Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

7S87
DownloadVisualize
BU of 7s87 by Molmil
Crystal Structure of Dihydroorotate dehydrogenase from Plasmodium falciparum in complex with Orotate, FMN, and inhibitor NCGC00600348-01
Descriptor: (4R)-3-methyl-5-[(4R)-4-methyl-3,4-dihydroisoquinolin-2(1H)-yl]thieno[2,3-e][1,2,4]triazolo[4,3-c]pyrimidine, ACETATE ION, Dihydroorotate dehydrogenase (quinone), ...
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2021-09-17
Release date:2021-09-29
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Crystal Structure of Dihydroorotate dehydrogenase from Plasmodium falciparum in complex with Orotate, FMN, and inhibitor NCGC00600348-01
To Be Published
5MVC
DownloadVisualize
BU of 5mvc by Molmil
Crystal structure of potent human Dihydroorotate Dehydrogenase inhibitors based on hydroxylated azole scaffolds
Descriptor: 4-oxidanyl-~{N}-[2,3,5,6-tetrakis(fluoranyl)-4-phenyl-phenyl]-1,2,5-thiadiazole-3-carboxamide, ACETATE ION, CHLORIDE ION, ...
Authors:Goyal, P, Andersson, M, Moritzer, A.C, Sainas, S, Pippione, A.C, Boschi, D, Al-Kadaraghi, S, Lolli, M, Friemann, R.
Deposit date:2017-01-16
Release date:2017-03-08
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Design, synthesis, biological evaluation and X-ray structural studies of potent human dihydroorotate dehydrogenase inhibitors based on hydroxylated azole scaffolds.
Eur J Med Chem, 129, 2017
5FI8
DownloadVisualize
BU of 5fi8 by Molmil
Crystal structure of plasmodium falciparum dihydroorotate dehydrogenase bounded with DSM422 (Tetrahydro-2-naphthyl and 2-indanyl triazolopyrimidine)
Descriptor: 2-[1,1-bis(fluoranyl)ethyl]-~{N}-[(2~{S})-7-bromanyl-1,2,3,4-tetrahydronaphthalen-2-yl]-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine, Dihydroorotate dehydrogenase (quinone), mitochondrial, ...
Authors:Deng, X, Kokkonda, S, Tomchick, D, Phillips, M.
Deposit date:2015-12-22
Release date:2016-05-18
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.32 Å)
Cite:Tetrahydro-2-naphthyl and 2-Indanyl Triazolopyrimidines Targeting Plasmodium falciparum Dihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity.
J.Med.Chem., 59, 2016
5XFV
DownloadVisualize
BU of 5xfv by Molmil
Crystal structures of FMN-bound form of dihydroorotate dehydrogenase from Trypanosoma brucei
Descriptor: Dihydroorotate dehydrogenase (fumarate), FLAVIN MONONUCLEOTIDE, MALONATE ION
Authors:Kubota, T, Tani, O, Yamaguchi, T, Namatame, I, Sakashita, H, Furukawa, K, Yamasaki, K.
Deposit date:2017-04-11
Release date:2018-04-25
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Crystal structures of FMN-bound and FMN-free forms of dihydroorotate dehydrogenase fromTrypanosoma brucei.
FEBS Open Bio, 8, 2018
8RAK
DownloadVisualize
BU of 8rak by Molmil
Crystal structure of human Dihydroorotate Dehydrogenase in complex with the inhibitor 2-Hydroxy-N-(2-isopropyl-5-methyl-4-(pyridin-4-yloxy)phenyl)pyrazolo[1,5-a]pyridine-3-carboxamide
Descriptor: ACETATE ION, Dihydroorotate dehydrogenase (quinone), mitochondrial, ...
Authors:Alberti, M, Miggiano, R.
Deposit date:2023-12-01
Release date:2024-06-19
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:An alternative conformation of the N-terminal loop of human dihydroorotate dehydrogenase drives binding to a potent antiproliferative agent.
Acta Crystallogr D Struct Biol, 80, 2024
4XQ6
DownloadVisualize
BU of 4xq6 by Molmil
CRYSTAL STRUCTURE OF DIHYDROOROTATE DEHYDROGENSE from MYCOBACTERIUM TUBERCULOSIS
Descriptor: CHLORIDE ION, Dihydroorotate dehydrogenase (quinone), FLAVIN MONONUCLEOTIDE, ...
