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6K8T
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Crystal structure of C-domain with CoA of baterial malonyl-CoA reductase
Descriptor: COENZYME A, GLYCEROL, NAD-dependent epimerase/dehydratase:Short-chain dehydrogenase/reductase SDR, ...
Authors:Kim, S, Kim, K.-J.
Deposit date:2019-06-13
Release date:2020-03-18
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural insight into bi-functional malonyl-CoA reductase.
Environ.Microbiol., 22, 2020
1Y5M
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The crystal structure of murine 11b-hydroxysteroid dehydrogenase: an important therapeutic target for diabetes
Descriptor: Corticosteroid 11-beta-dehydrogenase, isozyme 1, N-OCTANE, ...
Authors:Zhang, J, Osslund, T.D, Plant, M.H, Clogston, C.L, Nybo, R.E, Xiong, F, Delaney, J.M, Jordan, S.R.
Deposit date:2004-12-02
Release date:2005-05-17
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Structure of Murine 11-Hydroxysteroid Dehydrogenase 1: An Important Therapeutic Target for Diabetes
Biochemistry, 44, 2005
1YB1
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BU of 1yb1 by Molmil
Crystal structure of human 17-beta-hydroxysteroid dehydrogenase type XI
Descriptor: 17-beta-hydroxysteroid dehydrogenase type XI, Androsterone, CHLORIDE ION, ...
Authors:Lukacik, P, Bunkoczi, G, Kavanagh, K, Ng, S, von Delft, F, Bray, J, Edwards, A, Arrowsmith, C, Sundstrom, M, Oppermann, U, Structural Genomics Consortium (SGC)
Deposit date:2004-12-18
Release date:2004-12-28
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal structure of human 17-beta-hydroxysteroid dehydrogenase type XI.
To be Published
1YO6
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BU of 1yo6 by Molmil
Crystal Structure of the putative Carbonyl Reductase Sniffer of Caenorhabditis elegans
Descriptor: Putative Carbonyl Reductase Sniffer
Authors:Southeast Collaboratory for Structural Genomics (SECSG)
Deposit date:2005-01-26
Release date:2005-02-15
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal Structure of the putative Carbonyl Reductase Sniffer of Caenorhabditis elegans
To be Published
6L1H
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BU of 6l1h by Molmil
Crystal structure of light-dependent protochlorophyllide oxidoreductase from Thermosynechococcus elongatus
Descriptor: NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, NADPH-protochlorophyllide oxidoreductase
Authors:Dong, C, Wang, X, Liu, L.
Deposit date:2019-09-29
Release date:2020-04-01
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.409 Å)
Cite:Crystal structures of cyanobacterial light-dependent protochlorophyllide oxidoreductase.
Proc.Natl.Acad.Sci.USA, 117, 2020
5B4V
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BU of 5b4v by Molmil
Crystal structure of D-3-hydroxybutyrate dehydrogenase from Alcaligenes faecalis complexed with NAD+ and an inhibitor methylmalonate
Descriptor: 3-hydroxybutyrate dehydrogenase, CHLORIDE ION, METHYLMALONIC ACID, ...
Authors:Kanazawa, H, Tsunoda, M, Hoque, M.M, Suzuki, K, Yamamoto, T, Takenaka, A.
Deposit date:2016-04-19
Release date:2016-08-17
Last modified:2020-02-26
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural insights into the catalytic reaction trigger and inhibition of D-3-hydroxybutyrate dehydrogenase
Acta Crystallogr.,Sect.F, 72, 2016
5B4T
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Crystal structure of D-3-hydroxybutyrate dehydrogenase from Alcaligenes faecalis complexed with NAD+ and a substrate D-3-hydroxybutyrate
Descriptor: (3R)-3-hydroxybutanoic acid, 3-hydroxybutyrate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
Authors:Kanazawa, H, Tsunoda, M, Hoque, M.M, Suzuki, K, Yamamoto, T, Takenaka, A.
