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2YMN
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BU of 2ymn by Molmil
Organization of the Influenza Virus Replication Machinery
Descriptor: NUCLEOPROTEIN
Authors:Moeller, A, Kirchdoerfer, R.N, Potter, C.S, Carragher, B, Wilson, I.A.
Deposit date:2012-10-09
Release date:2012-12-05
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (20 Å)
Cite:Organization of the Influenza Virus Replication Machinery.
Science, 338, 2012
6J1U
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BU of 6j1u by Molmil
influenza virus nucleoprotein with a specific inhibitor
Descriptor: Nucleoprotein, ~{N}-[4-[(4-~{tert}-butylphenyl)carbonylamino]phenyl]-2,3-dihydro-1,4-benzodioxine-6-carboxamide
Authors:Pang, B, Zhang, W.Z, Zhang, H.M, Hao, Q.
Deposit date:2018-12-29
Release date:2020-01-01
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Discovery of a Novel Specific Inhibitor Targeting Influenza A Virus Nucleoprotein with Pleiotropic Inhibitory Effects on Various Steps of the Viral Life Cycle.
J.Virol., 95, 2021
5N2U
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BU of 5n2u by Molmil
Influenza D virus nucleoprotein
Descriptor: Nucleoprotein
Authors:Labaronne, A, Ruigrok, R.W.H, Crepin, T.
Deposit date:2017-02-08
Release date:2018-02-28
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The structure of the nucleoprotein of Influenza D shows that all Orthomyxoviridae nucleoproteins have a similar NPCORE, with or without a NPTAILfor nuclear transport.
Sci Rep, 9, 2019
4IRY
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BU of 4iry by Molmil
Influenza A virus tail-loop free nucleoprotein at 2.8 A resolution
Descriptor: Nucleocapsid protein
Authors:Ye, Q, Mata, D.A, Tao, Y.J.
Deposit date:2013-01-15
Release date:2013-02-13
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Biochemical and structural evidence in support of a coherent model for the formation of the double-helical influenza a virus ribonucleoprotein.
MBio, 4, 2012
2IQH
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BU of 2iqh by Molmil
Influenza A virus nucleoprotein NP at 3.2A resolution
Descriptor: Nucleocapsid protein
Authors:Ye, Q, Tao, Y.J.
Deposit date:2006-10-13
Release date:2006-12-26
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:The mechanism by which influenza A virus nucleoprotein forms oligomers and binds RNA.
Nature, 444, 2006
6H9G
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BU of 6h9g by Molmil
Influenza A nucleoprotein docked into 3D helical structure of the wild type ribonucleoprotein complex obtained using cryoEM. Conformation 1.
Descriptor: Nucleoprotein, Polypeptide loop
Authors:Coloma, R, Arranz, R, de la Rosa-Trevin, J.M, Sorzano, C.O.S, Munier, S, Carlero, D, Naffakh, N, Ortin, J, Martin-Benito, J.
Deposit date:2018-08-03
Release date:2020-02-12
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (11 Å)
Cite:Structural insights into influenza A virus ribonucleoproteins reveal a processive helical track as transcription mechanism.
Nat Microbiol, 5, 2020
9BJL
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BU of 9bjl by Molmil
Crystal structure of Influenza D virus Nucleoprotein (Oklahoma)
Descriptor: CHLORIDE ION, Nucleoprotein
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2024-04-25
Release date:2024-05-08
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:Crystal structure of Influenza D virus Nucleoprotein (Oklahoma)
To be published
2WFS
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BU of 2wfs by Molmil
Fitting of influenza virus NP structure into the 9-fold symmetryzed cryoEM reconstruction of an active RNP particle.
Descriptor: NUCLEOPROTEIN
Authors:Coloma, R, Valpuesta, J.M, Arranz, R, Carrascosa, J.L, Ortin, J, Martin-Benito, J.
Deposit date:2009-04-15
Release date:2009-07-07
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (12 Å)
Cite:The Structure of a Biologically Active Influenza Virus Ribonucleoprotein Complex.
Plos Pathog., 5, 2009
5TJW
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BU of 5tjw by Molmil
Influenza A virus Nucleoprotein in Complex with Inhibitory Nanobody
Descriptor: NP-specific inhibitory VHH, Nucleoprotein
Authors:Hanke, L, Knockenhauer, K.E, Ploegh, H.L, Schwartz, T.U.
Deposit date:2016-10-05
Release date:2016-12-21
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.231 Å)
Cite:The Antiviral Mechanism of an Influenza A Virus Nucleoprotein-Specific Single-Domain Antibody Fragment.
MBio, 7, 2016
5B7B
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BU of 5b7b by Molmil
Crystal structure of Nucleoprotein-nucleozin complex
Descriptor: Nucleoprotein, [4-(2-chloro-4-nitrophenyl)piperazin-1-yl](5-methyl-3-phenyl-1,2-oxazol-4-yl)methanone
Authors:Pang, B, Zhang, W.Z, Zhang, H.M, Hao, Q.
