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6PBY
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BU of 6pby by Molmil
Single particle cryo-EM structure of the voltage-gated K+ channel Eag1 3-13 deletion mutant bound to calmodulin (conformation 1)
Descriptor: Calmodulin-1, Potassium voltage-gated channel subfamily H member 1
Authors:Whicher, J.R, MacKinnon, R.
Deposit date:2019-06-14
Release date:2019-09-18
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3.67 Å)
Cite:Regulation of Eag1 gating by its intracellular domains.
Elife, 8, 2019
2WC2
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BU of 2wc2 by Molmil
Nmr structure of catabolite activator protein in the unliganded state
Descriptor: CATABOLITE GENE ACTIVATOR
Authors:Popovych, N, Tzeng, S.R, Kalodimos, C.G.
Deposit date:2009-03-06
Release date:2009-04-21
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Structural Basis for Camp-Mediated Allosteric Control of the Catabolite Activator Protein.
Proc.Natl.Acad.Sci.USA, 106, 2009
2CGP
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BU of 2cgp by Molmil
CATABOLITE GENE ACTIVATOR PROTEIN/DNA COMPLEX, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE
Descriptor: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, DNA (5'-D(*AP*TP*TP*AP*AP*TP*GP*TP*GP*AP*CP*AP*TP*AP*T)-3'), DNA (5'-D(*GP*TP*CP*AP*CP*AP*TP*TP*AP*AP*T)-3'), ...
Authors:Passner, J.M, Steitz, T.A.
Deposit date:1997-01-31
Release date:1998-02-04
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The structure of a CAP-DNA complex having two cAMP molecules bound to each monomer.
Proc.Natl.Acad.Sci.USA, 94, 1997
1CGP
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BU of 1cgp by Molmil
CATABOLITE GENE ACTIVATOR PROTEIN (CAP)/DNA COMPLEX + ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE
Descriptor: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, DNA (5'-D(*GP*CP*GP*AP*AP*AP*AP*GP*TP*GP*TP*GP*AP*CP*AP*TP*AP*T)-3'), DNA (5'-D(*GP*TP*CP*AP*CP*AP*CP*TP*TP*TP*TP*CP*G)-3'), ...
Authors:Schultz, S.C, Shields, G.C, Steitz, T.A.
Deposit date:1991-08-12
Release date:1994-01-31
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of a CAP-DNA complex: the DNA is bent by 90 degrees.
Science, 253, 1991
1G6N
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BU of 1g6n by Molmil
2.1 ANGSTROM STRUCTURE OF CAP-CAMP
Descriptor: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, CATABOLITE GENE ACTIVATOR PROTEIN
Authors:Passner, J.M, Schultz, S.C, Steitz, T.A.
Deposit date:2000-11-07
Release date:2000-12-15
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Modeling the cAMP-induced allosteric transition using the crystal structure of CAP-cAMP at 2.1 A resolution.
J.Mol.Biol., 304, 2000
2QVS
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BU of 2qvs by Molmil
Crystal Structure of Type IIa Holoenzyme of cAMP-dependent Protein Kinase
Descriptor: cAMP-dependent protein kinase type II-alpha regulatory subunit, cAMP-dependent protein kinase, alpha-catalytic subunit
Authors:Wu, J, Brown, S.H.J, von Daake, S, Taylor, S.S.
Deposit date:2007-08-08
Release date:2007-10-23
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:PKA type IIalpha holoenzyme reveals a combinatorial strategy for isoform diversity.
Science, 318, 2007
4LLO
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BU of 4llo by Molmil
Structure of the eag domain-CNBHD complex of the mouse EAG1 channel
Descriptor: Potassium voltage-gated channel subfamily H member 1
Authors:Haitin, Y, Carlson, A.E, Zagotta, W.N.
Deposit date:2013-07-09
Release date:2013-08-28
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.995 Å)
Cite:The structural mechanism of KCNH-channel regulation by the eag domain.
Nature, 501, 2013
4MH0
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BU of 4mh0 by Molmil
Selective activation of Epac1 and Epac2
Descriptor: (2S,4aR,6R,7R,7aS)-6-{6-amino-8-[(4-fluorobenzyl)sulfanyl]-9H-purin-9-yl}-2-sulfanyltetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol 2-oxide, Rap guanine nucleotide exchange factor 4, Ras-related protein Rap-1b, ...
Authors:Rehmann, H.
Deposit date:2013-08-29
Release date:2014-09-03
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Selective activation of Epac1 and Epac2
To be Published
4MGI
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BU of 4mgi by Molmil
Selective activation of Epac1 and Epac2
Descriptor: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Rap guanine nucleotide exchange factor 4, Ras-related protein Rap-1b, ...
Authors:Rehmann, H.
Deposit date:2013-08-28
Release date:2014-09-03
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Selective activation of Epac1 and Epac2
To be Published
4MGY
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BU of 4mgy by Molmil
Selective activation of Epac1 and Epac2
Descriptor: (2S,4aR,6R,7R,7aR)-6-{6-amino-8-[(4-chlorophenyl)sulfanyl]-9H-purin-9-yl}-7-methoxytetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-2-ol 2-oxide, Rap guanine nucleotide exchange factor 4, Ras-related protein Rap-1b, ...
