PDB: 6 resultsInfo pagesStatus searchChemie searchBIRD

---

6DC0	Tribbles (TRIB1) pseudokinase fused to CCAAT-enhancer binding protein (C/EBPalpha) degron Descriptor: Tribbles homolog 1,CCAAT/enhancer-binding protein alpha Authors: Jamieson, S.A, Brewster, J.L, Mace, P.D. Deposit date: 2018-05-03 Release date: 2018-10-10 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Substrate binding allosterically relieves autoinhibition of the pseudokinase TRIB1. Sci Signal, 11, 2018
1NWQ	CRYSTAL STRUCTURE OF C/EBPALPHA-DNA COMPLEX Descriptor: 5'-D(*AP*AP*AP*CP*TP*GP*GP*AP*TP*TP*GP*CP*GP*CP*AP*AP*TP*AP*GP*GP*A)-3', 5'-D(*TP*TP*CP*CP*TP*AP*TP*TP*GP*CP*GP*CP*AP*AP*TP*CP*CP*AP*GP*TP*T)-3', CCAAT/enhancer binding protein alpha Authors: Miller, M, Shuman, J.D, Sebastian, T, Dauter, Z, Johnson, P.F. Deposit date: 2003-02-06 Release date: 2003-05-13 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Structural Basis for DNA Recognition by the Basic Region Leucine Zipper Transcription Factor CCAAT/enhancer Binding Protein Alpha J.Biol.Chem., 278, 2003
8K8C	Crystal structure of C/EBPalpha BZIP domain bound to a high affinity DNA Descriptor: CCAAT/enhancer-binding protein alpha, DNA (5'-D(*CP*AP*TP*TP*AP*CP*GP*TP*AP*AP*TP*GP*A)-3'), DNA (5'-D(*CP*AP*TP*TP*AP*CP*GP*TP*AP*AP*TP*GP*T)-3'), ... Authors: Min, J.R, Chen, S.Z, Liu, K. Deposit date: 2023-07-29 Release date: 2024-03-06 Last modified: 2024-03-27 Method: X-RAY DIFFRACTION (2.06 Å) Cite: Structural basis for specific DNA sequence recognition by the transcription factor NFIL3. J.Biol.Chem., 300, 2024
4QL1	Crystal structure of human WDR5 in complex with compound OICR-9429 Descriptor: 1,2-ETHANEDIOL, GLYCEROL, N-(4-(4-methylpiperazin-1-yl)-3'-(morpholinomethyl)-[1,1'-biphenyl]-3-yl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridine-3-carboxamide, ... Authors: Dong, A, Dombrovski, L, Walker, J.R, Getlik, M, Kuznetsova, E, Smil, D, Barsyte, D, Li, F, Poda, G, Senisterra, G, Marcellus, R, Al-Awar, R, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Schapira, M, Vedadi, M, Wu, H, Structural Genomics Consortium (SGC) Deposit date: 2014-06-10 Release date: 2014-12-17 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Pharmacological targeting of the Wdr5-MLL interaction in C/EBP alpha N-terminal leukemia. Nat.Chem.Biol., 11, 2015
6Q6F	Crystal structure of IDH1 R132H in complex with HMS101 Descriptor: (2~{R})-2-[2-[(3~{R})-3-(4-fluorophenyl)pyrrolidin-1-yl]ethyl]-1,4-dimethyl-piperazine, Isocitrate dehydrogenase [NADP] cytoplasmic Authors: Chaturvedi, A, Goparaju, R, Gupta, C, Kluenemann, T, Araujo Cruz, M.M, Kloos, A, Goerlich, K, Schottmann, R, Struys, E.A, Ganser, A, Preller, M, Heuser, M. Deposit date: 2018-12-10 Release date: 2019-10-16 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (3.3 Å) Cite: In vivo efficacy of mutant IDH1 inhibitor HMS-101 and structural resolution of distinct binding site. Leukemia, 34, 2020
4CRL	Crystal structure of human CDK8-Cyclin C in complex with cortistatin A Descriptor: CORTISTATIN A, CYCLIN-C, CYCLIN-DEPENDENT KINASE 8, ... Authors: Myers, A.G, Shair, M.D. Deposit date: 2014-02-27 Release date: 2015-09-23 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Mediator Kinase Inhibition Further Activates Super-Enhancer- Associated Genes in Aml Nature, 526, 2015