Deposit date:2016-04-19
Release date:2016-08-17
Last modified:2020-02-26
Method:X-RAY DIFFRACTION (1.19 Å)
Cite:Structural insights into the catalytic reaction trigger and inhibition of D-3-hydroxybutyrate dehydrogenase
Acta Crystallogr.,Sect.F, 72, 2016
5BT9
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BU of 5bt9 by Molmil
Crystal Structure of FolM Alternative dihydrofolate reductase 1 from Brucella canis complexed with NADP
Descriptor: 3-oxoacyl-(Acyl-carrier-protein) reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2015-06-02
Release date:2015-07-29
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal structures of FolM alternative dihydrofolate reductase 1 from Brucella suis and Brucella canis.
Acta Crystallogr.,Sect.F, 78, 2022
6L1G
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BU of 6l1g by Molmil
Crystal structure of light-dependent protochlorophyllide oxidoreductase from Synechocystis sp. PCC 6803
Descriptor: Light-dependent protochlorophyllide reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, SULFATE ION
Authors:Dong, C, Wang, X, Liu, L.
Deposit date:2019-09-29
Release date:2020-04-01
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structures of cyanobacterial light-dependent protochlorophyllide oxidoreductase.
Proc.Natl.Acad.Sci.USA, 117, 2020
5B4U
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BU of 5b4u by Molmil
Crystal structure of D-3-hydroxybutyrate dehydrogenase from Alcaligenes faecalis complexed with NAD+ and an inhibitor malonate
Descriptor: 3-hydroxybutyrate dehydrogenase, CHLORIDE ION, MALONIC ACID, ...
Authors:Kanazawa, H, Tsunoda, M, Hoque, M.M, Suzuki, K, Yamamoto, T, Takenaka, A.
Deposit date:2016-04-19
Release date:2016-08-17
Last modified:2020-02-26
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Structural insights into the catalytic reaction trigger and inhibition of D-3-hydroxybutyrate dehydrogenase
Acta Crystallogr.,Sect.F, 72, 2016
1ZEM
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BU of 1zem by Molmil
Crystal Structure of NAD+-Bound Xylitol Dehydrogenase
Descriptor: MAGNESIUM ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, xylitol dehydrogenase
Authors:Ehrensberger, A.H, Elling, R.A, Wilson, D.K.
Deposit date:2005-04-19
Release date:2006-03-28
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure-guided engineering of xylitol dehydrogenase cosubstrate specificity.
Structure, 14, 2006
1Z6Z
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BU of 1z6z by Molmil
Crystal Structure of Human Sepiapterin Reductase in complex with NADP+
Descriptor: CHLORIDE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, SULFATE ION, ...
Authors:Ugochukwu, E, Kavanagh, K, Ng, S, Arrowsmith, C, Edwards, A, Sundstrom, M, von Delft, F, Oppermann, U, Structural Genomics Consortium (SGC)
Deposit date:2005-03-23
Release date:2005-04-05
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal Structure of Human Sepiapterin Reductase
To be Published
1ZBQ
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BU of 1zbq by Molmil
Crystal Structure Of Human 17-Beta-Hydroxysteroid Dehydrogenase Type 4 In Complex With NAD
Descriptor: 17-beta-hydroxysteroid dehydrogenase 4, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Lukacik, P, Shafqat, N, Kavanagh, K, Bray, J, von Delft, F, Edwards, A, Arrowsmith, C, Sundstrom, M, Oppermann, U, Structural Genomics Consortium (SGC)
Deposit date:2005-04-08
Release date:2005-04-26
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Crystal Structure Of Human 17-Beta-Hydroxysteroid Dehydrogenase Type 4 In Complex With NAD
To be Published
6MNE
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BU of 6mne by Molmil
CRYSTAL STRUCTURE OF HUMAN 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 COMPLEXED WITH ESTRONE AND NADP+
Descriptor: (9beta,13alpha)-3-hydroxyestra-1,3,5(10)-trien-17-one, Estradiol 17-beta-dehydrogenase 1, GLYCEROL, ...
Authors:Li, T, Lin, S.X.
Deposit date:2018-10-01
Release date:2019-04-03
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Crystal structures of human 17 beta-hydroxysteroid dehydrogenase type 1 complexed with estrone and NADP+reveal the mechanism of substrate inhibition.
