structure of an active Kaposi's Sarcoma-Associated Herpesvirus-G Protein-Coupled Receptor (KSHV-GPCR) in complex with Gi protein
Descriptor: G protein-coupled receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ...
Authors:Liu, Y.Z, Liu, A.J.
Deposit date:2023-07-20
Release date:2024-07-24
Method:ELECTRON MICROSCOPY (2.81 Å)
Cite:Cryo-EM structure of active Kaposi's Sarcoma-Associated Herpesvirus-G Protein-Coupled Receptor (KSHV-GPCR) in complex with Gi protein
To Be Published
8K4O
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BU of 8k4o by Molmil
Cryo-EM structure of Kaposi's Sarcoma-Associated Herpesvirus-G Protein-Coupled Receptor (KSHV-GPCR)in complex with CXC chemokine CXCL1
Descriptor: G protein-coupled receptor, Growth-regulated alpha protein, Guanine nucleotide-binding protein G(I) subunit alpha-1, ...
Authors:Liu, Y.Z, Liu, A.J.
Deposit date:2023-07-20
Release date:2024-07-24
Method:ELECTRON MICROSCOPY (3.01 Å)
Cite:Cryo-EM structure of Kaposi's Sarcoma Herpesvirus GPCR (KSHV-GPCR)in complex with CXCL1
To Be Published

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PDB entries from 2024-09-18

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