PDB: 8 resultsInfo pagesStatus searchChemie searchBIRD

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1M7W	HNF4a ligand binding domain with bound fatty acid Descriptor: Hepatocyte nuclear factor 4-alpha, LAURIC ACID Authors: Dhe-Paganon, S, Duda, K, Iwamoto, M, Chi, Y.I, Shoelson, S.E. Deposit date: 2002-07-22 Release date: 2003-07-01 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Crystal structure of the HNF4 alpha ligand binding domain in complex with endogenous fatty acid ligand J.Biol.Chem., 277, 2002
3FS1	Crystal structure of HNF4a LBD in complex with the ligand and the coactivator PGC-1a fragment Descriptor: Hepatocyte nuclear factor 4-alpha, MYRISTIC ACID, PPARgamma Coactivator-1a (PGC-1a) Authors: Rha, G, Wu, G, Chi, Y. Deposit date: 2009-01-08 Release date: 2009-10-27 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Multiple binding modes between HNF4alpha and the LXXLL motifs of PGC-1alpha lead to full activation J.Biol.Chem., 284, 2009
1PZL	Crystal structure of HNF4a LBD in complex with the ligand and the coactivator SRC-1 peptide Descriptor: Hepatocyte nuclear factor 4-alpha, MYRISTIC ACID, steroid receptor coactivator-1 Authors: Duda, K, Chi, Y.-I, Dhe-paganon, S, Shoelson, S. Deposit date: 2003-07-11 Release date: 2004-06-01 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structural Basis for HNF-4alpha Activation by Ligand and Coactivator Binding J.Biol.Chem., 279, 2004
8C1L	Crystal structure of HNF4 alpha LBD in complexes with palmitic acid and GRIP-1 peptide Descriptor: 1,2-ETHANEDIOL, Hepatocyte nuclear factor 4-alpha, Nuclear receptor coactivator 2, ... Authors: Ni, X, Merk, D, Zhubi, R, Knapp, S, Structural Genomics Consortium (SGC) Deposit date: 2022-12-20 Release date: 2024-01-10 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal structure of HNF4 alpha LBD in complexes with palmitic acid and GRIP-1 peptide To Be Published
4B7W	Ligand binding domain human hepatocyte nuclear factor 4alpha: Apo form Descriptor: HEPATOCYTE NUCLEAR FACTOR 4-ALPHA Authors: Dudasova, Z, Okvist, M, Kretova, M, Ondrovicova, G, Skrabana, R, LeGuevel, R, Salbert, G, Leonard, G, McSweeney, S, Barath, P. Deposit date: 2012-08-24 Release date: 2013-09-11 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (4 Å) Cite: Fatty Acids are not Essential Structural Components of Hepatocyte Nuclear Factor 4Alpha To be Published
3CBB	Crystal Structure of Hepatocyte Nuclear Factor 4alpha in complex with DNA: Diabetes Gene Product Descriptor: Hepatocyte Nuclear Factor 4-alpha promoter element DNA, Hepatocyte Nuclear Factor 4-alpha, DNA binding domain, ... Authors: Lu, P, Rha, G.B, Melikishvili, M, Adkins, B.C, Fried, M.G, Chi, Y.I. Deposit date: 2008-02-21 Release date: 2008-10-07 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural basis of natural promoter recognition by a unique nuclear receptor, HNF4alpha. Diabetes gene product. J.Biol.Chem., 283, 2008
4IQR	Multi-Domain Organization of the HNF4alpha Nuclear Receptor Complex on DNA Descriptor: DNA (5'-D(*CP*CP*TP*GP*AP*CP*CP*TP*TP*TP*GP*AP*CP*CP*TP*AP*GP*TP*TP*C)-3'), DNA (5'-D(*GP*GP*AP*AP*CP*TP*AP*GP*GP*TP*CP*AP*AP*AP*GP*GP*TP*CP*AP*G)-3'), Hepatocyte nuclear factor 4-alpha, ... Authors: Chandra, V, Huang, P, Kim, Y, Rastinejad, F. Deposit date: 2013-01-13 Release date: 2013-03-20 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Multidomain integration in the structure of the HNF-4 alpha nuclear receptor complex. Nature, 495, 2013
6CHT	HNF4alpha in complex with the corepressor EBP1 fragment Descriptor: Hepatocyte nuclear factor 4-alpha, LAURIC ACID, Proliferation-associated protein 2G4 Authors: Chi, Y.I, Singh, P, Lee, I.K. Deposit date: 2018-02-22 Release date: 2019-02-27 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (3.174 Å) Cite: ErbB3-binding protein 1 (EBP1) represses HNF4 alpha-mediated transcription and insulin secretion in pancreatic beta-cells. J.Biol.Chem., 294, 2019