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4BW5
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Crystal structure of human two pore domain potassium ion channel TREK2 (K2P10.1)
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CADMIUM ION, POTASSIUM CHANNEL SUBFAMILY K MEMBER 10, ...
Authors:Pike, A.C.W, Dong, Y.Y, Dong, L, Quigley, A, Shrestha, L, Mukhopadhyay, S, Strain-Damerell, C, Goubin, S, Grieben, M, Shintre, C.A, Mackenzie, A, Vollmar, M, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Burgess-Brown, N, Carpenter, E.P.
Deposit date:2013-06-30
Release date:2013-07-31
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:K2P Channel Gating Mechanisms Revealed by Structures of Trek-2 and a Complex with Prozac
Science, 347, 2015
4CBC
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BU of 4cbc by Molmil
Open-form NavMS Sodium Channel Pore (with C-terminal Domain) after thallium soak
Descriptor: HEGA-10, ION TRANSPORT PROTEIN, SODIUM ION
Authors:Bagneris, C, Naylor, C.E, Wallace, B.A.
Deposit date:2013-10-12
Release date:2014-05-28
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.664 Å)
Cite:Prokaryotic Navms Channel as a Structural and Functional Model for Eukaryotic Sodium Channel Antagonism.
Proc.Natl.Acad.Sci.USA, 111, 2014
4H37
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BU of 4h37 by Molmil
Crystal structure of a voltage-gated K+ channel pore domain in a closed state in lipid membranes
Descriptor: Lmo2059 protein, POTASSIUM ION
Authors:Santos, J.S, Asmar-Rovira, G.A, Han, G.W, Liu, W, Syeda, R, Cherezov, V, Baker, K.A, Stevens, R.C, Montal, M.
Deposit date:2012-09-13
Release date:2012-11-07
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.35 Å)
Cite:Crystal Structure of a Voltage-gated K+ Channel Pore Module in a Closed State in Lipid Membranes.
J.Biol.Chem., 287, 2012
6WB8
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Cryo-EM structure of PKD2 C331S disease variant
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Polycystin-2
Authors:Cao, E, Wang, J, Decaen, P.G.
Deposit date:2020-03-26
Release date:2020-04-22
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.24 Å)
Cite:Molecular dysregulation of ciliary polycystin-2 channels caused by variants in the TOP domain.
Proc.Natl.Acad.Sci.USA, 117, 2020
6W0B
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BU of 6w0b by Molmil
Open-gate KcsA soaked in 2 mM BaCl2
Descriptor: BARIUM ION, Fab Heavy Chain, Fab Light Chain, ...
Authors:Rohaim, A, Gong, L, Li, J.
Deposit date:2020-02-29
Release date:2020-07-08
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.604 Å)
Cite:Open and Closed Structures of a Barium-Blocked Potassium Channel.
J.Mol.Biol., 432, 2020
6W0H
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BU of 6w0h by Molmil
Closed-gate KcsA soaked in 5mM KCl/5mM BaCl2
Descriptor: Fab Heavy Chain, Fab Light Chain, POTASSIUM ION, ...
Authors:Rohaim, A, Gong, L, Li, J.
Deposit date:2020-02-29
Release date:2020-07-08
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Open and Closed Structures of a Barium-Blocked Potassium Channel.
J.Mol.Biol., 432, 2020
6VX3
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BU of 6vx3 by Molmil
NaChBac in GDN
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, BH1501 protein
Authors:Yan, N, Gao, S.
Deposit date:2020-02-21
Release date:2020-06-24
Last modified:2020-07-08
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Employing NaChBac for cryo-EM analysis of toxin action on voltage-gated Na+channels in nanodisc.
Proc.Natl.Acad.Sci.USA, 117, 2020
6W0G
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BU of 6w0g by Molmil
Closed-gate KcsA soaked in 1mM KCl/5mM BaCl2
Descriptor: Fab Heavy Chain, Fab Light Chain, POTASSIUM ION, ...
Authors:Rohaim, A, Gong, L, Li, J.
Deposit date:2020-02-29
Release date:2020-07-08
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Open and Closed Structures of a Barium-Blocked Potassium Channel.
J.Mol.Biol., 432, 2020
6VXO
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BU of 6vxo by Molmil
NaChBac-Nav1.7VSDII chimera in nanodisc
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, NaChBac-Nav1.7VSDII chimera
Authors:Yan, N, Gao, S.
