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7UL5
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BU of 7ul5 by Molmil
CryoEM Structure of Inactive SSTR2 bound to Nb6
Descriptor: Nanobody 6, Somatostatin receptor type 2
Authors:Robertson, M.J, Skiniotis, G.
Deposit date:2022-04-03
Release date:2022-06-29
Last modified:2022-12-28
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structure determination of inactive-state GPCRs with a universal nanobody.
Nat.Struct.Mol.Biol., 29, 2022
7UL2
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CryoEM Structure of Inactive NTSR1 Bound to SR48692 and Nb6
Descriptor: 2-[[1-(7-chloranylquinolin-4-yl)-5-(2,6-dimethoxyphenyl)pyrazol-3-yl]carbonylamino]adamantane-2-carboxylic acid, Nanobody 6, Neurotensin receptor 1, ...
Authors:Robertson, M.J, Skiniotis, G.
Deposit date:2022-04-03
Release date:2022-06-29
Last modified:2022-12-28
Method:ELECTRON MICROSCOPY (2.4 Å)
Cite:Structure determination of inactive-state GPCRs with a universal nanobody.
Nat.Struct.Mol.Biol., 29, 2022
7UL3
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CryoEM Structure of Inactive H2R Bound to Famotidine, Nb6M, and NabFab
Descriptor: Histamine H2 receptor, NabFab HC, NabFab LC, ...
Authors:Robertson, M.J, Skiniotis, G.
Deposit date:2022-04-03
Release date:2022-06-29
Last modified:2022-12-28
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structure determination of inactive-state GPCRs with a universal nanobody.
Nat.Struct.Mol.Biol., 29, 2022
7UL4
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CryoEM Structure of Inactive MOR Bound to Alvimopan and Mb6
Descriptor: Megabody 6, Mu-type opioid receptor, N-[(2S)-2-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]methyl}-3-phenylpropanoyl]glycine
Authors:Robertson, M.J, Skiniotis, G.
Deposit date:2022-04-03
Release date:2022-06-29
Last modified:2022-12-28
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Structure determination of inactive-state GPCRs with a universal nanobody.
Nat.Struct.Mol.Biol., 29, 2022
7VV0
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Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with PAMP-12, local
Descriptor: CHOLESTEROL, Mas-related G-protein coupled receptor member X2, peptide from Pro-adrenomedullin
Authors:Li, Y, Yang, F.
Deposit date:2021-11-04
Release date:2021-12-01
Last modified:2022-07-20
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structure, function and pharmacology of human itch receptor complexes.
Nature, 600, 2021
7VV6
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Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with C48/80 (local)
Descriptor: 2-[4-methoxy-3-[[2-methoxy-3-[[2-methoxy-5-[2-(methylamino)ethyl]phenyl]methyl]-5-[2-(methylamino)ethyl]phenyl]methyl]phenyl]-~{N}-methyl-ethanamine, CHOLESTEROL, Mas-related G-protein coupled receptor member X2
Authors:Li, Y, Yang, F.
Deposit date:2021-11-04
Release date:2021-12-01
Last modified:2022-07-20
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structure, function and pharmacology of human itch receptor complexes.
Nature, 600, 2021
7WC4
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BU of 7wc4 by Molmil
Crystal structure of serotonin 2A receptor in complex with serotonin
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 5-hydroxytryptamine receptor 2A,5-hydroxytryptamine receptor 2A,5-hydroxytryptamine receptor 2A,Soluble cytochrome b562, CHOLESTEROL, ...
Authors:Cao, D, Yu, J, Wang, H, Luo, Z, Liu, X, He, L, Qi, J, Fan, L, Tang, L, Chen, Z, Li, J, Cheng, J, Wang, S.
Deposit date:2021-12-18
Release date:2022-01-26
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structure-based discovery of nonhallucinogenic psychedelic analogs.
Science, 375, 2022
7WC5
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Crystal structure of serotonin 2A receptor in complex with psilocin
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 3-[2-(dimethylamino)ethyl]-1~{H}-indol-4-ol, 5-hydroxytryptamine receptor 2A, ...
Authors:Cao, D, Yu, J, Wang, H, Luo, Z, Liu, X, He, L, Qi, J, Fan, L, Tang, L, Chen, Z, Li, J, Cheng, J, Wang, S.
Deposit date:2021-12-18
Release date:2022-01-26
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structure-based discovery of nonhallucinogenic psychedelic analogs.
Science, 375, 2022
7XRR
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BU of 7xrr by Molmil
Crystal structure of the human OX2R bound to the insomnia drug lemborexant.
Descriptor: (1~{R},2~{S})-2-[(2,4-dimethylpyrimidin-5-yl)oxymethyl]-~{N}-(5-fluoranylpyridin-2-yl)-2-(3-fluorophenyl)cyclopropane-1-carboxamide, Orexin receptor type 2
Authors:Asada, H, Im, D, Iwata, S.
