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6XLV
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BU of 6xlv by Molmil
Crystal structure of leukemia-associated N196K mutant of U2AF65 bound to AdML splice site
Descriptor: DNA/RNA (5'-R(P*UP*UP*(UD)P*UP*U)-D(P*(BRU))-R(P*CP*C)-3'), Splicing factor U2AF 65 kDa subunit
Authors:Maji, D, Jenkins, J.L, Kielkopf, C.L.
Deposit date:2020-06-29
Release date:2020-10-07
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Representative cancer-associated U2AF2 mutations alter RNA interactions and splicing.
J.Biol.Chem., 295, 2020
6SXW
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BU of 6sxw by Molmil
Crystal structure of the first RRM domain of human Zinc finger protein 638 (ZNF638)
Descriptor: SULFATE ION, Zinc finger protein 638
Authors:Newman, J.A, Aitkenhead, H, Wang, D, Burgess-Brown, N.A, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O.
Deposit date:2019-09-26
Release date:2019-10-16
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.751 Å)
Cite:Crystal structure of the first RRM domain of human Zinc finger protein 638 (ZNF638)
To Be Published
6XH0
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BU of 6xh0 by Molmil
Co-crystal structure of HIV-1 TAR RNA in complex with lab-evolved RRM TBP6.9
Descriptor: MAGNESIUM ION, TAR binding protein 6.9, TRANS-ACTIVATION RESPONSE ELEMENT
Authors:Chavali, S.S, Jenkins, J.L, Wedekind, J.E.
Deposit date:2020-06-18
Release date:2020-10-14
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Co-crystal structures of HIV TAR RNA bound to lab-evolved proteins show key roles for arginine relevant to the design of cyclic peptide TAR inhibitors.
J.Biol.Chem., 295, 2020
6N3E
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BU of 6n3e by Molmil
Structure of HIV Tat-specific factor 1 U2AF Homology Motif bound to U2AF ligand motif 4
Descriptor: FORMIC ACID, GLYCEROL, HIV Tat-specific factor 1, ...
Authors:Loerch, S, Jenkins, J.L, Kielkopf, C.L.
Deposit date:2018-11-15
Release date:2019-01-02
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.893 Å)
Cite:The pre-mRNA splicing and transcription factor Tat-SF1 is a functional partner of the spliceosome SF3b1 subunit via a U2AF homology motif interface.
J. Biol. Chem., 294, 2019
6XLX
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BU of 6xlx by Molmil
Crystal structure of cancer-associated G301D mutant of U2AF65 bound to AdML splice site
Descriptor: DNA/RNA (5'-R(P*UP*UP*(UD)P*UP*U)-D(P*(BRU))-R(P*CP*C)-3'), Splicing factor U2AF 65 kDa subunit
Authors:Maji, D, Jenkins, J.L, Kielkopf, C.L.
Deposit date:2020-06-29
Release date:2020-10-07
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Representative cancer-associated U2AF2 mutations alter RNA interactions and splicing.
J.Biol.Chem., 295, 2020
3CUL
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BU of 3cul by Molmil
Aminoacyl-tRNA synthetase ribozyme
Descriptor: MAGNESIUM ION, POTASSIUM ION, RNA (92-MER), ...
Authors:Xiao, H, Murakami, H, Suga, H, Ferre-D'Amare, A.R.
Deposit date:2008-04-16
Release date:2008-06-24
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis of specific tRNA aminoacylation by a small in vitro selected ribozyme.
Nature, 454, 2008
6SQV
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BU of 6sqv by Molmil
Structure of the U1A variant A1-98 Y31H/Q36R/R70W
Descriptor: SULFATE ION, U1 small nuclear ribonucleoprotein A
Authors:Rosenbach, H, Span, I.
Deposit date:2019-09-04
Release date:2020-05-13
Last modified:2024-05-15
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Expanding crystallization tools for nucleic acid complexes using U1A protein variants.
J.Struct.Biol., 210, 2020
3G8S
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BU of 3g8s by Molmil
Crystal structure of the pre-cleaved Bacillus anthracis glmS ribozyme
Descriptor: GLMS RIBOZYME, MAGNESIUM ION, RNA (5'-R(*AP*(A2M)P*GP*CP*GP*CP*CP*AP*GP*AP*AP*CP*U)-3'), ...
Authors:Strobel, S.A, Cochrane, J.C, Lipchock, S.V, Smith, K.D.
Deposit date:2009-02-12
Release date:2009-11-03
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural and chemical basis for glucosamine 6-phosphate binding and activation of the glmS ribozyme
Biochemistry, 48, 2009
2KH9
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BU of 2kh9 by Molmil
Solution structure of yeast Prp24-RRM2 bound to a fragment of U6 RNA
Descriptor: 5'-R(*AP*GP*AP*GP*AP*U)-3', U4/U6 snRNA-associated-splicing factor PRP24
Authors:Martin-Tumasz, S.A, Butcher, S.E.
