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6XWM
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BU of 6xwm by Molmil
Mechanism of substrate release in neurotransmitter:sodium symporters: the structure of LeuT in an inward-facing occluded conformation
Descriptor: Na(+):neurotransmitter symporter (Snf family), PHENYLALANINE, SODIUM ION
Authors:Boesen, T, Nissen, P, Gotfryd, K, Loland, C.J, Gether, U.
Deposit date:2020-01-24
Release date:2020-05-06
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:X-ray structure of LeuT in an inward-facing occluded conformation reveals mechanism of substrate release.
Nat Commun, 11, 2020
5JAF
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BU of 5jaf by Molmil
LeuT Na+-free Return State, C2 form at pH 5
Descriptor: Transporter, octyl beta-D-glucopyranoside
Authors:Malinauskaite, L, Sahin, C, Said, S, Grouleff, J, Shahsavar, A, Bjerregaard, H, Noer, P, Severinsen, K, Boesen, T, Schiott, B, Sinning, S, Nissen, P.
Deposit date:2016-04-12
Release date:2016-06-01
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.021 Å)
Cite:A conserved leucine occupies the empty substrate site of LeuT in the Na(+)-free return state.
Nat Commun, 7, 2016
8GNK
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BU of 8gnk by Molmil
CryoEM structure of cytosol-facing, substrate-bound ratGAT1
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, CHOLESTEROL, ...
Authors:Nayak, S.R, Joseph, D, Penmatsa, A.
Deposit date:2022-08-24
Release date:2023-05-31
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Cryo-EM structure of GABA transporter 1 reveals substrate recognition and transport mechanism.
Nat.Struct.Mol.Biol., 30, 2023
3QS5
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BU of 3qs5 by Molmil
Crystal structure of LeuT mutant I359Q bound to sodium and L-tryptophan
Descriptor: Na(+):neurotransmitter symporter (Snf family), SODIUM ION, TRYPTOPHAN, ...
Authors:Piscitelli, C.L, Gouaux, E.
Deposit date:2011-02-19
Release date:2011-10-12
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Insights into transport mechanism from LeuT engineered to transport tryptophan.
Embo J., 31, 2012
3QS6
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BU of 3qs6 by Molmil
Crystal structure of LeuT mutant F259V,I359Q bound to sodium and L-tryptophan
Descriptor: Na(+):neurotransmitter symporter (Snf family), SODIUM ION, TRYPTOPHAN, ...
Authors:Piscitelli, C.L, Gouaux, E.
Deposit date:2011-02-19
Release date:2011-10-12
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.801 Å)
Cite:Insights into transport mechanism from LeuT engineered to transport tryptophan.
Embo J., 31, 2012
3QS4
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BU of 3qs4 by Molmil
Crystal structure of LeuT mutant F259V bound to sodium and L-tryptophan
Descriptor: Na(+):neurotransmitter symporter (Snf family), SODIUM ION, TRYPTOPHAN, ...
Authors:Piscitelli, C.L, Gouaux, E.
Deposit date:2011-02-19
Release date:2011-10-12
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.631 Å)
Cite:Insights into transport mechanism from LeuT engineered to transport tryptophan.
Embo J., 31, 2012
4XP4
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BU of 4xp4 by Molmil
X-ray structure of Drosophila dopamine transporter in complex with cocaine
Descriptor: 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE, ANTIBODY FRAGMENT HEAVY CHAIN-PROTEIN, 9D5-HEAVY CHAIN, ...
Authors:Aravind, P, Wang, K, Gouaux, E.
Deposit date:2015-01-16
Release date:2015-05-06
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Neurotransmitter and psychostimulant recognition by the dopamine transporter.
Nature, 521, 2015
4XNU
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BU of 4xnu by Molmil
X-ray structure of Drosophila dopamine transporter in complex with nisoxetine
Descriptor: CHLORIDE ION, CHOLESTEROL, Integral membrane protein-dopamine transporter, ...
Authors:Aravind, P, Wang, K, Gouaux, E.
Deposit date:2015-01-16
Release date:2015-05-13
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.98 Å)
Cite:X-ray structures of Drosophila dopamine transporter in complex with nisoxetine and reboxetine.
Nat.Struct.Mol.Biol., 22, 2015
4XPF
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BU of 4xpf by Molmil
X-ray structure of Drosophila dopamine transporter with subsiteB mutations (D121G/S426M) bound to RTI-55
Descriptor: 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE, ANTIBODY FRAGMENT HEAVY CHAIN-PROTEIN, 9D5-HEAVY CHAIN, ...
