PDB: 14 resultsInfo pagesStatus searchChemie searchBIRD

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8VTT	Meis1 homeobox domain bound to neomycin fragment Descriptor: Homeobox protein Meis1, RIBOSTAMYCIN, SULFATE ION Authors: Tomchick, D.R, Ahmed, M.S, Nguyen, N.U.N, Sadek, H.A. Deposit date: 2024-01-27 Release date: 2024-02-14 Method: X-RAY DIFFRACTION (2.45 Å) Cite: Identification of FDA-Approved Drugs That Induce Heart Regeneration in Mammals to be published
4XRS	Heterodimeric complex of transcription factors MEIS1 and DLX3 on specific DNA Descriptor: DNA (5'-D(P*AP*CP*AP*AP*TP*TP*AP*TP*CP*CP*TP*GP*TP*CP*AP*AP*C)-3'), DNA (5'-D(P*CP*AP*AP*TP*TP*AP*TP*CP*CP*TP*GP*TP*CP*AP*A)-3'), DNA (5'-D(P*GP*TP*TP*GP*AP*CP*AP*GP*GP*AP*TP*AP*AP*TP*TP*GP*TP*T)-3'), ... Authors: Jorma, A, Yin, Y, Nitta, K.R, Dave, K, Enge, M, Kivioja, T, Popov, A, Morgunova, E, Taipale, J. Deposit date: 2015-01-21 Release date: 2015-11-04 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (3.5 Å) Cite: DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature, 527, 2015
8VTS	Meis1 homeobox domain bound to paromomycin fragment Descriptor: 1,2-ETHANEDIOL, Homeobox protein Meis1, ISOPROPYL ALCOHOL, ... Authors: Tomchick, D.R, Ahmed, M.S, Nguyen, N.U.N. Deposit date: 2024-01-27 Release date: 2024-02-14 Method: X-RAY DIFFRACTION (1.91 Å) Cite: Identification of FDA-Approved Drugs That Induce Heart Regeneration in Mammals to be published
5EGO	HOXB13-MEIS1 heterodimer bound to methylated DNA Descriptor: DNA (5'-D(*CP*CP*TP*(5CM)P*GP*TP*AP*AP*AP*AP*CP*TP*GP*TP*CP*AP*AP*C)-3'), DNA (5'-D(P*GP*TP*TP*GP*AP*CP*AP*GP*TP*TP*TP*TP*AP*(5CM)P*GP*AP*GP*G)-3'), Homeobox protein Hox-B13, ... Authors: Morgunova, E, Yin, Y, Jolma, A, Popov, A, Taipale, J. Deposit date: 2015-10-27 Release date: 2016-11-09 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.54 Å) Cite: Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science, 356, 2017
4XRM	homodimer of TALE type homeobox transcription factor MEIS1 complexes with specific DNA Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DNA (5'-D(P*AP*GP*CP*TP*GP*AP*CP*AP*GP*CP*TP*GP*TP*CP*AP*AP*G)-3'), DNA (5'-D(P*TP*CP*TP*TP*GP*AP*CP*AP*GP*CP*TP*GP*TP*CP*AP*GP*C)-3'), ... Authors: Morgunova, E, Jorma, A, Yin, Y, Nitta, K.R, Dave, K, Enge, M, Kivioja, T, Popov, A, Taipale, J. Deposit date: 2015-01-21 Release date: 2015-11-04 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.6 Å) Cite: DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature, 527, 2015
5BNG	monomer of TALE type homeobox transcription factor MEIS1 complexes with specific DNA Descriptor: DNA (5'-D(P*AP*AP*TP*TP*AP*GP*CP*TP*GP*TP*CP*A)-3'), DNA (5'-D(P*TP*GP*AP*CP*AP*GP*CP*TP*AP*A)-3'), DNA (5'-D(P*TP*GP*AP*CP*AP*GP*CP*TP*AP*A-3'), ... Authors: Morgunova, E, Jolma, A, Yin, Y, Nitta, K, Dave, K, Popov, A, Taipale, M, Enge, M, Kivioja, T, Taipale, J. Deposit date: 2015-05-26 Release date: 2015-11-04 Last modified: 2015-12-02 Method: X-RAY DIFFRACTION (3.5 Å) Cite: DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature, 527, 2015
