5FR6
 
 | | The structure of polycomb ULD complex | | Descriptor: | POLYCOMB COMPLEX PROTEIN BMI-1 | | Authors: | Gray, F, Cho, H.J, Cierpicki, T. | | Deposit date: | 2015-12-15 | | Release date: | 2016-11-16 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.51 Å) | | Cite: | Bmi1 Regulates Prc1 Architecture and Activity Through Homo-and Hetero-Oligomerization
Nat.Commun., 7, 2016
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3RPG
 | | Bmi1/Ring1b-UbcH5c complex structure | | Descriptor: | E3 ubiquitin-protein ligase RING2, Polycomb complex protein BMI-1, Ubiquitin-conjugating enzyme E2 D3, ... | | Authors: | Bentley, M.L, Dong, K.C, Cochran, A.G. | | Deposit date: | 2011-04-26 | | Release date: | 2011-08-17 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.6485 Å) | | Cite: | Recognition of UbcH5c and the nucleosome by the Bmi1/Ring1b ubiquitin ligase complex.
Embo J., 30, 2011
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2NA1
 | | ULD complex | | Descriptor: | Polycomb complex protein BMI-1, Polyhomeotic-like 2 | | Authors: | Cierpicki, T, Gray, F, Cho, H. | | Deposit date: | 2015-12-17 | | Release date: | 2016-11-16 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | BMI1 regulates PRC1 architecture and activity through homo- and hetero-oligomerization.
Nat Commun, 7, 2016
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2CKL
 | | Ring1b-Bmi1 E3 catalytic domain structure | | Descriptor: | IODIDE ION, POLYCOMB GROUP RING FINGER PROTEIN 4, UBIQUITIN LIGASE PROTEIN RING2, ... | | Authors: | Buchwald, G, van der Stoop, P, Weichenrieder, O, Perrakis, A, van Lohuizen, M, Sixma, T.K. | | Deposit date: | 2006-04-20 | | Release date: | 2006-05-11 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structure and E3-Ligase Activity of the Ring-Ring Complex of Polycomb Proteins Bmi1 and Ring1B.
Embo J., 25, 2006
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6WI7
 | | RING1B-BMI1 fusion in closed conformation | | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, E3 ubiquitin-protein ligase RING2, Polycomb complex protein BMI-1 chimera, ... | | Authors: | Cho, H.J, Cierpicki, T. | | Deposit date: | 2020-04-08 | | Release date: | 2021-04-14 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (1.702 Å) | | Cite: | Small-molecule inhibitors targeting Polycomb repressive complex 1 RING domain.
Nat.Chem.Biol., 17, 2021
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4S3O
 | | PCGF5-RING1B-UbcH5c complex | | Descriptor: | E3 ubiquitin-protein ligase RING2, Polycomb group RING finger protein 5, Ubiquitin-conjugating enzyme E2 D3, ... | | Authors: | Taherbhoy, A.M, Cochran, A.G. | | Deposit date: | 2015-03-23 | | Release date: | 2015-07-15 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | BMI1-RING1B is an autoinhibited RING E3 ubiquitin ligase.
Nat Commun, 6, 2015
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6WI8
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4R8P
 | | Crystal structure of the Ring1B/Bmi1/UbcH5c PRC1 ubiquitylation module bound to the nucleosome core particle | | Descriptor: | DNA (147-mer), E3 ubiquitin-protein ligase RING2, Ubiquitin-conjugating enzyme E2 D3, ... | | Authors: | McGinty, R.K, Henrici, R.C, Tan, S. | | Deposit date: | 2014-09-02 | | Release date: | 2014-11-05 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (3.2846 Å) | | Cite: | Crystal structure of the PRC1 ubiquitylation module bound to the nucleosome.
