2JX2
 
 | | Solution conformation of RNA-bound NELF-E RRM | | Descriptor: | Negative elongation factor E | | Authors: | Jampani, N, Schweimer, K, Wenzel, S, Woehrl, B.M, Roesch, P. | | Deposit date: | 2007-11-02 | | Release date: | 2008-04-08 | | Last modified: | 2024-05-08 | | Method: | SOLUTION NMR | | Cite: | NELF-E RRM Undergoes Major Structural Changes in Flexible Protein Regions on Target RNA Binding
Biochemistry, 47, 2008
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2BZ2
 | | Solution structure of NELF E RRM | | Descriptor: | NEGATIVE ELONGATION FACTOR E | | Authors: | Schweimer, K, Rao, J.N, Neumann, L, Rosch, P, Wohrl, B.M. | | Deposit date: | 2005-08-10 | | Release date: | 2006-08-16 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Structural studies on the RNA-recognition motif of NELF E, a cellular negative transcription elongation factor involved in the regulation of HIV transcription.
Biochem. J., 400, 2006
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8JJ6
 | | Structure of the NELF-BCE complex | | Descriptor: | NELF-E, Negative elongation factor B, Negative elongation factor complex member C/D | | Authors: | Wang, Z, Cao, Y, Qin, Y. | | Deposit date: | 2023-05-29 | | Release date: | 2023-08-30 | | Last modified: | 2024-09-11 | | Method: | X-RAY DIFFRACTION (2.72 Å) | | Cite: | Structural basis of the human negative elongation factor NELF-B/C/E ternary complex.
Biochem.Biophys.Res.Commun., 677, 2023
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6GML
 | | Structure of paused transcription complex Pol II-DSIF-NELF | | Descriptor: | DNA-directed RNA polymerase II subunit RPB9, DNA-directed RNA polymerase subunit, DNA-directed RNA polymerase subunit beta, ... | | Authors: | Vos, S.M, Farnung, L, Urlaub, H, Cramer, P. | | Deposit date: | 2018-05-27 | | Release date: | 2018-09-05 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structure of paused transcription complex Pol II-DSIF-NELF.
Nature, 560, 2018
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5OOB
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8UI0
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8UHG
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8UHA
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8UHD
 | | Structure of paused transcription complex Pol II-DSIF-NELF - post-translocated | | Descriptor: | DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit RPB3, DNA-directed RNA polymerase II subunit RPB7, ... | | Authors: | Su, B.G, Vos, S.M. | | Deposit date: | 2023-10-08 | | Release date: | 2024-03-20 | | Last modified: | 2024-09-11 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Distinct negative elongation factor conformations regulate RNA polymerase II promoter-proximal pausing.
Mol.Cell, 84, 2024
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5OO6
 | | Complex of human nuclear cap-binding complex with ARS2 C-terminal peptide | | Descriptor: | 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, Nuclear cap-binding protein subunit 1, Nuclear cap-binding protein subunit 2, ... | | Authors: | Cusack, S, Schulze, W.M. | | Deposit date: | 2017-08-06 | | Release date: | 2017-11-15 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structural basis for mutually exclusive co-transcriptional nuclear cap-binding complexes with either NELF-E or ARS2.
Nat Commun, 8, 2017
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8RBX
 | | Structure of Integrator-PP2A bound to a paused RNA polymerase II-DSIF-NELF-nucleosome complex | | Descriptor: | DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit RPB11-a, DNA-directed RNA polymerase II subunit RPB3, ... | | Authors: | Fianu, I, Ochmann, M, Walshe, J.L, Cramer, P. | | Deposit date: | 2023-12-05 | | Release date: | 2024-02-07 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (4.1 Å) | | Cite: | Structural basis of Integrator-dependent RNA polymerase II termination.
Nature, 629, 2024
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6EIH
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8W8E
 | | human co-transcriptional RNA capping enzyme RNGTT | | Descriptor: | DNA (36-MER), DNA (45-MER), DNA-directed RNA polymerase II subunit E, ... | | Authors: | Li, Y, Wang, Q, Xu, Y, Li, Z. | | Deposit date: | 2023-09-02 | | Release date: | 2024-04-10 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Structures of co-transcriptional RNA capping enzymes on paused transcription complex.
Nat Commun, 15, 2024
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5L3X
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8UIS
 | | Structure of transcription complex Pol II-DSIF-NELF-TFIIS | | Descriptor: | DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit RPB3, DNA-directed RNA polymerase II subunit RPB7, ... | | Authors: | Su, B.G, Vos, S.M. | | Deposit date: | 2023-10-10 | | Release date: | 2024-03-20 | | Last modified: | 2024-04-17 | | Method: | ELECTRON MICROSCOPY (3.23 Å) | | Cite: | Distinct negative elongation factor conformations regulate RNA polymerase II promoter-proximal pausing.
