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7OR1
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BU of 7or1 by Molmil
Cryo-EM structure of the human TRPA1 ion channel in complex with the antagonist 3-60, conformation 1
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Grieben, M, Pike, A.C.W, Saward, B.G, Wang, D, Mukhopadhyay, S.M.M, Moreira, T, Chalk, R, MacLean, E.M, Marsden, B.D, Burgess-Brown, N.A, Bountra, C, Schofield, C.J, Carpenter, E.P, Structural Genomics Consortium (SGC)
Deposit date:2021-06-04
Release date:2022-06-22
Method:ELECTRON MICROSCOPY (2.64 Å)
Cite:Cryo-EM structure of the human TRPA1 ion channel in complex with the antagonist 3-60
TO BE PUBLISHED
7OR0
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BU of 7or0 by Molmil
Cryo-EM structure of the human TRPA1 ion channel in complex with the antagonist 3-60, conformation 2
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Grieben, M, Pike, A.C.W, Saward, B.G, Wang, D, Mukhopadhyay, S.M.M, Moreira, T, Chalk, R, MacLean, E.M, Marsden, B.D, Burgess-Brown, N.A, Bountra, C, Schofield, C.J, Carpenter, E.P.
Deposit date:2021-06-04
Release date:2022-06-22
Method:ELECTRON MICROSCOPY (2.64 Å)
Cite:Cryo-EM structure of the human TRPA1 ion channel in complex with the antagonist 3-60
To Be Published
7AA5
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BU of 7aa5 by Molmil
Human TRPV4 structure in presence of 4a-PDD
Descriptor: CALCIUM ION, Transient receptor potential cation channel subfamily V member 4,Green fluorescent protein
Authors:Botte, M, Ulrich, A.K.G, Adaixo, R, Gnutt, D, Brockmann, A, Bucher, D, Chami, M, Bocquet, M, Ebbinghaus-Kintscher, U, Puetter, V, Becker, A, Egner, U, Stahlberg, H, Hennig, M, Holton, S.J.
Deposit date:2020-09-03
Release date:2021-08-18
Last modified:2024-07-10
Method:ELECTRON MICROSCOPY (4.18 Å)
Cite:Cryo-EM structural studies of the agonist complexed human TRPV4 ion-channel reveals novel structural rearrangements resulting in an open-conformation
To Be Published
5D68
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BU of 5d68 by Molmil
Crystal structure of KRIT1 ARD-FERM
Descriptor: Krev interaction trapped protein 1
Authors:Zhang, R, Li, X, Boggon, T.J.
Deposit date:2015-08-11
Release date:2015-10-21
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.908 Å)
Cite:Structural analysis of the KRIT1 ankyrin repeat and FERM domains reveals a conformationally stable ARD-FERM interface.
J.Struct.Biol., 192, 2015
5CZY
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BU of 5czy by Molmil
Crystal structure of LegAS4
Descriptor: GLYCEROL, Legionella effector LegAS4, S-ADENOSYLMETHIONINE
Authors:Son, J, Hwang, K.Y, Lee, W.C.
Deposit date:2015-08-01
Release date:2015-09-23
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of Legionella pneumophila type IV secretion system effector LegAS4
Biochem.Biophys.Res.Commun., 465, 2015
2F8X
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BU of 2f8x by Molmil
Crystal structure of activated Notch, CSL and MAML on HES-1 promoter DNA sequence
Descriptor: 5'-D(*GP*TP*TP*AP*CP*TP*GP*TP*GP*GP*GP*AP*AP*AP*GP*AP*AP*A)-3', 5'-D(*TP*TP*TP*CP*TP*TP*TP*CP*CP*CP*AP*CP*AP*GP*TP*AP*AP*C)-3', Mastermind-like protein 1, ...
Authors:Nam, Y, Sliz, P, Blacklow, S.C.
Deposit date:2005-12-04
Release date:2006-04-04
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes.
Cell(Cambridge,Mass.), 124, 2006
1NFI
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BU of 1nfi by Molmil
I-KAPPA-B-ALPHA/NF-KAPPA-B COMPLEX
Descriptor: I-KAPPA-B-ALPHA, NF-KAPPA-B P50, NF-KAPPA-B P65
Authors:Jacobs, M.D, Harrison, S.C.
Deposit date:1998-08-25
Release date:1998-11-18
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure of an IkappaBalpha/NF-kappaB complex.
Cell(Cambridge,Mass.), 95, 1998
6PBF
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BU of 6pbf by Molmil
ZINC9155420-bound TRPV5 in nanodiscs
Descriptor: (1S)-1-(4-oxo-5-phenyl-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)ethyl [(2S)-3-oxo-3,4-dihydro-2H-1,4-benzothiazin-2-yl]acetate, Transient receptor potential cation channel subfamily V member 5
Authors:Hughes, T.E.T, Rosario, J.S.D, Kapoor, A, Yazici, A.T, Fluck, E.C, Filizola, M, Rohacs, T, Moiseenkova-Bell, V.Y.
