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7DJ1
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BU of 7dj1 by Molmil
Crystal structure of the G26C mutant of LeuT
Descriptor: LEUCINE, Na(+):neurotransmitter symporter (Snf family), SODIUM ION
Authors:Fan, J, Xiao, Y, Sun, Z, Zhou, X.
Deposit date:2020-11-19
Release date:2021-04-07
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3.528 Å)
Cite:Crystal structures of LeuT reveal conformational dynamics in the outward-facing states.
J.Biol.Chem., 296, 2021
7DII
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BU of 7dii by Molmil
Crystal structure of LeuT in lipidic cubic phase at pH 7
Descriptor: LEUCINE, Na(+):neurotransmitter symporter (Snf family), SODIUM ION
Authors:Fan, J, Xiao, Y, Sun, Z, Zhou, X.
Deposit date:2020-11-19
Release date:2021-04-07
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.403 Å)
Cite:Crystal structures of LeuT reveal conformational dynamics in the outward-facing states.
J.Biol.Chem., 296, 2021
7DIX
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BU of 7dix by Molmil
Crystal structure of LeuT in lipidic cubic phase at pH 5
Descriptor: Na(+):neurotransmitter symporter (Snf family), SELENOMETHIONINE, SODIUM ION
Authors:Fan, J, Xiao, Y, Sun, Z, Zhou, X.
Deposit date:2020-11-19
Release date:2021-04-07
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3.49 Å)
Cite:Crystal structures of LeuT reveal conformational dynamics in the outward-facing states.
J.Biol.Chem., 296, 2021
7DJ2
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BU of 7dj2 by Molmil
Crystal structure of the G26C/E290S mutant of LeuT
Descriptor: LEUCINE, Na(+):neurotransmitter symporter (Snf family), SODIUM ION, ...
Authors:Fan, J, Xiao, Y, Sun, Z, Zhou, X.
Deposit date:2020-11-19
Release date:2021-04-07
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structures of LeuT reveal conformational dynamics in the outward-facing states.
J.Biol.Chem., 296, 2021
7DJC
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BU of 7djc by Molmil
Crystal structure of the G26C/Q250A mutant of LeuT
Descriptor: LEUCINE, Na(+):neurotransmitter symporter (Snf family), SODIUM ION, ...
Authors:Fan, J, Xiao, Y, Sun, Z, Zhou, X.
Deposit date:2020-11-20
Release date:2021-04-07
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.701 Å)
Cite:Crystal structures of LeuT reveal conformational dynamics in the outward-facing states.
J.Biol.Chem., 296, 2021
3F3A
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BU of 3f3a by Molmil
Crystal Structure of LeuT bound to L-Tryptophan and Sodium
Descriptor: SODIUM ION, TETRADECANE, TRYPTOPHAN, ...
Authors:Singh, S.K, Piscitelli, C.L, Yamashita, A, Gouaux, E.
Deposit date:2008-10-30
Release date:2008-12-23
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:A competitive inhibitor traps LeuT in an open-to-out conformation.
Science, 322, 2008
3F3D
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BU of 3f3d by Molmil
Crystal structure of LeuT bound to L-Methionine and sodium
Descriptor: METHIONINE, SODIUM ION, Transporter, ...
Authors:Singh, S.K, Piscitelli, C.L, Yamashita, A, Gouaux, E.
Deposit date:2008-10-30
Release date:2008-12-23
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A competitive inhibitor traps LeuT in an open-to-out conformation.
Science, 322, 2008
3F4J
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BU of 3f4j by Molmil
Crystal structure of LeuT bound to glycine and sodium
Descriptor: GLYCINE, SODIUM ION, Transporter, ...
Authors:Singh, S.K, Piscitelli, C.L, Yamashita, A, Gouaux, E.
Deposit date:2008-10-31
Release date:2008-12-23
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:A competitive inhibitor traps LeuT in an open-to-out conformation.
Science, 322, 2008
3F3C
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BU of 3f3c by Molmil
Crystal structure of LeuT bound to 4-Fluoro-L-Phenylalanine and sodium
Descriptor: 4-FLUORO-L-PHENYLALANINE, SODIUM ION, Transporter, ...
Authors:Singh, S.K, Piscitelli, C.L, Yamashita, A, Gouaux, E.
Deposit date:2008-10-30
Release date:2008-12-23
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A competitive inhibitor traps LeuT in an open-to-out conformation.
Science, 322, 2008
3F48
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BU of 3f48 by Molmil
Crystal structure of LeuT bound to L-alanine and sodium
Descriptor: ALANINE, SODIUM ION, Transporter, ...
