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2FC6
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Solution structure of the zf-CCCH domain of target of EGR1, member 1 (Nuclear)
Descriptor: ZINC ION, target of EGR1, member 1
Authors:Dang, W, Muto, Y, Inoue, M, Kigawa, T, Shirouzu, M, Terada, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-12-12
Release date:2006-06-12
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:Solution structure of the zf-CCCH domain of target of EGR1, member 1 (Nuclear)
To be published
4R2A
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Egr1/Zif268 zinc fingers in complex with methylated DNA
Descriptor: 1,2-ETHANEDIOL, DNA (5'-D(*AP*GP*CP*GP*TP*GP*GP*GP*(5CM)P*GP*T)-3'), DNA (5'-D(*TP*AP*(5CM)P*GP*CP*CP*CP*AP*CP*GP*C)-3'), ...
Authors:Hashimoto, H, Olanrewaju, Y.O, Zheng, Y, Wilson, G.G, Zhang, X, Cheng, X.
Deposit date:2014-08-11
Release date:2014-10-08
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.591 Å)
Cite:Wilms tumor protein recognizes 5-carboxylcytosine within a specific DNA sequence.
Genes Dev., 28, 2014
4R2D
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Egr1/Zif268 zinc fingers in complex with formylated DNA
Descriptor: DNA (5'-D(*AP*GP*CP*GP*TP*GP*GP*GP*(5FC)P*GP*T)-3'), DNA (5'-D(*TP*AP*(5FC)P*GP*CP*CP*CP*AP*CP*GP*C)-3'), Early growth response protein 1, ...
Authors:Hashimoto, H, Olanrewaju, Y.O, Zheng, Y, Wilson, G.G, Zhang, X, Cheng, X.
Deposit date:2014-08-11
Release date:2014-10-08
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.088 Å)
Cite:Wilms tumor protein recognizes 5-carboxylcytosine within a specific DNA sequence.
Genes Dev., 28, 2014
4R2C
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Egr1/Zif268 zinc fingers in complex with hydroxymethylated DNA
Descriptor: DNA (5'-D(*AP*GP*CP*GP*TP*GP*GP*GP*(5HC)P*GP*T)-3'), DNA (5'-D(*TP*AP*(5HC)P*GP*CP*CP*CP*AP*CP*GP*C)-3'), Early growth response protein 1, ...
Authors:Hashimoto, H, Olanrewaju, Y.O, Zheng, Y, Wilson, G.G, Zhang, X, Cheng, X.
Deposit date:2014-08-11
Release date:2014-10-08
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Wilms tumor protein recognizes 5-carboxylcytosine within a specific DNA sequence.
Genes Dev., 28, 2014
6U6T
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Neuronal growth regulator 1 (NEGR1)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Neuronal growth regulator 1, ...
Authors:Machius, M, Venkannagari, H, Misra, A, Rudenko, G.
Deposit date:2019-08-30
Release date:2020-08-12
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.01 Å)
Cite:Highly Conserved Molecular Features in IgLONs Contrast Their Distinct Structural and Biological Outcomes.
J.Mol.Biol., 432, 2020
6DLD
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BU of 6dld by Molmil
Crystal structure of IgLON5/NEGR1 heterodimer
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, IgLON family member 5, Neuronal growth regulator 1, ...
Authors:Ranaivoson, F.M, Turk, L.S, Ozkan, E, Montelione, G.T, Comoletti, D.
Deposit date:2018-06-01
Release date:2019-04-10
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structure of a heterodimer of neuronal cell surface proteins
Structure, 2019
4X9J
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EGR-1 with Doubly Methylated DNA
Descriptor: DNA (5'-D(*AP*GP*(5CM)P*GP*TP*GP*GP*GP*(5CM)P*GP*T)-3'), DNA (5'-D(*TP*AP*(5CM)P*GP*CP*CP*CP*AP*(5CM)P*GP*C)-3'), Early growth response protein 1, ...
Authors:White, M.A, Zandarashvili, L, Iwahara, J.
Deposit date:2014-12-11
Release date:2015-05-13
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.412 Å)
Cite:Structural impact of complete CpG methylation within target DNA on specific complex formation of the inducible transcription factor Egr-1.