Deposit date:2019-06-13
Release date:2019-11-06
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Structure-based characterization of novel TRPV5 inhibitors.
Elife, 8, 2019
6PBE
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BU of 6pbe by Molmil
ZINC17988990-bound TRPV5 in nanodiscs
Descriptor: (4-oxo-5-phenyl-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)methyl 3-(3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)propanoate, Transient receptor potential cation channel subfamily V member 5
Authors:Hughes, T.E.T, Rosario, J.S.D, Kapoor, A, Yazici, A.T, Fluck, E.C, Filizola, M, Rohacs, T, Moiseenkova-Bell, V.Y.
Deposit date:2019-06-13
Release date:2019-11-06
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3.78 Å)
Cite:Structure-based characterization of novel TRPV5 inhibitors.
Elife, 8, 2019
6PQP
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BU of 6pqp by Molmil
Cryo-EM structure of the human TRPA1 ion channel in complex with the covalent agonist BITC
Descriptor: 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, N-benzylthioformamide, ...
Authors:Suo, Y, Wang, Z, Zubcevic, L, Hsu, A.L, He, Q, Borgnia, M.J, Ji, R.-R, Lee, S.-Y.
Deposit date:2019-07-09
Release date:2020-01-08
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.06 Å)
Cite:Structural Insights into Electrophile Irritant Sensing by the Human TRPA1 Channel.
Neuron, 105, 2020
1AWC
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BU of 1awc by Molmil
MOUSE GABP ALPHA/BETA DOMAIN BOUND TO DNA
Descriptor: DNA (5'-D(*AP*AP*(BRU)P*GP*AP*CP*CP*GP*GP*AP*AP*GP*TP*AP*(CBR)P*AP*CP*(CBR)P*GP*GP*A)-3'), DNA (5'-D(*TP*TP*CP*CP*GP*GP*(BRU)P*GP*(BRU)P*AP*CP*TP*TP*CP*CP*GP*GP*TP*CP*AP*T)-3'), PROTEIN (GA BINDING PROTEIN ALPHA), ...
Authors:Batchelor, A.H, Wolberger, C.
Deposit date:1997-10-01
Release date:1998-03-18
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:The structure of GABPalpha/beta: an ETS domain- ankyrin repeat heterodimer bound to DNA.
Science, 279, 1998
4QQI
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BU of 4qqi by Molmil
Crystal structure of ANKRA2-RFX7 complex
Descriptor: Ankyrin repeat family A protein 2, DNA-binding protein RFX7, SULFATE ION, ...
Authors:Xu, C, Tempel, W, Dong, A, Mackenzie, F, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
Deposit date:2014-06-27
Release date:2014-09-03
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Crystal structure of ANKRA2-RFX7 complex
To Be Published
2FO1
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BU of 2fo1 by Molmil
Crystal Structure of the CSL-Notch-Mastermind ternary complex bound to DNA
Descriptor: 5'-D(*AP*AP*TP*CP*TP*TP*TP*CP*CP*CP*AP*CP*AP*GP*T)-3', 5'-D(*TP*TP*AP*CP*TP*GP*TP*GP*GP*GP*AP*AP*AP*GP*A)-3', Lin-12 and glp-1 phenotype protein 1, ...
Authors:Wilson, J.J, Kovall, R.A.
Deposit date:2006-01-12
Release date:2006-03-21
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (3.12 Å)
Cite:Crystal structure of the CSL-Notch-Mastermind ternary complex bound to DNA.
Cell(Cambridge,Mass.), 124, 2006
1AP7
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BU of 1ap7 by Molmil
P19-INK4D FROM MOUSE, NMR, 20 STRUCTURES
Descriptor: P19-INK4D
Authors:Archer, S.J, Luh, F.Y, Domaille, P.J, Smith, B.O, Laue, E.D.
Deposit date:1997-07-25
Release date:1998-09-16
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:Structure of the cyclin-dependent kinase inhibitor p19Ink4d.
Nature, 389, 1997
1BLX
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BU of 1blx by Molmil
P19INK4D/CDK6 COMPLEX
Descriptor: CALCIUM ION, CYCLIN-DEPENDENT KINASE 6, P19INK4D
Authors:Brotherton, D.H, Dhanaraj, V, Wick, S, Brizuela, L, Domaille, P.J, Volyanik, E, Xu, X, Parisini, E, Smith, B.O, Archer, S.J, Serrano, M, Brenner, S.L, Blundell, T.L, Laue, E.D.
Deposit date:1998-07-21
Release date:1999-06-01
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of the complex of the cyclin D-dependent kinase Cdk6 bound to the cell-cycle inhibitor p19INK4d.
Nature, 395, 1998
1OY3
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BU of 1oy3 by Molmil
CRYSTAL STRUCTURE OF AN IKBBETA/NF-KB P65 HOMODIMER COMPLEX
Descriptor: Transcription factor p65, transcription factor inhibitor I-kappa-B-beta
Authors:Malek, S, Huang, D.B, Huxford, T, Ghosh, S, Ghosh, G.
