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3U0E
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BU of 3u0e by Molmil
Crystal structure of beta-ketoacyl synthase from Brucella melitensis in complex with fragment 9320
Descriptor: 8-methylquinolin-4-amine, Beta-ketoacyl synthase, CHLORIDE ION, ...
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2011-09-28
Release date:2011-10-26
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural characterization of beta-ketoacyl ACP synthase I bound to platencin and fragment screening molecules at two substrate binding sites.
Proteins, 88, 2020
1J3N
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BU of 1j3n by Molmil
Crystal Structure of 3-oxoacyl-(acyl-carrier protein) Synthase II from Thermus thermophilus HB8
Descriptor: 3-oxoacyl-(acyl-carrier protein) synthase II, CITRIC ACID, MAGNESIUM ION
Authors:Bagautdinov, B, Miyano, M, Tahirov, T.H, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2003-02-10
Release date:2003-03-11
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of 3-oxoacyl-(acyl-carrier protein) synthase II from Thermus thermophilus HB8.
Acta Crystallogr.,Sect.F, 64, 2008
1OXH
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BU of 1oxh by Molmil
The crystal structure of beta-ketoacyl-[acyl carrier protein] synthase II from Streptococcus Pneumoniae, Triclinic form
Descriptor: Beta ketoacyl-acyl carrier protein synthase, MAGNESIUM ION
Authors:Price, A.C, Rock, C.O, White, S.W.
Deposit date:2003-04-02
Release date:2003-04-22
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:The 1.3-Angstrom-Resolution Crystal Structure of beta-Ketoacyl-Acyl Carrier Protein Synthase II from Streptococcus pneumoniae.
J.Bacteriol., 185, 2003
4WKY
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BU of 4wky by Molmil
Streptomcyes albus JA3453 oxazolomycin ketosynthase domain OzmN KS2
Descriptor: 1,2-ETHANEDIOL, Beta-ketoacyl synthase, GLYCEROL, ...
Authors:Cuff, M.E, Mack, J.C, Endres, M, Babnigg, G, Bingman, C.A, Yennamalli, R, Lohman, J.R, Ma, M, Shen, B, Phillips Jr, G.N, Joachimiak, A, Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro)
Deposit date:2014-10-03
Release date:2014-10-29
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and evolutionary relationships of "AT-less" type I polyketide synthase ketosynthases.
Proc.Natl.Acad.Sci.USA, 112, 2015
5KOF
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BU of 5kof by Molmil
Crosslinked Crystal Structure of Type II Fatty Acid Synthase Ketosynthase, FabB, and Acyl Carrier Protein, AcpP
Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase 1, Acyl carrier protein, [(3~{S})-2,2-dimethyl-3-oxidanyl-4-oxidanylidene-4-[[3-oxidanylidene-3-[2-(prop-2-enoylamino)ethylamino]propyl]amino]butyl] dihydrogen phosphate
Authors:Milligan, J.C, Jackson, D.R, Barajas, J.F, Tsai, S.C.
Deposit date:2016-06-30
Release date:2018-01-24
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Molecular basis for interactions between an acyl carrier protein and a ketosynthase.
Nat.Chem.Biol., 15, 2019
6WC7
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BU of 6wc7 by Molmil
Acyl carrier protein (ACP) domain bound to dehydratase (DH) domain in fungal fatty acid synthase (FAS)
Descriptor: Fatty acid synthase subunit alpha, Fatty acid synthase subunit beta
Authors:Lou, J.W, Mazhab-Jafari, M.T.
Deposit date:2020-03-29
Release date:2020-06-03
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (5.8 Å)
Cite:Steric occlusion regulates proximal interactions of acyl carrier protein domain in fungal fatty acid synthase.
Commun Biol, 3, 2020
6Y2I
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BU of 6y2i by Molmil
Crystal structure of M. tuberculosis KasA in complex with N-(1H-indazol-5-yl)butane-1-sulfonamide
Descriptor: 1,2-ETHANEDIOL, 3-oxoacyl-[acyl-carrier-protein] synthase 1, SODIUM ION, ...
Authors:Chung, C.
Deposit date:2020-02-16
Release date:2020-04-08
Last modified:2024-05-15
Method:X-RAY DIFFRACTION (1.533 Å)
Cite:Exploring the SAR of the beta-Ketoacyl-ACP Synthase Inhibitor GSK3011724A and Optimization around a Genotoxic Metabolite.
Acs Infect Dis., 6, 2020
3U0F
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BU of 3u0f by Molmil
The structure of Beta-ketoacyl synthase from Brucella melitensis bound to the fragment 7-hydroxycoumarin
Descriptor: 7-hydroxy-2H-chromen-2-one, Beta-ketoacyl synthase, CHLORIDE ION, ...
Authors:Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2011-09-28
Release date:2011-10-12
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Structural characterization of beta-ketoacyl ACP synthase I bound to platencin and fragment screening molecules at two substrate binding sites.