Febs Lett., 589, 2015
1P47
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Crystal Structure of tandem Zif268 molecules complexed to DNA
Descriptor: 5'-D(*CP*AP*CP*GP*CP*CP*CP*AP*CP*GP*CP*CP*GP*CP*CP*CP*AP*CP*GP*CP*CP*A)-3', 5'-D(*GP*TP*GP*GP*CP*GP*TP*GP*GP*GP*CP*GP*GP*CP*GP*TP*GP*GP*GP*CP*GP*T)-3', Early growth response protein 1, ...
Authors:Peisach, E, Pabo, C.O.
Deposit date:2003-04-21
Release date:2003-06-24
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Constraints for Zinc Finger Linker Design as Inferred from X-ray Crystal Structure of Tandem Zif268-DNA Complexes
J.Mol.Biol., 330, 2003
1ZAA
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ZINC FINGER-DNA RECOGNITION: CRYSTAL STRUCTURE OF A ZIF268-DNA COMPLEX AT 2.1 ANGSTROMS
Descriptor: DNA (5'-D(*AP*GP*CP*GP*TP*GP*GP*GP*CP*GP*T)-3'), DNA (5'-D(*TP*AP*CP*GP*CP*CP*CP*AP*CP*GP*C)-3'), PROTEIN (ZIF268), ...
Authors:Pavletich, N.P, Pabo, C.O.
Deposit date:1992-09-17
Release date:1993-10-31
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Zinc finger-DNA recognition: crystal structure of a Zif268-DNA complex at 2.1 A.
Science, 252, 1991
1JK2
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Zif268 D20A mutant bound to the GCT DNA site
Descriptor: 5'-D(*AP*GP*CP*GP*TP*GP*GP*GP*CP*TP*G)-3', 5'-D(*TP*CP*AP*GP*CP*CP*CP*AP*CP*GP*C)-3', ZIF268, ...
Authors:Miller, J.C, Pabo, C.O.
Deposit date:2001-07-11
Release date:2001-10-19
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Rearrangement of side-chains in a Zif268 mutant highlights the complexities of zinc finger-DNA recognition.
J.Mol.Biol., 313, 2001
1JK1
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Zif268 D20A Mutant Bound to WT DNA Site
Descriptor: 5'-D(*AP*GP*CP*GP*TP*GP*GP*GP*CP*GP*G)-3', 5'-D(*TP*CP*CP*GP*CP*CP*CP*AP*CP*GP*C)-3', ZIF268, ...
Authors:Miller, J.C, Pabo, C.O.
Deposit date:2001-07-11
Release date:2001-10-19
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Rearrangement of side-chains in a Zif268 mutant highlights the complexities of zinc finger-DNA recognition.
J.Mol.Biol., 313, 2001
1G2F
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BU of 1g2f by Molmil
STRUCTURE OF A CYS2HIS2 ZINC FINGER/TATA BOX COMPLEX (TATAZF;CLONE #6)
Descriptor: 5'-D(*GP*AP*CP*GP*CP*TP*AP*TP*AP*AP*AP*AP*GP*GP*AP*G)-3', 5'-D(*TP*CP*CP*TP*TP*TP*TP*AP*TP*AP*GP*CP*GP*TP*CP*C)-3', TATA BOX ZINC FINGER PROTEIN, ...
Authors:Wolfe, S.A, Grant, R.A, Elrod-Erickson, M, Pabo, C.O.
Deposit date:2000-10-18
Release date:2001-09-07
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2 Å)
Cite:Beyond the "recognition code": structures of two Cys2His2 zinc finger/TATA box complexes.
Structure, 9, 2001
1G2D
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BU of 1g2d by Molmil
STRUCTURE OF A CYS2HIS2 ZINC FINGER/TATA BOX COMPLEX (CLONE #2)
Descriptor: 5'-D(*GP*AP*CP*GP*CP*TP*AP*TP*AP*AP*AP*AP*GP*GP*AP*G)-3', 5'-D(*TP*CP*CP*TP*TP*TP*TP*AP*TP*AP*GP*CP*GP*TP*CP*C)-3', TATA BOX ZINC FINGER PROTEIN, ...
Authors:Wolfe, S.A, Grant, R.A, Elrod-Erickson, M, Pabo, C.O.
Deposit date:2000-10-18
Release date:2001-09-07
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Beyond the "recognition code": structures of two Cys2His2 zinc finger/TATA box complexes.