Deposit date:2003-04-03
Release date:2003-05-20
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:X-ray crystal structure of an IkappaBbeta x NF-kappaB p65 homodimer complex.
J.Biol.Chem., 278, 2003
2HE0
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BU of 2he0 by Molmil
Crystal structure of a human Notch1 ankyrin domain mutant
Descriptor: 1,2-ETHANEDIOL, Notch1 preproprotein variant
Authors:Gupta, D, Ehebauer, M.T, Chirgadze, D.Y, Martinez Arias, A, Blundell, T.L.
Deposit date:2006-06-21
Release date:2006-07-04
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of a human Notch1 ankyrin domain mutant
TO BE PUBLISHED
2F8Y
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BU of 2f8y by Molmil
Crystal structure of human Notch1 ankyrin repeats to 1.55A resolution.
Descriptor: Notch homolog 1, translocation-associated (Drosophila), SULFATE ION
Authors:Nam, Y, Sliz, P, Blacklow, S.C.
Deposit date:2005-12-04
Release date:2006-04-04
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes.
Cell(Cambridge,Mass.), 124, 2006
7S89
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BU of 7s89 by Molmil
Open apo-state cryo-EM structure of human TRPV6 in cNW11 nanodiscs
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CALCIUM ION, ...
Authors:Neuberger, A, Nadezhdin, K.D, Sobolevsky, A.I.
Deposit date:2021-09-17
Release date:2021-11-17
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (2.54 Å)
Cite:Structural mechanisms of TRPV6 inhibition by ruthenium red and econazole.
Nat Commun, 12, 2021
7S8C
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BU of 7s8c by Molmil
Cryo-EM structure of human TRPV6 in complex with inhibitor econazole
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 1-[(2R)-2-[(4-chlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole, CALCIUM ION, ...
Authors:Neuberger, A, Nadezhdin, K.D, Sobolevsky, A.I.
Deposit date:2021-09-17
Release date:2021-11-17
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (2.85 Å)
Cite:Structural mechanisms of TRPV6 inhibition by ruthenium red and econazole.
Nat Commun, 12, 2021
7S88
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BU of 7s88 by Molmil
Open apo-state cryo-EM structure of human TRPV6 in glyco-diosgenin detergent
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CALCIUM ION, ...
Authors:Neuberger, A, Nadezhdin, K.D, Sobolevsky, A.I.
Deposit date:2021-09-17
Release date:2021-11-17
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (2.69 Å)
Cite:Structural mechanisms of TRPV6 inhibition by ruthenium red and econazole.
Nat Commun, 12, 2021
7S8B
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BU of 7s8b by Molmil
Cryo-EM structure of human TRPV6 in complex with channel blocker ruthenium red
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CALCIUM ION, ...
Authors:Nadezhdin, K.D, Neuberger, A, Sobolevsky, A.I.
Deposit date:2021-09-17
Release date:2021-11-17
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (2.43 Å)
Cite:Structural mechanisms of TRPV6 inhibition by ruthenium red and econazole.
Nat Commun, 12, 2021
8CSL
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BU of 8csl by Molmil
Sub-tomogram averaging of erythrocyte ankyrin-1 complex
Descriptor: Ammonium transporter Rh type A, Ankyrin-1, Band 3 anion transport protein, ...
Authors:Vallese, F, Kim, K, Yen, L.Y, Johnston, J.D, Noble, A.J, Cali, T, Clarke, O.B.
Deposit date:2022-05-12
Release date:2022-07-20
Last modified:2024-02-14
Method:ELECTRON MICROSCOPY (25 Å)
Cite:Architecture of the human erythrocyte ankyrin-1 complex.
Nat.Struct.Mol.Biol., 29, 2022
4OAV
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BU of 4oav by Molmil
Complete human RNase L in complex with 2-5A (5'-ppp heptamer), AMPPCP and RNA substrate.
Descriptor: (2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-hydroxy-2-({[(S)-hydroxy{[(2R,3S,4S)-4-hydroxy-2-(hydroxymethyl)tetrahydrofuran-3-yl]oxy}phosphoryl]oxy}methyl)tetrahydrofuran-3-yl dihydrogen phosphate, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ...
Authors:Han, Y, Donovan, J, Rath, S, Whitney, G, Chitrakar, A, Korennykh, A.
Deposit date:2014-01-06
Release date:2014-03-12
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of human RNase L reveals the basis for regulated RNA decay in the IFN response.
Science, 343, 2014
8CTE
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BU of 8cte by Molmil
Class 2 of erythrocyte ankyrin-1 complex (Composite map)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Ammonium transporter Rh type A, Ankyrin-1, ...
Authors:Vallese, F, Kim, K, Yen, L.Y, Johnston, J.D, Noble, A.J, Cali, T, Clarke, O.B.
Deposit date:2022-05-14
Release date:2022-07-20
Last modified:2022-07-27
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Architecture of the human erythrocyte ankyrin-1 complex.
Nat.Struct.Mol.Biol., 29, 2022

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