Proteins, 88, 2020
5LD8
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BU of 5ld8 by Molmil
GSK3011724A cocrystallised with Mycobacterium tuberculosis H37Rv KasA
Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase 1, SODIUM ION, TETRAETHYLENE GLYCOL, ...
Authors:Chung, C.W, Neu, M.
Deposit date:2016-06-23
Release date:2016-09-21
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:Identification of KasA as the cellular target of an anti-tubercular scaffold.
Nat Commun, 7, 2016
1KAS
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BU of 1kas by Molmil
BETA-KETOACYL-ACP SYNTHASE II FROM ESCHERICHIA COLI
Descriptor: BETA-KETOACYL ACP SYNTHASE II
Authors:Huang, W, Jia, J, Edwards, P, Dehesh, K, Schneider, G, Lindqvist, Y.
Deposit date:1997-12-22
Release date:1999-03-02
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of beta-ketoacyl-acyl carrier protein synthase II from E.coli reveals the molecular architecture of condensing enzymes.
EMBO J., 17, 1998
1OX0
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BU of 1ox0 by Molmil
The crystal structure of beta-ketoacyl-[acyl carrier protein] synthase II from Streptococcus pneumoniae
Descriptor: Beta ketoacyl-acyl carrier protein synthase, MAGNESIUM ION
Authors:Price, A.C, Rock, C.O, White, S.W.
Deposit date:2003-03-31
Release date:2003-04-22
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:The 1.3-Angstrom-Resolution Crystal Structure of beta-Ketoacyl-Acyl Carrier Protein Synthase II from Streptococcus pneumoniae.
J.Bacteriol., 185, 2003
3O04
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BU of 3o04 by Molmil
Crystal structure of the beta-keto-acyl carrier protein synthase II (lmo2201) from Listeria monocytogenes
Descriptor: beta-keto-acyl carrier protein synthase II
Authors:Anderson, S.M, Wawrzak, Z, Onopriyenko, O, Anderson, W.F, Savchenko, A, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2010-07-19
Release date:2010-08-04
Last modified:2021-10-06
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal structure of the beta-keto-acyl carrier protein synthase II (lmo2201) from Listeria monocytogenes
To be Published
3G11
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BU of 3g11 by Molmil
Structure of E. coli FabF(C163Q) in complex with dihydrophenyl platensimycin
Descriptor: 3-({3-[(1S,4S,4aS,6S,7S,9S,9aR)-1,6-dimethyl-2-oxo-4-phenyldecahydro-6,9-epoxy-4a,7-methanobenzo[7]annulen-1-yl]propanoyl}amino)-2,4-dihydroxybenzoic acid, 3-oxoacyl-[acyl-carrier-protein] synthase 2
Authors:Soisson, S.M, Parthasarathy, G.
Deposit date:2009-01-29
Release date:2009-03-17
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Synthesis and biological evaluation of platensimycin analogs.
Bioorg.Med.Chem.Lett., 19, 2009
8CG5
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BU of 8cg5 by Molmil
The ACP crosslinked to the KS of the cercosporin fungal non-reducing polyketide synthase (NR-PKS) CTB1 (SAT-KS:ACP-MAT)
Descriptor: Acyl carrier protein (ACP) of Non-reducing polyketide synthase CTB1, Non-reducing polyketide synthase CTB1, N~3~-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-N-[2-(propanoylamino)ethyl]-beta-alaninamide
Authors:Munoz-Hernandez, H, Tittes, Y.U, Maier, T.
Deposit date:2023-02-03
Release date:2024-02-21
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:CryoEM structure of ACP crosslinked to KS of the cercosporin fungal non-reducing polyketide synthase (NR-PKS) CTB1 (SAT-KS:ACP-MAT) at 2.7 Angstroms resolution
To Be Published
8CG4
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BU of 8cg4 by Molmil
The organise full-length structure of the fungal non-reducing polyketide synthase (NR-PKS) PksA
Descriptor: Norsolorinic acid synthase
Authors:Munoz-Hernandez, H, Maier, T.
Deposit date:2023-02-03
Release date:2024-02-21
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:CryoEM structure of the Aspergilus sp. fungal non-reducing polyketide synthase (NR-PKS) PksA at 2.6 Angstroms resolution
To Be Published
7OC1
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BU of 7oc1 by Molmil
Structure of Pseudomonas aeruginosa FabF mutant C164Q in complex with Platensimycin
Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase 2, DIMETHYL SULFOXIDE, GLYCEROL, ...
Authors:Georgiou, C, Brenk, R, Espeland, L.O, Klein, R.
Deposit date:2021-04-25
Release date:2021-08-25
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:An Experimental Toolbox for Structure-Based Hit Discovery for P. aeruginosa FabF, a Promising Target for Antibiotics.
Chemmedchem, 16, 2021
7OC0
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BU of 7oc0 by Molmil
Structure of Pseudomonas aeruginosa FabF mutant C164Q in complex with a ligand (2S,4R)-2-(thiophen-2-yl)thiazolidine-4-carboxylic acid
Descriptor: (2S,4R)-2-(thiophen-2-yl)thiazolidine-4-carboxylic acid, 3-oxoacyl-[acyl-carrier-protein] synthase 2, DIMETHYL SULFOXIDE, ...
