4BW5

Crystal structure of human two pore domain potassium ion channel TREK2 (K2P10.1)

Summary for 4BW5

• Entry DOI: 10.2210/pdb4bw5/pdb
• Descriptor: POTASSIUM CHANNEL SUBFAMILY K MEMBER 10, POTASSIUM ION, CADMIUM ION, ... (4 entities in total)
• Functional Keywords: transport protein, outward rectification, membrane protein, k2p
• Biological source: HOMO SAPIENS (HUMAN)
• Total number of polymer chains: 4
• Total formula weight: 126358.34

Authors

Pike, A.C.W.,Dong, Y.Y.,Dong, L.,Quigley, A.,Shrestha, L.,Mukhopadhyay, S.,Strain-Damerell, C.,Goubin, S.,Grieben, M.,Shintre, C.A.,Mackenzie, A.,Vollmar, M.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Burgess-Brown, N.,Carpenter, E.P. (deposition date: 2013-06-30, release date: 2013-07-31, Last modification date: 2023-12-20)

• Primary citation: Pike, A.C.W.,Mackenzie, A.,Mcclenaghan, C.,Aryal, P.,Dong, L.,Quigley, A.,Grieben, M.,Goubin, S.,Mukhopadhyay, S.,Ruda, G.F.,Clausen, M.V.,Cao, L.,Brennan, P.E.,Burgess-Brown, N.A.,Sansom, M.S.P.,Tucker, S.J.,Carpenter, E.P.; K2P Channel Gating Mechanisms Revealed by Structures of Trek-2 and a Complex with Prozac; Science, 347:1256-, 2015; PubMed: 25766236; DOI: 10.1126/SCIENCE.1261512

Experimental method

X-RAY DIFFRACTION (3.2 Å)