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3KU0
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BU of 3ku0 by Molmil
Structure of GAP31 with adenine at its binding pocket
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, ADENINE, Ribosome-inactivating protein gelonin
Authors:Kong, X.-P.
Deposit date:2009-11-26
Release date:2010-01-26
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A new activity of anti-HIV and anti-tumor protein GAP31: DNA adenosine glycosidase--structural and modeling insight into its functions.
Biochem.Biophys.Res.Commun., 391, 2010
5CIX
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BU of 5cix by Molmil
Structure of the complex of type 1 Ribosome inactivating protein with triethanolamine at 1.88 Angstrom resolution
Descriptor: 2,2',2''-NITRILOTRIETHANOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, PHOSPHATE ION, ...
Authors:Singh, P.K, Pandey, S, Tyagi, T.K, Singh, A, Kaur, P, Sharma, S, Singh, T.P.
Deposit date:2015-07-13
Release date:2015-08-12
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Structure of the complex of type 1 Ribosome inactivating protein with triethanolamine at 1.88 Angstrom resolution.
To Be Published
3LC9
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BU of 3lc9 by Molmil
Ricin A-chain variant 1-33/44-198 with engineered disulfide bond
Descriptor: Ricin A chain, SULFATE ION
Authors:Compton, J.R, Legler, P.M, Millard, C.B.
Deposit date:2010-01-10
Release date:2010-11-10
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Introduction of a disulfide bond leads to stabilization and crystallization of a ricin immunogen.
Proteins, 79, 2011
3LE7
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BU of 3le7 by Molmil
Crystal structure of PD-L1 from P. dioica in complex with adenine
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, ADENINE, Ribosome-inactivating protein PD-L1/PD-L2
Authors:Ruggiero, A, Berisio, R.
Deposit date:2010-01-14
Release date:2010-04-14
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:The role of the glycan moiety on the structure-function relationships of PD-L1, type 1 ribosome-inactivating protein from P. dioica leaves
Mol Biosyst, 6, 2010
8TAD
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BU of 8tad by Molmil
RTA in complex with inhibitor RUNT-206
Descriptor: (9aM)-5,5-dimethyl-4,5-dihydronaphtho[1,2-b]thiophene-2-carboxylic acid, CHLORIDE ION, NONAETHYLENE GLYCOL, ...
Authors:Rudolph, M.J, Tumer, N.
Deposit date:2023-06-27
Release date:2024-05-01
Method:X-RAY DIFFRACTION (2.76 Å)
Cite:Structure-based design and optimization of a new class of small molecule inhibitors targeting the P-stalk binding pocket of ricin.
Bioorg.Med.Chem., 100, 2024
8T9V
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BU of 8t9v by Molmil
RTA-RUNT-59 complex structure
Descriptor: (9aP)-7-fluoro-4,5-dihydronaphtho[1,2-b]thiophene-2-carboxylic acid, NONAETHYLENE GLYCOL, Ricin
Authors:Rudolph, M.J, Tumer, N.
Deposit date:2023-06-26
Release date:2024-05-01
Method:X-RAY DIFFRACTION (1.945 Å)
Cite:Structure-based design and optimization of a new class of small molecule inhibitors targeting the P-stalk binding pocket of ricin.
Bioorg.Med.Chem., 100, 2024
8TAB
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BU of 8tab by Molmil
RTA-PD00589
Descriptor: 1,2-ETHANEDIOL, 4H,5H-naphtho[1,2-b]thiophene-2-carboxylic acid, CHLORIDE ION, ...
Authors:Rudolph, M.J, Tumer, N.
Deposit date:2023-06-27
Release date:2024-05-01
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Structure-based design and optimization of a new class of small molecule inhibitors targeting the P-stalk binding pocket of ricin.
Bioorg.Med.Chem., 100, 2024
8SZ2
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BU of 8sz2 by Molmil
Stx2A1 bound to P8 stalk peptide
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, NONAETHYLENE GLYCOL, ...
Authors:rudolph, M.J, Li, X.P.
Deposit date:2023-05-26
Release date:2024-05-29
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Structure of Shiga toxin 2 A1 subunit with peptides that bind at the ribosome binding site and inhibit activity
To Be Published
5E1H
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BU of 5e1h by Molmil
Ricin toxin in complex with neutralizing single chain monoclonal antibodies (VHHs)
Descriptor: CHLORIDE ION, F8(JOB10) VHH antibody, Ricin
Authors:Rudolph, M.J, Vance, D, Shoemaker, C, Mantis, N.
Deposit date:2015-09-29
Release date:2016-08-03
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.032 Å)
Cite:Structural analysis of nested neutralizing and non-neutralizing B cell epitopes on ricin toxin's enzymatic subunit.
Proteins, 84, 2016
3MRW
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BU of 3mrw by Molmil
Crystal Structure of type I ribosome inactivating protein from Momordica balsamina at 1.7 A resolution
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
Authors:Kushwaha, G.S, Pandey, N, Sinha, M, Kaur, P, Sharma, S, Singh, T.P.