Mol.Cell, 84, 2024
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1X5P
 | | Solution structure of RRM domain in Parp14 | | Descriptor: | Negative elongation factor E | | Authors: | Dang, W, Muto, Y, Inoue, M, Kigawa, T, Shirouzu, M, Terada, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2005-05-16 | | Release date: | 2005-11-16 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Solution structure of RRM domain in Parp14
To be Published
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7YCX
 | | The structure of INTAC-PEC complex | | Descriptor: | DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, DNA-directed RNA polymerase II subunit RPB1,DNA-directed RNA polymerase II subunit RPB1, ... | | Authors: | Zheng, H, Jin, Q, Wang, X, Qi, Y, Liu, W, Ren, Y, Zhao, D, Chen, F.X, Cheng, J, Chen, X, Xu, Y. | | Deposit date: | 2022-07-02 | | Release date: | 2023-03-15 | | Last modified: | 2023-09-27 | | Method: | ELECTRON MICROSCOPY (4.18 Å) | | Cite: | Structural basis of INTAC-regulated transcription.
Protein Cell, 14, 2023
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7PKS
 | | Structural basis of Integrator-mediated transcription regulation | | Descriptor: | DNA Template, DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, ... | | Authors: | Fianu, I, Chen, Y, Dienemann, C, Cramer, P. | | Deposit date: | 2021-08-26 | | Release date: | 2021-12-08 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Structural basis of Integrator-mediated transcription regulation.
Science, 374, 2021
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6CF6
 | | RNF146 TBM-Tankyrase ARC2-3 complex | | Descriptor: | RNF146, Tankyrase-1 | | Authors: | Da Rosa, P.A, Xu, W. | | Deposit date: | 2018-02-13 | | Release date: | 2018-04-18 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (1.93 Å) | | Cite: | Structural basis for tankyrase-RNF146 interaction reveals noncanonical tankyrase-binding motifs.
Protein Sci., 27, 2018
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8W8F
 | | human co-transcriptional RNA capping enzyme RNGTT-CMTR1 | | Descriptor: | Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1, DNA (36-MER), DNA (45-MER), ... | | Authors: | Li, Y, Wang, Q, Xu, Y, Li, Z. | | Deposit date: | 2023-09-02 | | Release date: | 2024-04-10 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | Structures of co-transcriptional RNA capping enzymes on paused transcription complex.
Nat Commun, 15, 2024
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6GME
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6GMH
 | | Structure of activated transcription complex Pol II-DSIF-PAF-SPT6 | | Descriptor: | CDC73, CTR9,RNA polymerase-associated protein CTR9 homolog,RNA polymerase-associated protein CTR9 homolog, DNA-directed RNA polymerase II subunit RPB9, ... | | Authors: | Vos, S.M, Farnung, L, Boehing, M, Linden, A, Wigge, C, Urlaub, H, Cramer, P. | | Deposit date: | 2018-05-26 | | Release date: | 2018-08-22 | | Last modified: | 2019-12-18 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structure of activated transcription complex Pol II-DSIF-PAF-SPT6.
Nature, 560, 2018
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8BY6
 | | Structure of the human nuclear cap-binding complex bound to NCBP3(560-620) and cap-analogue m7GpppG | | Descriptor: | 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE, Nuclear cap-binding protein subunit 1, Nuclear cap-binding protein subunit 2, ... | | Authors: | Dubiez, E, Pellegrini, E, Foucher, A.E, Cusack, S, Kadlec, J. | | Deposit date: | 2022-12-12 | | Release date: | 2024-01-24 | | Last modified: | 2024-01-31 | | Method: | ELECTRON MICROSCOPY (3.19 Å) | | Cite: | Structural basis for competitive binding of productive and degradative co-transcriptional effectors to the nuclear cap-binding complex.
Cell Rep, 43, 2024
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6I84
 | | Structure of transcribing RNA polymerase II-nucleosome complex | | Descriptor: | DNA (158-MER), DNA (170-MER), DNA-directed RNA polymerase II subunit RPB1, ... | | Authors: | Farnung, L, Vos, S.M, Cramer, P. | | Deposit date: | 2018-11-19 | | Release date: | 2019-01-02 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (4.4 Å) | | Cite: | Structure of transcribing RNA polymerase II-nucleosome complex.
Nat Commun, 9, 2018
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3H7H
 | | Crystal structure of the human transcription elongation factor DSIF, hSpt4/hSpt5 (176-273) | | Descriptor: | BETA-MERCAPTOETHANOL, Transcription elongation factor SPT4, Transcription elongation factor SPT5, ... | | Authors: | Wenzel, S, Wohrl, B.M, Rosch, P, Martins, B.M. | | Deposit date: | 2009-04-27 | | Release date: | 2009-12-08 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | Crystal structure of the human transcription elongation factor DSIF hSpt4 subunit in complex with the hSpt5 dimerization interface
Biochem.J., 425, 2010
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