5EG0	HOXB13-MEIS1 heterodimer bound to DNA Descriptor: DNA (5'-D(*CP*CP*TP*CP*GP*TP*AP*AP*AP*AP*CP*TP*GP*TP*CP*AP*AP*C)-3'), DNA (5'-D(P*GP*TP*TP*GP*AP*CP*AP*GP*TP*TP*TP*TP*AP*CP*GP*AP*GP*G)-3'), Homeobox protein Hox-B13, ... Authors: Morgunova, E, Yin, Y, Jolma, A, Popov, A, Taipale, J. Deposit date: 2015-10-26 Release date: 2016-11-09 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (3.101 Å) Cite: Molecular basis of recognition of two distinct DNA sequences by a single transcription factor To Be Published
3MDF	Crystal structure of the RRM domain of Cyclophilin 33 Descriptor: Peptidyl-prolyl cis-trans isomerase E Authors: Hom, R.A, Chang, P.Y, Roy, S, Mussleman, C.A, Glass, K.C, Seleznevia, A.I, Gozani, O, Ismagilov, R.F, Cleary, M.L, Kutateladze, T.G. Deposit date: 2010-03-30 Release date: 2010-05-12 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Molecular mechanism of MLL PHD3 and RNA recognition by the Cyp33 RRM domain. J.Mol.Biol., 400, 2010
6O5I	Menin in complex with MI-3454 Descriptor: DIMETHYL SULFOXIDE, Menin, SULFATE ION, ... Authors: Linhares, B.M, Klossowski, S, Cierpicki, T, Grembecka, J. Deposit date: 2019-03-03 Release date: 2020-01-08 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.24025619 Å) Cite: Menin inhibitor MI-3454 induces remission in MLL1-rearranged and NPM1-mutated models of leukemia. J.Clin.Invest., 130, 2020
6WXK	PHF23 PHD Domain Apo Descriptor: PHD finger protein 23, ZINC ION Authors: Vann, K.R, Zhang, J, Zhang, Y, Kutateladze, T. Deposit date: 2020-05-11 Release date: 2020-07-15 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Mechanistic insights into chromatin targeting by leukemic NUP98-PHF23 fusion. Nat Commun, 11, 2020
3GL6	Crystal structure of JARID1A-PHD3 complexed with H3(1-9)K4me3 peptide Descriptor: Histone H3, Histone demethylase JARID1A, ZINC ION Authors: Wang, Z, Song, J, Patel, D.J. Deposit date: 2009-03-11 Release date: 2009-05-05 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger. Nature, 459, 2009
3K2A	Crystal structure of the homeobox domain of human homeobox protein Meis2 Descriptor: ACETATE ION, CHLORIDE ION, Homeobox protein Meis2 Authors: Lam, R, Soloveychik, M, Battaile, K.P, Romanov, V, Lam, K, Beletskaya, I, Gordon, E, Pai, E.F, Chirgadze, N.Y. Deposit date: 2009-09-29 Release date: 2010-10-13 Last modified: 2017-11-01 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Crystal structure of the homeobox domain of human homeobox protein Meis2 To be Published
2KGG	Solution Structure of JARID1A C-terminal PHD finger Descriptor: Histone demethylase JARID1A, ZINC ION Authors: Song, J, Wang, Z, Patel, D.J. Deposit date: 2009-03-11 Release date: 2009-05-05 Last modified: 2020-02-26 Method: SOLUTION NMR Cite: Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger. Nature, 459, 2009
2KGI	Solution structure of JARID1A C-terminal PHD finger in complex with H3(1-9)K4me3 Descriptor: H3(1-9)K4me3, Histone demethylase JARID1A, ZINC ION Authors: Song, J, Wang, Z, Patel, D.J. Deposit date: 2009-03-12 Release date: 2009-05-05 Last modified: 2020-02-26 Method: SOLUTION NMR Cite: Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger. Nature, 459, 2009