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4GM8

Crystal structure of human WD repeat domain 5 with compound MM-102

Summary for 4GM8
Entry DOI10.2210/pdb4gm8/pdb
Related4GM3 4GM9 4GMB
Related PRD IDPRD_000894
DescriptorWD repeat-containing protein 5, MM-102 (3 entities in total)
Functional Keywordsmll1, histone methyltransferase, wd40, transcription-transcription inhibitor complex, transcription/transcription inhibitor
Biological sourceHomo sapiens (human)
Cellular locationNucleus: P61964
Total number of polymer chains8
Total formula weight140247.22
Authors
Karatas, H.,Townsend, E.C.,Chen, Y.,Bernard, D.,Cao, F.,Liu, L.,Lei, M.,Dou, Y.,Wang, S. (deposition date: 2012-08-15, release date: 2013-07-31, Last modification date: 2023-11-15)
Primary citationKaratas, H.,Townsend, E.C.,Cao, F.,Chen, Y.,Bernard, D.,Liu, L.,Lei, M.,Dou, Y.,Wang, S.
High-affinity, small-molecule peptidomimetic inhibitors of MLL1/WDR5 protein-protein interaction.
J.Am.Chem.Soc., 135:669-682, 2013
Cited by
PubMed: 23210835
DOI: 10.1021/ja306028q
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.601 Å)
Structure validation

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