Authors:Kishor, C, Addlagatta, A.
Deposit date:2015-01-19
Release date:2016-01-20
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of Dihydroorotate Dehydrogenase form Mycobacterium Tuberculosis
To Be Published
6ET4
DownloadVisualize
BU of 6et4 by Molmil
HUMAN DIHYDROOROTATE DEHYDROGENASE IN COMPLEX WITH NOVEL INHIBITOR
Descriptor: (4S)-2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, ACETIC ACID, CHLORIDE ION, ...
Authors:Hakansson, M, Walse, B, Gustavsson, A.-L, Lain, S.
Deposit date:2017-10-25
Release date:2018-03-28
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage.
Nat Commun, 9, 2018
6QU7
DownloadVisualize
BU of 6qu7 by Molmil
Crystal structure of human DHODH in complex with BAY 2402234
Descriptor: ACETATE ION, Dihydroorotate dehydrogenase (quinone), mitochondrial, ...
Authors:Friberg, A, Gradl, S.
Deposit date:2019-02-26
Release date:2019-06-05
Last modified:2024-05-15
Method:X-RAY DIFFRACTION (1.52 Å)
Cite:The novel dihydroorotate dehydrogenase (DHODH) inhibitor BAY 2402234 triggers differentiation and is effective in the treatment of myeloid malignancies.
Leukemia, 33, 2019
4WZH
DownloadVisualize
BU of 4wzh by Molmil
Dihydroorotate dehydrogenase from Leishmania Viannia braziliensis
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Dihydroorotate dehydrogenase, FLAVIN MONONUCLEOTIDE, ...
Authors:Reis, R.A.G, Lorenzato, E, Silva, V.C, Nonato, M.C.
Deposit date:2014-11-19
Release date:2015-05-13
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Recombinant production, crystallization and crystal structure determination of dihydroorotate dehydrogenase from Leishmania (Viannia) braziliensis.
Acta Crystallogr.,Sect.F, 71, 2015
7K2U
DownloadVisualize
BU of 7k2u by Molmil
DHODH IN COMPLEX WITH LIGAND 13
Descriptor: 6-fluoro-2-(2'-fluoro[1,1'-biphenyl]-4-yl)-N-methoxy-3-methylquinoline-4-carboxamide, ACETATE ION, Dihydroorotate dehydrogenase (quinone), ...
Authors:Shaffer, P.L.
Deposit date:2020-09-09
Release date:2020-10-21
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:A carboxylic acid isostere screen of the DHODH inhibitor Brequinar.
Bioorg.Med.Chem.Lett., 30, 2020
1OVD
DownloadVisualize
BU of 1ovd by Molmil
THE K136E MUTANT OF LACTOCOCCUS LACTIS DIHYDROOROTATE DEHYDROGENASE A IN COMPLEX WITH OROTATE
Descriptor: DIHYDROOROTATE DEHYDROGENASE A, FLAVIN MONONUCLEOTIDE, GLYCEROL, ...
Authors:Norager, S, Arent, S, Bjornberg, O, Ottosen, M, Lo Leggio, L, Jensen, K.F, Larsen, S.
Deposit date:2003-03-26
Release date:2003-08-19
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Lactococcus lactis dihydroorotate dehydrogenase A mutants reveal important facets of the enzymatic function.
J.Biol.Chem., 278, 2003
2WV8
DownloadVisualize
BU of 2wv8 by Molmil
Complex of human dihydroorotate dehydrogenase with the inhibitor 221290
Descriptor: 2-ACETAMIDO-5-(4-PHENYLPHENYL)BENZOIC ACID, ACETATE ION, DECYLAMINE-N,N-DIMETHYL-N-OXIDE, ...
Authors:Walse, B, Svensson, B, Fritzson, I, Dahlberg, L, Wellmar, U, Al-Karadaghi, S.
Deposit date:2009-10-15
Release date:2010-08-25
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Inhibition of Human Dhodh by 4-Hydroxycoumarins, Fenamic Acids, and N-(Alkylcarbonyl)Anthranilic Acids Identified by Structure-Guided Fragment Selection.