Authors:Georgiou, C, Brenk, R, Espeland, L.O, Klein, R.
Deposit date:2021-04-25
Release date:2021-08-25
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:An Experimental Toolbox for Structure-Based Hit Discovery for P. aeruginosa FabF, a Promising Target for Antibiotics.
Chemmedchem, 16, 2021
7VEF
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BU of 7vef by Molmil
The structure of GfsA KSQ-AT didomain in complex with a malonate substrate analog
Descriptor: GLYCEROL, N-(2-acetamidoethyl)-2-nitro-ethanamide, Polyketide synthase
Authors:Chisuga, T, Miyanaga, A, Nagai, A, Kudo, F, Eguchi, T.
Deposit date:2021-09-08
Release date:2022-01-12
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structural Insight into the Reaction Mechanism of Ketosynthase-Like Decarboxylase in a Loading Module of Modular Polyketide Synthases.
Acs Chem.Biol., 17, 2022
7VEE
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BU of 7vee by Molmil
The ligand-free structure of GfsA KSQ-AT didomain
Descriptor: GLYCEROL, Polyketide synthase
Authors:Chisuga, T, Miyanaga, A, Nagai, A, Kudo, F, Eguchi, T.
Deposit date:2021-09-08
Release date:2022-01-12
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structural Insight into the Reaction Mechanism of Ketosynthase-Like Decarboxylase in a Loading Module of Modular Polyketide Synthases.
Acs Chem.Biol., 17, 2022
8CJH
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BU of 8cjh by Molmil
Architecture of a PKS-NRPS hybrid megaenzyme involved in the biosynthesis of the genotoxin colibactin
Descriptor: Colibactin hybrid non-ribosomal peptide synthetase/type I polyketide synthase ClbK
Authors:Bonhomme, S, Dessen, A, Macheboeuf, P.
Deposit date:2023-02-13
Release date:2023-04-26
Last modified:2024-06-19
Method:X-RAY DIFFRACTION (2.982 Å)
Cite:Architecture of a PKS-NRPS hybrid megaenzyme involved in the biosynthesis of the genotoxin colibactin.
Structure, 31, 2023
3KZU
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BU of 3kzu by Molmil
Crystal structure of 3-oxoacyl-(acyl carrier protein) synthase II from Brucella melitensis
Descriptor: 1,2-ETHANEDIOL, 3-oxoacyl-(Acyl-carrier-protein) synthase ii, SULFATE ION
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2009-12-08
Release date:2009-12-15
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Crystal structure of 3-oxoacyl-(acyl carrier protein) synthase II from Brucella melitensis
TO BE PUBLISHED
4Z37
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BU of 4z37 by Molmil
Structure of the ketosynthase of module 2 of C0ZGQ5 (trans-AT PKS) from Brevibacillus brevis
Descriptor: Putative mixed polyketide synthase/non-ribosomal peptide synthetase
Authors:Martin, S.F, Jakob, R.P, Herbst, D.A, Maier, T.
Deposit date:2015-03-31
Release date:2016-04-13
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.998 Å)
Cite:The structural organization of trans-AT polyketide synthases: ketoacyl synthase and trans-acting enoyl reductase
To Be Published
4EWG
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BU of 4ewg by Molmil
Crystal structure of a Beta-ketoacyl synthase from Burkholderia phymatum STM815
Descriptor: 1,2-ETHANEDIOL, Beta-ketoacyl synthase, CALCIUM ION, ...
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2012-04-26
Release date:2012-05-16
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Combining functional and structural genomics to sample the essential Burkholderia structome.
Plos One, 8, 2013
4F32
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BU of 4f32 by Molmil
Crystal structure of 3-oxoacyl-[acyl-carrier-protein] synthase II from Burkholderia vietnamiensis in complex with platencin
Descriptor: 1,2-ETHANEDIOL, 2,4-dihydroxy-3-({3-[(2S,4aS,8S,8aR)-8-methyl-3-methylidene-7-oxo-1,3,4,7,8,8a-hexahydro-2H-2,4a-ethanonaphthalen-8-yl]propanoyl}amino)benzoic acid, 3-oxoacyl-[acyl-carrier-protein] synthase 2, ...
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2012-05-08
Release date:2012-05-23
Last modified:2014-02-12
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Combining functional and structural genomics to sample the essential Burkholderia structome.
Plos One, 8, 2013
3LRF
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BU of 3lrf by Molmil
Crystal structure of beta-ketoacyl synthase from brucella melitensis
Descriptor: Beta-ketoacyl synthase, SODIUM ION
Authors:Abendroth, J, Edwards, T, Staker, B, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2010-02-11
Release date:2010-03-31
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural characterization of beta-ketoacyl ACP synthase I bound to platencin and fragment screening molecules at two substrate binding sites.
Proteins, 88, 2020

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