1W96

Crystal Structure of Biotin Carboxylase Domain of Acetyl-coenzyme A Carboxylase from Saccharomyces cerevisiae in Complex with Soraphen A

Summary for 1W96

Entry DOI	10.2210/pdb1w96/pdb
Related	1OD2 1OD4 1UYR 1UYS 1UYT 1UYV 1W2X 1W93
Descriptor	ACETYL-COENZYME A CARBOXYLASE, SORAPHEN A (3 entities in total)
Functional Keywords	ligase, obesity, diabetes, fatty acid metabolism, structure-based drug design, allosteric inhibition, polyketide
Biological source	SACCHAROMYCES CEREVISIAE (BAKER'S YEAST)
Cellular location	Cytoplasm: Q00955
Total number of polymer chains	3
Total formula weight	186519.02
Authors	Shen, Y.,Volrath, S.L.,Weatherly, S.C.,Elich, T.D.,Tong, L. (deposition date: 2004-10-06, release date: 2005-01-04, Last modification date: 2011-07-13)
Primary citation	Shen, Y.,Volrath, S.L.,Weatherly, S.C.,Elich, T.D.,Tong, L. A Mechanism for the Potent Inhibition of Eukaryotic Acetyl-Coenzyme a Carboxylase by Soraphen A, a Macrocyclic Polyketide Natural Product Mol.Cell, 16:881-, 2004 Cited by PubMed: 15610732 DOI: 10.1016/J.MOLCEL.2004.11.034 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation