4K1L

4,4-Dioxo-5,6-dihydro-[1,4,3]oxathiazines, a novel class of 11 beta-HSD1 inhibitors for the treatment of diabetes

Summary for 4K1L

Entry DOI	10.2210/pdb4k1l/pdb
Descriptor	Corticosteroid 11-beta-dehydrogenase isozyme 1, (4aS,8aR)-N-cyclohexyl-4a,5,6,7,8,8a-hexahydro-4,1,2-benzoxathiazin-3-amine 1,1-dioxide, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (4 entities in total)
Functional Keywords	11-beta-hydroxysteroid dehydrogenase 1, 11-dh, 11-beta-hsd1, short chain dehydrogenase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Endoplasmic reticulum membrane; Single-pass type II membrane protein: P28845
Total number of polymer chains	4
Total formula weight	131474.74
Authors	Loenze, P.,Schimanski-Breves, S.,Von der Heyden, C.,Engel, C.K. (deposition date: 2013-04-05, release date: 2014-04-09, Last modification date: 2023-09-20)
Primary citation	Bohme, T.,Engel, C.K.,Farjot, G.,Gussregen, S.,Haack, T.,Tschank, G.,Ritter, K. 1,1-Dioxo-5,6-dihydro-[4,1,2]oxathiazines, a novel class of 11-HSD1 inhibitors for the treatment of diabetes. Bioorg.Med.Chem.Lett., 23:4685-4691, 2013 Cited by PubMed: 23845218 DOI: 10.1016/j.bmcl.2013.05.102 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.96 Å)

Structure validation