Deposit date:2010-04-29
Release date:2010-06-23
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal Structure of type I ribosome inactivating protein from Momordica balsamina at 1.7 A resolution
To be Published
7TGF
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BU of 7tgf by Molmil
Single-domain VHH intrabodies neutralize ricin toxin.
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Ricin chain A, ...
Authors:Rudolph, M.J, Mantis, N.
Deposit date:2022-01-07
Release date:2022-10-12
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.347 Å)
Cite:Single-domain antibodies neutralize ricin toxin intracellularly by blocking access to ribosomal P-stalk proteins.
J.Biol.Chem., 298, 2022
7TGI
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BU of 7tgi by Molmil
Single-domain VHH intrabodies neutralize ricin toxin
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Ricin chain A, ...
Authors:Rudolph, M.J.
Deposit date:2022-01-07
Release date:2022-10-12
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.104 Å)
Cite:Single-domain antibodies neutralize ricin toxin intracellularly by blocking access to ribosomal P-stalk proteins.
J.Biol.Chem., 298, 2022
7TH3
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BU of 7th3 by Molmil
Single-domain VHH intrabodies neutralize ricin toxin
Descriptor: Ricin chain A, VHH antibody
Authors:Rudolph, M.J.
Deposit date:2022-01-10
Release date:2022-10-12
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.292 Å)
Cite:Single-domain antibodies neutralize ricin toxin intracellularly by blocking access to ribosomal P-stalk proteins.
J.Biol.Chem., 298, 2022
7TH2
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BU of 7th2 by Molmil
Single-domain VHH intrabodies neutralize ricin toxin
Descriptor: 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, ...
Authors:Rudolph, M.J, Mantis, N.
Deposit date:2022-01-10
Release date:2022-10-12
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.838 Å)
Cite:Single-domain antibodies neutralize ricin toxin intracellularly by blocking access to ribosomal P-stalk proteins.
J.Biol.Chem., 298, 2022
3MK9
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BU of 3mk9 by Molmil
Stabilized Ricin Immunogen 1-33/44-198
Descriptor: Ricin, SULFATE ION
Authors:Legler, P.M, Compton, J.R, Millard, C.B.
Deposit date:2010-04-14
Release date:2010-11-10
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:Introduction of a disulfide bond leads to stabilization and crystallization of a ricin immunogen.
Proteins, 79, 2011
3MVG
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BU of 3mvg by Molmil
Native structure of IRIP, a type I ribosome inactivating protein from Iris hollandica var. at 1.25 A
Descriptor: GLYCEROL, Ribosome inactivating type 1 protein, SULFATE ION
Authors:Meyer, A, Weber, W, Singh, T.P, Betzel, C.
Deposit date:2010-05-04
Release date:2011-06-01
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Native structure of IRIP, a type I ribosome inactivating protein from Iris hollandica var. at 1.25 A
to be published
5CSO
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BU of 5cso by Molmil
Structure of the complex of type 1 ribosome inactivating protein from Momordica balsamina with a nucleoside, cytidine at 1.78 A resolution
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-AMINO-1-BETA-D-RIBOFURANOSYL-2(1H)-PYRIMIDINONE, GLYCEROL, ...
Authors:Yamin, S, Pandey, S, Kaur, P, Sharma, S, Singh, T.P.
Deposit date:2015-07-23
Release date:2015-08-12
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Binding and structural studies of the complexes of type 1 ribosome inactivating protein fromMomordica balsaminawith cytosine, cytidine, and cytidine diphosphate.
Biochem Biophys Rep, 4, 2015
5CST
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BU of 5cst by Molmil
Structure of the complex of type 1 ribosome inactivating protein from Momordica balsamina with a nucleotide, cytidine diphosphate at 1.78 A resolution
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CYTIDINE-5'-DIPHOSPHATE, GLYCEROL, ...
Authors:Yamin, S, Pandey, S, Kaur, P, Sharma, S, Singh, T.P.
Deposit date:2015-07-23
Release date:2015-08-12
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Binding and structural studies of the complexes of type 1 ribosome inactivating protein fromMomordica balsaminawith cytosine, cytidine, and cytidine diphosphate.
Biochem Biophys Rep, 4, 2015
5DDZ
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BU of 5ddz by Molmil
Crystal structure of the RTA-c10-P2 complex
Descriptor: 60S acidic ribosomal protein P2, Ricin
Authors:Zhu, Y, Fan, X, Wang, C, Niu, L, Li, X, Teng, M.
Deposit date:2015-08-25
Release date:2016-09-07
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural insights into the interaction of the ribosomal P stalk protein P2 with a type II ribosome-inactivating protein ricin
Sci Rep, 6, 2016
5CF9
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BU of 5cf9 by Molmil
Cleavage of nicotinamide adenine dinucleotide by the ribosome inactivating protein of Momordica charantia - enzyme-NADP+ co-crystallisation.
