PDB: 12 resultsInfo pagesStatus searchChemie searchBIRD

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4N8M	Structural polymorphism in the N-terminal oligomerization domain of NPM1 Descriptor: COBALT (II) ION, Nucleophosmin Authors: Mitrea, D, Royappa, G, Buljan, M, Yun, M, Pytel, N, Satumba, J, Nourse, A, Park, C, Babu, M.M, White, S.W, Kriwacki, R.W. Deposit date: 2013-10-17 Release date: 2014-03-12 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.802 Å) Cite: Structural polymorphism in the N-terminal oligomerization domain of NPM1. Proc.Natl.Acad.Sci.USA, 111, 2014
6O5I	Menin in complex with MI-3454 Descriptor: DIMETHYL SULFOXIDE, Menin, SULFATE ION, ... Authors: Linhares, B.M, Klossowski, S, Cierpicki, T, Grembecka, J. Deposit date: 2019-03-03 Release date: 2020-01-08 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.24025619 Å) Cite: Menin inhibitor MI-3454 induces remission in MLL1-rearranged and NPM1-mutated models of leukemia. J.Clin.Invest., 130, 2020
8IG0	Crystal structure of menin in complex with DS-1594b Descriptor: (1R,2S,4R)-4-[[4-(5,6-dimethoxypyridazin-3-yl)phenyl]methylamino]-2-[methyl-[6-[2,2,2-tris(fluoranyl)ethyl]thieno[2,3-d]pyrimidin-4-yl]amino]cyclopentan-1-ol, DIMETHYL SULFOXIDE, Menin, ... Authors: Suzuki, M, Yoneyama, T, Imai, E. Deposit date: 2023-02-20 Release date: 2023-03-22 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.6 Å) Cite: A novel Menin-MLL1 inhibitor, DS-1594a, prevents the progression of acute leukemia with rearranged MLL1 or mutated NPM1. Cancer Cell Int, 23, 2023
2LLH	NMR structure of Npm1_c70 Descriptor: Nucleophosmin Authors: Banci, L, Bertini, I, Brunori, M, Di Matteo, A, Federici, L, Gallo, A, Lo Sterzo, C, Mori, M. Deposit date: 2011-11-09 Release date: 2012-06-27 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Structure of Nucleophosmin DNA-binding Domain and Analysis of Its Complex with a G-quadruplex Sequence from the c-MYC Promoter. J.Biol.Chem., 287, 2012
8AH2	Crystal structure of human 14-3-3 zeta fused to the NPM1 peptide including phosphoserine-48 Descriptor: 14-3-3 protein zeta/delta,Nucleophosmin Authors: Boyko, K.M, Kapitonova, A.A, Tugaeva, K.V, Varfolomeeva, L.A, Sluchanko, N.N. Deposit date: 2022-07-20 Release date: 2022-09-14 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Structural basis for the recognition by 14-3-3 proteins of a conditional binding site within the oligomerization domain of human nucleophosmin. Biochem.Biophys.Res.Commun., 627, 2022
7OBH	Crystal structure of 14-3-3 sigma in complex with NPM1 phosphopeptide and stabilizer Fusicoccin-A Descriptor: 14-3-3 protein sigma, CHLORIDE ION, FUSICOCCIN, ... Authors: Centorrino, F, Andlovic, B, Ottmann, C. Deposit date: 2021-04-22 Release date: 2022-05-04 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2 Å) Cite: IFN alpha primes cancer cells for Fusicoccin-induced cell death via 14-3-3 PPI stabilization. Cell Chem Biol, 2023
7OBG	Crystal structure of 14-3-3 sigma in complex with NPM1 phosphopeptide Descriptor: 14-3-3 protein sigma, CHLORIDE ION, MAGNESIUM ION, ... Authors: Centorrino, F, Andlovic, B, Ottmann, C. Deposit date: 2021-04-22 Release date: 2022-05-04 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.8 Å) Cite: IFN alpha primes cancer cells for Fusicoccin-induced cell death via 14-3-3 PPI stabilization. Cell Chem Biol, 2023
8AS5	CryoEM structure of the human Nucleophosmin 1 core Descriptor: Nucleophosmin Authors: Valentin Gese, G, Hallberg, B.M. Deposit date: 2022-08-18 Release date: 2023-02-15 Last modified: 2024-07-24 Method: ELECTRON MICROSCOPY (3.53 Å) Cite: A "grappling hook" interaction connects self-assembly and chaperone activity of Nucleophosmin 1. Pnas Nexus, 2, 2023
2VXD	The structure of the C-terminal domain of Nucleophosmin Descriptor: NUCLEOPHOSMIN Authors: Bycroft, M, Grummitt, C.G. Deposit date: 2008-07-03 Release date: 2008-07-15 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Structural Consequences of Nucleophosmin Mutations in Acute Myeloid Leukemia. J.Biol.Chem., 283, 2008
8E90	Inhibition of Human Menin by SNDX-5613 Descriptor: 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-({4-[7-({(1r,4r)-4-[(ethanesulfonyl)amino]cyclohexyl}methyl)-2,7-diazaspiro[3.5]nonan-2-yl]pyrimidin-5-yl}oxy)-N-ethyl-5-fluoro-N-(propan-2-yl)benzamide, ... Authors: McKeever, B.M, KULKARNI, S, McGeehan, G.M. Deposit date: 2022-08-26 Release date: 2022-12-14 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.85 Å) Cite: MEN1 mutations mediate clinical resistance to menin inhibition. Nature, 615, 2023
7UJ4	Inhibition of Human Menin by SNDX-5613 Descriptor: 2-({4-[7-({(1r,4r)-4-[(ethanesulfonyl)amino]cyclohexyl}methyl)-2,7-diazaspiro[3.5]nonan-2-yl]pyrimidin-5-yl}oxy)-N-ethyl-5-fluoro-N-(propan-2-yl)benzamide, Isoform 2 of Menin, MAGNESIUM ION Authors: McKeever, B.M, Kulkarni, S, McGeehan, G.M. Deposit date: 2022-03-30 Release date: 2022-12-14 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.96 Å) Cite: MEN1 mutations mediate clinical resistance to menin inhibition. Nature, 615, 2023
5EHD	Crystal structure of human nucleophosmin-core in complex with cytochrome c Descriptor: CHLORIDE ION, Nucleophosmin Authors: Bernardo-Garcia, N, Hermoso, J.A, Gonzalez-Arzola, K, Diaz-Moreno, I, De la Rosa, M.A. Deposit date: 2015-10-28 Release date: 2016-11-09 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.55 Å) Cite: Crystal structure of human nucleophosmin-core in complex with cytochrome c To Be Published