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2JX2
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BU of 2jx2 by Molmil
Solution conformation of RNA-bound NELF-E RRM
Descriptor: Negative elongation factor E
Authors:Jampani, N, Schweimer, K, Wenzel, S, Woehrl, B.M, Roesch, P.
Deposit date:2007-11-02
Release date:2008-04-08
Last modified:2024-05-08
Method:SOLUTION NMR
Cite:NELF-E RRM Undergoes Major Structural Changes in Flexible Protein Regions on Target RNA Binding
Biochemistry, 47, 2008
2BZ2
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BU of 2bz2 by Molmil
Solution structure of NELF E RRM
Descriptor: NEGATIVE ELONGATION FACTOR E
Authors:Schweimer, K, Rao, J.N, Neumann, L, Rosch, P, Wohrl, B.M.
Deposit date:2005-08-10
Release date:2006-08-16
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Structural studies on the RNA-recognition motif of NELF E, a cellular negative transcription elongation factor involved in the regulation of HIV transcription.
Biochem. J., 400, 2006
8JJ6
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BU of 8jj6 by Molmil
Structure of the NELF-BCE complex
Descriptor: NELF-E, Negative elongation factor B, Negative elongation factor complex member C/D
Authors:Wang, Z, Cao, Y, Qin, Y.
Deposit date:2023-05-29
Release date:2023-08-30
Last modified:2024-09-11
Method:X-RAY DIFFRACTION (2.72 Å)
Cite:Structural basis of the human negative elongation factor NELF-B/C/E ternary complex.
Biochem.Biophys.Res.Commun., 677, 2023
6GML
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BU of 6gml by Molmil
Structure of paused transcription complex Pol II-DSIF-NELF
Descriptor: DNA-directed RNA polymerase II subunit RPB9, DNA-directed RNA polymerase subunit, DNA-directed RNA polymerase subunit beta, ...
Authors:Vos, S.M, Farnung, L, Urlaub, H, Cramer, P.
Deposit date:2018-05-27
Release date:2018-09-05
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structure of paused transcription complex Pol II-DSIF-NELF.
Nature, 560, 2018
5OOB
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BU of 5oob by Molmil
COMPLEX OF HUMAN NUCLEAR CAP-BINDING COMPLEX WITH M7GTP AND NELF-E C-TERMINAL PEPTIDE
Descriptor: 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, Negative elongation factor E, Nuclear cap-binding protein subunit 1, ...
Authors:Cusack, S, Schulze, W.M.
Deposit date:2017-08-07
Release date:2017-11-15
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.79 Å)
Cite:Structural basis for mutually exclusive co-transcriptional nuclear cap-binding complexes with either NELF-E or ARS2.
Nat Commun, 8, 2017
8UI0
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BU of 8ui0 by Molmil
Structure of poised transcription complex Pol II-DSIF-NELF - pre-translocated
Descriptor: DNA, DNA (38-MER), DNA-directed RNA polymerase II subunit E, ...
Authors:Vos, S.M, Su, B.G.
Deposit date:2023-10-09
Release date:2024-03-20
Last modified:2024-09-11
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Distinct negative elongation factor conformations regulate RNA polymerase II promoter-proximal pausing.
Mol.Cell, 84, 2024
8UHG
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BU of 8uhg by Molmil
Structure of paused transcription complex Pol II-DSIF-NELF - poised post-translocated
Descriptor: DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit RPB11-a, DNA-directed RNA polymerase II subunit RPB3, ...
Authors:Vos, S.M, Su, B.G.
Deposit date:2023-10-09
Release date:2024-03-20
Last modified:2024-04-17
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Distinct negative elongation factor conformations regulate RNA polymerase II promoter-proximal pausing.
Mol.Cell, 84, 2024
8UHA
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BU of 8uha by Molmil
Structure of paused transcription complex Pol II-DSIF-NELF - tilted
Descriptor: DNA (28-MER), DNA (38-MER), DNA-directed RNA polymerase II subunit E, ...
Authors:Vos, S.M, Su, B.G.
Deposit date:2023-10-08
Release date:2024-03-20
Last modified:2024-09-11
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Distinct negative elongation factor conformations regulate RNA polymerase II promoter-proximal pausing.
