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1ERJ
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BU of 1erj by Molmil
CRYSTAL STRUCTURE OF THE C-TERMINAL WD40 DOMAIN OF TUP1
Descriptor: TRANSCRIPTIONAL REPRESSOR TUP1
Authors:Sprague, E.R, Redd, M.J, Johnson, A.D, Wolberger, C.
Deposit date:2000-04-06
Release date:2000-07-26
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of the C-terminal domain of Tup1, a corepressor of transcription in yeast.
EMBO J., 19, 2000
1NR0
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BU of 1nr0 by Molmil
Two Seven-Bladed Beta-Propeller Domains Revealed By The Structure Of A C. elegans Homologue Of Yeast Actin Interacting Protein 1 (AIP1).
Descriptor: Actin interacting protein 1, MANGANESE (II) ION
Authors:Vorobiev, S.M, Mohri, K, Ono, S, Almo, S.C, Burley, S.K, New York SGX Research Center for Structural Genomics (NYSGXRC)
Deposit date:2003-01-23
Release date:2003-07-01
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Identification of Functional Residues on Caenorhabditis elegans Actin-interacting Protein 1 (UNC-78) for Disassembly of Actin Depolymerizing Factor/Cofilin-bound Actin Filaments
J.Biol.Chem., 279, 2004
6W7F
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BU of 6w7f by Molmil
Structure of EED bound to inhibitor 5285
Descriptor: 8-(6-cyclopropylpyridin-3-yl)-N-[(5-fluoro-2,3-dihydro-1-benzofuran-4-yl)methyl]-1-(methylsulfonyl)imidazo[1,5-c]pyrimidin-5-amine, GLYCEROL, Polycomb protein EED
Authors:Petrunak, E.M, Stuckey, J.A.
Deposit date:2020-03-19
Release date:2020-07-08
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:EEDi-5285: An Exceptionally Potent, Efficacious, and Orally Active Small-Molecule Inhibitor of Embryonic Ectoderm Development.
J.Med.Chem., 63, 2020
3UR4
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BU of 3ur4 by Molmil
Crystal structure of human WD repeat domain 5 with compound
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, SULFATE ION, ...
Authors:Dong, A, Dombrovski, L, Senisterra, G, Wernimont, A, Wasney, G.A, Allali Hassani, A, Nguyen, K.T, Smil, D, Bolshan, Y, Hajian, T, Poda, G, Chau, I, Al-Awar, R, Bountra, C, Weigelt, J, Edwards, A.M, Arrowsmith, C.H, Brown, P, Schapira, M, Vedadi, M, Wu, H, Structural Genomics Consortium (SGC)
Deposit date:2011-11-21
Release date:2011-12-14
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5.
Biochem. J., 449, 2013
3UVL
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Crystal structure of WDR5 in complex with the WDR5-interacting motif of MLL3
Descriptor: Histone-lysine N-methyltransferase MLL3, WD repeat-containing protein 5
Authors:Zhang, P, Lee, H, Brunzelle, J.S, Couture, J.-F.
Deposit date:2011-11-30
Release date:2011-12-14
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases.
Nucleic Acids Res., 40, 2012
3UVK
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BU of 3uvk by Molmil
Crystal structure of WDR5 in complex with the WDR5-interacting motif of MLL2
Descriptor: 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Histone-lysine N-methyltransferase MLL2, SULFATE ION, ...
Authors:Zhang, P, Lee, H, Brunzelle, J.S, Couture, J.-F.
Deposit date:2011-11-30
Release date:2011-12-14
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases.
Nucleic Acids Res., 40, 2012
1GXR
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BU of 1gxr by Molmil
WD40 Region of Human Groucho/TLE1
Descriptor: CALCIUM ION, TRANSDUCIN-LIKE ENHANCER PROTEIN 1
Authors:Pearl, L.H, Roe, S.M, Pickles, L.M.
Deposit date:2002-04-10
Release date:2002-06-13
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Crystal Structure of the C-Terminal Wd40 Repeat Domain of the Human Groucho/Tle1 Transcriptional Corepressor
Structure, 10, 2002
5OV3
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BU of 5ov3 by Molmil
Structure of the RbBP5 beta-propeller domain
Descriptor: Retinoblastoma-binding protein 5, TETRAETHYLENE GLYCOL, TRIETHYLENE GLYCOL
Authors:Mittal, A, Zhang, Y, Gamblin, S.J, Wilson, J.R.