Deposit date:2020-02-22
Release date:2020-06-24
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Employing NaChBac for cryo-EM analysis of toxin action on voltage-gated Na+channels in nanodisc.
Proc.Natl.Acad.Sci.USA, 117, 2020
7SJ1
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BU of 7sj1 by Molmil
Structure of shaker-W434F
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, POTASSIUM ION, Potassium voltage-gated channel protein Shaker
Authors:Tan, X, Bae, C, Stix, R, Fernandez, A.I, Huffer, K, Chang, T, Jiang, J, Faraldo-Gomez, J.D, Swartz, K.J.
Deposit date:2021-10-15
Release date:2022-03-30
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structure of the Shaker Kv channel and mechanism of slow C-type inactivation.
Sci Adv, 8, 2022
7SIP
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BU of 7sip by Molmil
Structure of shaker-IR
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, POTASSIUM ION, Potassium voltage-gated channel protein Shaker
Authors:Tan, X, Bae, C, Stix, R, Fernandez, A.I, Huffer, K, Chang, T, Jiang, J, Faraldo-Gomez, J.D, Swartz, K.J.
Deposit date:2021-10-14
Release date:2022-03-30
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structure of the Shaker Kv channel and mechanism of slow C-type inactivation.
Sci Adv, 8, 2022
3EFF
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BU of 3eff by Molmil
The Crystal Structure of Full-Length KcsA in its Closed Conformation
Descriptor: FAB, Voltage-gated potassium channel
Authors:Uysal, S, Vasquez, V, Tereshko, T, Esaki, K, Fellouse, F.A, Sidhu, S.S, Koide, S, Perozo, E, Kossiakoff, A.
Deposit date:2008-09-08
Release date:2009-04-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:Crystal structure of full-length KcsA in its closed conformation.
Proc.Natl.Acad.Sci.USA, 106, 2009
3FB5
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BU of 3fb5 by Molmil
KcsA potassium channel in the partially open state with 14.5 A opening at T112
Descriptor: POTASSIUM ION, Voltage-gated potassium channel, antibody Fab fragment heavy chain, ...
Authors:Cuello, L.G, Jogini, V, Cortes, D.M, Perozo, E.
Deposit date:2008-11-18
Release date:2010-05-19
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:KcsA potassium channel in the partially open state with 14.5 A opening at T112
TO BE PUBLISHED
3FB6
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BU of 3fb6 by Molmil
KcsA Potassium channel in the partially open state with 16 A opening at T112
Descriptor: POTASSIUM ION, Voltage-gated potassium channel, antibody fab fragment heavy chain, ...
Authors:Cuello, L.G, Jogini, V, Cortes, D.M, Perozo, E.
Deposit date:2008-11-18
Release date:2010-05-19
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3 Å)
Cite:KcsA Potassium channel in the partially open state with 16 A opening at T112
TO BE PUBLISHED
3FB7
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BU of 3fb7 by Molmil
Open KcsA potassium channel in the presence of Rb+ ion
Descriptor: RUBIDIUM ION, Voltage-gated potassium channel, antibody fab fragment heavy chain, ...
Authors:Cuello, L.G, Jogini, V, Cortes, D.M, Pan, A.C, Gagnon, D.H, Cordero-Morales, J.F, Chakrapani, S, Roux, B, Perozo, E.
Deposit date:2008-11-18
Release date:2010-07-14
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Open KcsA potassium channel in the presence of Rb+ ion
TO BE PUBLISHED
3F7Y
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BU of 3f7y by Molmil
KcsA Potassium channel in the partially open state with 17 A opening at T112
Descriptor: POTASSIUM ION, Voltage-gated potassium channel, antibody fab fragment heavy chain, ...
Authors:Cuello, L.G, Jogini, V, Cortes, D.M, Perozo, E.
Deposit date:2008-11-10
Release date:2010-05-19
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:KcsA Potassium channel in the partially open state with 17 A opening at T112
TO BE PUBLISHED
3F5W
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BU of 3f5w by Molmil
KcsA Potassium channel in the open-inactivated state with 32 A opening at T112
Descriptor: Antibody heavy chain, Antibody light chain, POTASSIUM ION, ...
Authors:Cuello, L.G, Jogini, V, Cortes, D.M, Perozo, E.
Deposit date:2008-11-04
Release date:2010-05-19
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:KcsA Potassium channel in the open-inactivated state with 32 A opening at T112
TO BE PUBLISHED
3FB8
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BU of 3fb8 by Molmil
KcsA Potassium channel in the open-conductive state with 20 A opening at T112 in the presence of Rb+ ion
Descriptor: RUBIDIUM ION, Voltage-gated potassium channel, antibody fab fragment heavy chain, ...