Febs J., 286, 2019
6MNC
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BU of 6mnc by Molmil
CRYSTAL STRUCTURE OF HUMAN 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 COMPLEXED WITH ESTRONE
Descriptor: (9beta,13alpha)-3-hydroxyestra-1,3,5(10)-trien-17-one, DI(HYDROXYETHYL)ETHER, Estradiol 17-beta-dehydrogenase 1
Authors:Li, T, Stephen, P, Zhu, D.W, Lin, S.X.
Deposit date:2018-10-01
Release date:2019-04-03
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structures of human 17 beta-hydroxysteroid dehydrogenase type 1 complexed with estrone and NADP+reveal the mechanism of substrate inhibition.
Febs J., 286, 2019
4HFR
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BU of 4hfr by Molmil
Human 11beta-Hydroxysteroid Dehydrogenase Type 1 in complex with an orally bioavailable acidic inhibitor AZD4017.
Descriptor: Corticosteroid 11-beta-dehydrogenase isozyme 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, {(3S)-1-[5-(cyclohexylcarbamoyl)-6-(propylsulfanyl)pyridin-2-yl]piperidin-3-yl}acetic acid
Authors:Ogg, D.J, Gerhardt, S, Hargreaves, D.
Deposit date:2012-10-05
Release date:2012-10-17
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.73 Å)
Cite:Discovery of a Potent, Selective, and Orally Bioavailable Acidic 11 -Hydroxysteroid Dehydrogenase Type 1 (11 -HSD1) Inhibitor: Discovery of 2-[(3S)-1-[5-(Cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]-3-piperidyl]acetic Acid (AZD4017)
J.Med.Chem., 55, 2012
4HBG
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BU of 4hbg by Molmil
Crystal structure of Saccharomyces cerevisiae 3 oxoacyl-[acyl carrier protein]-reductase complexed with NADPH (form2)
Descriptor: 3-oxoacyl-[acyl-carrier-protein] reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Zhang, Y.J, Gao, Y.X, Teng, M.K.
Deposit date:2012-09-27
Release date:2013-10-30
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Crystal structure of yeast mitochondria 3-Oxoacyl-ACP Reductase OAR1
To be Published
4HX5
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BU of 4hx5 by Molmil
Crystal structure of 11 beta-HSD1 in complex with SAR184841
Descriptor: 4-[5-(4-tert-butylpiperazin-1-yl)pyridin-2-yl]-N-[(1R,2S,3S,5S,7s)-5-carbamoyltricyclo[3.3.1.1~3,7~]dec-2-yl]-3,4-dihydroquinoxaline-1(2H)-carboxamide, Corticosteroid 11-beta-dehydrogenase isozyme 1, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Loenze, P, Schimanski-Breves, S, Engel, C.K.
Deposit date:2012-11-09
Release date:2013-05-08
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Discovery of SAR184841, a potent and long-lasting inhibitor of 11beta-hydroxysteroid dehydrogenase type 1, active in a physiopathological animal model of T2D
Bioorg.Med.Chem.Lett., 23, 2013
4HWK
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BU of 4hwk by Molmil
Crystal structure of human sepiapterin reductase in complex with sulfapyridine
Descriptor: 4-amino-N-(pyridin-2-yl)benzenesulfonamide, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
Authors:Groenlund Pedersen, M, Pojer, F, Johnsson, K.
Deposit date:2012-11-08
Release date:2013-06-05
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Tetrahydrobiopterin biosynthesis as an off-target of sulfa drugs.
Science, 340, 2013
4IJV
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BU of 4ijv by Molmil
Crystal structure of 11b-HSD1 double mutant (L262R, F278E) in complex with 3-[1-(4-chlorophenyl)cyclopropyl]-8-(2-fluorophenoxy)[1,2,4]triazolo[4,3-a]pyridine
Descriptor: 3-[1-(4-chlorophenyl)cyclopropyl]-8-(2-fluorophenoxy)[1,2,4]triazolo[4,3-a]pyridine, Corticosteroid 11-beta-dehydrogenase isozyme 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Sheriff, S.
Deposit date:2012-12-23
Release date:2014-06-11
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Optimization of 1,2,4-Triazolopyridines as Inhibitors of Human 11 beta-Hydroxysteroid Dehydrogenase Type 1 (11 beta-HSD-1).