Structure, 9, 2001
1LLM
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BU of 1llm by Molmil
Crystal Structure of a Zif23-GCN4 Chimera Bound to DNA
Descriptor: 5'-D(*TP*CP*CP*CP*AP*CP*GP*CP*GP*TP*GP*GP*G)-3', ZINC ION, chimera of Zif23-GCN4
Authors:Wolfe, S.A, Grant, R.A, Pabo, C.O.
Deposit date:2002-04-29
Release date:2003-09-30
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure of a designed dimeric zinc finger protein bound to DNA.
Biochemistry, 42, 2003
1F2I
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BU of 1f2i by Molmil
COCRYSTAL STRUCTURE OF SELECTED ZINC FINGER DIMER BOUND TO DNA
Descriptor: 5'-D(*AP*TP*GP*GP*GP*CP*GP*CP*GP*CP*CP*CP*AP*T)-3', FUSION OF N-TERMINAL 17-MER PEPTIDE EXTENSION TO ZIF12, ZINC ION
Authors:Wang, B.S, Grant, R.A, Pabo, C.O.
Deposit date:2000-05-25
Release date:2001-09-14
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Selected peptide extension contacts hydrophobic patch on neighboring zinc finger and mediates dimerization on DNA.
Nat.Struct.Biol., 8, 2001
1A1F
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BU of 1a1f by Molmil
DSNR (ZIF268 VARIANT) ZINC FINGER-DNA COMPLEX (GACC SITE)
Descriptor: DNA (5'-D(*AP*GP*CP*GP*TP*GP*GP*GP*AP*CP*C)-3'), DNA (5'-D(*TP*GP*GP*TP*CP*CP*CP*AP*CP*GP*C)-3'), THREE-FINGER ZIF268 PEPTIDE, ...
Authors:Elrod-Erickson, M, Benson, T.E, Pabo, C.O.
Deposit date:1997-12-10
Release date:1998-06-10
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:High-resolution structures of variant Zif268-DNA complexes: implications for understanding zinc finger-DNA recognition.
Structure, 6, 1998
1A1J
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RADR (ZIF268 VARIANT) ZINC FINGER-DNA COMPLEX (GCGT SITE)
Descriptor: DNA (5'-D(*AP*GP*CP*GP*TP*GP*GP*GP*CP*GP*T)-3'), DNA (5'-D(*TP*AP*CP*GP*CP*CP*CP*AP*CP*GP*C)-3'), PROTEIN (RADR ZIF268 ZINC FINGER PEPTIDE), ...
Authors:Elrod-Erickson, M, Benson, T.E, Pabo, C.O.
Deposit date:1997-12-10
Release date:1998-06-17
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2 Å)
Cite:High-resolution structures of variant Zif268-DNA complexes: implications for understanding zinc finger-DNA recognition.
Structure, 6, 1998
1A1H
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BU of 1a1h by Molmil
QGSR (ZIF268 VARIANT) ZINC FINGER-DNA COMPLEX (GCAC SITE)
Descriptor: DNA (5'-D(*AP*GP*CP*GP*TP*GP*GP*GP*CP*AP*C)-3'), DNA (5'-D(*TP*GP*TP*GP*CP*CP*CP*AP*CP*GP*C)-3'), QGSR ZINC FINGER PEPTIDE, ...
Authors:Elrod-Erickson, M, Benson, T.E, Pabo, C.O.
Deposit date:1997-12-10
Release date:1998-06-10
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:High-resolution structures of variant Zif268-DNA complexes: implications for understanding zinc finger-DNA recognition.
Structure, 6, 1998
1A1I
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RADR (ZIF268 VARIANT) ZINC FINGER-DNA COMPLEX (GCAC SITE)
Descriptor: DNA (5'-D(*AP*GP*CP*GP*TP*GP*GP*GP*CP*AP*C)-3'), DNA (5'-D(*TP*GP*TP*GP*CP*CP*CP*AP*CP*GP*C)-3'), RADR ZIF268 ZINC FINGER PEPTIDE, ...
Authors:Elrod-Erickson, M, Benson, T.E, Pabo, C.O.
Deposit date:1997-12-10
Release date:1998-06-17
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:High-resolution structures of variant Zif268-DNA complexes: implications for understanding zinc finger-DNA recognition.
