PDB: 433 resultsInfo pagesStatus searchChemie searchBIRD

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3V1G	Forestalling insulin fibrillation by insertion of a chiral clamp mechanism-based application of protein engineering to global health Descriptor: CHLORIDE ION, Insulin, PHENOL, ... Authors: Wan, Z.L, Hua, Q.X, Wickramasinghe, N.P, Huang, K, Petkova, A.T, Hu, S.Q, Phillips, N.B, Yeh, I.J, Whittake, J, Ismail-Beigi, F, Katsoyyannis, P.G, Tycko, R, Weiss, M.A. Deposit date: 2011-12-09 Release date: 2012-12-12 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Forestalling insulin fibrillation by insertion of a chiral clamp mechanism-based application of protein engineering to global health To be Published
2ZPP	Neutron crystal structure of cubic insulin at pD9 Descriptor: Insulin A chain, Insulin B chain Authors: Ishikawa, T, Tanaka, I, Niimura, N. Deposit date: 2008-07-26 Release date: 2008-10-28 Last modified: 2023-11-01 Method: NEUTRON DIFFRACTION (2.5 Å) Cite: An abnormal pK(a) value of internal histidine of the insulin molecule revealed by neutron crystallographic analysis Biochem.Biophys.Res.Commun., 376, 2008
3W7Y	0.92A structure of 2Zn human insulin at 100K Descriptor: Insulin, ZINC ION Authors: Sakabe, N, Sakabe, K, Sasaki, K, Murayoshi, M. Deposit date: 2013-03-11 Release date: 2013-07-03 Last modified: 2018-03-07 Method: X-RAY DIFFRACTION (0.92 Å) Cite: 0.92A structure of 2Zn human insulin at 100K To be Published
3W80	Crystal structure of dodecamer human insulin with double C-axis length of the hexamer 2 Zn insulin cell Descriptor: Insulin, ZINC ION Authors: Murayoshi, M, Sasaki, K, Sakabe, N, Sakabe, K. Deposit date: 2013-03-11 Release date: 2013-07-03 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Crystal structure of dodecamer insulin with double C-axis length of the hexamer 2 Zn insulin celll To be Published
2ZP6	Crystal structure of Bovine Insulin (Hexameric form) Descriptor: Insulin A chain, Insulin B chain, ZINC ION Authors: Jaimohan, S.M, Naresh, M.D, Mandal, A.B. Deposit date: 2008-06-27 Release date: 2008-07-22 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.56 Å) Cite: Crystal structure of Bovine Insulin (Hexameric form) To be Published
3W7Z	1.15A structure of human 2Zn insulin at 293K Descriptor: Insulin, ZINC ION Authors: Hoshikawa, N, Sasaki, K, Sakabe, N, Sakabe, K. Deposit date: 2013-03-11 Release date: 2013-07-03 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.15 Å) Cite: 1.15A structure of human 2Zn insulin at 293K To be Published
5L3M	D11 bound [S39_PQ]-IGF-II Descriptor: Insulin-like growth factor II Authors: Hexnerova, R. Deposit date: 2016-05-23 Release date: 2016-08-10 Last modified: 2023-06-14 Method: SOLUTION NMR Cite: Probing Receptor Specificity by Sampling the Conformational Space of the Insulin-like Growth Factor II C-domain. J.Biol.Chem., 291, 2016
3GF1	SOLUTION STRUCTURE OF HUMAN INSULIN-LIKE GROWTH FACTOR 1: A NUCLEAR MAGNETIC RESONANCE AND RESTRAINED MOLECULAR DYNAMICS STUDY Descriptor: INSULIN-LIKE GROWTH FACTOR I Authors: Cooke, R.M, Harvey, T.S, Campbell, I.D. Deposit date: 1991-01-24 Release date: 1993-04-15 Last modified: 2022-03-16 Method: SOLUTION NMR Cite: Solution structure of human insulin-like growth factor 1: a nuclear magnetic resonance and restrained molecular dynamics study. Biochemistry, 30, 1991