Chemmedchem, 5, 2010
5TBO
DownloadVisualize
BU of 5tbo by Molmil
Crystal structure of Plasmodium falciparum dihydroorotate dehydrogenase bound with Inhibitor DSM421
Descriptor: 2-(1,1-difluoroethyl)-5-methyl-N-[6-(trifluoromethyl)pyridin-3-yl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine, Dihydroorotate dehydrogenase (quinone), mitochondrial, ...
Authors:Deng, X, Phillips, M.
Deposit date:2016-09-12
Release date:2016-09-28
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.151 Å)
Cite:A Triazolopyrimidine-Based Dihydroorotate Dehydrogenase Inhibitor with Improved Drug-like Properties for Treatment and Prevention of Malaria.
ACS Infect Dis, 2, 2016
4CQ9
DownloadVisualize
BU of 4cq9 by Molmil
Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) in complex with IDI-6253
Descriptor: 6-(3,4-dihydroisoquinolin-2(1H)-yl)-3-methyl-[1,2,4]triazolo[3,4-a]phthalazine, DIHYDROOROTATE DEHYDROGENASE, FLAVIN MONONUCLEOTIDE, ...
Authors:Rowland, P.
Deposit date:2014-02-12
Release date:2014-04-30
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.72 Å)
Cite:In Vitro Resistance Selections for Plasmodium Falciparum Dihydroorotate Dehydrogenase Inhibitors Give Mutants with Multiple Point Mutations in the Drug-Binding Site and Altered Growth.
J.Biol.Chem., 289, 2014
4CQA
DownloadVisualize
BU of 4cqa by Molmil
Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) in complex with IDI-6273
Descriptor: 2-(4-chlorobenzyl)-8-ethoxy-1,3-dimethylcyclohepta[c]pyrrol-4(2H)-one, DIHYDROOROTATE DEHYDROGENASE, FLAVIN MONONUCLEOTIDE, ...
Authors:Rowland, P.
Deposit date:2014-02-12
Release date:2014-04-30
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.82 Å)
Cite:In Vitro Resistance Selections for Plasmodium Falciparum Dihydroorotate Dehydrogenase Inhibitors Give Mutants with Multiple Point Mutations in the Drug-Binding Site and Altered Growth.
J.Biol.Chem., 289, 2014
4EF9
DownloadVisualize
BU of 4ef9 by Molmil
Crystal structure of dihydroorotate dehydrogenase from Leishmania major in complex with 4-Nitrophenyl isothiocyanate
Descriptor: Dihydroorotate dehydrogenase, FLAVIN MONONUCLEOTIDE, GLYCEROL, ...
Authors:Pinheiro, M.P, Emery, F.S, Nonato, M.C.
Deposit date:2012-03-29
Release date:2012-12-12
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Target sites for the design of anti-trypanosomatid drugs based on the structure of dihydroorotate dehydrogenase.
Curr.Pharm.Des., 19, 2013
4EF8
DownloadVisualize
BU of 4ef8 by Molmil
Crystal structure of dihydroorotate dehydrogenase from Leishmania major in complex with Phenyl isothiocyanate
Descriptor: Dihydroorotate dehydrogenase, FLAVIN MONONUCLEOTIDE, GLYCEROL, ...
Authors:Pinheiro, M.P, Emery, F.S, Nonato, M.C.
Deposit date:2012-03-29
Release date:2012-12-12
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:Target sites for the design of anti-trypanosomatid drugs based on the structure of dihydroorotate dehydrogenase.
Curr.Pharm.Des., 19, 2013
5MUT
DownloadVisualize
BU of 5mut by Molmil
Crystal structure of potent human Dihydroorotate Dehydrogenase inhibitors based on hydroxylated azole scaffolds
Descriptor: 2-methyl-5-oxidanyl-~{N}-[2,3,5,6-tetrakis(fluoranyl)-4-phenyl-phenyl]-1,2,3-triazole-4-carboxamide, ACETATE ION, CHLORIDE ION, ...
Authors:Goyal, P, Andersson, M, Moritzer, A.C, Sainas, S, Pippione, A.C, Boschi, D, Al-Kadaraghi, S, Lolli, M, Friemann, R.
Deposit date:2017-01-14
Release date:2017-03-08
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Design, synthesis, biological evaluation and X-ray structural studies of potent human dihydroorotate dehydrogenase inhibitors based on hydroxylated azole scaffolds.