Authors:Penmatsa, A, Wang, K.H, Gouaux, E.
Deposit date:2015-01-16
Release date:2015-05-06
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.273 Å)
Cite:Neurotransmitter and psychostimulant recognition by the dopamine transporter.
Nature, 521, 2015
4XPG
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BU of 4xpg by Molmil
X-ray structure of Drosophila dopamine transporter with subsiteB mutations (D121G/S426M) bound to beta-CFT or Win35428
Descriptor: CHLORIDE ION, CHOLESTEROL, Dopamine transporter, ...
Authors:Penmatsa, A, Wang, K.H, Gouaux, E.
Deposit date:2015-01-16
Release date:2015-05-06
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.21 Å)
Cite:Neurotransmitter and psychostimulant recognition by the dopamine transporter.
Nature, 521, 2015
6DZY
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BU of 6dzy by Molmil
Cryo-EM structure of the ts2-active human serotonin transporter in complex with 15B8 Fab and 8B6 ScFv bound to ibogaine
Descriptor: (5beta)-12-methoxyibogamine, 15B8 antibody heavy chain, 15B8 antibody light chain, ...
Authors:Coleman, J.A, Yang, D, Gouaux, E.
Deposit date:2018-07-05
Release date:2019-04-24
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Serotonin transporter-ibogaine complexes illuminate mechanisms of inhibition and transport.
Nature, 569, 2019
6DZV
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BU of 6dzv by Molmil
Wild type human serotonin transporter in complex with 15B8 Fab bound to ibogaine in occluded conformation
Descriptor: (5beta)-12-methoxyibogamine, 15B8 antibody heavy chain, 15B8 antibody light chain, ...
Authors:Coleman, J.A, Yang, D, Gouaux, E.
Deposit date:2018-07-05
Release date:2019-04-24
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Serotonin transporter-ibogaine complexes illuminate mechanisms of inhibition and transport.
Nature, 569, 2019
6DZZ
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BU of 6dzz by Molmil
Cryo-EM Structure of the wild-type human serotonin transporter in complex with ibogaine and 15B8 Fab in the inward conformation
Descriptor: (5beta)-12-methoxyibogamine, 15B8 antibody heavy chain, 15B8 antibody light chain, ...
Authors:Yang, D, Coleman, J.A, Gouaux, E.
Deposit date:2018-07-05
Release date:2019-04-24
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Serotonin transporter-ibogaine complexes illuminate mechanisms of inhibition and transport.
Nature, 569, 2019
6DZW
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BU of 6dzw by Molmil
Cryo-EM structure of the ts2-inactive human serotonin transporter in complex with paroxetine and 15B8 Fab and 8B6 ScFv
Descriptor: 15B8 antibody heavy chain, 15B8 antibody light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Coleman, J.A, Yang, D, Gouaux, E.
Deposit date:2018-07-05
Release date:2019-04-24
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Serotonin transporter-ibogaine complexes illuminate mechanisms of inhibition and transport.
Nature, 569, 2019
3GWV
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BU of 3gwv by Molmil
Leucine transporter LeuT in complex with R-fluoxetine
Descriptor: (3R)-N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine, LEUCINE, SODIUM ION, ...
Authors:Zhou, Z, Zhen, J, Karpowich, N.K, Law, C.J, Reith, M.E.A, Wang, D.N.
Deposit date:2009-04-01
Release date:2009-05-12
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Antidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structures.
Nat.Struct.Mol.Biol., 16, 2009
3GWW
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BU of 3gww by Molmil
Leucine transporter LeuT in complex with S-fluoxetine
Descriptor: (3S)-N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine, LEUCINE, SODIUM ION, ...
Authors:Zhou, Z, Zhen, J, Karpowich, N.K, Law, C.J, Reith, M.E.A, Wang, D.N.
Deposit date:2009-04-01
Release date:2009-05-12
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.46 Å)
Cite:Antidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structures.
Nat.Struct.Mol.Biol., 16, 2009
3GJD
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BU of 3gjd by Molmil
Crystal Structure of LeuT with bound OG
Descriptor: CHLORIDE ION, LEUCINE, SODIUM ION, ...
Authors:Winther, A.M.L, Quick, M, Javitch, J.A, Nissen, P.
