6S4C
| Crystal Structure of the vWFA2 subdomain of type VII collagen | Descriptor: | Collagen alpha-1(VII) chain, MAGNESIUM ION, PHOSPHATE ION, ... | Authors: | Gebauer, J.M, Flachsenberg, F, Baumann, U, Seeger, K. | Deposit date: | 2019-06-27 | Release date: | 2020-02-19 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural and biophysical characterization of the type VII collagen vWFA2 subdomain leads to identification of two binding sites. Febs Open Bio, 10, 2020
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6SNK
| Crystal structure of the Collagen VI alpha3 N2 domain | Descriptor: | Collagen alpha-3(VI) chain | Authors: | Gebauer, J.M, Degefa, H.S, Paulsson, M, Wagener, R, Baumann, U. | Deposit date: | 2019-08-26 | Release date: | 2020-07-29 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structure of a collagen VI alpha 3 chain VWA domain array: adaptability and functional implications of myopathy causing mutations. J.Biol.Chem., 295, 2020
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6ADR
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3M6F
| CD11A I-domain complexed with 6-((5S,9R)-9-(4-CYANOPHENYL)-3-(3,5-DICHLOROPHENYL)-1-METHYL-2,4-DIOXO-1,3,7- TRIAZASPIRO[4.4]NON-7-YL)NICOTINIC ACID | Descriptor: | 6-[(5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non-7-yl]pyridine-3-carboxylic acid, Integrin alpha-L, NITRATE ION | Authors: | Sheriff, S. | Deposit date: | 2010-03-15 | Release date: | 2010-05-12 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Small molecule antagonist of leukocyte function associated antigen-1 (LFA-1): structure-activity relationships leading to the identification of 6-((5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)nicotinic acid (BMS-688521). J.Med.Chem., 53, 2010
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3BQN
| LFA-1 I domain bound to inhibitors | Descriptor: | 4-{(2E)-3-[4-{[2-(pyridin-3-ylmethoxy)phenyl]sulfanyl}-2,3-bis(trifluoromethyl)phenyl]prop-2-enoyl}morpholine, Integrin alpha-L | Authors: | Silvian, L.F. | Deposit date: | 2007-12-20 | Release date: | 2008-08-19 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure-activity relationship of ortho- and meta-phenol based LFA-1 ICAM inhibitors Bioorg.Med.Chem.Lett., 18, 2008
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3N2N
| The Crystal Structure of Tumor Endothelial Marker 8 (TEM8) extracellular domain | Descriptor: | ACETATE ION, Anthrax toxin receptor 1, MAGNESIUM ION | Authors: | Fu, S, Tong, X.H, Wu, Y, Li, Y.Y, Rao, Z.H. | Deposit date: | 2010-05-18 | Release date: | 2011-01-05 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | The structure of tumor endothelial marker 8 (TEM8) extracellular domain and implications for its receptor function for recognizing anthrax toxin. Plos One, 5, 2010
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3BQM
| LFA-1 I domain bound to inhibitors | Descriptor: | 3-({4-[(1E)-3-morpholin-4-yl-3-oxoprop-1-en-1-yl]-2,3-bis(trifluoromethyl)phenyl}sulfanyl)aniline, Integrin alpha-L | Authors: | Silvian, L.F. | Deposit date: | 2007-12-20 | Release date: | 2008-08-19 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Design and synthesis of a series of meta aniline-based LFA-1 ICAM inhibitors Bioorg.Med.Chem.Lett., 18, 2008
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3PPV
| Crystal structure of an engineered VWF A2 domain (N1493C and C1670S) | Descriptor: | CALCIUM ION, SULFATE ION, von Willebrand factor | Authors: | Zhou, M, Dong, X, Zhong, C, Ding, J. | Deposit date: | 2010-11-25 | Release date: | 2011-05-04 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | A novel calcium-binding site of von Willebrand factor A2 domain regulates its cleavage by ADAMTS13 Blood, 117, 2011
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3PPX
