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2WGE
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BU of 2wge by Molmil
Crystal structure of KasA of Mycobacterium tuberculosis with bound TLM
Descriptor: 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE 1, GLYCEROL, ISOPROPYL ALCOHOL, ...
Authors:Luckner, S.R, Kisker, C.
Deposit date:2009-04-17
Release date:2009-07-21
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal Structures of Mycobacterium Tuberculosis Kasa Show Mode of Action within Cell Wall Biosynthesis and its Inhibition by Thiolactomycin
Structure, 17, 2009
2WGG
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BU of 2wgg by Molmil
Crystal Structure of Mycobacterium tuberculosis C171Q KasA variant with bound TLM
Descriptor: 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE 1, DI(HYDROXYETHYL)ETHER, NONAETHYLENE GLYCOL, ...
Authors:Luckner, S.R, Kisker, C.
Deposit date:2009-04-17
Release date:2009-07-21
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structures of Mycobacterium Tuberculosis Kasa Show Mode of Action within Cell Wall Biosynthesis and its Inhibition by Thiolactomycin
Structure, 17, 2009
7F0D
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BU of 7f0d by Molmil
Cryo-EM structure of Mycobacterium tuberculosis 50S ribosome subunit bound with clarithromycin
Descriptor: 23S rRNA, 50S ribosomal protein L13, 50S ribosomal protein L14, ...
Authors:Zhang, W, Sun, Y, Gao, N, Li, Z.
Deposit date:2021-06-03
Release date:2022-06-29
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Cryo-EM structure of Mycobacterium tuberculosis 50S ribosomal subunit bound with clarithromycin reveals dynamic and specific interactions with macrolides.
Emerg Microbes Infect, 11, 2022
1Q0Z
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BU of 1q0z by Molmil
Crystal structure of aclacinomycin methylesterase (RdmC) with bound product analogue, 10-decarboxymethylaclacinomycin A (DcmA)
Descriptor: 10-DECARBOXYMETHYLACLACINOMYCIN A (DCMAA), PENTAETHYLENE GLYCOL, SULFATE ION, ...
Authors:Jansson, A, Niemi, J, Mantsala, P, Schneider, G, Structural Proteomics in Europe (SPINE)
Deposit date:2003-07-18
Release date:2003-11-25
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal structure of aclacinomycin methylesterase with bound product analogues: implications for anthracycline recognition and mechanism.
J.Biol.Chem., 278, 2003
4BGE
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BU of 4bge by Molmil
Crystal structure of InhA(S94A) mutant in complex with pyridomycin
Descriptor: Enoyl-[acyl-carrier-protein] reductase [NADH], Pyridomycin
Authors:Pojer, F, Hartkoorn, R.C, Cole, S.T.
Deposit date:2013-03-26
Release date:2013-12-04
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Pyridomycin bridges the NADH- and substrate-binding pockets of the enoyl reductase InhA.
Nat. Chem. Biol., 10, 2014
4BII
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BU of 4bii by Molmil
How nature bridges the gap: Crystallographic elucidation of pyridomycin binding to InhA
Descriptor: ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Pyridomycin
Authors:Read, J.A, Gingell, H.
Deposit date:2013-04-10
Release date:2013-12-04
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Pyridomycin Bridges the Nadh and Substrate Binding Pockets of the Enoyl Reductase Inha
Nat.Chem.Biol., 10, 2014
7WIV
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BU of 7wiv by Molmil
Cryo-EM structure of Mycobacterium tuberculosis irtAB in complex with an AMP-PNP
Descriptor: Mycobactin import ATP-binding/permease protein IrtA, Mycobactin import ATP-binding/permease protein IrtB, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Zhang, B, Sun, S, Yang, H, Rao, Z.
Deposit date:2022-01-05
Release date:2023-01-25
Last modified:2024-04-10
Method:ELECTRON MICROSCOPY (2.88 Å)
Cite:Cryo-EM structures for the Mycobacterium tuberculosis iron-loaded siderophore transporter IrtAB.
Protein Cell, 14, 2023
7WIU
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BU of 7wiu by Molmil
Cryo-EM structure of Mycobacterium tuberculosis irtAB in inward-facing state
Descriptor: Mycobactin import ATP-binding/permease protein IrtA, Mycobactin import ATP-binding/permease protein IrtB
Authors:Zhang, B, Sun, S, Yang, H, Rao, Z.
Deposit date:2022-01-05
Release date:2023-01-25
Last modified:2024-04-10
Method:ELECTRON MICROSCOPY (3.48 Å)
Cite:Cryo-EM structures for the Mycobacterium tuberculosis iron-loaded siderophore transporter IrtAB.
Protein Cell, 14, 2023
6CCE
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BU of 6cce by Molmil
Crystal structure of a Mycobacterium smegmatis RNA polymerase transcription initiation complex with inhibitor Kanglemycin A
Descriptor: 1,2-ETHANEDIOL, DNA (57-MER), DNA-directed RNA polymerase subunit alpha, ...
Authors:Lilic, M, Darst, S.A, Campbell, E.A.