Authors:Cuello, L.G, Jogini, V, Cortes, D.M, Perozo, E.
Deposit date:2008-11-18
Release date:2010-05-19
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:KcsA Potassium channel in the open-conductive state with 20 A opening at T112 in the presence of Rb+ ion
TO BE PUBLISHED
3F7V
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BU of 3f7v by Molmil
KcsA Potassium channel in the open-inactivated state with 23 A opening at T112
Descriptor: POTASSIUM ION, Voltage-gated potassium channel, antibody fab fragment Heavy chain, ...
Authors:Cuello, L.G, Jogini, V, Cortes, D.M, Perozo, E.
Deposit date:2008-11-10
Release date:2010-05-19
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:KcsA Potassium channel in the open-inactivated state with 23 A opening at T112
TO BE PUBLISHED
5K47
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CryoEM structure of the human Polycystin-2/PKD2 TRP channel
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Polycystin-2
Authors:Pike, A.C.W, Grieben, M, Shintre, C.A, Tessitore, A, Shrestha, L, Mukhopadhyay, S, Mahajan, P, Chalk, R, Burgess-Brown, N.A, Huiskonen, J.T, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Carpenter, E.P, Structural Genomics Consortium (SGC)
Deposit date:2016-05-20
Release date:2016-08-24
Last modified:2020-10-21
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Structure of the polycystic kidney disease TRP channel Polycystin-2 (PC2).
Nat. Struct. Mol. Biol., 24, 2017
5KMD
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BU of 5kmd by Molmil
Structure of CavAb in complex with amlodipine
Descriptor: 1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE, CALCIUM ION, Ion transport protein, ...
Authors:Tang, L, Gamal EL-Din, T.M, Swanson, T.M, Pryde, D.C, Scheuer, T, Zheng, N, Catterall, W.A.
Deposit date:2016-06-26
Release date:2016-08-31
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural basis for inhibition of a voltage-gated Ca(2+) channel by Ca(2+) antagonist drugs.
Nature, 537, 2016
5KLB
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BU of 5klb by Molmil
Crystal structure of the CavAb voltage-gated calcium channel(wild-type, 2.7A)
Descriptor: 1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, CALCIUM ION, ...
Authors:Tang, L, Gamal EL-Din, T.M, Swanson, T.M, Pryde, D.C, Scheuer, T, Zheng, N, Catterall, W.A.
Deposit date:2016-06-23
Release date:2016-08-31
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis for inhibition of a voltage-gated Ca(2+) channel by Ca(2+) antagonist drugs.
Nature, 537, 2016
5KLS
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Structure of CavAb in complex with Br-dihydropyridine derivative UK-59811
Descriptor: 1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE, CALCIUM ION, Ion transport protein, ...
Authors:Tang, L, Gamal EL-Din, T.M, Swanson, T.M, Pryde, D.C, Scheuer, T, Zheng, N, Catterall, W.A.
Deposit date:2016-06-25
Release date:2016-08-31
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (3.299 Å)
Cite:Structural basis for inhibition of a voltage-gated Ca(2+) channel by Ca(2+) antagonist drugs.
Nature, 537, 2016
5KMH
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BU of 5kmh by Molmil
Structure of CavAb in complex with Br-verapamil
Descriptor: (2~{R})-2-(2-bromophenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methyl-amino]-2-propan-2-yl-pentanenitrile, 1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHATE, ...
Authors:Tang, L, Gamal EL-Din, T.M, Swanson, T.M, Pryde, D.C, Scheuer, T, Zheng, N, Catterall, W.A.
Deposit date:2016-06-27
Release date:2016-08-31
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural basis for inhibition of a voltage-gated Ca(2+) channel by Ca(2+) antagonist drugs.
Nature, 537, 2016
5KMF
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Structure of CavAb in complex with nimodipine
Descriptor: 1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE, CALCIUM ION, Ion transport protein, ...
Authors:Tang, L, Gamal EL-Din, T.M, Swanson, T.M, Pryde, D.C, Scheuer, T, Zheng, N, Catterall, W.A.
Deposit date:2016-06-26
Release date:2016-08-31
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural basis for inhibition of a voltage-gated Ca(2+) channel by Ca(2+) antagonist drugs.
Nature, 537, 2016

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