Deposit date:2009-03-27
Release date:2010-03-09
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:Structure and functional implications of a complex containing a segment of U6 RNA bound by a domain of Prp24.
Rna, 16, 2010
3G8T
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BU of 3g8t by Molmil
Crystal structure of the G33A mutant Bacillus anthracis glmS ribozyme bound to GlcN6P
Descriptor: 2-amino-2-deoxy-6-O-phosphono-alpha-D-glucopyranose, MAGNESIUM ION, RNA (5'-R(*AP*(A2M)P*GP*CP*GP*CP*CP*AP*GP*AP*AP*CP*U)-3'), ...
Authors:Strobel, S.A, Cochrane, J.C, Lipchock, S.V, Smith, K.D.
Deposit date:2009-02-12
Release date:2009-11-03
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural and chemical basis for glucosamine 6-phosphate binding and activation of the glmS ribozyme
Biochemistry, 48, 2009
2KRB
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BU of 2krb by Molmil
Solution structure of EIF3B-RRM bound to EIF3J peptide
Descriptor: Eukaryotic translation initiation factor 3 subunit B, Eukaryotic translation initiation factor 3 subunit J
Authors:Elantak, L, Wagner, S, Herrmannova, A, Janoskova, M, Rutkai, E, Lukavsky, P.J, Valasek, L.
Deposit date:2009-12-16
Release date:2010-01-05
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:The indispensable N-terminal half of eIF3j/HCR1 co-operates with its structurally conserved binding partner eIF3b/PRT1-RRM and eIF1A in stringent AUG selection
To be Published
2KYX
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BU of 2kyx by Molmil
Solution structure of the RRM domain of CYP33
Descriptor: Peptidyl-prolyl cis-trans isomerase E
Authors:Park, S, Bushweller, J.H.
Deposit date:2010-06-09
Release date:2010-08-25
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:The PHD3 domain of MLL acts as a CYP33-regulated switch between MLL-mediated activation and repression .
Biochemistry, 49, 2010
2KXH
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BU of 2kxh by Molmil
Solution structure of the first two RRM domains of FIR in the complex with FBP Nbox peptide
Descriptor: Poly(U)-binding-splicing factor PUF60, peptide of Far upstream element-binding protein 1
Authors:Cukier, C.D, Ramos, A, Hollingworth, D, Diaz-Moreno, I, Kelly, G.
Deposit date:2010-05-05
Release date:2010-08-18
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Molecular basis of FIR-mediated c-myc transcriptional control.
Nat.Struct.Mol.Biol., 17, 2010
2KVI
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BU of 2kvi by Molmil
Structure of Nab3 RRM
Descriptor: Nuclear polyadenylated RNA-binding protein 3
Authors:Pergoli, R, Kubicek, K, Hobor, F, Pasulka, J, Stefl, R.
Deposit date:2010-03-15
Release date:2010-11-17
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Solution structure and RNA-binding study of RNA-recognition motif of Nab3
J.Biol.Chem., 2010
2KXF
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BU of 2kxf by Molmil
Solution structure of the first two RRM domains of FBP-interacting repressor (FIR)
Descriptor: Poly(U)-binding-splicing factor PUF60
Authors:Cukier, C.D, Ramos, A, Hollingworth, D, Diaz-Moreno, I, Kelly, G.
Deposit date:2010-05-04
Release date:2010-08-18
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Molecular basis of FIR-mediated c-myc transcriptional control.
Nat.Struct.Mol.Biol., 17, 2010
2KXN
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BU of 2kxn by Molmil
NMR structure of human Tra2beta1 RRM in complex with AAGAAC RNA
Descriptor: 5'-R(*AP*AP*GP*AP*AP*C)-3', Transformer-2 protein homolog beta
Authors:Clery, A, Jayne, S, Benderska, N, Dominguez, C, Stamm, S, Allain, F.H.-T.
Deposit date:2010-05-10
Release date:2011-03-16
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Molecular basis of purine-rich RNA recognition by the human SR-like protein Tra2-beta1
Nat.Struct.Mol.Biol., 18, 2011
2KM8
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BU of 2km8 by Molmil
Interdomain RRM packing contributes to RNA recognition in the rna15, hrp1, anchor RNA 3' processing ternary complex
Descriptor: 5'-R(P*UP*AP*UP*AP*UP*AP*UP*AP*AP*UP*AP*AP*U)-3', Nuclear polyadenylated RNA-binding protein 4, mRNA 3'-end-processing protein RNA15
Authors:Leeper, T.C, Varani, G.