Deposit date:2022-05-11
Release date:2022-11-23
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.89 Å)
Cite:Molecular basis for anti-insomnia drug design from structure of lemborexant-bound orexin 2 receptor.
Structure, 30, 2022
7YMJ
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BU of 7ymj by Molmil
Cryo-EM structure of alpha1AAR-Nb6 complex bound to tamsulosin
Descriptor: Nb6, Tamsulosin, alpha1A-adrenergic receptor
Authors:Toyoda, Y, Zhu, A, Yan, C, Kobilka, B.K, Liu, X.
Deposit date:2022-07-28
Release date:2023-07-05
Method:ELECTRON MICROSCOPY (3.35 Å)
Cite:Structural basis of alpha 1A -adrenergic receptor activation and recognition by an extracellular nanobody.
Nat Commun, 14, 2023
7YU4
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BU of 7yu4 by Molmil
Human Lysophosphatidic Acid Receptor 1-Gi complex bound to ONO-0740556, focused on receptor
Descriptor: Lysophosphatidic acid receptor 1, [(2~{R})-2-[5-(2-hexylphenyl)pentanoylamino]-3-oxidanyl-propyl] dihydrogen phosphate
Authors:Akasaka, H, Shihoya, W, Nureki, O.
Deposit date:2022-08-16
Release date:2022-10-05
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structure of the active G i -coupled human lysophosphatidic acid receptor 1 complexed with a potent agonist.
Nat Commun, 13, 2022
2G87
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BU of 2g87 by Molmil
Crystallographic model of bathorhodopsin
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, HEPTANE-1,2,3-TRIOL, MERCURY (II) ION, ...
Authors:Nakamichi, H, Okada, T.
Deposit date:2006-03-02
Release date:2006-09-02
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystallographic analysis of primary visual photochemistry
Angew.Chem.Int.Ed.Engl., 45, 2006
1U19
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BU of 1u19 by Molmil
Crystal Structure of Bovine Rhodopsin at 2.2 Angstroms Resolution
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, HEPTANE-1,2,3-TRIOL, MERCURY (II) ION, ...
Authors:Okada, T, Sugihara, M, Bondar, A.N, Elstner, M, Entel, P, Buss, V.
Deposit date:2004-07-15
Release date:2004-10-12
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The retinal conformation and its environment in rhodopsin in light of a new 2.2 A crystal structure
J.Mol.Biol., 342, 2004
7JJO
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BU of 7jjo by Molmil
Structural Basis of the Activation of Heterotrimeric Gs-protein by Isoproterenol-bound Beta1-Adrenergic Receptor
Descriptor: Beta1-Adrenergic Receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Su, M, Zhu, L, Zhang, Y, Paknejad, N, Dey, R, Huang, J, Lee, M.Y, Williams, D, Jordan, K.D, Eng, E.T, Ernst, O.P, Meyerson, J.R, Hite, R.K, Walz, T, Liu, W, Huang, X.Y.
Deposit date:2020-07-27
Release date:2020-09-02
Last modified:2020-10-14
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Structural Basis of the Activation of Heterotrimeric Gs-Protein by Isoproterenol-Bound beta 1 -Adrenergic Receptor.
Mol.Cell, 80, 2020
1JFP
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BU of 1jfp by Molmil
Structure of bovine rhodopsin (dark adapted)
Descriptor: RETINAL, rhodopsin
Authors:Yeagle, P.L, Choi, G, Albert, A.D.
Deposit date:2001-06-21
Release date:2001-10-05
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:Studies on the structure of the G-protein-coupled receptor rhodopsin including the putative G-protein binding site in unactivated and activated forms.
Biochemistry, 40, 2001
7JV5
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BU of 7jv5 by Molmil
Cryo-EM structure of SKF-81297-bound dopamine receptor 1 in complex with Gs protein
Descriptor: (1R)-6-chloro-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol, CHOLESTEROL, D(1A) dopamine receptor, ...
Authors:Zhuang, Y, Xu, P, Mao, C, Wang, L, Krumm, B, Zhou, X.E, Huang, S, Liu, H, Cheng, X, Huang, X.-P, Sheng, D.-D, Xu, T, Liu, Y.-F, Wang, Y, Guo, J, Jiang, Y, Jiang, H, Melcher, K, Roth, B.L, Zhang, Y, Zhang, C, Xu, H.E.
Deposit date:2020-08-20
Release date:2021-02-24
Last modified:2021-03-03
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural insights into the human D1 and D2 dopamine receptor signaling complexes.