3GKY	The Structural Basis of an ER Stress-Associated Bottleneck in a Protein Folding Landscape Descriptor: CHLORIDE ION, Insulin A chain, Insulin B chain, ... Authors: Liu, M, Wan, Z.L, Chu, Y.C, Alddin, H, Klaproth, B, Weiss, M.A. Deposit date: 2009-03-11 Release date: 2009-03-24 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Crystal structure of a "nonfoldable" insulin: IMPAIRED FOLDING EFFICIENCY DESPITE NATIVE ACTIVITY. J.Biol.Chem., 284, 2009
5L3N	D11 bound [N29, S39_PQ]-IGF-II Descriptor: Insulin-like growth factor II Authors: Hexnerova, R. Deposit date: 2016-05-23 Release date: 2016-08-10 Last modified: 2023-06-14 Method: SOLUTION NMR Cite: Probing Receptor Specificity by Sampling the Conformational Space of the Insulin-like Growth Factor II C-domain. J.Biol.Chem., 291, 2016
5L3L	D11 bound IGF-II Descriptor: Insulin-like growth factor II Authors: Hexnerova, R. Deposit date: 2016-05-23 Release date: 2016-08-10 Last modified: 2023-06-14 Method: SOLUTION NMR Cite: Probing Receptor Specificity by Sampling the Conformational Space of the Insulin-like Growth Factor II C-domain. J.Biol.Chem., 291, 2016
5LIS	Insulin solved by Native SAD from a dataset collected in one second Descriptor: Insulin Authors: Casanas, A, Finke, A, Wang, M. Deposit date: 2016-07-15 Release date: 2016-08-03 Last modified: 2016-09-28 Method: X-RAY DIFFRACTION (2.293 Å) Cite: EIGER detector: application in macromolecular crystallography. Acta Crystallogr D Struct Biol, 72, 2016
3I40	Human insulin Descriptor: Insulin A chain, Insulin B chain Authors: Timofeev, V.I, Bezuglov, V.V, Miroshnikov, K.A, Chuprov-Netochin, R.N, Kuranova, I.P. Deposit date: 2009-07-01 Release date: 2010-01-05 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.85 Å) Cite: X-ray investigation of gene-engineered human insulin crystallized from a solution containing polysialic acid. Acta Crystallogr.,Sect.F, 66, 2010
3I3Z	Human insulin Descriptor: Insulin A chain, Insulin B chain Authors: Timofeev, V.I, Bezuglov, V.V, Miroshnikov, K.A, Cuprov-Netochin, R.N, Samigina, V.R, Kuranova, I.P. Deposit date: 2009-07-01 Release date: 2010-01-05 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.6 Å) Cite: X-ray investigation of gene-engineered human insulin crystallized from a solution containing polysialic acid. Acta Crystallogr.,Sect.F, 66, 2010
5MIZ	MD ensemble of bovine insulin Descriptor: Insulin Authors: Efimov, S.V, Zgadzay, Y.O, Klochkov, V.V. Deposit date: 2016-11-29 Release date: 2017-01-25 Last modified: 2019-05-08 Method: SOLUTION NMR Cite: MD ensemble of bovine insulin To Be Published
5MHD	Biosynthetic engineered A22S-B3K-B31R human insulin monomer structure in water/acetonitrile solutions. Descriptor: Insulin Authors: Bocian, W, Kozerski, L, Bednarek, E, Sitkowski, J. Deposit date: 2016-11-24 Release date: 2017-08-09 Last modified: 2019-05-08 Method: SOLUTION NMR Cite: Structure and pharmaceutical formulation development of a new long-acting recombinant human insulin analog studied by NMR and MS. J Pharm Biomed Anal, 135, 2017
3INC	Crystal structure of human insulin with Ni+2 complex Descriptor: Insulin A chain, Insulin B chain, NICKEL (II) ION Authors: Raghavendra, N, Pattabhi, V, Rajan, S.S. Deposit date: 2009-08-12 Release date: 2010-08-18 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Metal induced conformational changes in human insulin: Crystal structures of Sr+2, Ni+2 and Cu+2 complexes of human insulin To be Published