Structure, 6, 1998
1A1L
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ZIF268 ZINC FINGER-DNA COMPLEX (GCAC SITE)
Descriptor: DNA (5'-D(*AP*GP*CP*GP*TP*GP*GP*GP*CP*AP*C)-3'), DNA (5'-D(*TP*GP*TP*GP*CP*CP*CP*AP*CP*GP*C)-3'), PROTEIN (ZIF268 ZINC FINGER PEPTIDE), ...
Authors:Elrod-Erickson, M, Benson, T.E, Pabo, C.O.
Deposit date:1997-12-10
Release date:1998-06-17
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:High-resolution structures of variant Zif268-DNA complexes: implications for understanding zinc finger-DNA recognition.
Structure, 6, 1998
1A1K
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BU of 1a1k by Molmil
RADR (ZIF268 VARIANT) ZINC FINGER-DNA COMPLEX (GACC SITE)
Descriptor: DNA (5'-D(*AP*GP*CP*GP*TP*GP*GP*GP*AP*CP*C)-3'), DNA (5'-D(*TP*GP*GP*TP*CP*CP*CP*AP*CP*GP*C)-3'), RADR ZIF268 VARIANT, ...
Authors:Elrod-Erickson, M, Benson, T.E, Pabo, C.O.
Deposit date:1997-12-10
Release date:1998-06-10
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:High-resolution structures of variant Zif268-DNA complexes: implications for understanding zinc finger-DNA recognition.
Structure, 6, 1998
1A1G
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BU of 1a1g by Molmil
DSNR (ZIF268 VARIANT) ZINC FINGER-DNA COMPLEX (GCGT SITE)
Descriptor: DNA (5'-D(*AP*GP*CP*GP*TP*GP*GP*GP*CP*GP*T)-3'), DNA (5'-D(*TP*AP*CP*GP*CP*CP*CP*AP*CP*GP*C)-3'), DSNR ZINC FINGER PEPTIDE, ...
Authors:Elrod-Erickson, M, Benson, T.E, Pabo, C.O.
Deposit date:1997-12-10
Release date:1998-06-10
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:High-resolution structures of variant Zif268-DNA complexes: implications for understanding zinc finger-DNA recognition.
Structure, 6, 1998
1AAY
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BU of 1aay by Molmil
ZIF268 ZINC FINGER-DNA COMPLEX
Descriptor: DNA (5'-D(*AP*GP*CP*GP*TP*GP*GP*GP*CP*GP*T)-3'), DNA (5'-D(*TP*AP*CP*GP*CP*CP*CP*AP*CP*GP*C)-3'), PROTEIN (ZIF268 ZINC FINGER PEPTIDE), ...
Authors:Elrod-Erickson, M, Rould, M.A, Pabo, C.O.
Deposit date:1997-01-18
Release date:1997-04-21
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Zif268 protein-DNA complex refined at 1.6 A: a model system for understanding zinc finger-DNA interactions.
Structure, 4, 1996
6ZJ3
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Cryo-EM structure of the highly atypical cytoplasmic ribosome of Euglena gracilis
Descriptor: 18S rRNA, 5.8S rRNA, 5S rRNA, ...
Authors:Matzov, D, Halfon, H, Zimmerman, E, Rozenberg, H, Bashan, A, Gray, M.W, Yonath, A.E, Shalev-Benami, M.
Deposit date:2020-06-27
Release date:2020-10-07
Last modified:2024-04-24
Method:ELECTRON MICROSCOPY (3.15 Å)
Cite:Cryo-EM structure of the highly atypical cytoplasmic ribosome of Euglena gracilis.
Nucleic Acids Res., 48, 2020
7YQ8
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Cryo-EM structure of human topoisomerase II beta in complex with DNA and etoposide
Descriptor: (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol -5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside, 50-mer DNA, DNA topoisomerase 2-beta, ...
Authors:Naganuma, M, Ehara, H, Kim, D, Nakagawa, R, Cong, A, Bu, H, Jeong, J, Jang, J, Schellenberg, M.J, Bunch, H, Sekine, S.
Deposit date:2022-08-05
Release date:2024-01-03
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:ERK2-topoisomerase II regulatory axis is important for gene activation in immediate early genes.
Nat Commun, 14, 2023

 

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