Deposit date:2016-06-06
Release date:2016-07-06
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural Characterization of H1N1 Nucleoprotein-Nucleozin Binding Sites
Sci Rep, 6, 2016
3RO5
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BU of 3ro5 by Molmil
Crystal structure of influenza A virus nucleoprotein with ligand
Descriptor: Nucleocapsid protein, [4-(2-chloro-4-nitrophenyl)piperazin-1-yl][3-(2-methoxyphenyl)-5-methyl-1,2-oxazol-4-yl]methanone
Authors:Pearce, B.C, Edavettal, S, McDonnell, P.A, Lewis, H.A, Steinbacher, S, Baldwin, E.T, Langley, D.R, Maskos, K, Mortl, M, Kiefersauer, R.
Deposit date:2011-04-25
Release date:2011-09-14
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.66 Å)
Cite:Inhibition of influenza virus replication via small molecules that induce the formation of higher-order nucleoprotein oligomers.
Proc.Natl.Acad.Sci.USA, 108, 2011
2Q06
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BU of 2q06 by Molmil
Crystal structure of Influenza A Virus H5N1 Nucleoprotein
Descriptor: Nucleoprotein
Authors:Ng, A.K.L, Zhang, H, Tan, K, Wang, J, Shaw, P.C.
Deposit date:2007-05-21
Release date:2008-05-27
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structure of the influenza virus A H5N1 nucleoprotein: implications for RNA binding, oligomerization, and vaccine design.
Faseb J., 22, 2008
3TJ0
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BU of 3tj0 by Molmil
Crystal Structure of Influenza B Virus Nucleoprotein
Descriptor: Nucleoprotein
Authors:Ng, A.K.L, Zhang, H, Liu, J, Au, S.W.N, Wang, J, Shaw, P.C.
Deposit date:2011-08-23
Release date:2012-06-20
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3.233 Å)
Cite:Structural basis for RNA binding and homo-oligomer formation by influenza B virus nucleoprotein
J.Virol., 86, 2012
4BBL
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BU of 4bbl by Molmil
Cryo-electron microscopy reconstruction of the helical part of influenza A virus ribonucleoprotein isolated from virions.
Descriptor: NUCLEOPROTEIN, RNA
Authors:Arranz, R, Coloma, R, Chichon, F.J, Conesa, J.J, Carrascosa, J.L, Valpuesta, J.M, Ortin, J, Martin-Benito, J.
Deposit date:2012-09-26
Release date:2012-12-05
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (18 Å)
Cite:The Structure of Native Influenza Virion Ribonucleoproteins
Science, 338, 2012
8PZQ
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BU of 8pzq by Molmil
Model for focused reconstruction of influenza A RNP-like particle
Descriptor: Nucleoprotein, RNA (5'P-(UC)6-FAM3')
Authors:Chenavier, F, Estrozi, L.F, Zarkadas, E, Ruigrok, R.W.H, Schoehn, G, Ballandras-Colas, A, Crepin, T.
Deposit date:2023-07-27
Release date:2023-12-27
Method:ELECTRON MICROSCOPY (5.3 Å)
Cite:Cryo-EM structure of influenza helical nucleocapsid reveals NP-NP and NP-RNA interactions as a model for the genome encapsidation.
Sci Adv, 9, 2023
8PZP
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BU of 8pzp by Molmil
Model for influenza A virus helical ribonucleoprotein-like structure
Descriptor: Nucleoprotein, RNA (5'P-(UC)6-FAM3')
Authors:Chenavier, F, Estrozi, L.F, Zarkadas, E, Ruigrok, R.W.H, Schoehn, G, Ballandras-Colas, A, Crepin, T.
Deposit date:2023-07-27
Release date:2023-12-27
Method:ELECTRON MICROSCOPY (8.7 Å)
Cite:Cryo-EM structure of influenza helical nucleocapsid reveals NP-NP and NP-RNA interactions as a model for the genome encapsidation.
Sci Adv, 9, 2023
3TG6
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BU of 3tg6 by Molmil
Crystal Structure of Influenza A Virus nucleoprotein with Ligand
Descriptor: Nucleocapsid protein, [4-(2-chloro-4-nitrophenyl)piperazin-1-yl][3-(2-chloropyridin-3-yl)-5-methyl-1,2-oxazol-4-yl]methanone
Authors:Pearce, B.C, Lewis, H.A, McDonnell, P.A, Steinbacher, S, Kiefersauer, R, Mortl, M, Maskos, K, Edavettal, S, Baldwin, E.T, Langley, D.R.