3INS	STRUCTURE OF INSULIN. RESULTS OF JOINT NEUTRON AND X-RAY REFINEMENT Descriptor: INSULIN (CHAIN A), INSULIN (CHAIN B), ZINC ION Authors: Wlodawer, A, Savage, H. Deposit date: 1988-10-14 Release date: 1989-01-09 Last modified: 2017-11-29 Method: NEUTRON DIFFRACTION (1.5 Å), X-RAY DIFFRACTION Cite: Structure of insulin: results of joint neutron and X-ray refinement. Acta Crystallogr.,Sect.B, 45, 1989
3IR0	Crystal Structure of Human Insulin complexed with Cu+2 metal ion Descriptor: COPPER (II) ION, Insulin A chain, Insulin B chain Authors: Raghavendra, N, Pattabhi, V, Rajan, S.S. Deposit date: 2009-08-21 Release date: 2010-09-01 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Metal induced structural changes observed in Human insulin To be Published
5MAM	Human insulin in complex with serotonin Descriptor: CHLORIDE ION, Insulin A chain, Insulin B chain, ... Authors: Brzozowski, A.M, Turkenburg, J.P, Jiracek, J, Zakova, L. Deposit date: 2016-11-03 Release date: 2017-04-05 Last modified: 2017-05-31 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Computational and structural evidence for neurotransmitter-mediated modulation of the oligomeric states of human insulin in storage granules. J. Biol. Chem., 292, 2017
3ILG	Crystal structure of humnan insulin Sr+2 complex Descriptor: Insulin A chain, Insulin B chain, STRONTIUM ION Authors: Raghavendra, N, Pattabhi, V, Rajan, S.S. Deposit date: 2009-08-07 Release date: 2010-08-11 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Metal induced conformational changes in human insulin: Crystal structures of Sr+2, Ni+2 and Cu+2 complexes of human insulin To be Published
5MT9	Human insulin in complex with serotonin and arginine Descriptor: ARGININE, CHLORIDE ION, Insulin, ... Authors: Brzozowski, A.M, Turkenburg, J.P, Jiracek, J, Zakova, L. Deposit date: 2017-01-07 Release date: 2017-04-05 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.88 Å) Cite: Computational and structural evidence for neurotransmitter-mediated modulation of the oligomeric states of human insulin in storage granules. J. Biol. Chem., 292, 2017
5MT3	Human insulin in complex with serotonin and arginine Descriptor: ARGININE, CHLORIDE ION, Insulin, ... Authors: Brzozowski, A.M, Turkenburg, J.P, Jiracek, J, Zakova, L. Deposit date: 2017-01-06 Release date: 2017-04-05 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.02 Å) Cite: Computational and structural evidence for neurotransmitter-mediated modulation of the oligomeric states of human insulin in storage granules. J. Biol. Chem., 292, 2017
5MWQ	Biosynthetic engineered A21K-B31K-B32R human insulin monomer structure in water/acetonitrile solution Descriptor: Insulin Authors: Bocian, W, Kozerski, L. Deposit date: 2017-01-19 Release date: 2018-02-14 Last modified: 2023-06-14 Method: SOLUTION NMR Cite: Lysine mis-incorporation at asparagine position during recombinant proteins production in E. coli To Be Published
3JSD	Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus Descriptor: CHLORIDE ION, Insulin A chain, Insulin B chain, ... Authors: Weiss, M.A, Wan, Z.L, Dodson, E.J, Liu, M, Xu, B, Hua, Q.X, Turkenburg, M, Whittingham, J, Nakagawa, S.H, Huang, K, Hu, S.Q, Jia, W.H, Wang, S.H, Brange, J, Whittaker, J, Arvan, P, Katsoyannis, P.G, Dodson, G.G. Deposit date: 2009-09-10 Release date: 2010-09-15 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus To be Published

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