Mol.Cell, 84, 2024
8UHD
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BU of 8uhd by Molmil
Structure of paused transcription complex Pol II-DSIF-NELF - post-translocated
Descriptor: DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit RPB3, DNA-directed RNA polymerase II subunit RPB7, ...
Authors:Su, B.G, Vos, S.M.
Deposit date:2023-10-08
Release date:2024-03-20
Last modified:2024-09-11
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Distinct negative elongation factor conformations regulate RNA polymerase II promoter-proximal pausing.
Mol.Cell, 84, 2024
5OO6
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BU of 5oo6 by Molmil
Complex of human nuclear cap-binding complex with ARS2 C-terminal peptide
Descriptor: 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, Nuclear cap-binding protein subunit 1, Nuclear cap-binding protein subunit 2, ...
Authors:Cusack, S, Schulze, W.M.
Deposit date:2017-08-06
Release date:2017-11-15
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis for mutually exclusive co-transcriptional nuclear cap-binding complexes with either NELF-E or ARS2.
Nat Commun, 8, 2017
8RBX
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BU of 8rbx by Molmil
Structure of Integrator-PP2A bound to a paused RNA polymerase II-DSIF-NELF-nucleosome complex
Descriptor: DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit RPB11-a, DNA-directed RNA polymerase II subunit RPB3, ...
Authors:Fianu, I, Ochmann, M, Walshe, J.L, Cramer, P.
Deposit date:2023-12-05
Release date:2024-02-07
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Structural basis of Integrator-dependent RNA polymerase II termination.
Nature, 629, 2024
6EIH
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BU of 6eih by Molmil
The crystal structure of 14-3-3 epsilon in complex with the phosphorylated NELFE peptide
Descriptor: 14-3-3 protein epsilon, SER-ILE-SEP-ARG
Authors:Akutsu, M, Wagner, S.A, Beli, P.
Deposit date:2017-09-19
Release date:2018-02-14
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:p38-MK2 signaling axis regulates RNA metabolism after UV-light-induced DNA damage.
Nat Commun, 9, 2018
8W8E
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BU of 8w8e by Molmil
human co-transcriptional RNA capping enzyme RNGTT
Descriptor: DNA (36-MER), DNA (45-MER), DNA-directed RNA polymerase II subunit E, ...
Authors:Li, Y, Wang, Q, Xu, Y, Li, Z.
Deposit date:2023-09-02
Release date:2024-04-10
Last modified:2024-06-19
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structures of co-transcriptional RNA capping enzymes on paused transcription complex.
Nat Commun, 15, 2024
5L3X
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BU of 5l3x by Molmil
Crystal structure of negative elongation factor subcomplex NELF-AC
Descriptor: CHLORIDE ION, Negative elongation factor A, Negative elongation factor C/D
Authors:Poellmann, D, Vos, S.M, Cramer, P.
Deposit date:2016-05-24
Release date:2016-06-22
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Architecture and RNA binding of the human negative elongation factor.
Elife, 5, 2016
8UIS
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BU of 8uis by Molmil
Structure of transcription complex Pol II-DSIF-NELF-TFIIS
Descriptor: DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit RPB3, DNA-directed RNA polymerase II subunit RPB7, ...
Authors:Su, B.G, Vos, S.M.
Deposit date:2023-10-10
Release date:2024-03-20
Last modified:2024-04-17
Method:ELECTRON MICROSCOPY (3.23 Å)
Cite:Distinct negative elongation factor conformations regulate RNA polymerase II promoter-proximal pausing.
Mol.Cell, 84, 2024
1X5P
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BU of 1x5p by Molmil
Solution structure of RRM domain in Parp14
Descriptor: Negative elongation factor E
Authors:Dang, W, Muto, Y, Inoue, M, Kigawa, T, Shirouzu, M, Terada, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-05-16
Release date:2005-11-16
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:Solution structure of RRM domain in Parp14
To be Published
7YCX
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BU of 7ycx by Molmil
The structure of INTAC-PEC complex
Descriptor: DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, DNA-directed RNA polymerase II subunit RPB1,DNA-directed RNA polymerase II subunit RPB1, ...
Authors:Zheng, H, Jin, Q, Wang, X, Qi, Y, Liu, W, Ren, Y, Zhao, D, Chen, F.X, Cheng, J, Chen, X, Xu, Y.
