PDB: 13 resultsInfo pagesStatus searchChemie searchBIRD

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5K5X	Crystal structure of human PDGFRA Descriptor: Platelet-derived growth factor receptor alpha, SULFATE ION Authors: Yan, X.E, Liang, L, Yun, C.H. Deposit date: 2016-05-24 Release date: 2016-08-17 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.168 Å) Cite: Structural and biochemical studies of the PDGFRA kinase domain Biochem.Biophys.Res.Commun., 477, 2016
5GRN	Crystal structure of PDGFRA in Complex with WQ-C-159 Descriptor: CHLORIDE ION, N-[2-(dimethylamino)ethyl]-N-[[4-[[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]carbamoyl]phenyl]methyl]pyridine-3-carboxamide, Platelet-derived growth factor receptor alpha Authors: Yan, X.E, Yun, C.H. Deposit date: 2016-08-11 Release date: 2017-08-16 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.77 Å) Cite: Crystal Structure of PDGFRA in Complex with WQ-C-159 To Be Published
6A32	Crystal structure of PDGFRA kinase domain mutant T674I Descriptor: Platelet-derived growth factor receptor alpha Authors: Yan, X.E, Liang, L, Yun, C.H. Deposit date: 2018-06-14 Release date: 2019-06-19 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.87 Å) Cite: Crystal structure of PDGFRA kinase domain mutant T674I To Be Published
7K95	Crystal structure of human CPSF30 in complex with hFip1 Descriptor: Isoform 2 of Cleavage and polyadenylation specificity factor subunit 4, Pre-mRNA 3'-end-processing factor FIP1, ZINC ION Authors: Hamilton, K, Tong, L. Deposit date: 2020-09-28 Release date: 2020-11-11 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Molecular mechanism for the interaction between human CPSF30 and hFip1. Genes Dev., 34, 2020
7ZYH	Crystal structure of human CPSF30 in complex with hFip1 Descriptor: Cleavage and polyadenylation specificity factor subunit 4, Isoform 4 of Pre-mRNA 3'-end-processing factor FIP1, ZINC ION Authors: Muckenfuss, L.M, Jinek, M, Migenda Herranz, A.C, Clerici, M. Deposit date: 2022-05-24 Release date: 2022-09-14 Last modified: 2024-06-19 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Fip1 is a multivalent interaction scaffold for processing factors in human mRNA 3' end biogenesis. Elife, 11, 2022
6JOJ	Crystal structure of PDGFRA T674I in complex with crenolanib by soaking Descriptor: 1-(2-{5-[(3-Methyloxetan-3-yl)methoxy]-1H-benzimidazol-1-yl}quinolin-8-yl)piperidin-4-amine, CHLORIDE ION, Platelet-derived growth factor receptor alpha, ... Authors: Liang, L, Yan, X.E, Yun, C.H. Deposit date: 2019-03-22 Release date: 2020-03-25 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Crystal structure of PDGFRA in complex with crenolanib by soaking To Be Published
6JOL	Crystal structure of PDGFRA in complex with imatinib by co-crystallization Descriptor: 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE, Platelet-derived growth factor receptor alpha Authors: Liang, L, Yan, X.E, Yun, C.H. Deposit date: 2019-03-22 Release date: 2020-03-25 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystal structure of PDGFRA in complex with imatinib by co-crystallization To Be Published
8PQH	PDGFRA T674I mutant kinase domain in complex with avapritinib Descriptor: Avapritinib, DI(HYDROXYETHYL)ETHER, Platelet-derived growth factor receptor alpha Authors: Teuber, A, Kleinboelting, S, Mueller, M.P, Rauh, D. Deposit date: 2023-07-11 Release date: 2023-12-27 Last modified: 2024-08-07 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Avapritinib-based SAR studies unveil a binding pocket in KIT and PDGFRA. Nat Commun, 15, 2024
8PQI	PDGFRA T674I mutant kinase domain in complex with avapritinib derivative 9 Descriptor: (1~{S})-~{N}-ethyl-1-(4-fluorophenyl)-1-[2-[4-[6-(1-methylpyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]piperazin-1-yl]pyrimidin-5-yl]ethanamine, DI(HYDROXYETHYL)ETHER, Platelet-derived growth factor receptor alpha Authors: Teuber, A, Kleinboelting, S, Mueller, M.P, Rauh, D. Deposit date: 2023-07-11 Release date: 2023-12-27 Last modified: 2024-08-07 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Avapritinib-based SAR studies unveil a binding pocket in KIT and PDGFRA. Nat Commun, 15, 2024
8PQJ	PDGFRA wild-type kinase domain Descriptor: Platelet-derived growth factor receptor alpha Authors: Teuber, A, Mueller, M.P, Rauh, D. Deposit date: 2023-07-11 Release date: 2023-12-27 Last modified: 2024-08-07 Method: X-RAY DIFFRACTION (1.82 Å) Cite: Avapritinib-based SAR studies unveil a binding pocket in KIT and PDGFRA. Nat Commun, 15, 2024
8PQK	APO crystal structure of PDGFRA-T674I kinase domain Descriptor: Platelet-derived growth factor receptor alpha Authors: Teuber, A, Mueller, M.P, Rauh, D. Deposit date: 2023-07-11 Release date: 2023-12-27 Last modified: 2024-08-07 Method: X-RAY DIFFRACTION (2 Å) Cite: Avapritinib-based SAR studies unveil a binding pocket in KIT and PDGFRA. Nat Commun, 15, 2024
6JOI	Crystal structure of PDGFRA T674I in complex with crenolanib by co-crystallization Descriptor: 1-(2-{5-[(3-Methyloxetan-3-yl)methoxy]-1H-benzimidazol-1-yl}quinolin-8-yl)piperidin-4-amine, Platelet-derived growth factor receptor alpha Authors: Liang, L, Yan, X.E, Yun, C.H. Deposit date: 2019-03-22 Release date: 2020-03-25 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (3.1 Å) Cite: Crystal structure of PDGFRA T674I in complex with crenolanib by co-crystallization To Be Published
6JOK	Crystal structure of PDGFRA in complex with sunitinib by soaking Descriptor: CHLORIDE ION, N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carbo xamide, Platelet-derived growth factor receptor alpha Authors: Liang, L, Yan, X.E, Yun, C.H. Deposit date: 2019-03-22 Release date: 2020-03-25 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (3.8 Å) Cite: Crystal structure of PDGFRA in complex with sunitinib by soaking To Be Published