Deposit date:2017-08-27
Release date:2018-03-28
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:The structure of the RbBP5 beta-propeller domain reveals a surface with potential nucleic acid binding sites.
Nucleic Acids Res., 46, 2018
5HQG
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BU of 5hqg by Molmil
WD40 domain of Human E3 Ubiquitin Ligase COP1 (RFWD2)
Descriptor: E3 ubiquitin-protein ligase RFWD2
Authors:Uljon, S, Blacklow, S.C.
Deposit date:2016-01-21
Release date:2016-04-20
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Basis for Substrate Selectivity of the E3 Ligase COP1.
Structure, 24, 2016
5I2T
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BU of 5i2t by Molmil
Domain characterization of the WD protein Pwp2 and their relevance in ribosome biogenesis
Descriptor: Periodic tryptophan protein 2, SULFATE ION
Authors:Fribourg, S, Boissier, F.
Deposit date:2016-02-09
Release date:2017-06-21
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.543 Å)
Cite:Pwp2 mediates UTP-B assembly via two structurally independent domains.
Sci Rep, 7, 2017
5IGO
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BU of 5igo by Molmil
WD40 domain of Arabidopsis thaliana E3 Ubiquitin Ligase COP1 in complex with peptide from Trib1
Descriptor: E3 ubiquitin-protein ligase COP1, Tribbles homolog 1
Authors:Uljon, S, Blacklow, S.C.
Deposit date:2016-02-28
Release date:2016-04-20
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural Basis for Substrate Selectivity of the E3 Ligase COP1.
Structure, 24, 2016
1YFQ
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High resolution S. cerevisiae Bub3 mitotic checkpoint protein
Descriptor: ACETATE ION, CALCIUM ION, Cell cycle arrest protein BUB3
Authors:Wilson, D.K, Cerna, D, Chew, E.
Deposit date:2005-01-03
Release date:2005-01-11
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:The 1.1-a structure of the spindle checkpoint protein bub3p reveals functional regions.
J.Biol.Chem., 280, 2005
1PEV
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BU of 1pev by Molmil
Crystal Structure of the Actin Interacting Protein from Caenorhabditis Elegans
Descriptor: Actin interacting protein 1
Authors:Vorobiev, S, Mohri, K, Fedorov, A.A, Ono, S, Almo, S.C, Burley, S.K, New York SGX Research Center for Structural Genomics (NYSGXRC)
Deposit date:2003-05-22
Release date:2003-07-01
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:Identification of functional residues on Caenorhabditis elegans actin-interacting protein 1 (UNC-78) for disassembly of actin depolymerizing factor/cofilin-bound actin filaments.
J.Biol.Chem., 279, 2004
5NUV
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BU of 5nuv by Molmil
Structure of the WD40-domain of human ATG16L1
Descriptor: (R,R)-2,3-BUTANEDIOL, Autophagy-related protein 16-1
Authors:Bajagic, M, Scrima, A.
Deposit date:2017-05-02
Release date:2017-07-19
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structure of the WD40-domain of human ATG16L1.
Protein Sci., 26, 2017
1PGU
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BU of 1pgu by Molmil
YEAST ACTIN INTERACTING PROTEIN 1 (AIP1), Se-Met PROTEIN, MONOCLINIC CRYSTAL FORM
Descriptor: Actin interacting protein 1, ZINC ION
Authors:Voegtli, W.C, Madrona, A.Y, Wilson, D.K.
Deposit date:2003-05-28
Release date:2003-07-15
Last modified:2021-10-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The structure of Aip1p, a WD repeat protein that regulates Cofilin-mediated actin depolymerization.
J.Biol.Chem., 278, 2003
1PI6
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BU of 1pi6 by Molmil
YEAST ACTIN INTERACTING PROTEIN 1 (Aip1), ORTHORHOMBIC CRYSTAL FORM
Descriptor: Actin interacting protein 1, ZINC ION
Authors:Voegtli, W.C, Madrona, A.Y, Wilson, D.K.
Deposit date:2003-05-29
Release date:2003-07-15
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The structure of Aip1p, a WD repeat protein that regulates Cofilin-mediated actin depolymerization.
J.Biol.Chem., 278, 2003
1R5M
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BU of 1r5m by Molmil
Crystal Structure Of The C-Terminal WD40 Domain Of Sif2
Descriptor: SIR4-interacting protein SIF2, SULFATE ION
Authors:Cerna, D, Wilson, D.K.
Deposit date:2003-10-10
Release date:2005-03-01
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:The structure of Sif2p, a WD repeat protein functioning in the SET3 corepressor complex.