Authors:Singh, S.K, Piscitelli, C.L, Yamashita, A, Gouaux, E.
Deposit date:2008-10-31
Release date:2008-12-23
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A competitive inhibitor traps LeuT in an open-to-out conformation.
Science, 322, 2008
3F4I
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BU of 3f4i by Molmil
Crystal Structure of LeuT bound to L-selenomethionine and sodium
Descriptor: SELENOMETHIONINE, SODIUM ION, Transporter, ...
Authors:Singh, S.K, Piscitelli, C.L, Yamashita, A, Gouaux, E.
Deposit date:2008-10-31
Release date:2008-12-23
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:A competitive inhibitor traps LeuT in an open-to-out conformation.
Science, 322, 2008
3F3E
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BU of 3f3e by Molmil
Crystal structure of LeuT bound to L-leucine (30 mM) and sodium
Descriptor: LEUCINE, SODIUM ION, Transporter, ...
Authors:Singh, S.K, Piscitelli, C.L, Yamashita, A, Gouaux, E.
Deposit date:2008-10-30
Release date:2008-12-23
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A competitive inhibitor traps LeuT in an open-to-out conformation.
Science, 322, 2008
6YU6
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BU of 6yu6 by Molmil
Crystal structure of MhsT in complex with L-leucine
Descriptor: DODECYL-BETA-D-MALTOSIDE, LEUCINE, SODIUM ION, ...
Authors:Focht, D, Neumann, C, Lyons, J, Eguskiza Bilbao, A, Blunck, R, Malinauskaite, L, Schwarz, I.O, Javitch, J.A, Quick, M, Nissen, P.
Deposit date:2020-04-25
Release date:2020-07-15
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:A non-helical region in transmembrane helix 6 of hydrophobic amino acid transporter MhsT mediates substrate recognition.
Embo J., 40, 2021
6YU4
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BU of 6yu4 by Molmil
Crystal structure of MhsT in complex with L-4F-phenylalanine
Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 4-FLUORO-L-PHENYLALANINE, DODECYL-BETA-D-MALTOSIDE, ...
Authors:Focht, D, Neumann, C, Lyons, J, Eguskiza Bilbao, A, Blunck, R, Malinauskaite, L, Schwarz, I.O, Javitch, J.A, Quick, M, Nissen, P.
Deposit date:2020-04-25
Release date:2020-07-15
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:A non-helical region in transmembrane helix 6 of hydrophobic amino acid transporter MhsT mediates substrate recognition.
Embo J., 40, 2021
6YU5
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BU of 6yu5 by Molmil
Crystal structure of MhsT in complex with L-valine
Descriptor: DODECYL-BETA-D-MALTOSIDE, SODIUM ION, Sodium-dependent transporter, ...
Authors:Focht, D, Neumann, C, Lyons, J, Eguskiza Bilbao, A, Blunck, R, Malinauskaite, L, Schwarz, I.O, Javitch, J.A, Quick, M, Nissen, P.
Deposit date:2020-04-25
Release date:2020-07-15
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A non-helical region in transmembrane helix 6 of hydrophobic amino acid transporter MhsT mediates substrate recognition.
Embo J., 40, 2021
6YU7
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BU of 6yu7 by Molmil
Crystal structure of MhsT in complex with L-tyrosine
Descriptor: DODECYL-BETA-D-MALTOSIDE, SODIUM ION, Sodium-dependent transporter, ...
Authors:Focht, D, Neumann, C, Lyons, J, Eguskiza Bilbao, A, Blunck, R, Malinauskaite, L, Schwarz, I.O, Javitch, J.A, Quick, M, Nissen, P.
Deposit date:2020-04-25
Release date:2020-07-15
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A non-helical region in transmembrane helix 6 of hydrophobic amino acid transporter MhsT mediates substrate recognition.
Embo J., 40, 2021
6YU2
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BU of 6yu2 by Molmil
Crystal structure of MhsT in complex with L-isoleucine
Descriptor: ISOLEUCINE, SODIUM ION, Sodium-dependent transporter, ...
Authors:Focht, D, Neumann, C, Lyons, J, Eguskiza Bilbao, A, Blunck, R, Malinauskaite, L, Schwarz, I.O, Javitch, J.A, Quick, M, Nissen, P.
Deposit date:2020-04-25
Release date:2020-07-15
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:A non-helical region in transmembrane helix 6 of hydrophobic amino acid transporter MhsT mediates substrate recognition.
Embo J., 40, 2021
6YU3
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BU of 6yu3 by Molmil
Crystal structure of MhsT in complex with L-phenylalanine
Descriptor: DODECYL-BETA-D-MALTOSIDE, GLYCEROL, PHENYLALANINE, ...
