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3RF4
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BU of 3rf4 by Molmil
Ancylostoma ceylanicum mif in complex with furosemide
Descriptor: 5-(AMINOSULFONYL)-4-CHLORO-2-[(2-FURYLMETHYL)AMINO]BENZOIC ACID, ACETATE ION, IMIDAZOLE, ...
Authors:Cho, Y, Lolis, E.
Deposit date:2011-04-05
Release date:2011-10-12
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Drug Repositioning and Pharmacophore Identification in the Discovery of Hookworm MIF Inhibitors.
Chem.Biol., 18, 2011
3RF5
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BU of 3rf5 by Molmil
Ancylostoma ceylanicum mif in complex with n-(2,3,4,5,6-pentafluoro-benzyl)-4-sulfamoyl-benzamide
Descriptor: 2-[(furan-2-ylmethyl)amino]benzoic acid, ACETATE ION, IMIDAZOLE, ...
Authors:Cho, Y, Lolis, E.
Deposit date:2011-04-05
Release date:2011-10-12
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Drug Repositioning and Pharmacophore Identification in the Discovery of Hookworm MIF Inhibitors.
Chem.Biol., 18, 2011
4Q3F
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BU of 4q3f by Molmil
Human D-DT complexed with tartrate
Descriptor: D-dopachrome decarboxylase, L(+)-TARTARIC ACID
Authors:Rajasekaran, D, Lolis, E.
Deposit date:2014-04-11
Release date:2014-06-04
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Targeting distinct tautomerase sites of D-DT and MIF with a single molecule for inhibition of neutrophil lung recruitment.
Faseb J., 28, 2014
3WNR
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BU of 3wnr by Molmil
Multiple binding modes of benzyl isothiocyanate inhibitor complexed with Macrophage Migration Inhibitory Factor
Descriptor: CHLORIDE ION, GLYCEROL, Macrophage migration inhibitory factor, ...
Authors:Spencer, E.S, Dale, E.J, Gommans, A.L, Rutledge, M.T, Gamble, A.B, Smith, R.A.J, Wilbanks, S.M, Hampton, M.B, Tyndall, J.D.A.
Deposit date:2013-12-16
Release date:2014-03-05
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.008 Å)
Cite:Multiple binding modes of isothiocyanates that inhibit macrophage migration inhibitory factor
Eur.J.Med.Chem., 93, 2015
3WNT
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BU of 3wnt by Molmil
Multiple binding modes of benzyl isothiocyanate inhibitor complexed with Macrophage Migration Inhibitory Factor
Descriptor: ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, N-benzylthioformamide, ...
Authors:Spencer, E.S, Dale, E.J, Gommans, A.L, Rutledge, M.T, Gamble, A.B, Smith, R.A.J, Wilbanks, S.M, Hampton, M.B, Tyndall, J.D.A.
Deposit date:2013-12-16
Release date:2014-03-05
Last modified:2015-04-01
Method:X-RAY DIFFRACTION (2.074 Å)
Cite:Multiple binding modes of isothiocyanates that inhibit macrophage migration inhibitory factor
Eur.J.Med.Chem., 93, 2015
3WNS
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BU of 3wns by Molmil
Allyl isothiocyanate inhibitor complexed with Macrophage Migration Inhibitory Factor
Descriptor: CHLORIDE ION, GLYCEROL, ISOPROPYL ALCOHOL, ...
Authors:Spencer, E.S, Dale, E.J, Gommans, A.L, Rutledge, M.T, Gamble, A.B, Smith, R.A.J, Wilbanks, S.M, Hampton, M.B, Tyndall, J.D.A.
Deposit date:2013-12-16
Release date:2014-03-05
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.658 Å)
Cite:Multiple binding modes of isothiocyanates that inhibit macrophage migration inhibitory factor
Eur.J.Med.Chem., 93, 2015
4TRF
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BU of 4trf by Molmil
Crystal structure of Macrophage Migration Inhibitory Factor in complex with N-(pyridin-3-ylmethyl)thioformamide
Descriptor: GLYCEROL, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ...
Authors:Pantouris, G, Lolis, E.
Deposit date:2014-06-16
Release date:2015-09-30
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:An Analysis of MIF Structural Features that Control Functional Activation of CD74.
Chem.Biol., 22, 2015
2XCZ
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BU of 2xcz by Molmil
Crystal Structure of macrophage migration inhibitory factor homologue from Prochlorococcus marinus
Descriptor: DI(HYDROXYETHYL)ETHER, POSSIBLE ATLS1-LIKE LIGHT-INDUCIBLE PROTEIN
Authors:Wasiel, A.A, Rozeboom, H.J, Hauke, D, Baas, B.J, Zandvoort, E, Quax, W.J, Thunnissen, A.M.W.H, Poelarends, G.J.
