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8FTB
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BU of 8ftb by Molmil
Crystal structure of integrin beta-2 tail bound to the FERM-folded talin head domain with a K306Q mutation
Descriptor: Integrin beta-2,Talin-1
Authors:Wu, J, Gao, T.
Deposit date:2023-01-11
Release date:2024-07-03
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Structure of Talin Bound to beta 2 Integrin Unveils the Molecular Mechanism of Species-Specific Integrin Activation
Biorxiv, 2024
3PZD
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BU of 3pzd by Molmil
Structure of the myosin X MyTH4-FERM/DCC complex
Descriptor: GLYCEROL, Myosin-X, Netrin receptor DCC
Authors:Wei, Z, Yan, J, Pan, L, Zhang, M.
Deposit date:2010-12-14
Release date:2011-02-23
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Cargo recognition mechanism of myosin X revealed by the structure of its tail MyTH4-FERM tandem in complex with the DCC P3 domain
Proc.Natl.Acad.Sci.USA, 108, 2011
3QIJ
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BU of 3qij by Molmil
Primitive-monoclinic crystal structure of the FERM domain of protein 4.1R
Descriptor: Protein 4.1, UNKNOWN ATOM OR ION
Authors:Nedyalkova, L, Zhong, N, Tong, Y, Tempel, W, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Park, H, Structural Genomics Consortium (SGC)
Deposit date:2011-01-27
Release date:2011-02-09
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Primitive-monoclinic crystal structure of the FERM domain of protein 4.1R
to be published
4P7I
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BU of 4p7i by Molmil
Crystal structure of the Merlin FERM/DCAF1 complex
Descriptor: GLYCEROL, Merlin, Protein VPRBP
Authors:Wei, Z, Li, Y, Zhang, M.
Deposit date:2014-03-27
Release date:2014-04-09
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural basis of the binding of Merlin FERM domain to the E3 ubiquitin ligase substrate adaptor DCAF1.
J.Biol.Chem., 289, 2014
7BYJ
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BU of 7byj by Molmil
Crystal structure of the FERM domain of FRMPD4
Descriptor: FERM and PDZ domain-containing protein 4
Authors:Lin, L, Wang, M, Wang, C, Zhu, J.
Deposit date:2020-04-23
Release date:2020-12-16
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:Structure of the FERM domain of a neural scaffold protein FRMPD4 implicated in X-linked intellectual disability.
Biochem.J., 477, 2020
5XQ0
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BU of 5xq0 by Molmil
Structural basis of kindlin-mediated integrin recognition and activation
Descriptor: Fermitin family homolog 2,Integrin beta-1, GLYCEROL
Authors:Li, H, Yang, H, Sun, K, Zhang, Z, Yu, C, Wei, Z.
Deposit date:2017-06-05
Release date:2017-07-26
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structural basis of kindlin-mediated integrin recognition and activation
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5MV7
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BU of 5mv7 by Molmil
Structure of human Myosin 7b C-terminal MyTH4-FERM MF2 domain
Descriptor: SULFATE ION, TRIS(HYDROXYETHYL)AMINOMETHANE, Unconventional myosin-VIIb
Authors:Planelles-Herrero, V.J, Sourigues, Y, Titus, M.A, Houdusse, A.
Deposit date:2017-01-15
Release date:2017-07-05
Last modified:2024-06-19
Method:X-RAY DIFFRACTION (2.44 Å)
Cite:Myosin 7 and its adaptors link cadherins to actin.
Nat Commun, 8, 2017
5MV9
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BU of 5mv9 by Molmil
Structure of human Myosin 7a C-terminal MyTH4-FERM domain in complex with harmonin-a PDZ3 domain
Descriptor: ACETATE ION, Unconventional myosin-VIIa, cDNA FLJ51329, ...
Authors:Yu, I, Sourigues, Y, Titus, M.A, Houdusse, A.
Deposit date:2017-01-16
Release date:2017-07-05
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Myosin 7 and its adaptors link cadherins to actin.
Nat Commun, 8, 2017
5MV8
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BU of 5mv8 by Molmil
Structure of human Myosin 7b C-terminal MyTH4-FERM domain in complex with harmonin-a PDZ3 domain
Descriptor: GLYCEROL, MAGNESIUM ION, Unconventional myosin-VIIb, ...
