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7TA5
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BU of 7ta5 by Molmil
Crystal structure of cyanophycin synthetase 2 from Gloeothece citriformis
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BICINE, D(-)-TARTARIC ACID, ...
Authors:Sharon, I, Schmeing, T.M.
Deposit date:2021-12-20
Release date:2022-03-02
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure and Function of the beta-Asp-Arg Polymerase Cyanophycin Synthetase 2.
Acs Chem.Biol., 17, 2022
2CQY
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BU of 2cqy by Molmil
Solution structure of B domain from human propionyl-CoA carboxylase alpha subunit
Descriptor: Propionyl-CoA carboxylase alpha chain, mitochondrial
Authors:Suetake, T, Hayashi, F, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-05-20
Release date:2005-11-20
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:Solution structure of B domain from human propionyl-CoA carboxylase alpha subunit
To be Published
8FXH
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BU of 8fxh by Molmil
Cryo-EM structure of Stanieria sp. CphA2
Descriptor: RimK domain-containing protein ATP-grasp
Authors:Markus, L.M, Sharon, I, Strauss, M, Schmeing, T.M.
Deposit date:2023-01-24
Release date:2023-06-14
Last modified:2023-11-08
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Structure and function of a hexameric cyanophycin synthetase 2.
Protein Sci., 32, 2023
8FXI
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BU of 8fxi by Molmil
Cryo-EM structure of Stanieria sp. CphA2 in complex with ADPCP and 4x(beta-Asp-Arg)
Descriptor: 1-[(4-aminopyrimidin-5-yl)amino]-2,5-anhydro-1-deoxy-6-O-[(S)-hydroxy{[(R)-hydroxy(phosphonomethyl)phosphoryl]oxy}phosphoryl]-D-allitol, 4x(beta-Asp-Arg), MAGNESIUM ION, ...
Authors:Markus, L.M, Sharon, I, Strauss, M, Schmeing, T.M.
Deposit date:2023-01-24
Release date:2023-06-14
Last modified:2023-11-08
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Structure and function of a hexameric cyanophycin synthetase 2.
Protein Sci., 32, 2023
6YBP
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BU of 6ybp by Molmil
Propionyl-CoA carboxylase of Methylorubrum extorquens with bound CoA
Descriptor: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, COENZYME A, Propionyl-CoA carboxylase alpha subunit, ...
Authors:Schuller, J.M, Schuller, S.K, Zarzycki, J, Scheffen, M, Marchal, D.M, Erb, T.J.
Deposit date:2020-03-17
Release date:2020-10-28
Last modified:2021-05-12
Method:ELECTRON MICROSCOPY (3.48 Å)
Cite:A new-to-nature carboxylation module to improve natural and synthetic CO2 fixation
Nat Catal, 2021
5MLK
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BU of 5mlk by Molmil
Biotin dependent carboxylase AccA3 dimer from Mycobacterium tuberculosis (Rv3285)
Descriptor: Acetyl-COA carboxylase
Authors:Bennett, M.D, Hogbom, M.
Deposit date:2016-12-07
Release date:2017-03-08
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.939 Å)
Cite:Crystal structure of the essential biotin-dependent carboxylase AccA3 from Mycobacterium tuberculosis.
FEBS Open Bio, 7, 2017
1M6V
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BU of 1m6v by Molmil
Crystal Structure of the G359F (small subunit) Point Mutant of Carbamoyl Phosphate Synthetase
Descriptor: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, L-ornithine, ...
Authors:Thoden, J.B, Huang, X, Raushel, F.M, Holden, H.M.
Deposit date:2002-07-17
Release date:2002-07-31
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Carbamoyl-phosphate synthetase. Creation of an escape route for ammonia
J.Biol.Chem., 277, 2002
6UEL
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BU of 6uel by Molmil
CPS1 bound to allosteric inhibitor H3B-193
Descriptor: Carbamoyl-phosphate synthase [ammonia], mitochondrial, N~1~-[(4-fluorophenyl)methyl]-N~1~-methyl-N~4~-(4-methyl-1,3-thiazol-2-yl)piperidine-1,4-dicarboxamide, ...
Authors:Larsen, N.A, Nguyen, T.V.
Deposit date:2019-09-21
Release date:2020-03-18
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Small Molecule Inhibition of CPS1 Activity through an Allosteric Pocket.
Cell Chem Biol, 27, 2020
6W2J
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BU of 6w2j by Molmil
CPS1 bound to allosteric inhibitor H3B-374
Descriptor: (2-fluoranyl-4-methoxy-phenyl)-[(3~{R},5~{R})-4-(2-fluoranyl-4-methoxy-phenyl)carbonyl-3,5-dimethyl-piperazin-1-yl]methanone, 1,2-ETHANEDIOL, Carbamoyl-phosphate synthase [ammonia], ...