Cell, 184, 2021
7JOZ
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BU of 7joz by Molmil
Crystal structure of dopamine D1 receptor in complex with G protein and a non-catechol agonist
Descriptor: 6-{4-[(furo[3,2-c]pyridin-4-yl)oxy]-2-methylphenyl}-1,5-dimethylpyrimidine-2,4(1H,3H)-dione, Endolysin,D(1A) dopamine receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Sun, B, Feng, D, Chu, M.L, Fish, I, Kelm, S, Lebon, F, Lovera, S, Valade, A, Wood, M, Ceska, T, Kobilka, T.S, Sands, Z, Kobilka, B.K.
Deposit date:2020-08-07
Release date:2021-04-14
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:Crystal structure of dopamine D1 receptor in complex with G protein and a non-catechol agonist.
Nat Commun, 12, 2021
1L9H
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BU of 1l9h by Molmil
Crystal structure of bovine rhodopsin at 2.6 angstroms RESOLUTION
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, HEPTANE-1,2,3-TRIOL, MERCURY (II) ION, ...
Authors:Okada, T, Fujiyoshi, Y, Silow, M, Navarro, J, Landau, E.M, Shichida, Y.
Deposit date:2002-03-23
Release date:2002-05-15
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Functional role of internal water molecules in rhodopsin revealed by X-ray crystallography.
Proc.Natl.Acad.Sci.USA, 99, 2002
1F88
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BU of 1f88 by Molmil
CRYSTAL STRUCTURE OF BOVINE RHODOPSIN
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, MERCURY (II) ION, RETINAL, ...
Authors:Okada, T, Palczewski, K, Stenkamp, R.E, Miyano, M.
Deposit date:2000-06-29
Release date:2000-08-04
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of rhodopsin: A G protein-coupled receptor.
Science, 289, 2000
1LN6
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BU of 1ln6 by Molmil
STRUCTURE OF BOVINE RHODOPSIN (Metarhodopsin II)
Descriptor: RETINAL, RHODOPSIN
Authors:Choi, G, Landin, J, Galan, J.F, Birge, R.R, Albert, A.D, Yeagle, P.L.
Deposit date:2002-05-03
Release date:2002-07-10
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:Structural studies of metarhodopsin II, the activated form of the G-protein coupled receptor, rhodopsin.
Biochemistry, 41, 2002
1GZM
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BU of 1gzm by Molmil
Structure of Bovine Rhodopsin in a Trigonal Crystal Form
Descriptor: (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, DI-PALMITOYL-3-SN-PHOSPHATIDYLETHANOLAMINE, LAURYL DIMETHYLAMINE-N-OXIDE, ...
Authors:Li, J.
Deposit date:2002-05-24
Release date:2003-11-20
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structure of Bovine Rhodopsin in a Trigonal Crystal Form
J.Mol.Biol., 343, 2004
1HZX
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BU of 1hzx by Molmil
CRYSTAL STRUCTURE OF BOVINE RHODOPSIN
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, HEPTANE-1,2,3-TRIOL, MERCURY (II) ION, ...
Authors:Teller, D.C, Okada, T, Behnke, C.A, Palczewski, K, Stenkamp, R.E.
Deposit date:2001-01-26
Release date:2001-07-04
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Advances in determination of a high-resolution three-dimensional structure of rhodopsin, a model of G-protein-coupled receptors (GPCRs).
Biochemistry, 40, 2001
3CAP
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BU of 3cap by Molmil
Crystal Structure of Native Opsin: the G Protein-Coupled Receptor Rhodopsin in its Ligand-free State
Descriptor: 2-O-octyl-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, PALMITIC ACID, ...
Authors:Park, J.H, Scheerer, P, Hofmann, K.P, Choe, H.-W, Ernst, O.P.
Deposit date:2008-02-20
Release date:2008-06-24
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structure of the ligand-free G-protein-coupled receptor opsin
Nature, 454, 2008
3D4S
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BU of 3d4s by Molmil
Cholesterol bound form of human beta2 adrenergic receptor.
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-1-(tert-butylamino)-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol, Beta-2 adrenergic receptor/T4-lysozyme chimera, ...
Authors:Hanson, M.A, Cherezov, V, Roth, C.B, Griffith, M.T, Jaakola, V.-P, Chien, E.Y.T, Velasquez, J, Kuhn, P, Stevens, R.C, Accelerated Technologies Center for Gene to 3D Structure (ATCG3D), GPCR Network (GPCR)
Deposit date:2008-05-14
Release date:2008-06-17
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:A specific cholesterol binding site is established by the 2.8 A structure of the human beta2-adrenergic receptor.
Structure, 16, 2008
4X1H
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Opsin/G(alpha) peptide complex stabilized by nonyl-glucoside
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose, C-terminal derived peptide of guanine nucleotide-binding protein G(t) subunit alpha-1, PALMITIC ACID, ...
Authors:Blankenship, E, Lodowski, D.T.
Deposit date:2014-11-24
Release date:2015-11-04
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:The High-Resolution Structure of Activated Opsin Reveals a Conserved Solvent Network in the Transmembrane Region Essential for Activation.
Structure, 23, 2015

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