Authors:Yu, I, Sourigues, Y, Titus, M.A, Houdusse, A.
Deposit date:2017-01-16
Release date:2017-07-05
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Myosin 7 and its adaptors link cadherins to actin.
Nat Commun, 8, 2017
3X23
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BU of 3x23 by Molmil
Radixin complex
Descriptor: Peptide from Matrix metalloproteinase-14, Radixin
Authors:Terawaki, S, Kitano, K, Aoyama, M, Mori, T, Hakoshima, T.
Deposit date:2014-12-09
Release date:2015-10-21
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.396 Å)
Cite:MT1-MMP recognition by ERM proteins and its implication in CD44 shedding
Genes Cells, 20, 2015
4RMA
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BU of 4rma by Molmil
Crystal structure of the FERM domain of human ezrin
Descriptor: Ezrin, SULFATE ION
Authors:Phang, J.M, Harrop, S.J, Duff, A.P, Wilk, K.E, Curmi, P.M.G.
Deposit date:2014-10-21
Release date:2015-12-09
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural characterization suggests models for monomeric and dimeric forms of full-length ezrin.
Biochem. J., 473, 2016
4RM8
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BU of 4rm8 by Molmil
Crystal structure of human ezrin in space group P21
Descriptor: Ezrin
Authors:Phang, J.M, Harrop, S.J, Davies, R, Duff, A.P, Wilk, K.E, Curmi, P.M.G.
Deposit date:2014-10-20
Release date:2015-12-09
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural characterization suggests models for monomeric and dimeric forms of full-length ezrin.
Biochem. J., 473, 2016
5XPY
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BU of 5xpy by Molmil
Structural basis of kindlin-mediated integrin recognition and activation
Descriptor: ACETATE ION, Fermitin family homolog 2, GLYCEROL
Authors:Li, H, Yang, H, Sun, K, Zhang, Z, Yu, C, Wei, Z.
Deposit date:2017-06-05
Release date:2017-07-26
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.099 Å)
Cite:Structural basis of kindlin-mediated integrin recognition and activation
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5XPZ
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BU of 5xpz by Molmil
Structural basis of kindlin-mediated integrin recognition and activation
Descriptor: Fermitin family homolog 2, GLYCEROL
Authors:Li, H, Yang, H, Sun, K, Zhang, Z, Yu, C, Wei, Z.
Deposit date:2017-06-05
Release date:2017-07-26
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.601 Å)
Cite:Structural basis of kindlin-mediated integrin recognition and activation
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
3U8Z
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BU of 3u8z by Molmil
human merlin FERM domain
Descriptor: Merlin
Authors:Yogesha, S.D, Sharff, A.J, Giovannini, M, Bricogne, G, Izard, T.
Deposit date:2011-10-17
Release date:2011-11-02
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.64 Å)
Cite:Unfurling of the band 4.1, ezrin, radixin, moesin (FERM) domain of the merlin tumor suppressor.
Protein Sci., 20, 2011
4RM9
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BU of 4rm9 by Molmil
Crystal structure of human ezrin in space group C2221
Descriptor: Ezrin
Authors:Phang, J.M, Harrop, S.J, Davies, R, Duff, A.P, Wilk, K.E, Curmi, P.M.G.
Deposit date:2014-10-21
Release date:2015-12-09
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural characterization suggests models for monomeric and dimeric forms of full-length ezrin.
Biochem. J., 473, 2016
7EDR
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BU of 7edr by Molmil
The crystal structure of the FERM and C-terminal domain complex of Drosophila Merlin
Descriptor: Moesin/ezrin/radixin homolog 2
Authors:Zhang, F, Long, J, Zhou, H.
Deposit date:2021-03-16
Release date:2021-04-14
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.527 Å)
Cite:The crystal structure of the FERM and C-terminal domain complex of Drosophila Merlin.
Biochem.Biophys.Res.Commun., 553, 2021
3ZDT
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BU of 3zdt by Molmil
Crystal structure of basic patch mutant FAK FERM domain FAK31- 405 K216A, K218A, R221A, K222A
Descriptor: FOCAL ADHESION KINASE 1
Authors:Goni, G.M, Epifano, C, Boskovic, J, Camacho-Artacho, M, Zhou, J, Martin, M.T, Eck, M.J, Kremer, L, Graeter, F, Gervasio, F.L, Perez-Moreno, M, Lietha, D.