Deposit date:2018-02-07
Release date:2018-08-15
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Rifamycin congeners kanglemycins are active against rifampicin-resistant bacteria via a distinct mechanism.
Nat Commun, 9, 2018
6DCF
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BU of 6dcf by Molmil
Crystal structure of a Mycobacterium smegmatis transcription initiation complex with Rifampicin-resistant RNA polymerase and bound to kanglemycin A
Descriptor: 1,2-ETHANEDIOL, DNA (26-MER), DNA (31-MER), ...
Authors:Lilic, M, Darst, S.A, Campbell, E.A.
Deposit date:2018-05-06
Release date:2018-09-05
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.45 Å)
Cite:Rifamycin congeners kanglemycins are active against rifampicin-resistant bacteria via a distinct mechanism.
Nat Commun, 9, 2018
1Q0R
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BU of 1q0r by Molmil
Crystal structure of aclacinomycin methylesterase (RdmC) with bound product analogue, 10-decarboxymethylaclacinomycin T (DcmaT)
Descriptor: 10-DECARBOXYMETHYLACLACINOMYCIN T (DCMAT), PENTAETHYLENE GLYCOL, SULFATE ION, ...
Authors:Jansson, A, Niemi, J, Mantsala, P, Schneider, G, Structural Proteomics in Europe (SPINE)
Deposit date:2003-07-17
Release date:2003-11-25
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Crystal structure of aclacinomycin methylesterase with bound product analogues: implications for anthracycline recognition and mechanism.
J.Biol.Chem., 278, 2003
4C6X
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BU of 4c6x by Molmil
Crystal structure of M. tuberculosis C171Q KasA in complex with thiolactomycin (TLM)
Descriptor: (2R)-2-(hexadecanoyloxy)-3-{[(10R)-10-methyloctadecanoyl]oxy}propyl phosphate, 1,2-ETHANEDIOL, 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE 1, ...
Authors:Schiebel, J, Kapilashrami, K, Fekete, A, Bommineni, G.R, Schaefer, C.M, Mueller, M.J, Tonge, P.J, Kisker, C.
Deposit date:2013-09-19
Release date:2013-10-09
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural Basis for the Recognition of Mycolic Acid Precursors by Kasa, a Condensing Enzyme and Drug Target from Mycobacterium Tuberculosis
J.Biol.Chem., 288, 2013
1XDS
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BU of 1xds by Molmil
Crystal structure of Aclacinomycin-10-hydroxylase (RdmB) in complex with S-adenosyl-L-methionine (SAM) and 11-deoxy-beta-rhodomycin (DbrA)
Descriptor: 11-DEOXY-BETA-RHODOMYCIN, Protein RdmB, S-ADENOSYLMETHIONINE
Authors:Jansson, A, Koskiniemi, H, Erola, A, Wang, J, Mantsala, P, Schneider, G, Niemi, J, Structural Proteomics in Europe (SPINE)
Deposit date:2004-09-08
Release date:2004-11-23
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Aclacinomycin 10-Hydroxylase Is a Novel Substrate-assisted Hydroxylase Requiring S-Adenosyl-L-methionine as Cofactor
J.Biol.Chem., 280, 2005
4F4S
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BU of 4f4s by Molmil
Structure of the yeast F1Fo ATPase c10 ring with bound oligomycin
Descriptor: ATP synthase subunit 9, mitochondrial, Oligomycin A
Authors:Symersky, J, Mueller, D.M.
Deposit date:2012-05-11
Release date:2012-08-15
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Oligomycin frames a common drug-binding site in the ATP synthase.
Proc.Natl.Acad.Sci.USA, 109, 2012
7NPU
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BU of 7npu by Molmil
MycP5-free ESX-5 inner membrane complex, state I
Descriptor: ESX-5 secretion system ATPase EccB5, ESX-5 secretion system protein EccC5, ESX-5 secretion system protein EccD5
Authors:Fahrenkamp, D, Bunduc, C.M, Wald, J, Ummels, R, Bitter, W, Houben, E.N.G, Marlovits, T.C.
Deposit date:2021-02-28
Release date:2021-06-02
Last modified:2024-07-10
Method:ELECTRON MICROSCOPY (4.48 Å)
Cite:Structure and dynamics of a mycobacterial type VII secretion system.
Nature, 593, 2021
7NPV
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BU of 7npv by Molmil
MycP5-free ESX-5 inner membrane complex, State II
Descriptor: ESX-5 secretion system ATPase EccB5, ESX-5 secretion system protein EccC5, ESX-5 secretion system protein EccD5
Authors:Fahrenkamp, D, Bunduc, C.M, Wald, J, Ummels, R, Bitter, W, Houben, E.N.G, Marlovits, T.C.
Deposit date:2021-02-28
Release date:2021-06-02
Last modified:2024-07-10
Method:ELECTRON MICROSCOPY (6.66 Å)
Cite:Structure and dynamics of a mycobacterial type VII secretion system.
Nature, 593, 2021
7WIW
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BU of 7wiw by Molmil
Cryo-EM structure of Mycobacterium tuberculosis irtAB complexed with ATP in an occluded conformation
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Mycobactin import ATP-binding/permease protein IrtA, ...