Deposit date:2009-07-24
Release date:2010-07-28
Last modified:2024-05-08
Method:SOLUTION NMR
Cite:Novel Protein-Protein Contacts Facilitate mRNA 3'-Processing Signal Recognition by Rna15 and Hrp1.
J.Mol.Biol., 401, 2010
7SN6
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BU of 7sn6 by Molmil
U2AF65 UHM BOUND TO SF3B155 ULM5
Descriptor: ISOPROPYL ALCOHOL, Splicing factor 3B subunit 1, Splicing factor U2AF 65 kDa subunit
Authors:Loerch, S, Jenkins, J.L, Kielkopf, C.L.
Deposit date:2021-10-27
Release date:2022-07-27
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A UHM-ULM interface with unusual structural features contributes to U2AF2 and SF3B1 association for pre-mRNA splicing.
J.Biol.Chem., 298, 2022
2LA6
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BU of 2la6 by Molmil
Solution NMR Structure of RRM domain of RNA-binding protein FUS from homo sapiens, Northeast Structural Genomics Consortium Target HR6430A
Descriptor: RNA-binding protein FUS
Authors:Liu, G, Xiao, R, Janjua, H, Ciccosanti, C, Wang, H, Lee, H, Acton, T.B, Everett, J.K, Huang, Y.J, Montelione, G.T, Northeast Structural Genomics Consortium (NESG)
Deposit date:2011-03-04
Release date:2011-05-04
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Northeast Structural Genomics Consortium Target HR6430A
To be Published
2LEC
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BU of 2lec by Molmil
Solution structure of human SRSF2 (SC35) RRM in complex with 5'-UGGAGU-3'
Descriptor: RNA (5'-R(*UP*GP*GP*AP*GP*U)-3'), Serine/arginine-rich splicing factor 2
Authors:Daubner, G.M, Clery, A, Jayne, S, Stevenin, J, Allain, F.H.-T.
Deposit date:2011-06-15
Release date:2011-11-23
Last modified:2024-05-08
Method:SOLUTION NMR
Cite:A syn-anti conformational difference allows SRSF2 to recognize guanines and cytosines equally well.
Embo J., 31, 2012
2LA4
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BU of 2la4 by Molmil
NMR structure of the C-terminal RRM domain of poly(U) binding 1
Descriptor: Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1
Authors:Santiveri, C.M, Mirassou, Y, Rico-Lastres, P, Martinez-Lumbreras, S, Perez-Canadillas, J.M.
Deposit date:2011-03-01
Release date:2011-09-28
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Pub1p C-terminal RRM domain interacts with Tif4631p through a conserved region neighbouring the Pab1p binding site
Plos One, 6, 2011
6JVX
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BU of 6jvx by Molmil
Crystal structure of RBM38 in complex with RNA
Descriptor: RNA (5'-R(*UP*GP*UP*GP*UP*GP*UP*GP*UP*GP*UP*G)-3'), RNA-binding protein 38, SULFATE ION
Authors:Qian, K, Li, M, Wang, J, Zhang, M, Wang, M.
Deposit date:2019-04-17
Release date:2020-01-01
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.301 Å)
Cite:Structural basis for mRNA recognition by human RBM38.
Biochem.J., 477, 2020
3IRW
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BU of 3irw by Molmil
Structure of a c-di-GMP riboswitch from V. cholerae
Descriptor: 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), IRIDIUM HEXAMMINE ION, MAGNESIUM ION, ...
Authors:Smith, K.D.
Deposit date:2009-08-24
Release date:2009-11-10
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis of ligand binding by a c-di-GMP riboswitch.
Nat.Struct.Mol.Biol., 16, 2009
6KOR
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BU of 6kor by Molmil
Crystal structure of the RRM domain of SYNCRIP
Descriptor: Heterogeneous nuclear ribonucleoprotein Q
Authors:Chen, Y, Chan, J, Chen, W, Jobichen, C.
Deposit date:2019-08-12
Release date:2020-01-22
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.602 Å)
Cite:SYNCRIP, a new player in pri-let-7a processing.
Rna, 26, 2020
6LAU
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BU of 6lau by Molmil
the wildtype SAM-VI riboswitch bound to SAH
Descriptor: CESIUM ION, GUANOSINE-5'-TRIPHOSPHATE, RNA (54-MER), ...
Authors:Ren, A, Sun, A.
Deposit date:2019-11-13
Release date:2020-01-01
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3.109 Å)
Cite:SAM-VI riboswitch structure and signature for ligand discrimination.
Nat Commun, 10, 2019

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PDB entries from 2024-09-18

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