Deposit date:2012-11-30
Release date:2012-12-12
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Phosphatidylinositol 4,5-Bisphosphate Triggers Activation of Focal Adhesion Kinase by Inducing Clustering and Conformational Changes.
Proc.Natl.Acad.Sci.USA, 111, 2014
3WA0
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BU of 3wa0 by Molmil
Crystal structure of merlin complexed with DCAF1/VprBP
Descriptor: Merlin, Protein VPRBP
Authors:Mori, T, Gotoh, S, Shirakawa, M, Hakoshima, T.
Deposit date:2013-04-20
Release date:2014-05-28
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Structural basis of DDB1-and-Cullin 4-associated Factor 1 (DCAF1) recognition by merlin/NF2 and its implication in tumorigenesis by CD44-mediated inhibition of merlin suppression of DCAF1 function.
Genes Cells, 19, 2014
8CIS
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BU of 8cis by Molmil
The FERM domain of human moesin with two bound peptides identified by phage display
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, C3P, ...
Authors:Bradshaw, W.J, Katis, V.L, Leisner, T.M, Fairhead, M, Bountra, C, von Delft, F, Pearce, K.H, Brennan, P.E.
Deposit date:2023-02-10
Release date:2023-03-01
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.52 Å)
Cite:Discovery of FERM domain protein-protein interaction inhibitors for MSN and CD44 as a potential therapeutic approach for Alzheimer's disease.
J.Biol.Chem., 299, 2023
8CIU
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BU of 8ciu by Molmil
The FERM domain of human moesin mutant H288A
Descriptor: Moesin
Authors:Bradshaw, W.J, Katis, V.L, Koekemoer, L, Bountra, C, von Delft, F, Brennan, P.E.
Deposit date:2023-02-10
Release date:2023-03-01
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.393 Å)
Cite:Discovery of FERM domain protein-protein interaction inhibitors for MSN and CD44 as a potential therapeutic approach for Alzheimer's disease.
J.Biol.Chem., 299, 2023
8CIT
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BU of 8cit by Molmil
The FERM domain of human moesin mutant L281R
Descriptor: Moesin
Authors:Bradshaw, W.J, Katis, V.L, Koekemoer, L, Bountra, C, von Delft, F, Brennan, P.E.
Deposit date:2023-02-10
Release date:2023-03-01
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.536 Å)
Cite:Discovery of FERM domain protein-protein interaction inhibitors for MSN and CD44 as a potential therapeutic approach for Alzheimer's disease.
J.Biol.Chem., 299, 2023
8CIR
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BU of 8cir by Molmil
The FERM domain of human moesin with a bound peptide identified by phage display
Descriptor: 1,2-ETHANEDIOL, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BROMIDE ION, ...
Authors:Bradshaw, W.J, Katis, V.L, Leisner, T.M, Fairhead, M, Bountra, C, von Delft, F, Pearce, K.H, Brennan, P.E.
Deposit date:2023-02-10
Release date:2023-03-01
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Discovery of FERM domain protein-protein interaction inhibitors for MSN and CD44 as a potential therapeutic approach for Alzheimer's disease.
J.Biol.Chem., 299, 2023
4ZRK
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BU of 4zrk by Molmil
Merlin-FERM and Lats1 complex
Descriptor: Merlin, Serine/threonine-protein kinase LATS1
Authors:Lin, Z, Li, Y, Wei, Z, Zhang, M.
Deposit date:2015-05-12
Release date:2015-06-17
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.316 Å)
Cite:Angiomotin binding-induced activation of Merlin/NF2 in the Hippo pathway
Cell Res., 25, 2015
4ZRI
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BU of 4zri by Molmil
Crystal structure of Merlin-FERM and Lats2
Descriptor: Merlin, Serine/threonine-protein kinase LATS2
Authors:Li, F, Zhou, H, Long, J, Shen, Y.
Deposit date:2015-05-12
Release date:2015-06-17
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Angiomotin binding-induced activation of Merlin/NF2 in the Hippo pathway
Cell Res., 25, 2015

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