ACS Med Chem Lett, 5, 2014
4IJW
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BU of 4ijw by Molmil
Crystal structure of 11b-HSD1 double mutant (L262R, F278E) in complex with 3-[1-(4-chlorophenyl)cyclopropyl]-8-cyclopropyl[1,2,4]triazolo[4,3-a]pyridine
Descriptor: 3-[1-(4-chlorophenyl)cyclopropyl]-8-cyclopropyl[1,2,4]triazolo[4,3-a]pyridine, Corticosteroid 11-beta-dehydrogenase isozyme 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Sheriff, S.
Deposit date:2012-12-23
Release date:2014-06-11
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Optimization of 1,2,4-Triazolopyridines as Inhibitors of Human 11 beta-Hydroxysteroid Dehydrogenase Type 1 (11 beta-HSD-1).
ACS Med Chem Lett, 5, 2014
4IJU
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BU of 4iju by Molmil
Crystal structure of 11b-HSD1 double mutant (L262R, F278E) in complex with (1S,4S)-4-[8-(2-fluorophenoxy)[1,2,4]triazolo[4,3-a]pyridin-3-yl]bicyclo[2.2.1]heptan-1-ol
Descriptor: (1s,4s)-4-[8-(2-fluorophenoxy)[1,2,4]triazolo[4,3-a]pyridin-3-yl]bicyclo[2.2.1]heptan-1-ol, CHLORIDE ION, Corticosteroid 11-beta-dehydrogenase isozyme 1, ...
Authors:Sheriff, S.
Deposit date:2012-12-23
Release date:2014-06-11
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Optimization of 1,2,4-Triazolopyridines as Inhibitors of Human 11 beta-Hydroxysteroid Dehydrogenase Type 1 (11 beta-HSD-1).
ACS Med Chem Lett, 5, 2014
4IMR
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BU of 4imr by Molmil
Crystal structure of 3-oxoacyl (acyl-carrier-protein) reductase (target EFI-506442) from agrobacterium tumefaciens C58 with NADP bound
Descriptor: 3-oxoacyl-(Acyl-carrier-protein) reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, UNKNOWN LIGAND
Authors:Patskovsky, Y, Toro, R, Bhosle, R, Hillerich, B, Seidel, R.D, Washington, E, Scott Glenn, A, Chowdhury, S, Evans, B, Hammonds, J, Zencheck, W.D, Imker, H.J, Al Obaidi, N.F, Stead, M, Love, J, Gerlt, J.A, Almo, S.C, Enzyme Function Initiative (EFI)
Deposit date:2013-01-03
Release date:2013-01-16
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Crystal Structure of 3-Oxoacyl (Acyl-Carrier-Protein) Reductase Atu5465 from Agrobacterium Tumefaciens
To be Published
4IS2
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BU of 4is2 by Molmil
Crystal structure of the apo form of a 3alpha-hydroxysteroid dehydrogenase (BaiA2) associated with secondary bile acid synthesis from Clostridium scindens VPI12708 at 1.90 A resolution
Descriptor: Bile acid 3-alpha hydroxysteroid dehydrogenase, CHLORIDE ION
Authors:Joint Center for Structural Genomics (JCSG)
Deposit date:2013-01-16
Release date:2013-04-03
Last modified:2023-02-01
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of the apo form of a 3alpha-hydroxysteroid dehydrogenase (BaiA2) associated with secondary bile acid synthesis from Clostridium scindens VPI12708 at 1.90 A resolution
To be published
4IS3
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BU of 4is3 by Molmil
Crystal structure of a 3alpha-hydroxysteroid dehydrogenase (BaiA2) associated with secondary bile acid synthesis from Clostridium scindens VPI12708 in complex with a putative NAD(+)-OH- adduct at 2.0 A resolution
Descriptor: ACETATE ION, Bile acid 3-alpha hydroxysteroid dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
Authors:Joint Center for Structural Genomics (JCSG)
Deposit date:2013-01-16
Release date:2013-04-24
Last modified:2023-02-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of a 3alpha-hydroxysteroid dehydrogenase (BaiA2) associated with secondary bile acid synthesis from Clostridium scindens VPI12708 in complex with a putative NAD(+)-OH- adduct at 2.0 A resolution
To be published

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