Deposit date:2009-03-08
Release date:2009-04-28
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Binding of an octylglucoside detergent molecule in the second substrate (S2) site of LeuT establishes an inhibitor-bound conformation
Proc.Natl.Acad.Sci.USA, 106, 2009
3GJC
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BU of 3gjc by Molmil
Crystal Structure of the E290S mutant of LeuT with bound OG
Descriptor: LEUCINE, SODIUM ION, Transporter, ...
Authors:Winther, A.M.L, Quick, M, Javitch, J.A, Nissen, P.
Deposit date:2009-03-08
Release date:2009-04-28
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Binding of an octylglucoside detergent molecule in the second substrate (S2) site of LeuT establishes an inhibitor-bound conformation
Proc.Natl.Acad.Sci.USA, 106, 2009
3GWU
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BU of 3gwu by Molmil
Leucine transporter LeuT in complex with sertraline
Descriptor: (1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine, LEUCINE, SODIUM ION, ...
Authors:Zhou, Z, Zhen, J, Karpowich, N.K, Law, C.J, Reith, M.E.A, Wang, D.N.
Deposit date:2009-04-01
Release date:2009-05-12
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Antidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structures.
Nat.Struct.Mol.Biol., 16, 2009
5I6Z
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BU of 5i6z by Molmil
X-ray structure of the ts2 human serotonin transporter
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 8B6 antibody, heavy chain, ...
Authors:Coleman, J.A, Green, E.M, Gouaux, E.
Deposit date:2016-02-16
Release date:2016-04-13
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (4.53 Å)
Cite:X-ray structures and mechanism of the human serotonin transporter.
Nature, 532, 2016
5I73
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BU of 5i73 by Molmil
X-ray structure of the ts3 human serotonin transporter complexed with s-citalopram at the central and allosteric sites
Descriptor: (1S)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile, 2-acetamido-2-deoxy-beta-D-glucopyranose, 6-AMINOHEXANOIC ACID, ...
Authors:Coleman, J.A, Green, E.M, Gouaux, E.
Deposit date:2016-02-16
Release date:2016-04-13
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (3.24 Å)
Cite:X-ray structures and mechanism of the human serotonin transporter.
Nature, 532, 2016
5I75
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BU of 5i75 by Molmil
X-ray structure of the ts3 human serotonin transporter complexed with s-citalopram at the central site and Br-citalopram at the allosteric site
Descriptor: (1S)-1-(4-bromophenyl)-1-[3-(dimethylamino)propyl]-1,3-dihydro-2-benzofuran-5-carbonitrile, (1S)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Coleman, J.A, Green, E.M, Gouaux, E.
Deposit date:2016-02-16
Release date:2016-04-13
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.49 Å)
Cite:X-ray structures and mechanism of the human serotonin transporter.
Nature, 532, 2016
5I74
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BU of 5i74 by Molmil
X-ray structure of the ts3 human serotonin transporter complexed with Br-citalopram at the central site
Descriptor: (1S)-1-(4-bromophenyl)-1-[3-(dimethylamino)propyl]-1,3-dihydro-2-benzofuran-5-carbonitrile, 2-acetamido-2-deoxy-beta-D-glucopyranose, 8B6 antibody, ...
Authors:Coleman, J.A, Green, E.M, Gouaux, E.
Deposit date:2016-02-16
Release date:2016-04-13
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.395 Å)
Cite:X-ray structures and mechanism of the human serotonin transporter.
Nature, 532, 2016
5I71
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BU of 5i71 by Molmil
X-ray structure of the ts3 human serotonin transporter complexed with s-citalopram at the central site
Descriptor: (1S)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile, 2-acetamido-2-deoxy-beta-D-glucopyranose, 8B6 antibody, ...
Authors:Coleman, J.A, Green, E.M, Gouaux, E.
Deposit date:2016-02-16
Release date:2016-04-13
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:X-ray structures and mechanism of the human serotonin transporter.
Nature, 532, 2016
5I6X
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BU of 5i6x by Molmil
X-ray structure of the ts3 human serotonin transporter complexed with paroxetine at the central site
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 8B6 antibody, heavy chain, ...
Authors:Coleman, J.A, Green, E.M, Gouaux, E.
Deposit date:2016-02-16
Release date:2016-04-13
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.14 Å)
Cite:X-ray structures and mechanism of the human serotonin transporter.
Nature, 532, 2016

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