Authors:Larsen, N.A, Nguyen, T.V.
Deposit date:2020-03-05
Release date:2021-01-13
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Discovery of 2,6-Dimethylpiperazines as Allosteric Inhibitors of CPS1.
Acs Med.Chem.Lett., 11, 2020
5KKN
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BU of 5kkn by Molmil
Crystal structure of human ACC2 BC domain in complex with ND-646, the primary amide of ND-630
Descriptor: 2-[1-[(2~{R})-2-(2-methoxyphenyl)-2-(oxan-4-yloxy)ethyl]-5-methyl-6-(1,3-oxazol-2-yl)-2,4-bis(oxidanylidene)thieno[2,3-d]pyrimidin-3-yl]-2-methyl-propanamide, Acetyl-CoA carboxylase 2
Authors:Wang, R, Paul, D, Tong, L.
Deposit date:2016-06-22
Release date:2016-07-13
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats.
Proc.Natl.Acad.Sci.USA, 113, 2016
4RCN
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BU of 4rcn by Molmil
Structure and function of a single-chain, multi-domain long-chain acyl-coa carboxylase
Descriptor: long-chain acyl-CoA carboxylase
Authors:Tran, T.H, Tong, L.
Deposit date:2014-09-16
Release date:2014-11-05
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.01 Å)
Cite:Structure and function of a single-chain, multi-domain long-chain acyl-CoA carboxylase.
Nature, 518, 2015
1T36
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BU of 1t36 by Molmil
Crystal structure of E. coli carbamoyl phosphate synthetase small subunit mutant C248D complexed with uridine 5'-monophosphate
Descriptor: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, Carbamoyl-phosphate synthase large chain, ...
Authors:Thoden, J.B, Huang, X, Raushel, F.M, Holden, H.M.
Deposit date:2004-04-24
Release date:2004-09-21
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Long-range allosteric transitions in carbamoyl phosphate synthetase.
Protein Sci., 13, 2004
5KS8
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BU of 5ks8 by Molmil
Crystal structure of two-subunit pyruvate carboxylase from Methylobacillus flagellatus
Descriptor: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, MANGANESE (II) ION, PYRUVIC ACID, ...
Authors:Choi, P.H, Tong, L.
Deposit date:2016-07-07
Release date:2016-10-19
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (3.01 Å)
Cite:A distinct holoenzyme organization for two-subunit pyruvate carboxylase.
Nat Commun, 7, 2016
1W96
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BU of 1w96 by Molmil
Crystal Structure of Biotin Carboxylase Domain of Acetyl-coenzyme A Carboxylase from Saccharomyces cerevisiae in Complex with Soraphen A
Descriptor: ACETYL-COENZYME A CARBOXYLASE, SORAPHEN A
Authors:Shen, Y, Volrath, S.L, Weatherly, S.C, Elich, T.D, Tong, L.
Deposit date:2004-10-06
Release date:2005-01-04
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A Mechanism for the Potent Inhibition of Eukaryotic Acetyl-Coenzyme a Carboxylase by Soraphen A, a Macrocyclic Polyketide Natural Product
Mol.Cell, 16, 2004
1W93
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BU of 1w93 by Molmil
Crystal Structure of Biotin Carboxylase Domain of Acetyl-Coenzyme A Carboxylase from Saccharomyces cerevisiae
Descriptor: ACETYL-COENZYME A CARBOXYLASE
Authors:Shen, Y, Volrath, S.L, Weatherly, S.C, Elich, T.D, Tong, L.
Deposit date:2004-10-05
Release date:2005-01-04
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A Mechanism for the Potent Inhibition of Eukaryotic Acetyl-Coenzyme a Carboxylase by Soraphen A, a Macrocyclic Polyketide Natural Product
Mol.Cell, 16, 2004
1JDB
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BU of 1jdb by Molmil
CARBAMOYL PHOSPHATE SYNTHETASE FROM ESCHERICHIA COLI
Descriptor: ADENOSINE-5'-DIPHOSPHATE, CARBAMOYL PHOSPHATE SYNTHETASE, CHLORIDE ION, ...
Authors:Thoden, J.B, Holden, H.M, Wesenberg, G, Raushel, F.M, Rayment, I.
Deposit date:1997-03-25
Release date:1998-06-17
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The structure of carbamoyl phosphate synthetase determined to 2.1 A resolution.
Acta Crystallogr.,Sect.D, 55, 1999
1KEE
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BU of 1kee by Molmil
Inactivation of the Amidotransferase Activity of Carbamoyl Phosphate Synthetase by the Antibiotic Acivicin
Descriptor: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, Carbamoyl-phosphate synthetase large chain, ...
Authors:Miles, B.W, Thoden, J.B, Holden, H.M, Raushel, F.M.