Deposit date:2010-04-27
Release date:2010-09-01
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Structural and Functional Characterization of a Macrophage Migration Inhibitory Factor Homologue from the Marine Cyanobacterium Prochlorococcus Marinus.
Biochemistry, 49, 2010
6LR3
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BU of 6lr3 by Molmil
Structural and functional insights into macrophage migration inhibitory factor from Oncomelania hupensis, the intermediate host of Schistosoma japonicum
Descriptor: Macrophage migration inhibitory factor, SULFATE ION
Authors:Su, Z.M, Tian, X.Y, Li, H.J, Wei, Z.M, Chen, L.F, Ren, H.X, Peng, W.F, Tang, C.T.
Deposit date:2020-01-15
Release date:2020-07-22
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Structural and functional insights into macrophage migration inhibitory factor from Oncomelania hupensis, the intermediate host of Schistosoma japonicum.
Biochem.J., 477, 2020
6LKV
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BU of 6lkv by Molmil
Structural and functional insights into macrophage migration inhibitory factor from Oncomelania hupensis, the intermediate host of Schistosoma japonicum
Descriptor: CHLORIDE ION, Macrophage migration inhibitory factor, SULFATE ION
Authors:Su, Z.M, Tian, X.Y, Li, H.J, Wei, Z.M, Chen, L.F, Ren, H.X, Peng, W.F, Tang, C.T.
Deposit date:2019-12-20
Release date:2020-07-22
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural and functional insights into macrophage migration inhibitory factor from Oncomelania hupensis, the intermediate host of Schistosoma japonicum.
Biochem.J., 477, 2020
4TRU
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BU of 4tru by Molmil
Crystal structure of Q24A Q25A mutant of human macrophage migration inhibitory factor
Descriptor: GLYCEROL, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ...
Authors:Pantouris, G, Lolis, E.
Deposit date:2014-06-17
Release date:2015-09-30
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:An Analysis of MIF Structural Features that Control Functional Activation of CD74.
Chem.Biol., 22, 2015
6LKW
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BU of 6lkw by Molmil
Structural and functional insights into macrophage migration inhibitory factor from Oncomelania hupensis, the intermediate host of Schistosoma japonicum
Descriptor: CHLORIDE ION, Macrophage migration inhibitory factor
Authors:Su, Z.M, Tian, X.Y, Li, H.J, Wei, Z.M, Chen, L.F, Ren, H.X, Peng, W.F, Tang, C.T.
Deposit date:2019-12-20
Release date:2020-07-22
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural and functional insights into macrophage migration inhibitory factor from Oncomelania hupensis, the intermediate host of Schistosoma japonicum.
Biochem.J., 477, 2020
3B9S
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BU of 3b9s by Molmil
Macrophage Migration Inhibitory Factor (MIF) complexed with Inhibitor, 4-IPP.
Descriptor: 4-phenylpyrimidine, GLYCEROL, Macrophage Migration Inhibitory Factor, ...
Authors:Zierow, S, Crichlow, G, Lolis, E.
Deposit date:2007-11-06
Release date:2008-09-23
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A novel, macrophage migration inhibitory factor suicide substrate inhibits motility and growth of lung cancer cells.
Cancer Res., 68, 2008
3B64
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BU of 3b64 by Molmil
Macrophage Migration Inhibitory Factor (MIF) From /Leishmania Major
Descriptor: ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor-like protein
Authors:Zierow, S, Cho, Y, Lolis, E.
Deposit date:2007-10-27
Release date:2008-06-10
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.03 Å)
Cite:A leishmania ortholog of macrophage migration inhibitory factor modulates host macrophage responses.
J.Immunol., 180, 2008
1P1G
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BU of 1p1g by Molmil
MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) WITH PRO-1 MUTATED TO GLY-1
Descriptor: PROTEIN (MACROPHAGE MIGRATION INHIBITORY FACTOR)
Authors:Lubetsky, J.B, Lolis, E.
Deposit date:1999-03-24
Release date:1999-06-07
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Pro-1 of macrophage migration inhibitory factor functions as a catalytic base in the phenylpyruvate tautomerase activity.
Biochemistry, 38, 1999
5HVT
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BU of 5hvt by Molmil
Crystal Structure of Macrophage Migration Inhibitory Factor (MIF) with a Potent Inhibitor (NVS-2)
Descriptor: 7-hydroxy-3-(4-methoxyphenyl)-3,4-dihydro-2H-1,3-benzoxazin-2-one, GLYCEROL, ISOPROPYL ALCOHOL, ...