Nature, 514, 2014
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5Y53
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7ND1
 | | First-in-class small molecule inhibitors of Polycomb Repressive Complex 1 (PRC1) RING domain | | Descriptor: | 3-(2-chlorophenyl)-4-ethyl-5-(1~{H}-indol-4-yl)-1~{H}-pyrrole-2-carboxylic acid, E3 ubiquitin-protein ligase RING2, Polycomb complex protein BMI-1, ... | | Authors: | Cierpicki, T, Lund, G, Jaremko, L. | | Deposit date: | 2021-01-29 | | Release date: | 2021-06-16 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Small-molecule inhibitors targeting Polycomb repressive complex 1 RING domain.
Nat.Chem.Biol., 17, 2021
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9DBY
 | | ncPRC1RYBP bound to singly modified H2AK119Ub nucleosome | | Descriptor: | DNA (187-MER), E3 ubiquitin-protein ligase RING2, Histone H2A type 1, ... | | Authors: | Godinez-Lopez, V, Valencia-Sanchez, M.I, Armache, J.P, Armache, K.-J. | | Deposit date: | 2024-08-24 | | Release date: | 2024-11-20 | | Last modified: | 2025-01-15 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Read-write mechanisms of H2A ubiquitination by Polycomb repressive complex 1.
Nature, 636, 2024
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9DDE
 | | ncPRC1RYBP bound to H2AK119Ub/H1.4 chromatosome | | Descriptor: | DNA (187-MER), E3 ubiquitin-protein ligase RING2, Histone H1.4, ... | | Authors: | Godinez-Lopez, V, Valencia-Sanchez, M.I, Armache, J.P, Armache, K.-J. | | Deposit date: | 2024-08-28 | | Release date: | 2024-11-20 | | Last modified: | 2025-01-15 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Read-write mechanisms of H2A ubiquitination by Polycomb repressive complex 1.
Nature, 636, 2024
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9DGG
 | | ncPRC1RYBP bound to unmodified nucleosome | | Descriptor: | DNA (187-MER), E3 ubiquitin-protein ligase RING2, Histone H2A type 1, ... | | Authors: | Godinez-Lopez, V, Valencia-Sanchez, M.I, Armache, J.P, Armache, K.-J. | | Deposit date: | 2024-09-02 | | Release date: | 2024-11-20 | | Last modified: | 2025-01-15 | | Method: | ELECTRON MICROSCOPY (2.98 Å) | | Cite: | Read-write mechanisms of H2A ubiquitination by Polycomb repressive complex 1.
Nature, 636, 2024
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8PP7
 | | human RYBP-PRC1 bound to mononucleosome | | Descriptor: | DNA (215-mer), E3 ubiquitin-protein ligase RING2, Histone H2A, ... | | Authors: | Ciapponi, M, Benda, C, Mueller, J. | | Deposit date: | 2023-07-06 | | Release date: | 2024-03-27 | | Last modified: | 2024-07-31 | | Method: | ELECTRON MICROSCOPY (2.91 Å) | | Cite: | Structural basis of the histone ubiquitination read-write mechanism of RYBP-PRC1.