Authors:Rehmann, H.
Deposit date:2013-08-29
Release date:2014-09-03
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Selective activation of Epac1 and Epac2
To be Published
3LA7
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BU of 3la7 by Molmil
Crystal structure of NtcA in apo-form
Descriptor: Global nitrogen regulator, octyl beta-D-glucopyranoside
Authors:Zhao, M.X, Jiang, Y.L, He, Y.X, Chen, Y.F, Teng, Y.B, Zhang, C.C, Chen, Y.X, Zhou, C.Z.
Deposit date:2010-01-06
Release date:2010-09-01
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis for the allosteric control of the global transcription factor NtcA by the nitrogen starvation signal 2-oxoglutarate.
Proc.Natl.Acad.Sci.USA, 107, 2010
3LA2
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BU of 3la2 by Molmil
Crystal structure of NtcA in complex with 2-oxoglutarate
Descriptor: 2-OXOGLUTARIC ACID, Global nitrogen regulator
Authors:Zhao, M.X, Jiang, Y.L, He, Y.X, Chen, Y.F, Teng, Y.B, Chen, Y.X, Zhang, C.C, Zhou, C.Z.
Deposit date:2010-01-06
Release date:2010-07-14
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural basis for the allosteric control of the global transcription factor NtcA by the nitrogen starvation signal 2-oxoglutarate.
Proc.Natl.Acad.Sci.USA, 107, 2010
3LA3
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BU of 3la3 by Molmil
Crystal structure of NtcA in complex with 2,2-difluoropentanedioic acid
Descriptor: 2,2-difluoropentanedioic acid, Global nitrogen regulator
Authors:Zhao, M.X, Jiang, Y.L, He, Y.X, Chen, Y.F, Teng, Y.B, Chen, Y.X, Zhang, C.C, Zhou, C.Z.
Deposit date:2010-01-06
Release date:2010-07-14
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis for the allosteric control of the global transcription factor NtcA by the nitrogen starvation signal 2-oxoglutarate.
Proc.Natl.Acad.Sci.USA, 107, 2010
4R8H
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BU of 4r8h by Molmil
The role of protein-ligand contacts in allosteric regulation of the Escherichia coli Catabolite Activator Protein
Descriptor: 6-(6-AMINO-PURIN-9-YL)-2-THIOXO-TETRAHYDRO-2-FURO[3,2-D][1,3,2]DIOXAPHOSPHININE-2,7-DIOL, GLYCEROL, cAMP-activated global transcriptional regulator CRP
Authors:Townsend, P.D, Pohl, E, McLeish, T.C.B, Rodgers, T.L, Glover, L.C, Korhonen, H.J, Wilson, M.R, Hodgson, D.R.W, Cann, M.J.
Deposit date:2014-09-02
Release date:2015-07-22
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.46 Å)
Cite:The Role of Protein-Ligand Contacts in Allosteric Regulation of the Escherichia coli Catabolite Activator Protein.
J.Biol.Chem., 290, 2015
4RZ7
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BU of 4rz7 by Molmil
Crystal Structure of PVX_084705 with bound PCI32765
Descriptor: 1-{(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}prop-2-en-1-one, UNKNOWN ATOM OR ION, cGMP-dependent protein kinase, ...
Authors:Jiang, D.Q, Tempel, W, Loppnau, P, Graslund, S, He, H, Seitova, A, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Hui, R, Hutchinson, A, El Bakkouri, M, Amani, M, Structural Genomics Consortium (SGC)
Deposit date:2014-12-18
Release date:2015-01-14
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.351 Å)
Cite:Crystal Structure of PVX_084705 with bound PCI32765
To be Published
1HW5
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BU of 1hw5 by Molmil
THE CAP/CRP VARIANT T127L/S128A
Descriptor: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, CATABOLITE GENE ACTIVATOR
Authors:Chu, S.Y, Tordova, M, Gilliland, G.L, Gorshkova, I, Shi, Y.
Deposit date:2001-01-09
Release date:2001-01-17
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:The structure of the T127L/S128A mutant of cAMP receptor protein facilitates promoter site binding
J.Biol.Chem., 276, 2001
1I6X
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BU of 1i6x by Molmil
STRUCTURE OF A STAR MUTANT CRP-CAMP AT 2.2 A
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, CATABOLITE GENE ACTIVATOR PROTEIN
Authors:White, M.A, Lee, J.C, Fox, R.O.
Deposit date:2001-03-06
Release date:2003-06-17
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The effect of the D53H point mutation on the macroscopic motions of E. coli Cyclic AMP Receptor Protein
To be Published
6WEK
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BU of 6wek by Molmil
Structure of cGMP-bound WT TAX-4 reconstituted in lipid nanodiscs
Descriptor: 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE, 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CYCLIC GUANOSINE MONOPHOSPHATE, ...