| Crystal structure of the N1602A mutant of an engineered VWF A2 domain (N1493C and C1670S) | Descriptor: | SODIUM ION, von Willebrand factor | Authors: | Zhou, M, Dong, X, Zhong, C, Ding, J. | Deposit date: | 2010-11-25 | Release date: | 2011-05-04 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.91 Å) | Cite: | A novel calcium-binding site of von Willebrand factor A2 domain regulates its cleavage by ADAMTS13 Blood, 117, 2011
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3E2M
| LFA-1 I domain bound to inhibitors | Descriptor: | Integrin alpha-L, cis-4-{[2-({4-[(1E)-3-morpholin-4-yl-3-oxoprop-1-en-1-yl]-2,3-bis(trifluoromethyl)phenyl}sulfanyl)phenoxy]methyl}cyclohexanecarboxylic acid | Authors: | Silvian, L.F. | Deposit date: | 2008-08-05 | Release date: | 2008-08-19 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure-activity relationship of ortho- and meta-phenol based LFA-1 ICAM inhibitors Bioorg.Med.Chem.Lett., 18, 2008
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3Q3G
| Crystal Structure of A-domain in complex with antibody | Descriptor: | 1,2-ETHANEDIOL, Antibody Heavy chain, Antibody Light Chain, ... | Authors: | Mahalingam, B, Xiong, J.P, Arnaout, M.A. | Deposit date: | 2010-12-21 | Release date: | 2011-11-30 | Last modified: | 2011-12-28 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Stable Coordination of the Inhibitory Ca2+ Ion at the Metal Ion-Dependent Adhesion Site in Integrin CD11b/CD18 by an Antibody-Derived Ligand Aspartate: Implications for Integrin Regulation and Structure-Based Drug Design. J.Immunol., 187, 2011
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3PPW
| Crystal structure of the D1596A mutant of an engineered VWF A2 domain (N1493C and C1670S) | Descriptor: | SODIUM ION, von Willebrand factor | Authors: | Zhou, M, Dong, X, Zhong, C, Ding, J. | Deposit date: | 2010-11-25 | Release date: | 2011-05-04 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | A novel calcium-binding site of von Willebrand factor A2 domain regulates its cleavage by ADAMTS13 Blood, 117, 2011
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3EOB
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3PPY
| Crystal structure of the D1596A/N1602A double mutant of an engineered VWF A2 domain (N1493C and C1670S) | Descriptor: | SODIUM ION, von Willebrand factor | Authors: | Zhou, M, Dong, X, Zhong, C, Ding, J. | Deposit date: | 2010-11-25 | Release date: | 2011-05-04 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | A novel calcium-binding site of von Willebrand factor A2 domain regulates its cleavage by ADAMTS13 Blood, 117, 2011
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3EOA
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3QA3
| Crystal Structure of A-domain in complex with antibody | Descriptor: | 1,2-ETHANEDIOL, Antibody Heavy chain, Antibody Light chain, ... | Authors: | Mahalingam, B, Xiong, J.P, Arnaout, M.A. | Deposit date: | 2011-01-10 | Release date: | 2011-11-30 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Stable Coordination of the Inhibitory Ca2+ Ion at the Metal Ion-Dependent Adhesion Site in Integrin CD11b/CD18 by an Antibody-Derived Ligand Aspartate: Implications for Integrin Regulation and Structure-Based Drug Design. J.Immunol., 187, 2011
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3F78
| Crystal structure of wild type LFA1 I domain complexed with isoflurane | Descriptor: | 1-CHLORO-2,2,2-TRIFLUOROETHYL DIFLUOROMETHYL ETHER, GLYCEROL, Integrin alpha-L, ... | Authors: | Zhang, H, Wang, J.-H. | Deposit date: | 2008-11-07 | Release date: | 2009-06-23 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Crystal structure of isoflurane bound to integrin LFA-1 supports a unified mechanism of volatile anesthetic action in the immune and central nervous systems. Faseb J., 23, 2009
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3F74