Deposit date:2011-08-17
Release date:2012-08-29
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3 Å)
Cite:Biophysical and Structural Characterization of a Novel Class of Influenza Virus Inhibitors
To be Published
7DXP
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BU of 7dxp by Molmil
Influenza H5N1 nucleoprotein in complex with nucleotides
Descriptor: 1,2-ETHANEDIOL, Nucleoprotein, RNA (5'-R(P*(OMU)P*(OMU)P*(OMU)P*(OMU))-3')
Authors:Tang, Y.S, Xu, S, Chen, Y.W, Wang, J.H, Shaw, P.C.
Deposit date:2021-01-19
Release date:2021-04-14
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structures of influenza nucleoprotein complexed with nucleic acid provide insights into the mechanism of RNA interaction.
Nucleic Acids Res., 49, 2021
8TWP
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BU of 8twp by Molmil
Influenza A virus (A/Aichi/2/1968(H3N2) nucleoprotein mutant - 2-7 deleted, R416A
Descriptor: Nucleoprotein
Authors:Yoon, J, Zhang, Y.M, Grant, R.A, Shoulders, M.D.
Deposit date:2023-08-21
Release date:2024-07-03
Last modified:2024-07-10
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:The immune-evasive proline-283 substitution in influenza nucleoprotein increases aggregation propensity without altering the native structure.
Sci Adv, 10, 2024
8TWR
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BU of 8twr by Molmil
Influenza A virus (A/Aichi/2/1968(H3N2) nucleoprotein mutant - 2-7 deleted, P283S, R416A
Descriptor: Nucleoprotein, SODIUM ION
Authors:Yoon, J, Zhang, Y.M, Grant, R.A, Shoulders, M.D.
Deposit date:2023-08-21
Release date:2024-07-03
Last modified:2024-07-10
Method:X-RAY DIFFRACTION (3.09 Å)
Cite:The immune-evasive proline-283 substitution in influenza nucleoprotein increases aggregation propensity without altering the native structure.
Sci Adv, 10, 2024
3ZDP
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BU of 3zdp by Molmil
R416A Monomeric nucleoprotein of influenza A virus
Descriptor: NUCLEOCAPSID PROTEIN, POTASSIUM ION
Authors:Chenavas, S, Ruigrok, R.W.H, Crepin, T.
Deposit date:2012-11-29
Release date:2013-04-17
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.69 Å)
Cite:Monomeric Nucleoprotein of Influenza a Virus.
Plos Pathog., 9, 2013
7DKG
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BU of 7dkg by Molmil
Influenza H5N1 nucleoprotein (truncated) in complex with nucleotides
Descriptor: Nucleoprotein, RNA (5'-R(P*(OMU)P*(OMU)P*(OMU))-3')
Authors:Tang, Y.S, Xu, S, Chen, Y.W, Wang, J.H, Shaw, P.C.
Deposit date:2020-11-24
Release date:2021-04-14
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structures of influenza nucleoprotein complexed with nucleic acid provide insights into the mechanism of RNA interaction.
Nucleic Acids Res., 49, 2021
6I54
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BU of 6i54 by Molmil
Influenza A nucleoprotein docked into 3D helical structure of the wild type ribonucleoprotein complex obtained using cryoEM. Conformation 2.
Descriptor: Influenza virus nucleoprotein, Nucleoprotein
Authors:Coloma, R, Arranz, R, de la Rosa-Trevin, J.M, Sorzano, C.O.S, Carlero, D, Ortin, J, Martin-Benito, J.
Deposit date:2018-11-12
Release date:2019-11-13
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (10 Å)
Cite:Structural insights into influenza A virus ribonucleoproteins reveal a processive helical track as transcription mechanism.
Nat Microbiol, 5, 2020
6I85
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BU of 6i85 by Molmil
Influenza A nucleoprotein docked into the 3D helical structure of the wild type ribonucleoprotein complex obtained using cryoEM. Conformation 5.
Descriptor: Influenza A nucleoprotein, Nucleoprotein
Authors:Coloma, R, Arranz, R, de la Rosa-Trevin, J.M, Sorzano, C.O.S, Carlero, D, Ortin, J, Martin-Benito, J.
Deposit date:2018-11-19
Release date:2020-01-29
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (24 Å)
Cite:Structural insights into influenza A virus ribonucleoproteins reveal a processive helical track as transcription mechanism.
Nat Microbiol, 5, 2020
6I7M
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BU of 6i7m by Molmil
Influenza A nucleoprotein docked into 3D helical structure of the wild type ribonucleoprotein complex obtained using cryoEM. Conformation 4.
Descriptor: Nucleoprotein
Authors:Coloma, R, Arranz, R, de la Rosa-Trevin, J.M, Sorzano, C.O.S, Carlero, D, Ortin, J, Martin-Benito, J.
Deposit date:2018-11-16
Release date:2020-02-12
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (10 Å)
Cite:Structural insights into influenza A virus ribonucleoproteins reveal a processive helical track as transcription mechanism.
Nat Microbiol, 5, 2020

 

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數據於2024-09-18公開中

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