Deposit date:2022-07-02
Release date:2023-03-15
Last modified:2023-09-27
Method:ELECTRON MICROSCOPY (4.18 Å)
Cite:Structural basis of INTAC-regulated transcription.
Protein Cell, 14, 2023
7PKS
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BU of 7pks by Molmil
Structural basis of Integrator-mediated transcription regulation
Descriptor: DNA Template, DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, ...
Authors:Fianu, I, Chen, Y, Dienemann, C, Cramer, P.
Deposit date:2021-08-26
Release date:2021-12-08
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structural basis of Integrator-mediated transcription regulation.
Science, 374, 2021
6CF6
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BU of 6cf6 by Molmil
RNF146 TBM-Tankyrase ARC2-3 complex
Descriptor: RNF146, Tankyrase-1
Authors:Da Rosa, P.A, Xu, W.
Deposit date:2018-02-13
Release date:2018-04-18
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Structural basis for tankyrase-RNF146 interaction reveals noncanonical tankyrase-binding motifs.
Protein Sci., 27, 2018
8W8F
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BU of 8w8f by Molmil
human co-transcriptional RNA capping enzyme RNGTT-CMTR1
Descriptor: Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1, DNA (36-MER), DNA (45-MER), ...
Authors:Li, Y, Wang, Q, Xu, Y, Li, Z.
Deposit date:2023-09-02
Release date:2024-04-10
Last modified:2024-06-19
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Structures of co-transcriptional RNA capping enzymes on paused transcription complex.
Nat Commun, 15, 2024
6GME
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BU of 6gme by Molmil
Structure of H. sapiens SPT6 tandem SH2 domain
Descriptor: SPT6 tandem SH2 domain,Transcription elongation factor SPT6
Authors:Vos, S.M, Farnung, L, Cramer, P.
Deposit date:2018-05-25
Release date:2018-08-22
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.802 Å)
Cite:Structure of activated transcription complex Pol II-DSIF-PAF-SPT6.
Nature, 560, 2018
6GMH
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BU of 6gmh by Molmil
Structure of activated transcription complex Pol II-DSIF-PAF-SPT6
Descriptor: CDC73, CTR9,RNA polymerase-associated protein CTR9 homolog,RNA polymerase-associated protein CTR9 homolog, DNA-directed RNA polymerase II subunit RPB9, ...
Authors:Vos, S.M, Farnung, L, Boehing, M, Linden, A, Wigge, C, Urlaub, H, Cramer, P.
Deposit date:2018-05-26
Release date:2018-08-22
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structure of activated transcription complex Pol II-DSIF-PAF-SPT6.
Nature, 560, 2018
8BY6
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BU of 8by6 by Molmil
Structure of the human nuclear cap-binding complex bound to NCBP3(560-620) and cap-analogue m7GpppG
Descriptor: 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE, Nuclear cap-binding protein subunit 1, Nuclear cap-binding protein subunit 2, ...
Authors:Dubiez, E, Pellegrini, E, Foucher, A.E, Cusack, S, Kadlec, J.
Deposit date:2022-12-12
Release date:2024-01-24
Last modified:2024-01-31
Method:ELECTRON MICROSCOPY (3.19 Å)
Cite:Structural basis for competitive binding of productive and degradative co-transcriptional effectors to the nuclear cap-binding complex.
Cell Rep, 43, 2024
6I84
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BU of 6i84 by Molmil
Structure of transcribing RNA polymerase II-nucleosome complex
Descriptor: DNA (158-MER), DNA (170-MER), DNA-directed RNA polymerase II subunit RPB1, ...
Authors:Farnung, L, Vos, S.M, Cramer, P.
Deposit date:2018-11-19
Release date:2019-01-02
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:Structure of transcribing RNA polymerase II-nucleosome complex.
Nat Commun, 9, 2018
3H7H
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BU of 3h7h by Molmil
Crystal structure of the human transcription elongation factor DSIF, hSpt4/hSpt5 (176-273)
Descriptor: BETA-MERCAPTOETHANOL, Transcription elongation factor SPT4, Transcription elongation factor SPT5, ...
Authors:Wenzel, S, Wohrl, B.M, Rosch, P, Martins, B.M.
Deposit date:2009-04-27
Release date:2009-12-08
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Crystal structure of the human transcription elongation factor DSIF hSpt4 subunit in complex with the hSpt5 dimerization interface
Biochem.J., 425, 2010

 

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