Eur J Med Chem, 129, 2017
6SYP
DownloadVisualize
BU of 6syp by Molmil
Human DHODH bound to inhibitor IPP/CNRS-A017
Descriptor: 2-[4-[2,6-bis(fluoranyl)phenoxy]-5-methyl-3-propan-2-yloxy-pyrazol-1-yl]-5-cyclopropyl-3-fluoranyl-pyridine, Dihydroorotate dehydrogenase, FLAVIN MONONUCLEOTIDE, ...
Authors:Kraemer, A, Janin, Y, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2019-09-30
Release date:2019-10-09
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Optimization of pyrazolo[1,5-a]pyrimidines lead to the identification of a highly selective casein kinase 2 inhibitor
Eur.J.Med.Chem., 208, 2020
5MVD
DownloadVisualize
BU of 5mvd by Molmil
Crystal structure of potent human Dihydroorotate Dehydrogenase inhibitors based on hydroxylated azole scaffolds
Descriptor: 1,5-dimethyl-3-oxidanyl-~{N}-[2,3,5,6-tetrakis(fluoranyl)-4-phenyl-phenyl]pyrazole-4-carboxamide, ACETATE ION, CHLORIDE ION, ...
Authors:Goyal, P, Andersson, M, Moritzer, A.C, Sainas, S, Pippione, A.C, Boschi, D, Al-Kadaraghi, S, Lolli, M, Friemann, R.
Deposit date:2017-01-16
Release date:2017-03-08
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Design, synthesis, biological evaluation and X-ray structural studies of potent human dihydroorotate dehydrogenase inhibitors based on hydroxylated azole scaffolds.
Eur J Med Chem, 129, 2017
8OFW
DownloadVisualize
BU of 8ofw by Molmil
Crystal structure of the full-length dihydroorotate dehydrogenase from Mycobacterium tuberculosis
Descriptor: Dihydroorotate dehydrogenase (quinone), FLAVIN MONONUCLEOTIDE
Authors:Alberti, M, Ferraris, D.M, Miggiano, R.
Deposit date:2023-03-17
Release date:2023-09-06
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:Biochemical characterization of Mycobacterium tuberculosis dihydroorotate dehydrogenase and identification of a selective inhibitor.
Febs Lett., 597, 2023
3OIX
DownloadVisualize
BU of 3oix by Molmil
Crystal structure of the putative dihydroorotate dehydrogenase from Streptococcus mutans
Descriptor: FLAVIN MONONUCLEOTIDE, GLYCEROL, Putative dihydroorotate dehydrogenase; dihydroorotate oxidase
Authors:Liu, Y, Gao, Z.Q, Liu, C.P, Dong, Y.H.
Deposit date:2010-08-20
Release date:2010-09-08
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.399 Å)
Cite:Structure of the putative dihydroorotate dehydrogenase from Streptococcus mutans
Acta Crystallogr.,Sect.F, 67, 2011
8K4F
DownloadVisualize
BU of 8k4f by Molmil
DHODH in complex with compound A0
Descriptor: 5-cyclopropyl-2-[1-[(2-fluorophenyl)methyl]pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-4-amine, 6-[bis(oxidanyl)methyl]-5~{H}-pyrimidine-2,4-dione, ACETATE ION, ...
Authors:Jian, L, Sun, Q.
Deposit date:2023-07-18
Release date:2024-05-29
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:Discovery and Optimization of Novel h DHODH Inhibitors for the Treatment of Inflammatory Bowel Disease.
J.Med.Chem., 66, 2023
7WYF
DownloadVisualize
BU of 7wyf by Molmil
Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) in complex with its inhibitor 50
Descriptor: Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, ...
Authors:Zhu, L, Li, H.
Deposit date:2022-02-16
Release date:2023-02-22
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) in complex with its inhibitor 50
To Be Published
6OC0
DownloadVisualize
BU of 6oc0 by Molmil
Crystal structure of human DHODH with OSU-03012
Descriptor: Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, ...
Authors:Durst, M.A, Lavie, A.
Deposit date:2019-03-21
Release date:2019-11-13
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Metabolic Modifier Screen Reveals Secondary Targets of Protein Kinase Inhibitors within Nucleotide Metabolism.
Cell Chem Biol, 27, 2020

225158

数据于2024-09-18公开中

PDB statisticsPDBj update infoContact PDBjnumon