Authors:Focht, D, Neumann, C, Lyons, J, Eguskiza Bilbao, A, Blunck, R, Malinauskaite, L, Schwarz, I.O, Javitch, J.A, Quick, M, Nissen, P.
Deposit date:2020-04-25
Release date:2020-07-15
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:A non-helical region in transmembrane helix 6 of hydrophobic amino acid transporter MhsT mediates substrate recognition.
Embo J., 40, 2021
6ZBV
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BU of 6zbv by Molmil
Inward-open structure of human glycine transporter 1 in complex with a benzoylisoindoline inhibitor and sybody Sb_GlyT1#7
Descriptor: Sodium- and chloride-dependent glycine transporter 1,Sodium- and chloride-dependent glycine transporter 1, Sybody Sb_GlyT1#7, [5-fluoranyl-6-(oxan-4-yloxy)-1,3-dihydroisoindol-2-yl]-[5-methylsulfonyl-2-[2,2,3,3,3-pentakis(fluoranyl)propoxy]phenyl]methanone
Authors:Shahsavar, A, Stohler, P, Bourenkov, G, Zimmermann, I, Siegrist, M, Guba, W, Pinard, E, Sinning, S, Seeger, M.A, Schneider, T.R, Dawson, R.J.P, Nissen, P.
Deposit date:2020-06-09
Release date:2021-03-17
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Structural insights into the inhibition of glycine reuptake.
Nature, 591, 2021
4XP1
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BU of 4xp1 by Molmil
X-ray structure of Drosophila dopamine transporter bound to neurotransmitter dopamine
Descriptor: 1,2-ETHANEDIOL, 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Gouaux, E, Penmatsa, A, Wang, K.
Deposit date:2015-01-16
Release date:2015-05-06
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.89 Å)
Cite:Neurotransmitter and psychostimulant recognition by the dopamine transporter.
Nature, 521, 2015
4XP5
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BU of 4xp5 by Molmil
X-ray structure of Drosophila dopamine transporter bound to cocaine analogue-RTI55
Descriptor: 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE, Antibody fragment heavy chain-protein, 9D5-heavy chain, ...
Authors:Gouaux, E, Penmatsa, A, Wang, K.
Deposit date:2015-01-16
Release date:2015-05-06
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Neurotransmitter and psychostimulant recognition by the dopamine transporter.
Nature, 521, 2015
4XPB
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BU of 4xpb by Molmil
X-ray structure of Drosophila dopamine transporter with subsiteB mutations (D121G/S426M) bound to cocaine
Descriptor: Antibody fragment heavy chain-protein, 9D5-heavy chain, Antibody fragment light chain-protein, ...
Authors:Aravind, P, Wang, K, Gouaux, E.
Deposit date:2015-01-16
Release date:2015-05-13
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Neurotransmitter and psychostimulant recognition by the dopamine transporter.
Nature, 521, 2015
4XPT
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BU of 4xpt by Molmil
X-ray structure of Drosophila dopamine transporter with subsiteB mutations D121G/S426M and EL2 deletion of 162-201 in complex with substrate analogue 3,4 dichlorophen ethylamine
Descriptor: 2-(3,4-dichlorophenyl)ethanamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ...
Authors:Aravind, P, Wang, K, Gouaux, E.
Deposit date:2015-01-17
Release date:2015-05-06
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.36 Å)
Cite:Neurotransmitter and psychostimulant recognition by the dopamine transporter.
Nature, 521, 2015
4XNX
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BU of 4xnx by Molmil
X-ray structure of Drosophila dopamine transporter in complex with reboxetine
Descriptor: (2R)-2-[(R)-(2-ethoxyphenoxy)(phenyl)methyl]morpholine, Antibody fragment heavy chain, CHLORIDE ION, ...
Authors:Aravind, P, Wang, K, Gouaux, E.
Deposit date:2015-01-16
Release date:2015-05-13
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3 Å)
Cite:X-ray structures of Drosophila dopamine transporter in complex with nisoxetine and reboxetine.
Nat.Struct.Mol.Biol., 22, 2015
4XP6
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BU of 4xp6 by Molmil
X-ray structure of Drosophila dopamine transporter bound to psychostimulant methamphetamine
Descriptor: (2S)-N-methyl-1-phenylpropan-2-amine, 2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody fragment heavy chain-protein, ...
Authors:Aravind, P, Wang, K, Gouaux, E.
Deposit date:2015-01-16
Release date:2015-05-13
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Neurotransmitter and psychostimulant recognition by the dopamine transporter.
Nature, 521, 2015

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