Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

4N8M
DownloadVisualize
BU of 4n8m by Molmil
Structural polymorphism in the N-terminal oligomerization domain of NPM1
Descriptor: COBALT (II) ION, Nucleophosmin
Authors:Mitrea, D, Royappa, G, Buljan, M, Yun, M, Pytel, N, Satumba, J, Nourse, A, Park, C, Babu, M.M, White, S.W, Kriwacki, R.W.
Deposit date:2013-10-17
Release date:2014-03-12
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.802 Å)
Cite:Structural polymorphism in the N-terminal oligomerization domain of NPM1.
Proc.Natl.Acad.Sci.USA, 111, 2014
6O5I
DownloadVisualize
BU of 6o5i by Molmil
Menin in complex with MI-3454
Descriptor: DIMETHYL SULFOXIDE, Menin, SULFATE ION, ...
Authors:Linhares, B.M, Klossowski, S, Cierpicki, T, Grembecka, J.
Deposit date:2019-03-03
Release date:2020-01-08
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.24025619 Å)
Cite:Menin inhibitor MI-3454 induces remission in MLL1-rearranged and NPM1-mutated models of leukemia.
J.Clin.Invest., 130, 2020
8IG0
DownloadVisualize
BU of 8ig0 by Molmil
Crystal structure of menin in complex with DS-1594b
Descriptor: (1R,2S,4R)-4-[[4-(5,6-dimethoxypyridazin-3-yl)phenyl]methylamino]-2-[methyl-[6-[2,2,2-tris(fluoranyl)ethyl]thieno[2,3-d]pyrimidin-4-yl]amino]cyclopentan-1-ol, DIMETHYL SULFOXIDE, Menin, ...
Authors:Suzuki, M, Yoneyama, T, Imai, E.
Deposit date:2023-02-20
Release date:2023-03-22
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A novel Menin-MLL1 inhibitor, DS-1594a, prevents the progression of acute leukemia with rearranged MLL1 or mutated NPM1.
Cancer Cell Int, 23, 2023
2LLH
DownloadVisualize
BU of 2llh by Molmil
NMR structure of Npm1_c70
Descriptor: Nucleophosmin
Authors:Banci, L, Bertini, I, Brunori, M, Di Matteo, A, Federici, L, Gallo, A, Lo Sterzo, C, Mori, M.
Deposit date:2011-11-09
Release date:2012-06-27
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Structure of Nucleophosmin DNA-binding Domain and Analysis of Its Complex with a G-quadruplex Sequence from the c-MYC Promoter.
J.Biol.Chem., 287, 2012
8AH2
DownloadVisualize
BU of 8ah2 by Molmil
Crystal structure of human 14-3-3 zeta fused to the NPM1 peptide including phosphoserine-48
Descriptor: 14-3-3 protein zeta/delta,Nucleophosmin
Authors:Boyko, K.M, Kapitonova, A.A, Tugaeva, K.V, Varfolomeeva, L.A, Sluchanko, N.N.
Deposit date:2022-07-20
Release date:2022-09-14
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis for the recognition by 14-3-3 proteins of a conditional binding site within the oligomerization domain of human nucleophosmin.
Biochem.Biophys.Res.Commun., 627, 2022
7OBH
DownloadVisualize
BU of 7obh by Molmil
Crystal structure of 14-3-3 sigma in complex with NPM1 phosphopeptide and stabilizer Fusicoccin-A
Descriptor: 14-3-3 protein sigma, CHLORIDE ION, FUSICOCCIN, ...
Authors:Centorrino, F, Andlovic, B, Ottmann, C.
Deposit date:2021-04-22
Release date:2022-05-04
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:IFN alpha primes cancer cells for Fusicoccin-induced cell death via 14-3-3 PPI stabilization.
Cell Chem Biol, 2023
7OBG
DownloadVisualize
BU of 7obg by Molmil
Crystal structure of 14-3-3 sigma in complex with NPM1 phosphopeptide
Descriptor: 14-3-3 protein sigma, CHLORIDE ION, MAGNESIUM ION, ...
Authors:Centorrino, F, Andlovic, B, Ottmann, C.
Deposit date:2021-04-22
Release date:2022-05-04
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:IFN alpha primes cancer cells for Fusicoccin-induced cell death via 14-3-3 PPI stabilization.
Cell Chem Biol, 2023
8AS5
DownloadVisualize
BU of 8as5 by Molmil
CryoEM structure of the human Nucleophosmin 1 core
Descriptor: Nucleophosmin
Authors:Valentin Gese, G, Hallberg, B.M.
Deposit date:2022-08-18
Release date:2023-02-15
Last modified:2024-07-24
Method:ELECTRON MICROSCOPY (3.53 Å)
Cite:A "grappling hook" interaction connects self-assembly and chaperone activity of Nucleophosmin 1.
Pnas Nexus, 2, 2023
2VXD
DownloadVisualize
BU of 2vxd by Molmil
The structure of the C-terminal domain of Nucleophosmin
Descriptor: NUCLEOPHOSMIN
Authors:Bycroft, M, Grummitt, C.G.
Deposit date:2008-07-03
Release date:2008-07-15
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Structural Consequences of Nucleophosmin Mutations in Acute Myeloid Leukemia.
J.Biol.Chem., 283, 2008
8E90
DownloadVisualize
BU of 8e90 by Molmil
Inhibition of Human Menin by SNDX-5613
Descriptor: 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-({4-[7-({(1r,4r)-4-[(ethanesulfonyl)amino]cyclohexyl}methyl)-2,7-diazaspiro[3.5]nonan-2-yl]pyrimidin-5-yl}oxy)-N-ethyl-5-fluoro-N-(propan-2-yl)benzamide, ...
Authors:McKeever, B.M, KULKARNI, S, McGeehan, G.M.
Deposit date:2022-08-26
Release date:2022-12-14
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:MEN1 mutations mediate clinical resistance to menin inhibition.
Nature, 615, 2023
7UJ4
DownloadVisualize
BU of 7uj4 by Molmil
Inhibition of Human Menin by SNDX-5613
Descriptor: 2-({4-[7-({(1r,4r)-4-[(ethanesulfonyl)amino]cyclohexyl}methyl)-2,7-diazaspiro[3.5]nonan-2-yl]pyrimidin-5-yl}oxy)-N-ethyl-5-fluoro-N-(propan-2-yl)benzamide, Isoform 2 of Menin, MAGNESIUM ION
Authors:McKeever, B.M, Kulkarni, S, McGeehan, G.M.
Deposit date:2022-03-30
Release date:2022-12-14
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:MEN1 mutations mediate clinical resistance to menin inhibition.
Nature, 615, 2023
5EHD
DownloadVisualize
BU of 5ehd by Molmil
Crystal structure of human nucleophosmin-core in complex with cytochrome c
Descriptor: CHLORIDE ION, Nucleophosmin
Authors:Bernardo-Garcia, N, Hermoso, J.A, Gonzalez-Arzola, K, Diaz-Moreno, I, De la Rosa, M.A.
Deposit date:2015-10-28
Release date:2016-11-09
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Crystal structure of human nucleophosmin-core in complex with cytochrome c
To Be Published

225158

PDB entries from 2024-09-18

PDB statisticsPDBj update infoContact PDBjnumon