| Crystal structure of wild type LFA1 I domain | Descriptor: | GLYCEROL, Integrin alpha-L, MAGNESIUM ION | Authors: | Zhang, H, Wang, J.-H. | Deposit date: | 2008-11-07 | Release date: | 2009-06-23 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Crystal structure of isoflurane bound to integrin LFA-1 supports a unified mechanism of volatile anesthetic action in the immune and central nervous systems. Faseb J., 23, 2009
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3ZQK
| Von Willebrand Factor A2 domain with calcium | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, GLYCEROL, ... | Authors: | Jakobi, A.J, Huizinga, E.G. | Deposit date: | 2011-06-09 | Release date: | 2011-07-27 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Calcium Modulates Force Sensing by the Von Willebrand Factor A2 Domain. Nat.Commun., 2, 2011
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4A0Q
| Activated Conformation of Integrin alpha1 I-Domain mutant | Descriptor: | INTEGRIN ALPHA-1, MAGNESIUM ION | Authors: | Lahti, M, Bligt, E, Niskanen, H, Parkash, V, Brandt, A.-M, Jokinen, J, Patrikainen, P, Kapyla, J, Heino, J, Salminen, T.A. | Deposit date: | 2011-09-12 | Release date: | 2011-10-26 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structure of Collagen Receptor Integrin Aplha1I Domain Carrying the Activating Mutation E317A. J.Biol.Chem., 286, 2011
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8FZ4
| The von Willebrand factor A domain of Anthrax toxin receptor 2 | Descriptor: | Anthrax toxin receptor 2, CHLORIDE ION, MAGNESIUM ION | Authors: | Pedroza-Romo, M.J, Soleimani, S, Lewis, A, Smith, T, Brown, S, Doukov, T, Moody, J.D. | Deposit date: | 2023-01-27 | Release date: | 2023-03-01 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.19 Å) | Cite: | Increasing the bulk of the 1TEL-target linker and retaining the 10xHis tag in a 1TEL-CMG2-vWa construct improves crystal order and diffraction limits Acta Crystallogr.,Sect.D, 79, 2023
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4C29
| Crystal Structure of High-Affinity von Willebrand Factor A1 domain with Disulfide Mutation | Descriptor: | ACETATE ION, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Blenner, M.A, Dong, X, Springer, T.A. | Deposit date: | 2013-08-16 | Release date: | 2014-01-08 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.202 Å) | Cite: | Towards the Structural Basis of Regulation of Von Willebrand Factor Binding to Glycoprotein Ib J.Biol.Chem., 289, 2014
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4CN9
| structure of proximal thread matrix protein 1 (PTMP1) from the mussel byssus with zinc occupied MIDAS motif | Descriptor: | 1,2-ETHANEDIOL, GLYCEROL, PROXIMAL THREAD MATRIX PROTEIN 1, ... | Authors: | Gertz, M, Suhre, M.H, Scheibel, T, Steegborn, C. | Deposit date: | 2014-01-21 | Release date: | 2014-03-12 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural and Functional Features of a Collagen-Binding Matrix Protein from the Mussel Byssus. Nat.Commun., 5, 2014
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4CNB
| Structure of proximal thread matrix protein 1 (PTMP1) from the mussel byssus - Crystal form 2 | Descriptor: | 1,2-ETHANEDIOL, PROXIMAL THREAD MATRIX PROTEIN 1, SULFATE ION | Authors: | Gertz, M, Suhre, M.H, Scheibel, T, Steegborn, C. | Deposit date: | 2014-01-21 | Release date: | 2014-03-12 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structural and Functional Features of a Collagen-Binding Matrix Protein from the Mussel Byssus. Nat.Commun., 5, 2014
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4CN8
| Structure of proximal thread matrix protein 1 (PTMP1) from the mussel byssus | Descriptor: | 1,2-ETHANEDIOL, PROXIMAL THREAD MATRIX PROTEIN 1, SULFATE ION | Authors: | Gertz, M, Suhre, M.H, Scheibel, T, Steegborn, C. | Deposit date: | 2014-01-21 | Release date: | 2014-03-12 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Structural and Functional Features of a Collagen-Binding Matrix Protein from the Mussel Byssus. Nat.Commun., 5, 2014
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