Authors:Zhang, B, Sun, S, Yang, H, Rao, Z.
Deposit date:2022-01-05
Release date:2023-01-25
Last modified:2024-04-10
Method:ELECTRON MICROSCOPY (3.12 Å)
Cite:Cryo-EM structures for the Mycobacterium tuberculosis iron-loaded siderophore transporter IrtAB.
Protein Cell, 14, 2023
7WIX
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BU of 7wix by Molmil
Cryo-EM structure of Mycobacterium tuberculosis irtAB in complex with ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Mycobactin import ATP-binding/permease protein IrtA, ...
Authors:Zhang, B, Sun, S, Yang, H, Rao, Z.
Deposit date:2022-01-05
Release date:2023-01-25
Last modified:2024-04-10
Method:ELECTRON MICROSCOPY (3.53 Å)
Cite:Cryo-EM structures for the Mycobacterium tuberculosis iron-loaded siderophore transporter IrtAB.
Protein Cell, 14, 2023
6C9N
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BU of 6c9n by Molmil
Mycobacterium tuberculosis adenosine kinase bound to sangivamycin
Descriptor: Adenosine kinase, GLYCEROL, SANGIVAMYCIN, ...
Authors:Crespo, R.A, TB Structural Genomics Consortium (TBSGC)
Deposit date:2018-01-28
Release date:2019-05-01
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure-Guided Drug Design of 6-Substituted Adenosine Analogues as Potent Inhibitors of Mycobacterium tuberculosis Adenosine Kinase.
J.Med.Chem., 62, 2019
8XZ3
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BU of 8xz3 by Molmil
Mycobacterium smegmatis 50S ribosomal subunit with Erythromycin
Descriptor: 23S rRNA, 50S ribosomal protein L14, 50S ribosomal protein L19, ...
Authors:Srinivasan, K, Banerjee, A, Sengupta, J.
Deposit date:2024-01-20
Release date:2024-07-31
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Cryo-EM structures reveal the molecular mechanism of HflX-mediated erythromycin resistance in mycobacteria.
Structure, 2024
7BX8
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BU of 7bx8 by Molmil
Mycobacterium smegmatis arabinosyltransferase complex EmbB2-AcpM2 in symmetric "resting state"
Descriptor: Integral membrane indolylacetylinositol arabinosyltransferase EmbB, Meromycolate extension acyl carrier protein
Authors:Gao, R.G, Zhang, L, Wang, Q, Rao, Z.H.
Deposit date:2020-04-17
Release date:2020-05-27
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Cryo-EM snapshots of mycobacterial arabinosyltransferase complex EmbB2-AcpM2.
Protein Cell, 11, 2020
7BWR
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BU of 7bwr by Molmil
Mycobacterium smegmatis arabinosyltransferase complex EmbB2-AcpM2 in substrate DPA bound asymmetric "active state"
Descriptor: CALCIUM ION, Integral membrane indolylacetylinositol arabinosyltransferase EmbB, Meromycolate extension acyl carrier protein, ...
Authors:Gao, R.G, Zhang, L, Wang, Q, Rao, Z.H.
Deposit date:2020-04-15
Release date:2020-05-27
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Cryo-EM snapshots of mycobacterial arabinosyltransferase complex EmbB2-AcpM2.
Protein Cell, 11, 2020
3NE3
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BU of 3ne3 by Molmil
Mycobacterium tuberculosis Acyl Carrier Protein Synthase Apo structure
Descriptor: Holo-[acyl-carrier-protein] synthase
Authors:Gokulan, K, Mycobacterium Tuberculosis Structural Proteomics Project (XMTB)
Deposit date:2010-06-08
Release date:2010-07-28
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Mycobacterium tuberculosis acyl carrier protein synthase adopts two different pH-dependent structural conformations.
Acta Crystallogr.,Sect.D, 67, 2011
1MYN
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BU of 1myn by Molmil
SOLUTION STRUCTURE OF DROSOMYCIN, THE FIRST INDUCIBLE ANTIFUNGAL PROTEIN FROM INSECTS, NMR, 15 STRUCTURES
Descriptor: DROSOMYCIN
Authors:Landon, C, Sodano, P, Hetru, C, Hoffmann, J.A, Ptak, M.
Deposit date:1996-12-26
Release date:1997-12-31
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:Solution structure of drosomycin, the first inducible antifungal protein from insects.
Protein Sci., 6, 1997
8F5V
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BU of 8f5v by Molmil
Crystal structure of Mycobacterium tuberculosis Mycothiol S-transferase enzyme in complex with mycothiol and Zn2+
Descriptor: Conserved protein, Mycothiol, ZINC ION
Authors:Jayasinghe, Y.P, Ronning, D.R.
Deposit date:2022-11-15
Release date:2023-04-05
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:The Mycobacterium tuberculosis mycothiol S -transferase is divalent metal-dependent for mycothiol binding and transfer.
Rsc Med Chem, 14, 2023

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PDB entries from 2024-09-18

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