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, NICOTINAMIDE, Ribosome-inactivating protein momordin I
Authors:Vinkovic, M, Wood, S.P, Gill, R, Husain, J, Wood, G.E, Dunn, G.
Deposit date:2015-07-08
Release date:2015-07-22
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.52 Å)
Cite:Cleavage of nicotinamide adenine dinucleotide by the ribosome-inactivating protein from Momordica charantia.
Acta Crystallogr.,Sect.F, 71, 2015
3HIQ
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BU of 3hiq by Molmil
Crystal structure of Saporin-L1 mutant (Y73A) from Saponaria officinalis
Descriptor: Vacuolar saporin
Authors:Ho, M, Sturm, M.B, Almo, S.C, Schramm, V.L.
Deposit date:2009-05-20
Release date:2009-12-08
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Transition state analogues in structures of ricin and saporin ribosome-inactivating proteins.
Proc.Natl.Acad.Sci.USA, 106, 2009
3HIV
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BU of 3hiv by Molmil
Crystal structure of Saporin-L1 in complex with the trinucleotide inhibitor, a transition state analogue
Descriptor: (2R,3R,4R,5R)-5-(2-amino-6-oxo-3,6-dihydro-9H-purin-9-yl)-2-({[(S)-({(3R,4R)-4-({[(S)-{[(2R,3R,4R,5R)-5-(2-amino-6-oxo-6,8-dihydro-9H-purin-9-yl)-2-(hydroxymethyl)-4-methoxytetrahydrofuran-3-yl]oxy}(hydroxy)phosphoryl]oxy}methyl)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]pyrrolidin-3-yl}oxy)(hydroxy)phosphoryl]oxy}methyl)-4-methoxytetrahydrofuran-3-yl 3-hydroxypropyl hydrogen (S)-phosphate, Vacuolar saporin
Authors:Ho, M, Sturm, M.B, Almo, S.C, Schramm, V.L.
Deposit date:2009-05-20
Release date:2009-12-08
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Transition state analogues in structures of ricin and saporin ribosome-inactivating proteins.
Proc.Natl.Acad.Sci.USA, 106, 2009
3HIT
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BU of 3hit by Molmil
Crystal structure of Saporin-L1 in complex with the dinucleotide inhibitor, a transition state analogue
Descriptor: 5'-O-[(S)-{[(3R,4R)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-({[(S)-hydroxy(3-hydroxypropoxy)phosphoryl]oxy}methyl)pyrrolidin-3-yl]oxy}(hydroxy)phosphoryl]-3'-O-[(R)-hydroxy(4-hydroxybutoxy)phosphoryl]-2'-O-methylguanosine, Vacuolar saporin
Authors:Ho, M, Sturm, M.B, Almo, S.C, Schramm, V.L.
Deposit date:2009-05-20
Release date:2009-12-08
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Transition state analogues in structures of ricin and saporin ribosome-inactivating proteins.
Proc.Natl.Acad.Sci.USA, 106, 2009
3HIO
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BU of 3hio by Molmil
Crystal structure of Ricin A-chain in complex with the cyclic tetranucleotide inhibitor, a transition state analogue
Descriptor: 9,9'-{(2R,3R,3aR,5S,7aR,9R,10R,10aR,12S,23R,25aR,27R,28R,28aR,30S,32aR,35aR,37S,39aR)-9-(6-amino-9H-purin-9-yl)-34-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-5,12,23,30,37-pentahydroxy-3,10,28-trimethoxy-5,12,23,30,37-pentaoxidotetracosahydro-2H,7H,25H-trifuro[3,2-f:3',2'-l:3'',2''-x]pyrrolo[3,4-r][1,3,5,9,11,15,17,21,23,27,29,2,4,10,16,22,28]undecaoxazapentaphosphacyclopentatriacontine-2,27-diyl}bis(2-amino-3,9-dihydro-6H-purin-6-one), Ricin, SULFATE ION
Authors:Ho, M, Sturm, M.B, Goldman, J.D, Almo, S.C, Schramm, V.L.
Deposit date:2009-05-20
Release date:2009-12-08
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2 Å)
Cite:Transition state analogues in structures of ricin and saporin ribosome-inactivating proteins.
Proc.Natl.Acad.Sci.USA, 106, 2009
6OCD
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BU of 6ocd by Molmil
Ricin A chain bound to VHH antibody V6D4
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, IMIDAZOLE, ...
Authors:Rudolph, M.J.
Deposit date:2019-03-22
Release date:2020-04-01
Last modified:2020-10-14
Method:X-RAY DIFFRACTION (2.103 Å)
Cite:Intracellular Neutralization of Ricin Toxin by Single-domain Antibodies Targeting the Active Site.
J.Mol.Biol., 432, 2020

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