Deposit date:2001-11-15
Release date:2001-12-21
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Inactivation of the amidotransferase activity of carbamoyl phosphate synthetase by the antibiotic acivicin.
J.Biol.Chem., 277, 2002
6YBQ
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BU of 6ybq by Molmil
Engineered glycolyl-CoA carboxylase (quintuple mutant) with bound CoA
Descriptor: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, COENZYME A, Propionyl-CoA carboxylase alpha subunit, ...
Authors:Schuller, J.M, Schuller, S.K, Zarzycki, J, Scheffen, M, Marchal, D.M, Erb, T.J.
Deposit date:2020-03-17
Release date:2020-10-28
Last modified:2021-05-12
Method:ELECTRON MICROSCOPY (1.96 Å)
Cite:A new-to-nature carboxylation module to improve natural and synthetic CO2 fixation
Nat Catal, 2021
4RZQ
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BU of 4rzq by Molmil
Structural Analysis of Substrate, Reaction Intermediate and Product Binding in Haemophilus influenzae Biotin Carboxylase
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Biotin carboxylase, methyl (3aS,4S,6aR)-4-(5-methoxy-5-oxopentyl)-2-oxohexahydro-1H-thieno[3,4-d]imidazole-1-carboxylate
Authors:Broussard, T.C, Pakhomova, S, Neau, D.B, Champion, T.S, Bonnot, R, Waldrop, G.L.
Deposit date:2014-12-23
Release date:2015-06-10
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Structural Analysis of Substrate, Reaction Intermediate, and Product Binding in Haemophilus influenzae Biotin Carboxylase.
Biochemistry, 54, 2015
1ULZ
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BU of 1ulz by Molmil
Crystal structure of the biotin carboxylase subunit of pyruvate carboxylase
Descriptor: pyruvate carboxylase n-terminal domain
Authors:Kondo, S, Nakajima, Y, Sugio, S, Yong-Biao, J, Sueda, S, Kondo, H.
Deposit date:2003-09-18
Release date:2004-03-09
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of the biotin carboxylase subunit of pyruvate carboxylase from Aquifex aeolicus at 2.2 A resolution.
Acta Crystallogr.,Sect.D, 60, 2004
3BG5
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BU of 3bg5 by Molmil
Crystal Structure of Staphylococcus Aureus Pyruvate Carboxylase
Descriptor: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, ADENOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, ...
Authors:Xiang, S, Tong, L.
Deposit date:2007-11-26
Release date:2008-02-26
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structures of human and Staphylococcus aureus pyruvate carboxylase and molecular insights into the carboxyltransfer reaction.
Nat.Struct.Mol.Biol., 15, 2008
2YL2
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BU of 2yl2 by Molmil
Crystal structure of human acetyl-CoA carboxylase 1, biotin carboxylase (BC) domain
Descriptor: ACETYL-COA CARBOXYLASE 1
Authors:Muniz, J.R.C, Froese, D.S, Krysztofinska, E, Vollmar, M, Beltrami, A, Krojer, T, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Yue, W.W, Oppermann, U.
Deposit date:2011-05-31
Release date:2011-06-15
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Structure of Human Acetyl-Coa Carboxylase 1, Biotin Carboxylase (Bc) Domain
To be Published
3RUP
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BU of 3rup by Molmil
Crystal structure of E.coli biotin carboxylase in complex with two ADP and two Ca ions
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Biotin carboxylase, CALCIUM ION, ...
Authors:Chou, C.Y, Tong, L.
Deposit date:2011-05-05
Release date:2011-05-18
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Structural and biochemical studies on the regulation of biotin carboxylase by substrate inhibition and dimerization.
J.Biol.Chem., 286, 2011
3RV4
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BU of 3rv4 by Molmil
Crystal structure of E.coli biotin carboxylase R16E mutant in complex with Mg-ADP and bicarbonate
Descriptor: ADENOSINE-5'-DIPHOSPHATE, BICARBONATE ION, Biotin carboxylase, ...
Authors:Chou, C.Y, Tong, L.
Deposit date:2011-05-05
Release date:2011-05-18
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Structural and biochemical studies on the regulation of biotin carboxylase by substrate inhibition and dimerization.
J.Biol.Chem., 286, 2011
6G2H
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BU of 6g2h by Molmil
Filament of acetyl-CoA carboxylase and BRCT domains of BRCA1 (ACC-BRCT) core at 4.6 A resolution
Descriptor: Acetyl-CoA carboxylase 1
Authors:Hunkeler, M, Hagmann, A, Stuttfeld, E, Chami, M, Stahlberg, H, Maier, T.
Deposit date:2018-03-23
Release date:2018-06-13
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (4.6 Å)
Cite:Structural basis for regulation of human acetyl-CoA carboxylase.
Nature, 558, 2018

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数据于2024-09-18公开中

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