J.Mol.Biol., 351, 2005
1U4C
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BU of 1u4c by Molmil
Structure of spindle checkpoint protein Bub3
Descriptor: Cell cycle arrest protein BUB3
Authors:Larsen, N.A, Harrison, S.C.
Deposit date:2004-07-23
Release date:2004-08-03
Last modified:2019-08-14
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Crystal structure of the spindle assembly checkpoint protein Bub3
J.Mol.Biol., 344, 2004
1TRJ
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BU of 1trj by Molmil
Homology Model of Yeast RACK1 Protein fitted into 11.7A cryo-EM map of Yeast 80S Ribosome
Descriptor: Guanine nucleotide-binding protein beta subunit-like protein, Helix 39 of 18S rRNA, Helix 40 of 18S rRNA
Authors:Sengupta, J, Nilsson, J, Gursky, R, Spahn, C.M, Nissen, P, Frank, J.
Deposit date:2004-06-21
Release date:2004-09-28
Last modified:2024-02-14
Method:ELECTRON MICROSCOPY (11.7 Å)
Cite:Identification of the versatile scaffold protein RACK1 on the eukaryotic ribosome by cryo-EM
Nat.Struct.Mol.Biol., 11, 2004
1SQ9
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BU of 1sq9 by Molmil
Structure of Ski8p, a WD repeat protein involved in mRNA degradation and meiotic recombination
Descriptor: Antiviral protein SKI8, SULFATE ION
Authors:Madrona, A.Y, Wilson, D.K.
Deposit date:2004-03-18
Release date:2004-05-25
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The structure of Ski8p, a protein regulating mRNA degradation: Implications for WD protein structure.
Protein Sci., 13, 2004
1S4U
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BU of 1s4u by Molmil
Crystal Structure analysis of the beta-propeller protein Ski8p
Descriptor: Antiviral protein SKI8
Authors:Cheng, Z, Song, H.
Deposit date:2004-01-18
Release date:2004-12-28
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of Ski8p, a WD-repeat protein with dual roles in mRNA metabolism and meiotic recombination
Protein Sci., 13, 2004
4GM9
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BU of 4gm9 by Molmil
Crystal structure of human WD repeat domain 5 with compound MM-401
Descriptor: MM-401, WD repeat-containing protein 5
Authors:Karatas, H, Townsend, E.C, Chen, Y, Bernard, D, Liu, L, Dou, Y, Lei, M, Wang, S.
Deposit date:2012-08-15
Release date:2014-02-19
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of human WD repeat domain 5 with compound MM-401
To be Published
4GM8
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BU of 4gm8 by Molmil
Crystal structure of human WD repeat domain 5 with compound MM-102
Descriptor: MM-102, WD repeat-containing protein 5
Authors:Karatas, H, Townsend, E.C, Chen, Y, Bernard, D, Cao, F, Liu, L, Lei, M, Dou, Y, Wang, S.
Deposit date:2012-08-15
Release date:2013-07-31
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.601 Å)
Cite:High-affinity, small-molecule peptidomimetic inhibitors of MLL1/WDR5 protein-protein interaction.
J.Am.Chem.Soc., 135, 2013
4GM3
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BU of 4gm3 by Molmil
Crystal structure of human WD repeat domain 5 with compound MM-101
Descriptor: MM-101, WD repeat-containing protein 5
Authors:Karatas, H, Townsend, E.C, Chen, Y, Bernard, D, Cao, F, Liu, L, Lei, M, Dou, Y, Wang, S.
Deposit date:2012-08-15
Release date:2013-07-31
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (3.393 Å)
Cite:High-affinity, small-molecule peptidomimetic inhibitors of MLL1/WDR5 protein-protein interaction.
J.Am.Chem.Soc., 135, 2013
4GMB
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Crystal structure of human WD repeat domain 5 with compound MM-402
Descriptor: MM-402, WD repeat-containing protein 5
Authors:Karatas, H, Townsend, E.C, Chen, Y, Bernard, D, Cao, F, Liu, L, Lei, M, Dou, Y, Wang, S.
Deposit date:2012-08-15
Release date:2014-02-19
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.781 Å)
Cite:Discovery of a Highly Potent, Cell-Permeable Macrocyclic Peptidomimetic (MM-589) Targeting the WD Repeat Domain 5 Protein (WDR5)-Mixed Lineage Leukemia (MLL) Protein-Protein Interaction.
J.Med.Chem., 60, 2017

225399

數據於2024-09-25公開中

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