Nat.Struct.Mol.Biol., 31, 2024
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5XVW
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2DJB
 | | Solution structure of the RING domain of the human Polycomb group RING finger protein 6 | | Descriptor: | Polycomb group RING finger protein 6, ZINC ION | | Authors: | Miyamoto, K, Kigawa, T, Sato, M, Koshiba, S, Inoue, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2006-03-31 | | Release date: | 2007-03-13 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Solution structure of the RING domain of the human Polycomb group RING finger protein 6
To be Published
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5XVL
 | | Crystal structure of AL2 PAL domain | | Descriptor: | PHD finger protein ALFIN-LIKE 2, SULFATE ION | | Authors: | Peng, L, Wang, L.L, Huang, Y. | | Deposit date: | 2017-06-28 | | Release date: | 2018-07-04 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (1.629 Å) | | Cite: | Structural Analysis of the Arabidopsis AL2-PAL and PRC1 Complex Provides Mechanistic Insight into Active-to-Repressive Chromatin State Switch
J. Mol. Biol., 430, 2018
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5XVJ
 | | Crystal structure of AL7 PAL domain | | Descriptor: | PHD finger protein ALFIN-LIKE 7, SULFATE ION | | Authors: | Peng, L, Wang, L.L, Huang, Y. | | Deposit date: | 2017-06-28 | | Release date: | 2018-07-04 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Structural Analysis of the Arabidopsis AL2-PAL and PRC1 Complex Provides Mechanistic Insight into Active-to-Repressive Chromatin State Switch
J. Mol. Biol., 430, 2018
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5Y21
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4HPL
 | | PCGF1 Ub fold (RAWUL)/BCOR PUFD Complex | | Descriptor: | BCL-6 corepressor, Polycomb group RING finger protein 1 | | Authors: | Junco, S.E, Wang, R, Gaipa, J, Taylor, A.B, Gearhart, M.D, Bardwell, V.J, Hart, P.J, Kim, C.A. | | Deposit date: | 2012-10-24 | | Release date: | 2013-05-01 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structure of the Polycomb Group Protein PCGF1 in Complex with BCOR Reveals Basis for Binding Selectivity of PCGF Homologs.
Structure, 21, 2013
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8GRM
 | | Cryo-EM structure of PRC1 bound to H2AK119-UbcH5b-Ub nucleosome | | Descriptor: | COMMD3 protein, DNA (144-MER), DNA (145-MER), ... | | Authors: | Ai, H.S, Zebin, T, Zhihend, D, Jiakun, T, Liying, Z, Jia-Bin, L, Man, P, Liu, L. | | Deposit date: | 2022-09-02 | | Release date: | 2023-04-12 | | Last modified: | 2024-07-03 | | Method: | ELECTRON MICROSCOPY (3.05 Å) | | Cite: | Synthetic E2-Ub-nucleosome conjugates for studying nucleosome ubiquitination.
Chem, 2023
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7JZV
 | | Cryo-EM structure of the BRCA1-UbcH5c/BARD1 E3-E2 module bound to a nucleosome | | Descriptor: | BRCA1,Ubiquitin-conjugating enzyme E2 D3, BRCA1-associated RING domain protein 1, Histone H2A type 2-A, ... | | Authors: | Witus, S.R, Burrell, A.L, Hansen, J.M, Farrell, D.P, Dimaio, F, Kollman, J.M, Klevit, R.E. | | Deposit date: | 2020-09-02 | | Release date: | 2021-02-17 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | BRCA1/BARD1 site-specific ubiquitylation of nucleosomal H2A is directed by BARD1.
Nat.Struct.Mol.Biol., 28, 2021
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4HPM
 | | PCGF1 Ub fold (RAWUL)/BCORL1 PUFD Complex | | Descriptor: | BCL-6 corepressor-like protein 1, PHOSPHATE ION, Polycomb group RING finger protein 1 | | Authors: | Junco, S.E, Wang, R, Gaipa, J, Taylor, A.B, Gearhart, M.D, Bardwell, V.J, Hart, P.J, Kim, C.A. | | Deposit date: | 2012-10-24 | | Release date: | 2013-05-01 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Structure of the Polycomb Group Protein PCGF1 in Complex with BCOR Reveals Basis for Binding Selectivity of PCGF Homologs.
Structure, 21, 2013
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9DG3
 | | ncPRC1RYBP Delta-linker mutant bound to singly modified H2AK119Ub nucleosome | | Descriptor: | DNA (187-MER), Histone H2A type 1, Histone H2B 1.1, ... | | Authors: | Godinez-Lopez, V, Valencia-Sanchez, M.I, Armache, J.P, Armache, K.-J. | | Deposit date: | 2024-09-01 | | Release date: | 2024-11-20 | | Last modified: | 2025-01-15 | | Method: | ELECTRON MICROSCOPY (3.46 Å) | | Cite: | Read-write mechanisms of H2A ubiquitination by Polycomb repressive complex 1.
Nature, 636, 2024
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