Authors:Zheng, X, Fu, Z, Su, D, Zhang, Y, Li, M, Pan, Y, Li, H, Li, S, Grassucci, R.A, Ren, Z, Hu, Z, Li, X, Zhou, M, Li, G, Frank, J, Yang, J.
Deposit date:2020-04-02
Release date:2020-06-03
Last modified:2020-07-22
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Mechanism of ligand activation of a eukaryotic cyclic nucleotide-gated channel.
Nat.Struct.Mol.Biol., 27, 2020
1J59
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BU of 1j59 by Molmil
CATABOLITE GENE ACTIVATOR PROTEIN (CAP)/DNA COMPLEX + ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE
Descriptor: 5'-D(*AP*TP*AP*TP*GP*TP*CP*AP*CP*AP*CP*TP*TP*TP*TP*CP*G )-3', 5'-D(*GP*CP*GP*AP*AP*AP*AP*GP*TP*GP*TP*GP*AP*C)-3', ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, ...
Authors:Parkinson, G, Wilson, C, Gunasekera, A, Ebright, Y.W, Ebright, R.H, Berman, H.M.
Deposit date:2002-03-01
Release date:2002-03-01
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of the CAP-DNA complex at 2.5 angstroms resolution: a complete picture of the protein-DNA interface.
J.Mol.Biol., 260, 1996
6WEL
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BU of 6wel by Molmil
Structure of cGMP-unbound F403V/V407A mutant TAX-4 reconstituted in lipid nanodiscs
Descriptor: 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE, 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Cyclic nucleotide-gated cation channel, ...
Authors:Zheng, X, Fu, Z, Su, D, Zhang, Y, Li, M, Pan, Y, Li, H, Li, S, Grassucci, R.A, Ren, Z, Hu, Z, Li, X, Zhou, M, Li, G, Frank, J, Yang, J.
Deposit date:2020-04-02
Release date:2020-06-03
Last modified:2020-07-22
Method:ELECTRON MICROSCOPY (2.5 Å)
Cite:Mechanism of ligand activation of a eukaryotic cyclic nucleotide-gated channel.
Nat.Struct.Mol.Biol., 27, 2020
5H3O
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BU of 5h3o by Molmil
Structure of a eukaryotic cyclic nucleotide-gated channel
Descriptor: CYCLIC GUANOSINE MONOPHOSPHATE, Cyclic nucleotide-gated cation channel, SODIUM ION
Authors:Li, M, Zhou, X, Wang, S, Michailidis, I, Gong, Y, Su, D, Li, H, Li, X, Yang, J.
Deposit date:2016-10-26
Release date:2017-01-25
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structure of a eukaryotic cyclic-nucleotide-gated channel.
Nature, 542, 2017
8T4Y
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BU of 8t4y by Molmil
Human HCN1 F186C S264C C309A bound to cAMP, reconstituted in LMNG + SPL
Descriptor: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
Authors:Burtscher, V, Mount, J, Cowgill, J, Chang, Y, Bickel, K, Yuan, P, Chanda, B.
Deposit date:2023-06-12
Release date:2024-06-19
Last modified:2024-07-03
Method:ELECTRON MICROSCOPY (3.58 Å)
Cite:Structural basis for hyperpolarization-dependent opening of human HCN1 channel.
Nat Commun, 15, 2024
8T50
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BU of 8t50 by Molmil
Open human HCN1 F186C S264C bound to cAMP, reconstituted in LMNG + SPL
Descriptor: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
Authors:Burtscher, V, Mount, J, Cowgill, J, Chang, Y, Bickel, K, Yuan, P, Chanda, B.
Deposit date:2023-06-12
Release date:2024-07-03
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structural basis for hyperpolarization-dependent opening of human HCN1 channel.
Nat Commun, 15, 2024
8T4M
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BU of 8t4m by Molmil
Closed human HCN1 F186C S264C bound to cAMP, reconstituted in LMNG + SPL
Descriptor: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
Authors:Burtscher, V, Mount, J, Cowgill, J, Chang, Y, Bickel, K, Yuan, P, Chanda, B.
Deposit date:2023-06-09
Release date:2024-06-12
Last modified:2024-07-03
Method:ELECTRON MICROSCOPY (3.16 Å)
Cite:Structural basis for hyperpolarization-dependent opening of human HCN1 channel.
Nat Commun, 15, 2024
6WEJ
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BU of 6wej by Molmil
Structure of cGMP-unbound WT TAX-4 reconstituted in lipid nanodiscs
Descriptor: 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE, 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Cyclic nucleotide-gated cation channel, ...
Authors:Zheng, X, Fu, Z, Su, D, Zhang, Y, Li, M, Pan, Y, Li, H, Li, S, Grassucci, R.A, Ren, Z, Hu, Z, Li, X, Zhou, M, Li, G, Frank, J, Yang, J.
Deposit date:2020-04-02
Release date:2020-06-03
Last modified:2020-07-22
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Mechanism of ligand activation of a eukaryotic cyclic nucleotide-gated channel.
Nat.Struct.Mol.Biol., 27, 2020

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