Authors:Robertson, M.J, Jorgensen, W.L.
Deposit date:2016-01-28
Release date:2016-06-29
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:A Fluorescence Polarization Assay for Binding to Macrophage Migration Inhibitory Factor and Crystal Structures for Complexes of Two Potent Inhibitors.
J.Am.Chem.Soc., 138, 2016
5HVV
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BU of 5hvv by Molmil
Crystal structure of Pro1 deletion and M2A double mutant of Macrophage Migration Inhibitory Factor
Descriptor: ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, SULFATE ION
Authors:Pantouris, G, Lolis, E.
Deposit date:2016-01-28
Release date:2016-02-10
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of P1 deletion and M2A double mutant of Macrophage Migration Inhibitory Factor
To Be Published
3SMC
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BU of 3smc by Molmil
Macrophage Migration Inhibitory Factor (MIF) with Covalently Bound L-sulforaphane
Descriptor: CHLORIDE ION, Macrophage migration inhibitory factor, N-{4-[(R)-methylsulfinyl]butyl}thioformamide, ...
Authors:Crichlow, G.V, Lolis, E.J.
Deposit date:2011-06-27
Release date:2012-10-03
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural interactions dictate the kinetics of macrophage migration inhibitory factor inhibition by different cancer-preventive isothiocyanates.
Biochemistry, 51, 2012
1MFF
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BU of 1mff by Molmil
MACROPHAGE MIGRATION INHIBITORY FACTOR Y95F MUTANT
Descriptor: MACROPHAGE MIGRATION INHIBITORY FACTOR
Authors:Taylor, A.B, Stamps, S.L, Wang, S.C, Hackert, M.L, Whitman, C.P.
Deposit date:1998-10-19
Release date:1999-07-12
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2 Å)
Cite:Mechanism of the phenylpyruvate tautomerase activity of macrophage migration inhibitory factor: properties of the P1G, P1A, Y95F, and N97A mutants.
Biochemistry, 39, 2000
1MIF
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BU of 1mif by Molmil
MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF)
Descriptor: MACROPHAGE MIGRATION INHIBITORY FACTOR
Authors:Sun, H.-W, Lolis, E.
Deposit date:1996-01-26
Release date:1996-12-07
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure at 2.6-A resolution of human macrophage migration inhibitory factor.
Proc.Natl.Acad.Sci.USA, 93, 1996
4GRN
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BU of 4grn by Molmil
crystal structure of PAAM mutant of human MIF
Descriptor: CHLORIDE ION, Macrophage migration inhibitory factor, SODIUM ION, ...
Authors:Fan, C, Lolis, E, Rajesekaran, D.
Deposit date:2012-08-26
Release date:2013-09-25
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:crystallographic and biological chacerterization of N- and C-terminus of MIF
To be Published
4GRO
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BU of 4gro by Molmil
Crystallographic and biological characterization of N- and C- terminus mutants of human MIF
Descriptor: CHLORIDE ION, Macrophage migration inhibitory factor
Authors:Fan, C, Lolis, E.
Deposit date:2012-08-26
Release date:2013-10-02
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:crystallographic and biological characterization of N- and C- terminus mutants of human MIF
To be Published
6OYB
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BU of 6oyb by Molmil
Crystal structure of H62G mutant of human macrophage migration inhibitory factor
Descriptor: GLYCEROL, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ...
Authors:Pantouris, G, Lolis, E.
Deposit date:2019-05-14
Release date:2020-04-22
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Regulation of MIF Enzymatic Activity by an Allosteric Site at the Central Solvent Channel.
Cell Chem Biol, 27, 2020
6OYE
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BU of 6oye by Molmil
Crystal structure of Y99F mutant of human macrophage migration inhibitory factor
Descriptor: GLYCEROL, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ...
Authors:Pantouris, G, Lolis, E.
Deposit date:2019-05-14
Release date:2020-04-29
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Regulation of MIF Enzymatic Activity by an Allosteric Site at the Central Solvent Channel.
Cell Chem Biol, 27, 2020
3T5S
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BU of 3t5s by Molmil
Structure of macrophage migration inhibitory factor from Giardia lamblia
Descriptor: CHLORIDE ION, Macrophage migration inhibitory factor, SULFATE ION
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2011-07-28
Release date:2011-08-24
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of a macrophage migration inhibitory factor from Giardia lamblia.
J.Struct.Funct.Genom., 14, 2013

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